790
Views
81
CrossRef citations to date
0
Altmetric
Review

Acetaminophen safety and hepatotoxicity – where do we go from here?

&
Pages 341-355 | Published online: 09 Aug 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Alan L Myers & Arthur H Jeske. (2023) Provider-directed analgesia for dental pain. Expert Review of Clinical Pharmacology 16:5, pages 435-451.
Read now
Zhaosheng Jin, Mingxi Zhu, Abhishek Gupta, Christopher Page, Tong J Gan & Sergio D Bergese. (2022) Evaluating oliceridine as a treatment option for moderate to severe acute post-operative pain in adults. Expert Opinion on Pharmacotherapy 23:1, pages 9-17.
Read now
Angela L. Chiew, Genaro Domingo, Nicholas A. Buckley, Paul Stathakis, Kirsty Ress & Darren M. Roberts. (2020) Hepatotoxicity in a child following an accidental overdose of liquid paracetamol. Clinical Toxicology 58:11, pages 1063-1066.
Read now
Xu Wang, Qinghua Wu, Aimei Liu, Arturo Anadón, José-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Zonghui Yuan & María-Aránzazu Martínez. (2017) Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro. Drug Metabolism Reviews 49:4, pages 395-437.
Read now
Qiuping Guo, Wei Yang, Baiquan Xiao, Hong Zhang, Xialing Lei, Huiyu Ou, Renan Qin & Ruomin Jin. (2015) Study on early biomarkers of zebrafish liver injury induced by acetaminophen. Toxin Reviews 34:1, pages 28-36.
Read now
Marzia Lecchi, Lidia D’Alonzo, Andrea Negro & Paolo Martelletti. (2014) Pharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches. Expert Opinion on Drug Metabolism & Toxicology 10:10, pages 1381-1395.
Read now
Esfandiar Heidarian, Javad Saffari & Effat Jafari-Dehkordi. (2014) Hepatoprotective Action of Echinophora platyloba DC Leaves Against Acute Toxicity of Acetaminophen in Rats. Journal of Dietary Supplements 11:1, pages 53-63.
Read now
Amal S Abdel-Azeem, Amany M Hegazy, Khadiga S Ibrahim, Abdel-Razik H. Farrag & Eman M. El-Sayed. (2013) Hepatoprotective, Antioxidant, and Ameliorative Effects of Ginger (Zingiber officinale Roscoe) and Vitamin E in Acetaminophen Treated Rats. Journal of Dietary Supplements 10:3, pages 195-209.
Read now

Articles from other publishers (73)

Kazi Nadim Hossain, Md. Shafiqul Islam, Sheikh Hasibur Rahman, Subroto Sarker, Milon Mondal, Mohammad Asikur Rahman, Sadeq K. Alhag, Laila A. Al-Shuraym, Othman A. Alghamdi, Muhammad Torequl Islam, Ammar AL-Farga, Mohamed El-Shazly, Md. Jahir Alam & Heba A. S. El-Nashar. (2023) In Vitro Antioxidant and In Vivo Hepatoprotective Properties of Wissadula periplocifolia Extract . ACS Omega.
Crossref
Fangyu Dai, Rensen Zhang, Ruyu Deng, Guoyong Wang, Hongjie Guo & Chunbao Guo. (2023) Regular use of low-dose of opioids after gastrointestinal surgery may lead to postoperative gastrointestinal tract dysfunction in children: a Chinese national regional health center experience sharing. BMC Gastroenterology 23:1.
Crossref
Nafiseh Gholizadeh, Jalal Hanaee, Elaheh Rahimpour & Abolghasem Jouyban. (2023) Solubility of acetaminophen in the ethanol and glycerol mixtures at different temperatures. Ovidius University Annals of Chemistry 34:2, pages 99-103.
Crossref
Darías Holgado & Thomas Zandonai. (2022) Comment on “What is the Effect of Paracetamol (Acetaminophen) Ingestion on Exercise Performance? Current Findings and Future Research Directions”. Sports Medicine 52:10, pages 2561-2562.
Crossref
Anna R. Schoenbrunner, Girish P. JoshiJeffrey E. Janis. (2022) Multimodal Analgesia in the Aesthetic Plastic Surgery: Concepts and Strategies. Plastic and Reconstructive Surgery - Global Open 10:5, pages e4310.
Crossref
Jasmine Cendejas-Hernandez, Joshua T. Sarafian, Victoria G. Lawton, Antara Palkar, Lauren G. Anderson, Vincent Larivière & William Parker. (2022) Paracetamol (acetaminophen) use in infants and children was never shown to be safe for neurodevelopment: a systematic review with citation tracking. European Journal of Pediatrics 181:5, pages 1835-1857.
Crossref
Pengfei Xu, Yue Xi, Pengcheng Wang, Zigmund Luka, Meishu Xu, Hung-Chun Tung, Jingyuan Wang, Songrong Ren, Dechun Feng, Bin Gao, Aatur D. Singhi, Satdarshan P. Monga, John D. York, Xiaochao Ma, Zhiying Huang & Wen Xie. (2022) Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure. Gastroenterology 162:4, pages 1226-1241.
Crossref
Nnaemeka Nweke, Vishal Bansal & Emanuel Narcis Husu. 2022. A Case-Based Approach to Hip Pain. A Case-Based Approach to Hip Pain 53 71 .
A.M. Abu Ahmed, Md. Atiar Rahman, Md. Amjad Hossen, A.S.M. Ali Reza, Md. Shahidul Islam, Md. Mamunur Rashid, Md. Khalid Juhani Rafi, Md. Tanvir Ahmed Siddiqui, Abdullah Al-Noman & Md. Nazim Uddin. (2021) Epiphytic Acampe ochracea orchid relieves paracetamol-induced hepatotoxicity by inhibiting oxidative stress and upregulating antioxidant genes in in vivo and virtual screening. Biomedicine & Pharmacotherapy 143, pages 112215.
Crossref
Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 41 77 .
Jennifer Wu, Pranamya Suri, Danielle Perret Karimi & Bi-Ying Yeh. 2021. Migraine. Migraine 29 49 .
Erin Maggie Jones, Gregory L. Barinsky, Anna A. Pashkova & Peter F. Svider. 2021. Perioperative Pain Control: Tools for Surgeons. Perioperative Pain Control: Tools for Surgeons 61 78 .
Rowan R Sheldon, Jessica B Weiss, Woo S Do, Dominic M Forte, Preston L Carter, Matthew J Eckert & Vance Y Sohn. (2020) Stemming the Tide of Opioid Addiction—Dramatic Reductions in Postoperative Opioid Requirements Through Preoperative Education and a Standardized Analgesic Regimen. Military Medicine 185:3-4, pages 436-443.
Crossref
Angela L Chiew, David Reith, Adam Pomerleau, Anselm Wong, Katherine Z Isoardi, Jessamine Soderstrom & Nicholas A Buckley. (2019) Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. Medical Journal of Australia 212:4, pages 175-183.
Crossref
Kazuma Kondo, Naohito YamadaYusuke SuzukiTatsuji HashimotoKaoru ToyodaTadakazu TakahashiAkio KobayashiShoichiro SugaiKouichi Yoshinari. (2020) Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats. The Journal of Toxicological Sciences 45:5, pages 245-260.
Crossref
Bruno T Saragiotto, Christina Abdel Shaheed & Chris G Maher. (2019) Paracetamol for pain in adults. BMJ, pages l6693.
Crossref
Min Hee ParkMisun LeeGeewoo NamMingeun KimJuhye KangByung Jo ChoiMin Seock JeongKang Ho ParkWan Hui HanEunyoung TakMin Sun KimJuri LeeYuxi LinYoung-Ho LeeIm-Sook SongMin-Koo Choi, Joo-Yong Lee, Hee Kyung JinJae-sung BaeMi Hee Lim. (2019) N , N ′-Diacetyl- p -phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice . Proceedings of the National Academy of Sciences 116:47, pages 23426-23436.
Crossref
Renata Monti-Rocha, Allysson Cramer, Paulo Gaio Leite, Maísa Mota Antunes, Rafaela Vaz Sousa Pereira, Andréia Barroso, Celso M. Queiroz-Junior, Bruna Araújo David, Mauro Martins Teixeira, Gustavo Batista Menezes & Fabiana Simão Machado. (2019) SOCS2 Is Critical for the Balancing of Immune Response and Oxidate Stress Protecting Against Acetaminophen-Induced Acute Liver Injury. Frontiers in Immunology 9.
Crossref
Eyal Shteyer, Ami Ben Ya'acov, Lidia Zolotaryova, Avital Sinai, Mordechai Slae, Smadar Cohen & Yaron Ilan. (2019) Prevention of acetaminophen-induced liver injury by alginate. Toxicology and Applied Pharmacology 363, pages 72-78.
Crossref
Ki-Young Kang, Jun-Kyu Shin & Sun-Mee Lee. (2019) Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux. Food and Chemical Toxicology 123, pages 536-545.
Crossref
Ashutosh Gupta & Abhay K. Pandey. 2019. Nutraceuticals and Natural Product Pharmaceuticals. Nutraceuticals and Natural Product Pharmaceuticals 71 104 .
Meir Mizrahi, Tomer Adar, Gadi Lalazar, Dean Nachman, Madi El Haj, Ami Ben Ya’acov, Yoav Lichtenstein, Yehudit Shabat, Dimitri Kanovich, Lida Zolotarov & Yaron Ilan. (2018) Glycosphingolipids Prevent APAP and HMG-CoA Reductase Inhibitors-mediated Liver Damage: A Novel Method for “Safer Drug” Formulation that Prevents Drug-induced Liver Injury. Journal of Clinical and Translational Hepatology 6:2, pages 1-8.
Crossref
Jürgen Borlak, Florian van Bömmel & Thomas Berg. (2018) N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury. Liver International 38:2, pages 365-376.
Crossref
Carole Mast, Charlène Pourpe, Guillaume Voyard, Didier Rémond, Carole Migné, Delphine Centeno, Dominique Dardevet, Isabelle Savary-Auzeloux & Isabelle Papet. (2017) Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats. British Journal of Nutrition 118:11, pages 889-896.
Crossref
Sujay Ramanathan, Botros B. Shenoda & Seena K. Ajit. (2018) Overview of microRNA Modulation in Analgesic Research. Current Protocols in Pharmacology 79:1.
Crossref
J. Tarrant. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 255 284 .
Saravanan Shanmugam, Parimelazhagan Thangaraj, Bruno dos Santos Lima, Rahul Chandran, Adriano Antunes de Souza Araújo, Narendra Narain, Mairim Russo Serafini & Lucindo José Quintans Júnior. (2016) Effects of luteolin and quercetin 3-β-d-glucoside identified from Passiflora subpeltata leaves against acetaminophen induced hepatotoxicity in rats. Biomedicine & Pharmacotherapy 83, pages 1278-1285.
Crossref
Nathanael Y S Lee, William K S Khoo, Mohammad Akmal Adnan, Tanes Prasat Mahalingam, Anne R Fernandez & Kamalan Jeevaratnam. (2016) The pharmacological potential of Phyllanthus niruri . Journal of Pharmacy and Pharmacology 68:8, pages 953-969.
Crossref
Bruno T Saragiotto, Gustavo C Machado, Manuela L Ferreira, Marina B Pinheiro, Christina Abdel Shaheed & Christopher G Maher. (2016) Paracetamol for low back pain. Cochrane Database of Systematic Reviews 2019:1.
Crossref
Hyun-Kyu ParkWoori JoHyun-Ji ChoiSungwoong JangJae-Eun RyuHyo-Ju LeeHyojin LeeHyejin KimEun-Sil YuWoo-Chan Son. (2016) Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats. Journal of Veterinary Science 17:1, pages 45.
Crossref
Souzan B. Yanni. 2015. Translational ADMET for Drug Therapy. Translational ADMET for Drug Therapy 179 204 .
Wen–Pei Chang & Chia–Chin Lin. (2015) Use of opioid analgesics or sleeping medication and survival of cancer patients. European Journal of Oncology Nursing 19:3, pages 199-206.
Crossref
Akio KobayashiKazuma KondoShoichiro Sugai. (2015) Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity臨床薬剤性肝障害リスク因子特定のためのバイオマーカーの探索:endogenous metabolite解析によるアセトアミノフェン誘発性肝障害に対する感受性予測. YAKUGAKU ZASSHI 135:5, pages 655-662.
Crossref
S Karadas, M Aslan, H Gonullu, C Kati, L Duran, S Olmez, ME Kucukoglu & H Demir. (2014) Acetaminophen intoxication is associated with decreased serum paraoxonase and arylesterase activities and increased lipid hydroperoxide levels. Human & Experimental Toxicology 33:11, pages 1134-1140.
Crossref
Catherine Crone & Andrea DiMartini. (2014) Liver Transplant for Intentional Acetaminophen Overdose: A Survey of Transplant Clinicians׳ Experiences With Recommendations. Psychosomatics 55:6, pages 602-612.
Crossref
Arne Trettin, Darko Modun, Sanja Madunic, Jonatan Vukovic, Maja Radman, Sandor Batkai, Thomas Thum, Jens Jordan & Dimitrios Tsikas. (2014) LC–MS/MS and GC–MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: Proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration. Journal of Chromatography B 959, pages 71-81.
Crossref
Chhaya Rani Majhi, Saleem Khan, Marie Dennis Marcus Leo, Shahid Prawez, Amit Kumar, Palanisamy Sankar, Avinash Gopal Telang & Souvendra Nath Sarkar. (2014) Acetaminophen increases the risk of arsenic-mediated development of hepatic damage in rats by enhancing redox-signaling mechanism. Environmental Toxicology 29:2, pages 187-198.
Crossref
Rumyana Simeonova, Magdalena Kondeva-Burdina, Vessela Vitcheva & Mitka Mitcheva. (2014) Some In Vitro/In Vivo Chemically-Induced Experimental Models of Liver Oxidative Stress in Rats . BioMed Research International 2014, pages 1-6.
Crossref
Bruno da Cruz Pádua, Joamyr Victor Rossoni Júnior, Cíntia Lopes de Brito Magalhães, Míriam Martins Chaves, Marcelo Eustáquio Silva, Maria Lucia Pedrosa, Gustavo Henrique Bianco de Souza, Geraldo Célio Brandão, Ivanildes Vasconcelos Rodrigues, Wanderson Geraldo Lima & Daniela Caldeira Costa. (2014) Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen . Mediators of Inflammation 2014, pages 1-14.
Crossref
Ian Laughlin & Anita H. Hickey. 2014. Orofacial Pain. Orofacial Pain 81 87 .
Ji Won Kim, Sung Ha Ryu, Siwon Kim, Hae Won Lee, Mi-sun Lim, Sook Jin Seong, Suhkmann Kim, Young-Ran Yoon & Kyu-Bong Kim. (2013) Pattern Recognition Analysis for Hepatotoxicity Induced by Acetaminophen Using Plasma and Urinary 1 H NMR-Based Metabolomics in Humans . Analytical Chemistry 85:23, pages 11326-11334.
Crossref
Sofie Starckx, Ameesha Batheja, Geert R. Verheyen, Sandra De Jonghe, Kristel Steemans, Bram Van Dijck, Monica Singer, Nancy Bogdan, Jan Snoeys, Petra Vinken, Jennifer C. Sasaki, Jacky Van Gompel, Peggy Guzzie-Peck, Ann Lampo & Lieve Lammens. (2012) Evaluation of miR-122 and Other Biomarkers in Distinct Acute Liver Injury in Rats. Toxicologic Pathology 41:5, pages 795-804.
Crossref
Willis C. Maddrey. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 229 240 .
Sharida Fakurazi, Syazana Akmal Sharifudin & Palanisamy Arulselvan. (2012) Moringa oleifera Hydroethanolic Extracts Effectively Alleviate Acetaminophen-Induced Hepatotoxicity in Experimental Rats through Their Antioxidant Nature. Molecules 17:7, pages 8334-8350.
Crossref
Bhowmik Salil Kumar, Bong Chul Chung, Oh-Seung Kwon & Byung Hwa Jung. (2012) Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics. Journal of Applied Toxicology 32:7, pages 505-520.
Crossref
S.M. Sabir, S.D. Ahmad, A. Hamid, M.Q. Khan, M.L. Athayde, D.B. Santos, A.A. Boligon & J.B.T. Rocha. (2012) Antioxidant and hepatoprotective activity of ethanolic extract of leaves of Solidago microglossa containing polyphenolic compounds. Food Chemistry 131:3, pages 741-747.
Crossref
Alexander V. LyubimovWei Zou, Robert A. Roth & Patricia E. Ganey. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 25 .
Kazuma KondoNaohito YamadaYusuke SuzukiKaoru ToyodaTatsuji HashimotoAkemi TakahashiAkio KobayashiToshiyuki ShodaHideyuki KunoShoichiro Sugai. (2012) Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients. The Journal of Toxicological Sciences 37:5, pages 911-929.
Crossref
Nam-Hun Lee, Chang-Seob Seo, Ho-young Lee, Da-Young Jung, Jun-Kyung Lee, Jin-Ah Lee, Kye Yong Song, Hyeun-kyoo Shin, Mee-Young Lee, Young Bae Seo, Hokyoung Kim & Hyekyung Ha. (2012) Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice . Evidence-Based Complementary and Alternative Medicine 2012, pages 1-8.
Crossref
Lena Smirnova, Alexandra Sittka & Andreas Luch. 2012. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 499 550 .
Jane R. Mort, Olayinka O. Shiyanbola, Lilian N. Ndehi, Yihua Xu & Jane N. Stacy. (2011) Opioid-Paracetamol Prescription Patterns and Liver Dysfunction. Drug Safety 34:11, pages 1079-1088.
Crossref
Cliona M. McHale, Luoping Zhang, Alan E. Hubbard & Martyn T. Smith. 2011. Applications of Toxicogenomics in Safety Evaluation and Risk Assessment. Applications of Toxicogenomics in Safety Evaluation and Risk Assessment 177 206 .
Valery Elie, Tiphaine de Beaumais, May Fakhoury & Evelyne Jacqz-Aigrain. (2011) Pharmacogenetics and individualized therapy in children: immunosuppressants, antidepressants, anticancer and anti-inflammatory drugs. Pharmacogenomics 12:6, pages 827-843.
Crossref
Daniel S. Budnitz, Maribeth C. Lovegrove & Alexander E. Crosby. (2011) Emergency Department Visits for Overdoses of Acetaminophen-Containing Products. American Journal of Preventive Medicine 40:6, pages 585-592.
Crossref
Anita Hickey & Ian Laughlin. 2011. Essentials of Pain Management. Essentials of Pain Management 725 746 .
Inmaculada Posadas, Pablo Santos, Almudena Blanco, Maríangeles Muñoz-Fernández & Valentín Ceña. (2010) Acetaminophen Induces Apoptosis in Rat Cortical Neurons. PLoS ONE 5:12, pages e15360.
Crossref
Kenneth R. Goldschneider & Anne W. Lucky. (2010) Pain Management in Epidermolysis Bullosa. Dermatologic Clinics 28:2, pages 273-282.
Crossref
Richard D. Beger, Jinchun Sun & Laura K. Schnackenberg. (2010) Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Toxicology and Applied Pharmacology 243:2, pages 154-166.
Crossref
Ayyasamy Manimaran, Souvendra Nath Sarkar & Palanisamy Sankar. (2010) Influence of repeated preexposure to arsenic on acetaminophen-induced oxidative stress in liver of male rats. Food and Chemical Toxicology 48:2, pages 605-610.
Crossref
Ayyasamy Manimaran, Souvendra Nath Sarkar & Palanisamy Sankar. (2010) Toxicodynamics of subacute co-exposure to groundwater contaminant arsenic and analgesic–antipyretic drug acetaminophen in rats. Ecotoxicology and Environmental Safety 73:1, pages 94-100.
Crossref
Curtis Klaassen & Hong Lu. 2010. Nuclear Receptors. Nuclear Receptors 287 305 .
Laura K. Schnackenberg, Jinchun Sun & Richard D. Beger. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
M. Anoush, M.A. Eghbal, F. Fathiazad, H. Hamzeiy & N.S. Kouzehkona. (2009) The Protective Effects of Garlic Extract Against Acetaminophen-Induced Oxidative Stress and Glutathione Depletion. Pakistan Journal of Biological Sciences 12:10, pages 765-771.
Crossref
Xiaomin Deng, James P. Luyendyk, Patricia E. Ganey & Robert A. Roth. (2009) Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models. Pharmacological Reviews 61:3, pages 262-282.
Crossref
Paul S. Casamassimo, Sarat Thikkurissy, Burton L. Edelstein & Elyse Maiorini. (2009) Beyond the dmft. The Journal of the American Dental Association 140:6, pages 650-657.
Crossref
Susanna Weiss. (2009) Compliance packaging for over-the-counter drug products. Journal of Public Health 17:2.
Crossref
Kai Wang, Shile Zhang, Bruz Marzolf, Pamela Troisch, Amy Brightman, Zhiyuan Hu, Leroy E. Hood & David J. Galas. (2009) Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proceedings of the National Academy of Sciences 106:11, pages 4402-4407.
Crossref
Dennis A. Smith & R. Scott Obach. (2009) Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment. Chemical Research in Toxicology 22:2, pages 267-279.
Crossref
Lena Lavie. (2009) Obstructive sleep apnoea and acetaminophen safety - is the liver at risk?. Experimental Physiology 94:2, pages 199-200.
Crossref
S.M. Sabir & J.B.T. Rocha. (2008) Antioxidant and hepatoprotective activity of aqueous extract of Solanum fastigiatum (false “Jurubeba”) against paracetamol-induced liver damage in mice. Journal of Ethnopharmacology 120:2, pages 226-232.
Crossref
Laura K SchnackenbergJim Kaput & Richard D Beger. (2008) Metabolomics: a tool for personalizing medicine?. Personalized Medicine 5:5, pages 495-504.
Crossref
William Norris, Angelo H Paredes & James H Lewis. (2008) Drug-induced liver injury in 2007. Current Opinion in Gastroenterology 24:3, pages 287-297.
Crossref
Jinghai J. Xu, Bart S. Hendriks, Jie Zhao & David de Graaf. (2008) Multiple effects of acetaminophen and p38 inhibitors: Towards pathway toxicology. FEBS Letters 582:8, pages 1276-1282.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.