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Proton pump inhibitors and histamine-2 receptor antagonists in the intensive care setting: focus on therapeutic and adverse events

, PharmD MPH FCCM FCCP (Professor) , , PharmD (Clinical Assistant Professor) , , PharmD (Associate Professor) & , PharmD FCCM FCCP (Professor)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Jianan Bao, Ling Zhou, Mengying Xu & Jingjing Ma. (2023) The impact of pharmacist intervention on the intravenous-to-oral switch therapy of proton pump inhibitors in cardiovascular surgery. Expert Opinion on Drug Safety 22:7, pages 611-619.
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Rawi Hazzan, Usama Darawsha, Ziv Neeman & Ariel Aviv. (2021) Association of proton pump inhibitor use with the development of febrile neutropenia in lymphoma patients. Expert Review of Hematology 14:5, pages 503-507.
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Chuanwei Xin, Zhu Dong, Mengmeng Lin & Gong-Hua Li. (2018) The impact of pharmaceutical interventions on the rational use of proton pump inhibitors in a Chinese hospital. Patient Preference and Adherence 12, pages 21-26.
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Articles from other publishers (10)

Bruna Gigante, Jerrold H Levy, Eric van Gorp, Alessandro Bartoloni, Marie-Luce Bochaton-Piallat, Magnus Bäck, Hugo ten Cate, Christina Christersson, José Luis Ferreiro, Tobias Geisler, Esther Lutgens, Sam Schulman, Robert F Storey, Jecko Thachil, Gemma Vilahur, Patricia C Liaw & Bianca Rocca. (2023) Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis. European Heart Journal.
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Carly Boyd, Tanna Hassig & Robert MacLaren. (2021) A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 41:10, pages 820-827.
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Chen Chen, Hui Liu, Ruqiao Duan, Fangfang Wang & Liping Duan. (2021) The efficacy and safety of acid suppressants for gastrointestinal bleeding prophylaxis in cardiac care unit patients. Journal of Gastroenterology and Hepatology 36:8, pages 2131-2140.
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Jeffrey F. Barletta, Mitchell S. Buckley & Robert MacLaren. (2019) The SUP-ICU Trial: Does It Confirm or Condemn the Practice of Stress Ulcer Prophylaxis?. Hospital Pharmacy 55:2, pages 96-101.
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Robert MacLaren, Richard A. Radcliffe, Edward T. Van Matre, Charles E. Robertson, Diana Ir & Daniel N. Frank. (2019) The Acute Influence of Acid Suppression with Esomeprazole on Gastrointestinal Microbiota and Brain Gene Expression Profiles in a Murine Model of Restraint Stress. Neuroscience 398, pages 206-217.
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Waleed Alhazzani, Fayez Alshamsi, Emilie Belley-Cote, Diane Heels-Ansdell, Romina Brignardello-Petersen, Mustafa Alquraini, Anders Perner, Morten Hylander Møller, Mette Krag, Saleh Almenawer, Bram Rochwerg, Joanna Dionne, Roman Jaeschke, Mohammed Alshahrani, Adam Deane, Dan Perri, Lehana Thebane, Awad Al-Omari, Simon Finfer, Deborah Cook & Gordon Guyatt. (2017) Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials. Intensive Care Medicine 44:1, pages 1-11.
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Nursel Çalık Başaran. (2017) Overutilization of proton pump inhibitors and H2 receptor antagonists in hospitalized medical patients. Cumhuriyet Medical Journal 39:2, pages 487-493.
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Jeffrey F. BarlettaJeffrey J. BrunoMitchell S. BuckleyDeborah J. Cook. (2016) Stress Ulcer Prophylaxis. Critical Care Medicine 44:7, pages 1395-1405.
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Francis K.L. Chan. (2016) Do Proton Pump Inhibitors Exacerbate Nonsteroidal Anti-Inflammatory Drug-Induced Small-Bowel Enteropathy?. Clinical Gastroenterology and Hepatology 14:6, pages 816-817.
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Christine Bernsmeier, Arjuna Singanayagam, Vishal C Patel, Julia Wendon & Charalambos G Antoniades. (2015) Immunotherapy in the treatment and prevention of infection in acute-on-chronic liver failure. Immunotherapy 7:6, pages 641-654.
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