Advanced search
Publication Cover
Expert Opinion on Drug Safety Volume 4, 2005 - Issue 4
Submit an article Journal homepage
536
Views
62
CrossRef citations to date
0
Altmetric
Review

A review of clozapine safety

Joanna Fitzsimons University of Melbourne, Department of Clinical and Biomedical Sciences, Barwon Health, Swanston Centre, PO Box 281, Geelong, Victoria 3220, Australia. [email protected]
,
Michael Berk University of Melbourne, Department of Clinical and Biomedical Sciences, Barwon Health, Swanston Centre, PO Box 281, Geelong, Victoria 3220, Australia. [email protected]
,
Timothy Lambert University of Melbourne, Department of Psychiatry, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
,
Michel Bourin Université de Nantes, Faculté de Médecine et de Pharmacie, 44035 Nantes, Cédex 1, France
&
Seetal Dodd University of Melbourne, Department of Clinical and Biomedical Sciences, Barwon Health, Swanston Centre, PO Box 281, Geelong, Victoria 3220, Australia. [email protected]
Pages 731-744 | Published online: 12 Jul 2005

Citations (62)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Demet Sağlam Aykut & Hasret Karabulut Gül. (2017) Pulmonary thromboembolism associated with quetiapine: a case report. Psychiatry and Clinical Psychopharmacology 27:4, pages 427-428.
Read now
L. Orsolini, C. Tomasetti, A. Valchera, R. Vecchiotti, I. Matarazzo, F. Vellante, F. Iasevoli, E. F. Buonaguro, M. Fornaro, A. L. C. Fiengo, G. Martinotti, M. Mazza, G. Perna, A. Carano, A. De Bartolomeis, M. Di Giannantonio & D. De Berardis. (2016) An update of safety of clinically used atypical antipsychotics. Expert Opinion on Drug Safety 15:10, pages 1329-1347.
Read now
Christoffer Polcwiartek, Kristian Kragholm, Ole Schjerning, Claus Graff & Jimmi Nielsen. (2016) Cardiovascular safety of antipsychotics: a clinical overview. Expert Opinion on Drug Safety 15:5, pages 679-688.
Read now
Chaveewan Ratanajamit, Chutima Musakopas, Sorayut Vasiknanonte & Wantana Reanmongkol. (2010) Incidence and risk for neutropenia/agranulocytosis among clozapine users: A retrospective cohort study. International Journal of Psychiatry in Clinical Practice 14:2, pages 109-115.
Read now
Rohan Dhillon, Tarun Bastiampillai & Sharon Hong. (2009) An unusual case of hospital-acquired infection: Legionella Longbeachae. Australasian Psychiatry 17:4, pages 337-338.
Read now
David Castle, Tim Lambert, Sue Melbourne, Andrew Cox, Gaylene Boardman, Katherine Fairest, Martin Davy, Joyce Goh, Bill Kuluris & Michael Berk. (2006) A clinical monitoring system for clozapine. Australasian Psychiatry 14:2, pages 156-168.
Read now

Articles from other publishers (56)

Yuichi Uwai & Tomohiro Nabekura. (2023) Data Mining for Risks of Clozapine Side Effects, Including Neutropenia, Associated with Lithium Carbonate Administration: Analysis Using the Japanese Adverse Drug Event Report Database. Drugs - Real World Outcomes.
Crossref
Melissa Renzenbrink & Anne Pamela Frances Wand. (2021) A systematic review of clozapine’s effectiveness for primary psychotic and bipolar disorders in older adults. International Psychogeriatrics 34:10, pages 875-887.
Crossref
Andrea de Bartolomeis, Licia Vellucci, Annarita Barone, Mirko Manchia, Vincenzo De Luca, Felice Iasevoli & Christoph U. Correll. (2022) Clozapine’s multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia. Pharmacology & Therapeutics 236, pages 108236.
Crossref
Maria Skokou, Eleni A. Karavia, Zoi Drakou, Vassiliki Konstantinopoulou, Christina-Anna Kavakioti, Philippos Gourzis, Kyriakos E. Kypreos & Ourania Andreopoulou. (2022) Adverse Drug Reactions in Relation to Clozapine Plasma Levels: A Systematic Review. Pharmaceuticals 15:7, pages 817.
Crossref
Ronald J. Gurrera, Priya F. Gearin, Jonathan Love, Kevin J. Li, Ashley Xu, Faith H. Donaghey & Matthew R. Gerace. (2022) Recognition and management of clozapine adverse effects: A systematic review and qualitative synthesis. Acta Psychiatrica Scandinavica 145:5, pages 423-441.
Crossref
David M. Taylor, Thomas R. E. Barnes & Allan H. Young. 2021. The Maudsley Prescribing Guidelines in Psychiatry. The Maudsley Prescribing Guidelines in Psychiatry 1 224 .
Mariko Tsukiji, Tsuyoshi Sasaki, Yusuke Nakata, Kiyomitsu Ota, Tsutomu Aoki, Koichiro Hara, Takashi Mamada, Jun Nakane, Masanobu Kogure, Ryota Seki, Keita Idemoto, Tasuku Hashimoto, Hiraki Koishikawa, Toshihiro Moriyama, Takaaki Suzuki, Nobuhisa Kanahara, Itsuko Ishii, Masaomi Iyo & Tomihisa Niitsu. (2021) Risk factors for early-phase clozapine discontinuation: A nested case-control study. Asian Journal of Psychiatry 62, pages 102745.
Crossref
Hiroshi Kimura, Nobuhisa Kanahara & Masaomi Iyo. (2021) Rationale and neurobiological effects of treatment with antipsychotics in patients with chronic schizophrenia considering dopamine supersensitivity. Behavioural Brain Research 403, pages 113126.
Crossref
Tomihisa Niitsu, Tatsuki Hata, Masahiko Nishimoto, Yutaka Hosoda, Atsushi Kimura, Yasunori Oda, Masatoshi Suzuki, Naoko Takase, Ryota Seki, Kiyoshi Fujita, Mitsugu Endo, Taisuke Yoshida, Masayuki Inoue, Noriaki Hattori, Tadashi Murakami, Yukitsugu Imamura, Kohei Ogawa, Goro Fukami, Takatoshi Sato, Yohei Kawasaki, Tasuku Hashimoto, Masatomo Ishikawa, Akihiro Shiina, Nobuhisa Kanahara & Masaomi Iyo. (2020) A randomized-controlled trial of blonanserin and olanzapine as adjunct to antipsychotics in the treatment of patients with schizophrenia and dopamine supersensitivity psychosis: The ROADS study. Asian Journal of Psychiatry 53, pages 102369.
Crossref
Julia E. H. Brown. (2019) Relegating Psychosis: Blood Work and “Routine Connection” in the Clozapine Clinic. Culture, Medicine, and Psychiatry 44:2, pages 263-285.
Crossref
Annamaria Mascolo, Cristina Scavone, Concetta Rafaniello & A. Capuano. 2020. Brain and Heart Dynamics. Brain and Heart Dynamics 721 729 .
James L. Roerig. (2019) Clozapine augmentation strategies. Mental Health Clinician 9:6, pages 336-348.
Crossref
Azizah Attard, Andrew Iles, Stephen Attard, Nathan Atkinson & Anita Patel. (2019) Clozapine: why wait to start a laxative?. BJPsych Advances 25:6, pages 377-386.
Crossref
A. Mascolo, C. Scavone, C. Rafaniello & A. Capuano. 2019. Brain and Heart Dynamics. Brain and Heart Dynamics 1 10 .
Heidi Taipale, Juha Mehtälä, Antti Tanskanen & Jari Tiihonen. (2018) Comparative Effectiveness of Antipsychotic Drugs for Rehospitalization in Schizophrenia—A Nationwide Study With 20-Year Follow-up. Schizophrenia Bulletin 44:6, pages 1381-1387.
Crossref
Maciej Gawlik & Robert Skibiński. (2018) Simulation of phase I metabolism reactions of clozapine by HLM and photocatalytic methods with the use of UHPLC-ESI-MS/MS. Biomedical Chromatography 32:10, pages e4297.
Crossref
Reinhard B. DettmeyerReinhard B. Dettmeyer. 2018. Forensic Histopathology. Forensic Histopathology 123 170 .
Kate Murphy, Ian Coombes, Vikas Moudgil, Susan Patterson & Amanda Wheeler. (2017) Clozapine and concomitant medications: Assessing the completeness and accuracy of medication records for people prescribed clozapine under shared care arrangements. Journal of Evaluation in Clinical Practice 23:6, pages 1164-1172.
Crossref
Kathlyn J. Ronaldson. (2017) Cardiovascular Disease in Clozapine-Treated Patients: Evidence, Mechanisms and Management. CNS Drugs 31:9, pages 777-795.
Crossref
Junhwan ShinSeung-Min OhWon-Hyoung KimJae-Nam BaeJeong-Seop LeeChul-Eung KimJi-Hyun Kim. (2017) Comparison of Hematologic Variability between Clozapine Monotherapy and Augmentation Therapy with Atypical Antipsychotics for Schizophrenia: Results from a 6-Month Retrospective Follow-Up Study. Korean Journal of Schizophrenia Research 20:2, pages 61.
Crossref
R. Haussmann, M. Bauer & M. Donix. (2015) Evidenz zur Behandlung der Parkinson-assoziierten PsychoseEvidence-based treatment of psychosis associated with Parkinson’s disease. Der Nervenarzt 87:5, pages 543-551.
Crossref
Sasha R Fehily, Rosaria Forlano & Paul B Fitzgerald. (2015) C-reactive protein: an early critical sign of clozapine-related myocarditis. Australasian Psychiatry 24:2, pages 181-184.
Crossref
F Salvo, A Pariente, S Shakir, P Robinson, M Arnaud, SHL Thomas, E Raschi, A Fourrier-Réglat, N Moore, M Sturkenboom & L Hazell on behalf of Investigators o. (2016) Sudden cardiac and sudden unexpected death related to antipsychotics: A meta-analysis of observational studies. Clinical Pharmacology & Therapeutics 99:3, pages 306-314.
Crossref
Memduha Aydin, Bilge Cetin Ilhan, Saliha Calisir, Seda Yildirim & Ibrahim Eren. (2015) Continuing clozapine treatment with lithium in schizophrenic patients with neutropenia or leukopenia: brief review of literature with case reports. Therapeutic Advances in Psychopharmacology 6:1, pages 33-38.
Crossref
Marc De Hert, Annelien De Beugher, Kim Sweers, Martien Wampers, Christoph U. Correll & Dan Cohen. (2016) Knowledge of Psychiatric Nurses About the Potentially Lethal Side-Effects of Clozapine. Archives of Psychiatric Nursing 30:1, pages 79-83.
Crossref
Jin-Woo ChoWon-Hyoung KimJun-Hwan ShinJi-Hyun KimJeong-Seop LeeJae-Nam BaeChul-Eung Kim. (2016) Reason for Clozapine Discontinuation. Korean Journal of Schizophrenia Research 19:1, pages 17.
Crossref
Robert J. Flanagan & Kathlyn J. Ronaldson. 2016. Life-Threatening Effects of Antipsychotic Drugs. Life-Threatening Effects of Antipsychotic Drugs 151 179 .
John Lally & Robert J. Flanagan. 2016. Life-Threatening Effects of Antipsychotic Drugs. Life-Threatening Effects of Antipsychotic Drugs 105 148 .
Kathlyn J. Ronaldson. 2016. Life-Threatening Effects of Antipsychotic Drugs. Life-Threatening Effects of Antipsychotic Drugs 27 58 .
Roberto Latini & Silvio Garattini. 2016. Psychotherapy for Ischemic Heart Disease. Psychotherapy for Ischemic Heart Disease 121 130 .
Marlene Bloechliger, Stephan Rüegg, Susan S. Jick, Christoph R. Meier & Michael Bodmer. (2015) Antipsychotic Drug Use and the Risk of Seizures: Follow-up Study with a Nested Case–Control Analysis. CNS Drugs 29:7, pages 591-603.
Crossref
Vincent Chow, Caroline Reddel, Gabrielle Pennings, Elizabeth Scott, Tundra Pasqualon, Austin C.C. Ng, Thomas Yeoh, Jennifer Curnow & Leonard Kritharides. (2015) Global hypercoagulability in patients with schizophrenia receiving long-term antipsychotic therapy. Schizophrenia Research 162:1-3, pages 175-182.
Crossref
Andrew M. Williams & Susie H. Park. (2014) Seizure Associated with Clozapine: Incidence, Etiology, and Management. CNS Drugs 29:2, pages 101-111.
Crossref
M. C. Davis, M. A. Fuller, M. E. Strauss, P. E. Konicki & G. E. Jaskiw. (2013) Discontinuation of clozapine: a 15‐year naturalistic retrospective study of 320 patients. Acta Psychiatrica Scandinavica 130:1, pages 30-39.
Crossref
Hadar Ben-Yoav, Thomas E. Winkler, Eunkyoung Kim, Sheryl E. Chocron, Deanna L. Kelly, Gregory F. Payne & Reza Ghodssi. (2014) Redox cycling-based amplifying electrochemical sensor for in situ clozapine antipsychotic treatment monitoring. Electrochimica Acta 130, pages 497-503.
Crossref
Wanlop Atsariyasing & Morris Goldman. 2014. Schizophrenia. Schizophrenia 225 262 .
Kazeem Olaide Adebayo, Nurudeen Ibrahim, Temilola Mosanya, Benjamin Eegunranti, Babatunde Suleiman & Akeem Ayankunle. (2013) Life-threatening haematemesis associated with clozapine: a case report and literature review. Therapeutic Advances in Psychopharmacology 3:5, pages 275-277.
Crossref
Sacha Filia, Stuart Lee, Kelly Sinclair, Alyson Wheelhouse, Sally Wilkins, Anthony de Castella & Jayashri Kulkarni. (2013) Demonstrating the effectiveness of less restrictive care pathways for the management of patients treated with clozapine. Australasian Psychiatry 21:5, pages 449-455.
Crossref
Hadar Ben-Yoav, Thomas E. Winkler, Eunkyoung Kim, Deanna L. Kelly, Gregory F. Payne & Reza Ghodssi. (2013) Catechol-modified Chitosan System as a Bio-amplifier for Schizophrenia Treatment Analysis. MRS Proceedings 1572.
Crossref
Joanne Y.T. Leung, Alasdair M. Barr, Ric M. Procyshyn, William G. Honer & Catherine C.Y. Pang. (2012) Cardiovascular side-effects of antipsychotic drugs: The role of the autonomic nervous system. Pharmacology & Therapeutics 135:2, pages 113-122.
Crossref
Sacha L Filia, Alyson Wheelhouse, Stuart J Lee, Maggie Main, Anthony de Castella, Sally Wilkins & Jayashri Kulkarni. (2012) Transitioning patients taking clozapine from the public to private/GP shared-care setting: Barriers and criteria. Australian & New Zealand Journal of Psychiatry 46:3, pages 225-231.
Crossref
Heidrun Appl, Tobias Holzammer, Stefan Dove, Ekkehard Haen, Andrea Straßer & Roland Seifert. (2011) Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics. Naunyn-Schmiedeberg's Archives of Pharmacology 385:2, pages 145-170.
Crossref
W. Wolfgang Fleischhacker & Alex Hofer. 2012. Handbuch der Psychopharmakotherapie. Handbuch der Psychopharmakotherapie 937 960 .
Kathrine R. Weeks, Donard S. Dwyer & Eric J. Aamodt. (2011) Clozapine and lithium require Caenorhabditis elegans β‐arrestin and serum‐ and glucocorticoid‐inducible kinase to affect Daf‐16 (Foxo) localization . Journal of Neuroscience Research 89:10, pages 1658-1665.
Crossref
Thomas RE Barnes. (2011) Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology 25:5, pages 567-620.
Crossref
Reinhard B. DettmeyerReinhard B. Dettmeyer. 2011. Forensic Histopathology. Forensic Histopathology 95 136 .
Felicity Ng, Oommen K Mammen, Ingeborg Wilting, Gary S Sachs, I Nicol Ferrier, Frederick Cassidy, Serge Beaulieu, Lakshmi N Yatham & Michael Berk. (2009) The International Society for Bipolar Disorders (ISBD) consensus guidelines for the safety monitoring of bipolar disorder treatments. Bipolar Disorders 11:6, pages 559-595.
Crossref
Timothy J R Lambert. (2009) The medical care of people with psychosis. Medical Journal of Australia 190:4, pages 171-172.
Crossref
Laurence Borras, Ariel Eytan, Philippe de Timary, Eric-Louis Constant, Philippe Huguelet & Cédric Hermans. (2008) Pulmonary Thromboembolism Associated with Olanzapine and Risperidone. The Journal of Emergency Medicine 35:2, pages 159-161.
Crossref
W. Wolfgang Fleischhacker, Martina Hummer & Alex Hofer. 2008. Handbuch der Psychopharmakotherapie. Handbuch der Psychopharmakotherapie 847 872 .
Robert J. Flanagan & Louisa Dunk. (2008) Haematological toxicity of drugs used in psychiatry. Human Psychopharmacology: Clinical and Experimental 23:S1, pages S27-S41.
Crossref
Paul Mackin. (2008) Cardiac side effects of psychiatric drugs. Human Psychopharmacology: Clinical and Experimental 23:S1, pages S3-S14.
Crossref
Roberto Manfredi & Sergio Sabbatani. (2007) Clozapine‐related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment. Pharmacoepidemiology and Drug Safety 16:12, pages 1285-1289.
Crossref
Fatima Abu-Tair, Jürgen Kopitz & Niels Bergemann. (2006) Clozapine Augmented With Aripiprazole in 5 Patients With Schizophrenia. Journal of Clinical Psychopharmacology 26:6, pages 669-671.
Crossref
W. W. Fleischhacker & M. Hummer. (2006) Pharmakotherapie der SchizophreniePharmacotherapy for schizophrenia. Der Nervenarzt 77:S03, pages S77-S98.
Crossref
Prakash S. Masand, Charles B. Nemeroff, John W. Newcomer, Jeffrey A. Lieberman, Alan F. Schatzberg, Peter J. Weiden, Clinton D. Kilts, Philip D. Harvey & David G. Daniel. (2014) From Clinical Research to Clinical Practice: A 4-Year Review of Ziprasidone. CNS Spectrums 10:S17, pages 1-20.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.