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Review

Pharmacotherapy of erectile dysfunction: focus on cardiovascular safety

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Pages 531-540 | Published online: 10 May 2005

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Amar Mohee, Laure Bretsztajn & Ian Eardley. (2012) The evaluation of apomorphine for the treatment of erectile dysfunction. Expert Opinion on Drug Metabolism & Toxicology 8:11, pages 1447-1453.
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Thorsten Reffelmann, Arne Kieback & Robert A Kloner. (2008) The cardiovascular safety of tadalafil. Expert Opinion on Drug Safety 7:1, pages 43-52.
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Thorsten Reffelmann & Robert A Kloner. (2006) Sexual function in hypertensive patients receiving treatment. Vascular Health and Risk Management 2:4, pages 447-455.
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Jorge Navarro-Dorado, Belén Climent, María Elvira López-Oliva, María Pilar Martínez, Marina Hernández-Martín, Ángel Agis-Torres, Paz Recio, María Victoria Barahona, Sara Benedito, Vítor S. Fernandes & Medardo Hernández. (2023) The bitter taste receptor (TAS2R) agonist denatonium promotes a strong relaxation of rat corpus cavernosum. Biochemical Pharmacology 215, pages 115754.
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Vítor S. Fernandes, María Elvira López-Oliva, María Pilar Martínez, Ángel Agis-Torres, Paz Recio, Jorge Navarro-Dorado, María Victoria Barahona, Sara Benedito, Dolores Prieto, Belén Climent & Medardo Hernández. (2022) In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters. Life Sciences 296, pages 120432.
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Matteo Borgini, Pravat Mondal, Ruiting Liu & Peter Wipf. (2021) Chemical modulation of Kv7 potassium channels. RSC Medicinal Chemistry 12:4, pages 483-537.
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Valéria Verri, Alessandro R. Nascimento, Andrea A. Brandao & Eduardo Tibirica. (2020) Effects of chronic type 5 phosphodiesterase inhibition on penile microvascular reactivity in hypertensive patients with erectile dysfunction: a randomized crossover placebo-controlled trial. Journal of Human Hypertension 35:4, pages 360-370.
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T A Jepps, S P Olesen, I A Greenwood & T Dalsgaard. (2016) Molecular and functional characterization of K v 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats . British Journal of Pharmacology 173:9, pages 1478-1490.
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T. Reffelmann & R. A. Kloner. (2009) Phosphodiesterase 5 inhibitors: are they cardioprotective?. Cardiovascular Research 83:2, pages 204-212.
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B H Chung, J Y Lee, S H Lee, S J Yoo, S W Lee & C Y Oh. (2009) Safety and efficacy of the simultaneous administration of udenafil and an α-blocker in men with erectile dysfunction concomitant with BPH/LUTS. International Journal of Impotence Research 21:2, pages 122-128.
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Lorna Hazell, Victoria Cornelius, Lynda V. Wilton & Saad A.W. Shakir. (2009) The safety profile of tadalafil as prescribed in general practice in England: results from a prescription-event monitoring study involving 16 129 patients. BJU International 103:4, pages 506-514.
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Pelin TanerM. Murad BaşarBirsen UnalErtan Batislam. (2007) Effects of Vardenafil on Intraocular Pressure and Orbital Hemodynamics. Journal of Ocular Pharmacology and Therapeutics 23:3, pages 275-279.
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Lorna Hazell, Andrew Boshier, Scott Harris, Lynda V. Wilton & Saad A.W. Shakir. (2007) An observational cohort study investigating the cardiovascular safety of tadalafil when prescribed in primary care in England: mortality due to ischaemic heart disease. BJU International 99:2, pages 387-393.
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Fadi N. Salloum, Yuko Takenoshita, Ramzi A. Ockaili, Vladimir P. Daoud, Eric Chou, Kazu-ichi Yoshida & Rakesh C. Kukreja. (2007) Sildenafil and vardenafil but not nitroglycerin limit myocardial infarction through opening of mitochondrial KATP channels when administered at reperfusion following ischemia in rabbits. Journal of Molecular and Cellular Cardiology 42:2, pages 453-458.
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Thorsten Reffelmann & Robert A. Kloner. 2006. Male Sexual Function. Male Sexual Function 61 75 .
Shahzad G Raja. (2005) Comment: acute myocardial infarction after sildenafil citrate ingestion. Annals of Pharmacotherapy 39:11, pages 1957-1957.
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