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Expert Opinion on Drug Safety Volume 14, 2015 - Issue 2
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Review

Safety assessment of FDA-approved (orlistat and lorcaserin) anti-obesity medications

Bruno HalpernHospital das Clínicas da Universidade de São Paulo, Department of Endocrinology and Metabology, Obesity Group, 462 cj 72-73, 7h floor, São Paulo-SP, CEP 05410-000, [email protected]
, MD &
Alfredo HalpernHospital das Clínicas da Universidade de São Paulo, Department of Endocrinology and Metabology, Obesity Group, 462 cj 72-73, 7h floor, São Paulo-SP, CEP 05410-000, [email protected]
, MD PhD
Pages 305-315 | Published online: 07 Jan 2015

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Bruno Halpern & Thiago Bosco Mendes. (2022) Obesity, weight loss and gynecologic neoplasms: a narrative review. Women & Health 62:5, pages 372-383.
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Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan & Zhong-Min Liu. (2016) Investigational glucagon-like peptide-1 agonists for the treatment of obesity. Expert Opinion on Investigational Drugs 25:10, pages 1167-1179.
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Michael Tagen, Daniel Mantuani, Liron van Heerden, Alex Holstein, Linda E. Klumpers & Richard Knowles. (2023) The risk of chronic psychedelic and MDMA microdosing for valvular heart disease. Journal of Psychopharmacology 37:9, pages 876-890.
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Bruno Halpern, Marcio C. Mancini, Simone van de Sande-Lee & Paulo Augusto Carvalho Miranda. (2023) “Anti-obesity medications” or “medications to treat obesity” instead of “weight loss drugs” – why language matters – an official statement of the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO) and the Brazilian Society of Endocrinology and Metabolism (SBEM). Archives of Endocrinology and Metabolism 67:4.
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Benudhara Pati, Satyabrata Sendh, Bijayashree Sahu, Sunil Pani, Nivedita Jena & Naresh Chandra Bal. (2023) Recent advancements in pharmacological strategies to modulate energy balance for combating obesity. RSC Medicinal Chemistry 14:8, pages 1429-1445.
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Freek Haerkens, Charlotte Kikken, Laurens Kirkels, Monique van Amstel, Willemijn Wouters, Els van Doornmalen, Christof Francke & Samantha Hughes. (2022) A new use for old drugs: identifying compounds with an anti-obesity effect using a high through-put semi-automated Caenorhabditis elegans screening platform. Heliyon 8:8, pages e10108.
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Shuai Wang, Yunxiao Wang, Shunxin Wang, Shuang Guo, Dongyu Gu, Jifeng Wang & Yi Yang. (2022) Lipase immobilization on multi-walled carbon nanotubes used as a target fishing tool and followed by molecular docking technique to analyze lipase inhibitor from Robinia pseudoacacia L.. Industrial Crops and Products 178, pages 114645.
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Agni Kakouri, Georgia Kanti, Efthymios Kapantais, Alexandros Kokkinos, Leonidas Lanaras, Paul Farajian, Christos Galanakis, Georgios Georgantopoulos, Nikos F. Vlahos, George Mastorakos, Alexandra Bargiota & Georgios Valsamakis. (2021) New Incretin Combination Treatments under Investigation in Obesity and Metabolism: A Systematic Review. Pharmaceuticals 14:9, pages 869.
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Xuelian Zhang, Bin Zhang, Chenyang Zhang, Guibo Sun & Xiaobo Sun. (2021) Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss. Frontiers in Pharmacology 11.
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Zaidatul Akmal Othman, Zaida Zakaria, Joseph Bagi Suleiman, Wan Syaheedah Wan Ghazali & Mahaneem Mohamed. (2021) Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model. Antioxidants 10:2, pages 251.
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Gayane Sargis Vardanyan, Hasmik Samvel Harutyunyan, Michail Iosif Aghajanov & Ruben Sargis Vardanyan. (2020) Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects. Future Medicinal Chemistry 12:20, pages 1865-1884.
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Bruno Halpern & Marcio C. Mancini. (2020) Should the Same Safety Scrutiny of Antiobesity Medications be Applied to Other Chronic Usage Drugs?. Obesity 28:7, pages 1171-1172.
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Hyunkyung Cho, Joo-Youn Lee, Sang Yoon Choi, Chaemin Lim, Min-Kyoung Park, Hyejin An, Jeong Ok Lee, Minsoo Noh, Seunghee Lee & Sanghee Kim. (2020) Identification of a New Chemotype of Anti-Obesity Compounds by Ensemble Screening. ACS Omega 5:8, pages 4338-4346.
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Qin-Qin Song, Yong Rao, Gui-Hua Tang, Zhang-Hua Sun, Jun-Sheng Zhang, Zhi-Shu Huang & Sheng Yin. (2019) Tigliane Diterpenoids as a New Type of Antiadipogenic Agents Inhibit GRα-Dexras1 Axis in Adipocytes. Journal of Medicinal Chemistry 62:4, pages 2060-2075.
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F.‐F. Wang, Y. Wu, Y.‐H. Zhu, T. Ding, R. L. Batterham, F. Qu & P. J. Hardiman. (2018) Pharmacologic therapy to induce weight loss in women who have obesity/overweight with polycystic ovary syndrome: a systematic review and network meta‐analysis. Obesity Reviews 19:10, pages 1424-1445.
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T. Azegami, Y. Yuki, S. Sawada, M. Mejima, K. Ishige, K. Akiyoshi, H. Itoh & H. Kiyono. (2017) Nanogel-based nasal ghrelin vaccine prevents obesity. Mucosal Immunology 10:5, pages 1351-1360.
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Sang Yeoup Lee. (2017) Medical Management of Obesity. The Korean Journal of Helicobacter and Upper Gastrointestinal Research 17:2, pages 66.
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M Thienel, A Fritsche, M Heinrichs, A Peter, M Ewers, H Lehnert, J Born & M Hallschmid. (2016) Oxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men. International Journal of Obesity 40:11, pages 1707-1714.
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Li-Hong Wan, Xiao-Lan Jiang, Yi-Ming Liu, Jin-Jie Hu, Jian Liang & Xun Liao. (2016) Screening of lipase inhibitors from Scutellaria baicalensis extract using lipase immobilized on magnetic nanoparticles and study on the inhibitory mechanism. Analytical and Bioanalytical Chemistry 408:9, pages 2275-2283.
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Yue Chen. (2016) Regulation of food intake and the development of anti-obesity drugs. Drug Discoveries & Therapeutics 10:2, pages 62-73.
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Jessica A. Darnobid & Stephanie B. Jones. (2016) The Perioperative Implications of New Weight Loss Drugs. Advances in Anesthesia 34:1, pages 1-11.
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Robin P. BlackstoneRobin P. Blackstone. 2016. Obesity. Obesity 231 260 .
Wayne Rankin & Gary Wittert. (2015) Anti-obesity drugs. Current Opinion in Lipidology 26:6, pages 536-543.
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Modjtaba Zandian, Cecilia Bergh, Ioannis Ioakimidis, Maryam Esfandiari, Julian Shield, Stafford Lightman, Michael Leon & Per Södersten. (2015) Control of Body Weight by Eating Behavior in Children. Frontiers in Pediatrics 3.
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