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Review

The safety of drugs for the treatment of nausea and vomiting of pregnancy

, MSc & , RN
Pages 685-694 | Published online: 30 Oct 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jessica A Spiteri, Gabrielle Camilleri, Carlo Piccinni & Janet Sultana. (2023) Safety of drugs used for the treatment of migraine during pregnancy: a narrative review. Expert Review of Clinical Pharmacology 16:3, pages 207-217.
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Julie Sartori, Rodney Petersen, David A. Coall & Julie Quinlivan. (2018) The impact of maternal nausea and vomiting in pregnancy on expectant fathers: findings from the Australian Fathers’ Study. Journal of Psychosomatic Obstetrics & Gynecology 39:4, pages 252-258.
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Yvonne Jelting, Christian Klein, Thomas Harlander, Leopold Eberhart, Norbert Roewer & Peter Kranke. (2017) Preventing nausea and vomiting in women undergoing regional anesthesia for cesarean section: challenges and solutions. Local and Regional Anesthesia 10, pages 83-90.
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Gideon Koren. (2017) Safety considerations surrounding use of treatment options for nausea and vomiting in pregnancy. Expert Opinion on Drug Safety 16:11, pages 1227-1234.
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Articles from other publishers (38)

Natalie Anderson. (2022) Non-medical midwifery prescribing of an antiemetic for a glucose tolerance test: a case study. Journal of Prescribing Practice 4:11, pages 482-489.
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Matthew Gray, Priyanka Priyanka, Sandra Kane-Gill, Lirong Wang & John A. Kellum. (2022) Kidney and Mortality Outcomes Associated with Ondansetron in Critically Ill Patients. Journal of Intensive Care Medicine 37:10, pages 1403-1410.
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David Moreno Ajona, María Dolores Villar Martínez, Calvin Chan & Peter J. Goadsby. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 548 589 .
Melissa L. Feigel, Anne Kennard & Kia Lannaman. (2021) Herbalism for Modern Obstetrics. Clinical Obstetrics & Gynecology 64:3, pages 611-634.
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Juanjuan Sun, Jing Liu, Juanjuan Zhang & Honghui Xia. (2021) Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability improvement. Journal of Drug Delivery Science and Technology 63, pages 102432.
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Yusra Khan. (2019) Hyperemesis gravidarum. InnovAiT: Education and inspiration for general practice 12:8, pages 434-441.
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Veronica Gillispie & Sherri Longo. 2019. Evidence-based Obstetrics and Gynecology. Evidence-based Obstetrics and Gynecology 225 232 .
Rabab A. Husseiny, Amr S. Abu Lila, Marwa H. Abdallah, Eslam E. Hamed & Hanaa A. El-ghamry. (2018) Design, in vitro/in vivo evaluation of meclizine HCl-loaded floating microspheres targeting pregnancy-related nausea and vomiting. Journal of Drug Delivery Science and Technology 47, pages 395-403.
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Yali Zhang, Zhiwen Li, Le Zhang, Jufen Liu, Lei Jin & Aiguo Ren. (2018) Association between severe nausea and vomiting in early pregnancy and the risk of neural tube defects in Northern China. Birth Defects Research 110:5, pages 406-412.
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. 2017. High-Risk Pregnancy. High-Risk Pregnancy.
Helen E. Ritchie, Diana J. Oakes, Debra Kennedy & Jaimie W. Polson. (2017) Early Gestational Hypoxia and Adverse Developmental Outcomes. Birth Defects Research 109:17, pages 1358-1376.
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Cift Tayfur, Dincgez Cakmak Burcu, Ozgen Gulten, Dundar Betul, Guclu Tugberk, Ozdenoglu Onur, Korkmazer Engin & Ozdemir Orcun. (2017) Association between platelet to lymphocyte ratio, plateletcrit and the presence and severity of hyperemesis gravidarum. Journal of Obstetrics and Gynaecology Research 43:3, pages 498-504.
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Rachel H. Westbrook, Geoffrey Dusheiko & Catherine Williamson. (2016) Pregnancy and liver disease. Journal of Hepatology 64:4, pages 933-945.
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G. Ducarme & V. Dochez. (2016) Vómitos incoercibles durante el embarazo. EMC - Ginecología-Obstetricia 52:1, pages 1-8.
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Guillaume Ducarme & Vincent Dochez. (2015) Vomissements incoercibles de la grossesse : mise au point. La Presse Médicale 44:12, pages 1226-1234.
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Catherine Nelson-Piercy. 2015. Handbook of Obstetric Medicine, Fifth Edition. Handbook of Obstetric Medicine, Fifth Edition 229 248 .
Lee H. Goldstein, Corinna Weber Schöndorfer & Matitiahu Berkovitch. 2015. Drugs During Pregnancy and Lactation. Drugs During Pregnancy and Lactation 75 91 .
Shannon M. Clark, Eryn Dutta & Gary D.V. Hankins. (2014) The outpatient management and special considerations of nausea and vomiting in pregnancy. Seminars in Perinatology 38:8, pages 496-502.
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Mei-Chun Liu, Shih-Hsien Kuo, Chao-Po Lin, Yung-Mei Yang, Fan-Hao Chou & Yi-Hsin Yang. (2013) Effects of Professional Support on Nausea, Vomiting, and Quality of Life During Early Pregnancy. Biological Research For Nursing 16:4, pages 378-386.
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C Janneke van der Woude, Herold J Metselaar & Silvio Danese. (2014) Management of gastrointestinal and liver diseases during pregnancy. Gut 63:6, pages 1014-1023.
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Svetlana Madjunkova, Caroline Maltepe & Gideon Koren. (2014) The Delayed-Release Combination of Doxylamine and Pyridoxine (Diclegis®/Diclectin®) for the Treatment of Nausea and Vomiting of Pregnancy. Pediatric Drugs 16:3, pages 199-211.
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Geethanjali Boregowda & Hassan A. Shehata. (2013) Gastrointestinal and Liver Disease in Pregnancy. Best Practice & Research Clinical Obstetrics & Gynaecology 27:6, pages 835-853.
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. (2013) Management of hyperemesis gravidarum. Drug and Therapeutics Bulletin 51:11, pages 126-129.
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Caroline Maltepe, Rachel Gow & Gideon Koren. 2013. Clinical Pharmacology During Pregnancy. Clinical Pharmacology During Pregnancy 157 171 .
Paola Sarchielli, Franco Granella, Maria Pia Prudenzano, Luigi Alberto Pini, Vincenzo Guidetti, Giorgio Bono, Lorenzo Pinessi, Massimo Alessandri, Fabio Antonaci, Marcello Fanciullacci, Anna Ferrari, Mario Guazzelli, Giuseppe Nappi, Grazia Sances, Giorgio Sandrini, Lidia Savi, Cristina Tassorelli & Giorgio Zanchin. (2012) Italian guidelines for primary headaches: 2012 revised version. The Journal of Headache and Pain 13:S2, pages 31-70.
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Kyeong Ok Kim. (2012) Nausea and Vomiting in Pregnancy. Korean Journal of Medicine 82:5, pages 525.
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Shannon M. Clark, Maged M. Costantine & Gary D. V. Hankins. (2012) Review of NVP and HG and Early Pharmacotherapeutic Intervention. Obstetrics and Gynecology International 2012, pages 1-8.
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Marlene Anderka, Allen A. Mitchell, Carol Louik, Martha M. Werler, Sonia Hernández‐Diaz & Sonja A. Rasmussen. (2011) Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects. Birth Defects Research Part A: Clinical and Molecular Teratology 94:1, pages 22-30.
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Caroline Maltepe. 2011. Cancer in Pregnancy and Lactation. Cancer in Pregnancy and Lactation 134 142 .
Deborah A. Kennedy. 2011. Cancer in Pregnancy and Lactation. Cancer in Pregnancy and Lactation 128 133 .
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Rohit Kumar, Kathryn L. Hayhurst & Andrew K. Robson. (2011) Ear, Nose, and Throat Manifestations during Pregnancy. Otolaryngology–Head and Neck Surgery 145:2, pages 188-198.
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Gideon Koren, Caroline Maltepe & Rachel Gow. (2011) Therapeutic Choices for Nausea and Vomiting of Pregnancy: A Critical Review of a Systematic Review. Journal of Obstetrics and Gynaecology Canada 33:7, pages 733-735.
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Shipra Sonkusare. (2011) The clinical management of hyperemesis gravidarum. Archives of Gynecology and Obstetrics 283:6, pages 1183-1192.
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J.-M. Thoulon. (2011) Malestar en el embarazo. EMC - Ginecología-Obstetricia 47:2, pages 1-9.
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J.-M. Thoulon. (2011) Petits maux de la grossesse. EMC - Obstétrique 6:1, pages 1-9.
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Byung Chul HwangSuk Young Kim. (2010) The effectiveness of antiemetics in hyperemesis gravidarum. Korean Journal of Obstetrics and Gynecology 53:1, pages 15.
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Cecilia Bottomley & Tom Bourne. (2009) Management strategies for hyperemesis. Best Practice & Research Clinical Obstetrics & Gynaecology 23:4, pages 549-564.
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