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Drug Safety Evaluation

Asunaprevir for hepatitis C: a safety evaluation

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Isabella Esposito, Sebastián Marciano & Julieta Trinks. (2018) Pharmacokinetic and pharmacodynamic evaluation of daclatasvir, asunaprevir plus beclabuvir as a fixed-dose co-formulation for the treatment of hepatitis C. Expert Opinion on Drug Metabolism & Toxicology 14:6, pages 649-657.
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Yoshihito Uchida, Kayoko Naiki, Jun-ichi Kouyama, Kayoko Sugawara, Masamitsu Nakao, Daisuke Motoya, Mie Inao, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya & Satoshi Mochida. (2018) Serum asunaprevir concentrations showing correlation with the extent of liver fibrosis as a factor inducing liver injuries in patients with genotype-1b hepatitis C virus receiving daclatasvir plus asunaprevir therapy. PLOS ONE 13:10, pages e0205600.
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Li Zhu, Hanbin Li, Phyllis Chan, Timothy Eley, Yash Gandhi, Marc Bifano, Mayu Osawa, Takayo Ueno, Eric Hughes, Malaz AbuTarif, Richard Bertz & Tushar Garimella. (2018) Population Pharmacokinetic Analysis of Asunaprevir in Subjects with Hepatitis C Virus Infection. Infectious Diseases and Therapy 7:2, pages 261-275.
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Shinya Maekawa, Mitsuaki Sato, Natsuhiko Kuratomi, Taisuke Inoue, Yuichiro Suzuki, Akihisa Tatsumi, Mika Miura, Shuya Matsuda, Masaru Muraoka, Natsuko Nakakuki, Fumitake Amemiya, Shinichi Takano, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Tadashi Sato, Minoru Sakamoto, Miyako Murakawa, Mina Nakagawa, Yasuhiro Asahina & Nobuyuki Enomoto. (2017) Association between alanine aminotransferase elevation and UGT1A1*6 polymorphisms in daclatasvir and asunaprevir combination therapy for chronic hepatitis C. Journal of Gastroenterology 53:6, pages 780-786.
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Christoph Welsch, Mira Efinger, Michael von Wagner, Eva Herrmann, Stefan Zeuzem, Tania M. Welzel & Christian M. Lange. (2017) Ongoing liver inflammation in patients with chronic hepatitis C and sustained virological response. PLOS ONE 12:2, pages e0171755.
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