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Drug Safety Evaluation

Tigecycline: a critical safety review

, MD & , MD FACP FIDSA FSHEA

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Yuanchao Zhu, Fei Zhao & Pengfei Jin. (2023) Clinical Manifestations and Risk Factors of Tigecycline-Associated Thrombocytopenia. Infection and Drug Resistance 16, pages 6225-6235.
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Hong Zhou, Xiangyu Sun, Shaocheng Lyu, Xiaojia Yu, Ran Li, Huaguang Wang & Zhuoling An. (2023) Evaluation of Tigecycline Utilization and Trends in Antibacterial Resistance from 2018 to 2021 in a Comprehensive Teaching Hospital in China. Infection and Drug Resistance 16, pages 879-889.
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Haibo Lei, Xiang Liu, Zuojun Li & Chunjiang Wang. (2023) Analysis of the clinical characteristics of tigecycline-induced hypofibrinogenemia. Journal of Chemotherapy 35:4, pages 292-297.
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Ning Du, En-Qiang Mao, Zhi-Tao Yang, Hong-Ping Qu, Xian Qian, Ying Shi, Xiao-Lan Bian, Juan He & Er-Zhen Chen. (2022) Intrathecal or Intraventricular Tigecycline Therapy for Central Nervous System Infection Associated with Carbapenem-Resistant Klebsiella pneumoniae. Infection and Drug Resistance 15, pages 7219-7226.
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Matteo Bassetti, Antonio Falletta, Giovanni Cenderello, Daniele R. Giacobbe & Antonio Vena. (2022) Safety evaluation of current therapies for high-risk severely ill patients with carbapenem-resistant infections. Expert Opinion on Drug Safety 21:4, pages 487-498.
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Gianpaolo Perletti, Alberto Trinchieri, Konstantinos Stamatiou & Vittorio Magri. (2022) Safety considerations with new antibacterial approaches for chronic bacterial prostatitis. Expert Opinion on Drug Safety 21:2, pages 171-182.
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X Li, L Li, T Liu, X Hai & B Sun. (2021) Leukocytosis induced by tigecycline in two patients with severe acute pancreatitis. British Journal of Biomedical Science 78:4, pages 225-228.
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Adrian Ceccato, Pierluigi Di Giannatale, Stefano Nogas & Antoni Torres. (2021) Safety considerations of current drug treatment strategies for nosocomial pneumonia. Expert Opinion on Drug Safety 20:2, pages 181-190.
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Aneela Majeed, Sumaiah Alarfaj, Rabih Darouiche & Mayar Mohajer. (2017) An update on emerging therapies for urinary tract infections. Expert Opinion on Emerging Drugs 22:1, pages 53-62.
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Bansi Rakholiya, Priyangi Shah, Yash Patel, Gayatri Patel, Samir Patel & Archita Patel. (2023) A Review on Analytical Methods for Tigecycline Estimation From Its Bulk and Dosage Form. Journal of AOAC International 106:6, pages 1689-1695.
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Andrew M Skinner, Laurica A Petrella, Adam Cheknis & Stuart Johnson. (2023) Antimicrobial susceptibility of Clostridioides difficile to omadacycline and comparator antimicrobials . Journal of Antimicrobial Chemotherapy 78:7, pages 1779-1784.
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João Pedro Rueda Furlan & Eliana Guedes Stehling. (2023) Predicting tigecycline susceptibility in multidrug-resistant Klebsiella species and Escherichia coli strains of environmental origin. Brazilian Journal of Microbiology.
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Yan Zhang, Jie Zhang, Ping Cai, Yang Lu, Ruan-Yang Sun, Meng-Tao Cao, Xiao-Li Xu, Mark A. Webber & Hong-Xia Jiang. (2023) IncHI1 plasmids are epidemic vectors that mediate transmission of tet(X4) in Escherichia coli isolated from China. Frontiers in Microbiology 14.
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Xiaoxuan Yang, Lu Jin, Xuemei Luo, Min Wang, Huaijun Zhu, Yujie Zhou & Weihong Ge. (2022) Serum concentration as a predictor of tigecycline-induced hypofibrinogenemia in critically ill patients: A retrospective cohort study. International Journal of Infectious Diseases 123, pages 136-142.
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Ivana Ćirković & Milena Švabić-Vlahović. (2022) Nosocomial antibiotic strain resistance. Galenika Medical Journal 1:3, pages 60-68.
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I-Hao Lin & Chun-Hao Tsai. (2021) Tigecycline sclerotherapy for recurrent pseudotumor in aseptic lymphocyte-dominant vasculitis-associated lesion after metal-on-metal total hip arthroplasty: A case report. World Journal of Clinical Cases 9:34, pages 10696-10701.
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Aura Rusu & Emanuela Lorena Buta. (2021) The Development of Third-Generation Tetracycline Antibiotics and New Perspectives. Pharmaceutics 13:12, pages 2085.
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Therese M. DuaneJared M. HustonMorgan CollomAdam BeyerSara ParliSara BuckmanMark ShapiroAmy McDonaldJose DiazJeffrey M. TessierJames Sanders. (2021) Surgical Infection Society 2020 Updated Guidelines on the Management of Complicated Skin and Soft Tissue Infections. Surgical Infections 22:4, pages 383-399.
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Niccolò RiccardiJacopo MonticelliRoberta Maria AntonelloGustavo Di LalloDomenico FrezzaRoberto LuzzatiStefano Di Bella. (2021) Therapeutic Options for Infections Due to vanB Genotype Vancomycin-Resistant Enterococci. Microbial Drug Resistance 27:4, pages 536-545.
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Junyan Qu, Chunlu Feng, Huan Li & Xiaoju Lv. (2021) Antibiotic strategies and clinical outcomes for patients with carbapenem-resistant Gram-negative bacterial bloodstream infection. International Journal of Antimicrobial Agents 57:3, pages 106284.
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Rong Zhang, Ning Dong, Zhangqi Shen, Yu Zeng, Jiauyue Lu, Congcong Liu, Hongwei Zhou, Yanyan Hu, Qiaoling Sun, Qipeng Cheng, Lingbing Shu, Jiachang Cai, Edward Wai-Chi Chan, Gongxiang Chen & Sheng Chen. (2020) Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X). Nature Communications 11:1.
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Selliamman Palaniyandi Nallusamy Sharavanan, Chidambaram Subramanian Venkatesan, Singaram Sathiyanarayanan & Senthamaraikannan Kabilan. (2020) Potential Impurities of Tigecycline: Synthesis, Isolation, Characterization and In Vitro Pharmacological Evaluation. Current Pharmaceutical Analysis 16:6, pages 730-742.
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Juan Hu, Yong-hong Xiao, Yi Zheng, Yang-xiao Lai, Xue-ling Fang & Qiang Fang. (2020) Clinical characteristics and risk factors of tigecycline-associated hypofibrinogenaemia in critically ill patients. European Journal of Clinical Pharmacology 76:7, pages 913-922.
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Jesus Ruiz, Paula Ramirez, Esther Villarreal, Mónica Gordon, María Ángeles Sánchez, María Martín & Álvaro Castellanos-Ortega. (2020) Effect of pharmacokinetic/pharmacodynamic ratio on tigecycline clinical response and toxicity in critically ill patients with multidrug-resistant Gram-negative infections. SAGE Open Medicine 8, pages 205031212095889.
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Kai Ming Chow, Wing Fai Pang, Gordon Chun Kau Chan, Chi Bon Leung, Cheuk Chun Szeto & Philip Kam Tao Li. (2019) Beware of drug interaction between tigecycline and tacrolimus. Nephrology 25:1, pages 99-100.
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