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Review

Drug delivery strategies for improved azole antifungal action

, , PharmD & , PhD
Pages 1199-1216 | Published online: 01 Nov 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Ruchika M. Bondre, Pranita S. Kanojiya, Rita N. Wadetwar & Priya S. Kangali. (2023) Sustained vaginal delivery of in situ gel containing Voriconazole nanostructured lipid carrier: formulation, in vitro and ex vivo evaluation. Journal of Dispersion Science and Technology 44:8, pages 1466-1478.
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Marieta Constantin, Bogdan Cosman, Paolo Ascenzi, Bogdan C. Simionescu & Gheorghe Fundueanu. (2022) New chromatographic insights on drug:cyclodextrin inclusion complexes and their potential use in drug delivery. Expert Opinion on Drug Delivery 19:12, pages 1696-1709.
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Brian Shing, Mina Balen, James H. McKerrow & Anjan Debnath. (2021) Acanthamoeba Keratitis: an update on amebicidal and cysticidal drug screening methodologies and potential treatment with azole drugs. Expert Review of Anti-infective Therapy 19:11, pages 1427-1441.
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Rofida Albash, Yasmina Elmahboub, Kholoud Baraka, Menna M. Abdellatif & Ahmed Adel Alaa-Eldin. (2020) Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies. Drug Delivery 27:1, pages 1514-1523.
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Ahmed A Abdelaziz, Tarek E Elbanna, Fatma I Sonbol, Noha M Gamaleldin & Gamal M El Maghraby. (2015) Optimization of niosomes for enhanced antibacterial activity and reduced bacterial resistance: in vitro and in vivo evaluation. Expert Opinion on Drug Delivery 12:2, pages 163-180.
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Gladious Naguib El-Hadidy, Howida Kamal Ibrahim, Magdi Ibrahim Mohamed & Mohamed Farid El-Milligi. (2012) Microemulsions as vehicles for topical administration of voriconazole: formulation and in vitro evaluation. Drug Development and Industrial Pharmacy 38:1, pages 64-72.
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Articles from other publishers (45)

Hriday Bera, Yasir Faraz Abbasi & Abhimanyu Thakur. (2023) Curdlan/Clay Nanocomposite-Reinforced Alginate Beads as Drug Carriers. Journal of Polymers and the Environment.
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Jaya AgnihotriPoonam YadavAnjali MauryaAkash Vishwakarma. (2023) Novel Chewable Gum Sticks for The Treatment of Oral Candidiasis. Research Journal of Pharmacy and Technology, pages 3843-3846.
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Iris Usach, Paula Martínez-Álvarez & José-Esteban Peris. (2023) Topical delivery systems containing clotrimazole for the management of candidiasis: effect of different excipients and enhanced antifungal activity of nanovesicles. International Journal of Pharmaceutics, pages 123287.
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Aldana B. Moroni, Elena Pérez Mayoral, Diego F. Lionello, Daniel R. Vega, Teodoro S. Kaufman & Natalia L. Calvo. (2023) Characterization of the hydrochloride salt hemihydrate as a new salt of the antifungal agent tioconazole. International Journal of Pharmaceutics 637, pages 122869.
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Vikas Agrawal, Rashmin Patel & Mrunali Patel. (2023) Design, characterization, and evaluation of efinaconazole loaded poly(D, L-lactide-co-glycolide) nanocapsules for targeted treatment of onychomycosis. Journal of Drug Delivery Science and Technology 80, pages 104157.
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Rishabh Gupta, Deblina Dan, Aanchal Singh & Nimisha. 2023. Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases. Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases 361 379 .
Jeanett Holzknecht, Sandrine Dubrac, Sarah Hedtrich, László Galgóczy & Florentine Marx. (2022) Small, Cationic Antifungal Proteins from Filamentous Fungi Inhibit Candida albicans Growth in 3D Skin Infection Models . Microbiology Spectrum 10:3.
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Kévin Brunet, Jean-Philippe Martellosio, Frédéric Tewes, Sandrine Marchand & Blandine Rammaert. (2022) Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections. Pharmaceutics 14:3, pages 641.
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Angelica Sharapova, Svetlana Blokhina, Marina Ol'khovich & German Perlovich. (2022) Thermodynamic analysis of solubility, distribution and solvation of antifungal miconazole in relevant pharmaceutical media. Journal of Molecular Liquids 347, pages 118248.
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Ksenia V. Drozd, Alex N. Manin, Denis E. Boycov, Andrei V. Churakov & German L. Perlovich. (2021) Pharmaceutical Multicomponent Crystals of Antifungal Drugs with Improved Dissolution Performance. Crystal Growth & Design 21:12, pages 7285-7297.
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Nehal A. Salahuddin, M. Ali, Hamad A. Al-Lohedan, Zuheir A. Issa, Assem Barakat & Mohamad M. Ayad. (2021) Aniline- co - o -anthranilic Acid Copolymer-Chitosan/Ag@AgCl Nanohybrid as a Carrier for ( E )- N ′-(Pyridin-2-ylmethylene) Hydrazinecarbothiohydrazide Release and Antimicrobial Activity . ACS Omega 6:34, pages 21939-21951.
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Pilar González-Perdomo, Jaime González, Diego Martínez-Otero, MV Basavanag Unnamatla, Marco A García-Eleno, David Corona-Becerril & Erick Cuevas-Yañez. (2020) Synthesis of 3-alkyl-1,2,3-triazol-1-ium hydrogen sulphate derivatives. Journal of Chemical Research 45:3-4, pages 322-325.
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Barbara Vörös-Horváth, Sourav Das, Ala’ Salem, Sándor Nagy, Andrea Böszörményi, Tamás Kőszegi, Szilárd Pál & Aleksandar Széchenyi. (2020) Formulation of Tioconazole and Melaleuca alternifolia Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment. Molecules 25:23, pages 5544.
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Marco Cabras, Alessio Gambino, Roberto Broccoletti, Giovanni Lodi & Paolo G. Arduino. (2019) Treatment of angular cheilitis: A narrative review and authors’ clinical experience. Oral Diseases 26:6, pages 1107-1115.
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Paula E.R. Bitencourt. 2020. Diabetes. Diabetes 343 350 .
Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad & Abdullah Safar Althubiani. (2019) Potential of Nanoparticles in Combating Candida Infections. Letters in Drug Design & Discovery 16:5, pages 478-491.
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Huijun Chen, Xiong Zhang, Yi Cheng & Feng Qian. (2019) Preparation of smectic itraconazole nanoparticles with tunable periodic order using microfluidics-based anti-solvent precipitation. CrystEngComm 21:14, pages 2362-2372.
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Lubhandwa Sebastian Biswaro, Mônica Pereira Garcia, Jaqueline Rodrigues da Silva, Laura Fernanda Neira Fuentes, Angelica Vera, Patricia Escobar & Ricardo Bentes Azevedo. (2018) Itraconazole encapsulated PLGA‐nanoparticles covered with mannose as potential candidates against leishmaniasis. Journal of Biomedical Materials Research Part B: Applied Biomaterials 107:3, pages 680-687.
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Jagadevappa S. Patil, Shivsharan B. Dhadde & Baburao N. Chandakavathe. 2019. Characterization and Biology of Nanomaterials for Drug Delivery. Characterization and Biology of Nanomaterials for Drug Delivery 165 197 .
Rajamani Lakshminarayanan, Enyi Ye, David James Young, Zibiao Li & Xian Jun Loh. (2018) Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens. Advanced Healthcare Materials 7:13.
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Halah Talal Sulaiman & Hanan Jalal Kassab. (2018) PREPARATION AND CHARACTERIZATION OF ECONAZOLE NITRATE INCLUSION COMPLEX FOR OCULAR DELIVERY SYSTEM. International Journal of Applied Pharmaceutics, pages 175-181.
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Cristina de Castro Spadari, Luciana B. Lopes & Kelly Ishida. (2017) Potential Use of Alginate-Based Carriers As Antifungal Delivery System. Frontiers in Microbiology 8.
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Pio Maria Furneri, Giulio P. Petronio, Virginia Fuochi, Sarha Cupri & Rosario Pignatello. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 697 748 .
Jean Yanique Petit, Paola Cavana, Sandra Thoumire, Jacques Guillot & Sébastien Perrot. (2016) Use of a modified hair strand test to assess the antifungal activity kinetics of dog hair after a 2% climbazole shampoo application. Veterinary Dermatology 27:3, pages 148-e38.
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Mansour Nassiri-Kashani, Roshanak Namdar, Shohreh Nafisi & Howard I. Maibach. (2016) Improved Voriconazole Topical Delivery by Nanoparticles (Minireview). Pharmaceutical Chemistry Journal 50:2, pages 76-79.
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Theerthagiri Revathy, Mangalam Achuthanandan Jayasri & Krishnamurthy Suthindhiran. 2016. Nanobiomaterials in Antimicrobial Therapy. Nanobiomaterials in Antimicrobial Therapy 67 101 .
Alireza Firooz, Shohreh Nafisi & Howard I. Maibach. (2015) Novel drug delivery strategies for improving econazole antifungal action. International Journal of Pharmaceutics 495:1, pages 599-607.
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Qi (Tony) Zhou, Sharon Shui Yee Leung, Patricia Tang, Thaigarajan Parumasivam, Zhi Hui Loh & Hak-Kim Chan. (2015) Inhaled formulations and pulmonary drug delivery systems for respiratory infections. Advanced Drug Delivery Reviews 85, pages 83-99.
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Mark Feldman, Julia Shenderovich, Abed Al Aziz Al-Quntar, Michael Friedman & Doron Steinberg. (2015) Sustained Release of a Novel Anti-Quorum-Sensing Agent against Oral Fungal Biofilms. Antimicrobial Agents and Chemotherapy 59:4, pages 2265-2272.
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Romain Merlos, Karim Amighi & Nathalie Wauthoz. (2014) Recent Developments in Inhaled Triazoles Against Invasive Pulmonary Aspergillosis. Current Fungal Infection Reports 8:4, pages 331-342.
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Bo?ena Karolewicz, Agata G?rniak, Artur Owczarek, Ewa ?urawska-P?aksej, Agnieszka Piwowar & Janusz Pluta. (2014) Thermal, spectroscopic, and dissolution studies of ketoconazole?Pluronic F127 system. Journal of Thermal Analysis and Calorimetry 115:3, pages 2487-2493.
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Varun Bhardwaj, Jitender Monga, Amit Sharma, Shailesh Sharma, Arun Sharma & Poonam Sharma. (2014) A novel surfactant aided micellar system of oxidation inhibitors in clotrimazole bioadhesive gel: development, characterization, in vitro and in vivo antifungal evaluation against Candida clinical isolates. RSC Adv. 4:88, pages 47207-47221.
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Stefano Veraldi. (2013) Isoconazole nitrate: a unique broad‐spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Mycoses 56:s1, pages 3-15.
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M. Pereiro FerreirósJr.Jr., F.J. García-Martínez & J. Alonso-González. (2012) Update on the Treatment of Superficial Mycoses. Actas Dermo-Sifiliográficas (English Edition) 103:9, pages 778-783.
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M. Pereiro FerreirósJr.Jr., F.J. García-Martínez & J. Alonso-González. (2012) Actualización en el tratamiento de las micosis cutáneas. Actas Dermo-Sifiliográficas 103:9, pages 778-783.
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Somayeh Jafarinejad, Kambiz Gilani, Esmaeil Moazeni, Mahmoud Ghazi-Khansari, Abdolhossein Rouholamini Najafabadi & Nasir Mohajel. (2012) Development of chitosan-based nanoparticles for pulmonary delivery of itraconazole as dry powder formulation. Powder Technology 222, pages 65-70.
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Koichi Izumikawa & Shigeru Kohno. (2012) Current Status of Drug Delivery Systems for Antifungal Drugs. Drug Delivery System 27:2, pages 93-105.
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Jian Zhang, Libo Wu, Hak-Kim Chan & Wiwik Watanabe. (2011) Formation, characterization, and fate of inhaled drug nanoparticles. Advanced Drug Delivery Reviews 63:6, pages 441-455.
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V Sankar, V Hearnden, K Hull, D Vidovic Juras, MS Greenberg, AR Kerr, PB Lockhart, LL Patton, S Porter & M Thornhill. (2011) Local drug delivery for oral mucosal diseases: challenges and opportunities. Oral Diseases 17:s1, pages 73-84.
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Nipur R Patel, Kenneth Damann, Claudia Leonardi & Cristina M Sabliov. (2010) Itraconazole-loaded poly(lactic- co -glycolic) acid nanoparticles for improved antifungal activity . Nanomedicine 5:7, pages 1037-1050.
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Claudia Salerno, Adriana M. Carlucci & Carlos Bregni. (2010) Study of In Vitro Drug Release and Percutaneous Absorption of Fluconazole from Topical Dosage Forms. AAPS PharmSciTech 11:2, pages 986-993.
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Wei Yang, Keat Theng Chow, Bo Lang, Nathan P. Wiederhold, Keith P. Johnston & Robert O. WilliamsIIIIII. (2010) In vitro characterization and pharmacokinetics in mice following pulmonary delivery of itraconazole as cyclodextrin solubilized solution. European Journal of Pharmaceutical Sciences 39:5, pages 336-347.
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Rakefet Czerninski, Sagi Sivan, Doron Steinberg, Irith Gati, Leonid Kagan & Michael Friedman. (2009) A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis. Clinical Oral Investigations 14:1, pages 71-78.
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Qamar Zia, Mohammad Farzuddin, Mairaj Ahmad Ansari, Maroof Alam, Azmat Ali, Iqbal Ahmad & Mohammad Owais. 2010. Combating Fungal Infections. Combating Fungal Infections 485 528 .
Justin A. Tolman, Nicole A. Nelson, Stephanie Bosselmann, Jay I. Peters, Jacqueline J. Coalson, Nathan P. Wiederhold & Robert O. WilliamsIIIIII. (2009) Dose tolerability of chronically inhaled voriconazole solution in rodents. International Journal of Pharmaceutics 379:1, pages 25-31.
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