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Review

Enhancing the nail permeability of topically applied drugs

Pages 1267-1282 | Published online: 01 Nov 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

Sameh Magdy Sarsik & Heba Saed El-Amawy. (2022) Uses of eye drops in dermatology, literature review. Journal of Dermatological Treatment 33:6, pages 2758-2770.
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Shari R. Lipner. (2019) Pharmacotherapy for onychomycosis: new and emerging treatments. Expert Opinion on Pharmacotherapy 20:6, pages 725-735.
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Aditya K. Gupta & Sarah G. Versteeg. (2016) Tavaborole – a treatment for onychomycosis of the toenails. Expert Review of Clinical Pharmacology 9:9, pages 1145-1152.
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Purnima Kataria, Gajanand Sharma, Kanika Thakur, Vikas Bansal, Sunil Dogra & Om Prakash Katare. (2016) Emergence of nail lacquers as potential transungual delivery system in the management of onchomycosis. Expert Opinion on Drug Delivery 13:7, pages 937-952.
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Sakine Tuncay Tanrıverdi, Süleyha Hilmioğlu Polat, Dilek Yeşim Metin, Gülşen Kandiloğlu & Özgen Özer. (2016) Terbinafine hydrochloride loaded liposome film formulation for treatment of onychomycosis: in vitro and in vivo evaluation. Journal of Liposome Research 26:2, pages 163-173.
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Aditya K. Gupta & Catherine Studholme. (2016) Novel investigational therapies for onychomycosis: an update. Expert Opinion on Investigational Drugs 25:3, pages 297-305.
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Rania A. El-Tatawy, Naeim M. Abd El-Naby, Esraa E. El-Hawary & Raghda A. Z. Talaat. (2015) A comparative clinical and mycological study of Nd-YAG laser versus topical terbinafine in the treatment of onychomycosis. Journal of Dermatological Treatment 26:5, pages 461-464.
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Aditya K Gupta & Fiona C Simpson. (2015) New pharmacotherapy for the treatment of onychomycosis: an update. Expert Opinion on Pharmacotherapy 16:2, pages 227-236.
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Manish V. Saner, Abhijeet D. Kulkarni & Chandrakantsing V. Pardeshi. (2014) Insights into drug delivery across the nail plate barrier. Journal of Drug Targeting 22:9, pages 769-789.
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Aditya K Gupta & Fiona C Simpson. (2014) Efinaconazole (Jublia) for the treatment of onychomycosis. Expert Review of Anti-infective Therapy 12:7, pages 743-752.
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Aditya K Gupta & Fiona C Simpson. (2014) Investigational drugs for onychomycosis. Expert Opinion on Investigational Drugs 23:1, pages 97-106.
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Shahindokht Bassiri-Jahromi, Amir houshang Ehsani, Mostafa Mirshams-Shahshahani & Behrooz Jamshidi. (2012) A comparative evaluation of combination therapy of fluconazole 1% and urea 40% compared with fluconazole 1% alone in a nail lacquer for treatment of onychomycosis: therapeutic trial. Journal of Dermatological Treatment 23:6, pages 453-456.
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Bárdur Sigurgeirsson & Mahmoud Ghannoum. (2012) Therapeutic potential of TDT 067 (terbinafine in Transfersome®): a carrier-based dosage form of terbinafine for onychomycosis. Expert Opinion on Investigational Drugs 21:10, pages 1549-1562.
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H. N. Shivakumar, Abhishek Juluri, B. G. Desai & S. Narasimha Murthy. (2012) Ungual and Transungual drug delivery. Drug Development and Industrial Pharmacy 38:8, pages 901-911.
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Maria Begoña Delgado-Charro. (2012) Iontophoretic drug delivery across the nail. Expert Opinion on Drug Delivery 9:1, pages 91-103.
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Siva Ram Kiran Vaka, Satyanarayana Narasimha Murthy, John H. O'Haver & Michael A. Repka. (2011) A platform for predicting and enhancing model drug delivery across the human nail plate. Drug Development and Industrial Pharmacy 37:1, pages 72-79.
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Anke Sieg & Valentine Wascotte. (2009) Diagnostic and therapeutic applications of iontophoresis. Journal of Drug Targeting 17:9, pages 690-700.
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Sandeep Kumar & Alexa B Kimball. (2009) New antifungal therapies for the treatment of onychomycosis. Expert Opinion on Investigational Drugs 18:6, pages 727-734.
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Articles from other publishers (87)

Wessam H. Abd-Elsalam & Samar M. Abouelatta. (2023) Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis. AAPS PharmSciTech 24:6.
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Anroop B. Nair, Bandar Aldhubiab, Jigar Shah, Shery Jacob, Mahesh Attimarad, Nagaraja Sreeharsha, Katharigatta N. Venugopala, Alex Joseph & Mohamed A. Morsy. (2023) Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole. Pharmaceutics 15:5, pages 1422.
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Siyu Wu, Wenlai Guo, Bo Li, Huidong Zhou, Hongqi Meng, Junyi Sun, Ruiyan Li, Deming Guo, Xi Zhang, Rui Li & Wenrui Qu. (2023) Progress of polymer-based strategies in fungal disease management: Designed for different roles. Frontiers in Cellular and Infection Microbiology 13.
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Preeti Chauhan, Rimpy Pahwa, Pooja Kumari, Tarun Kumar & Munish Ahuja. (2023) Development and Evaluation of Luliconazole Nail Lacquer Containing Potential Permeation Enhancers for an Enhanced Transungual Drug Delivery. Drug Delivery Letters 13:1, pages 35-47.
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Aditya K. Gupta, Shruthi Polla Ravi, Su Yong Choi, Adarsh Konda & Elizabeth A. Cooper. (2022) Strategies for the enhancement of nail plate permeation of drugs to treat onychomycosis. Journal of the European Academy of Dermatology and Venereology 37:2, pages 243-255.
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Khushbu Mahajan, Chander Grover, Vineet Relhan, Sushil Tahiliani, Archana Singal, MManjunath Shenoy & Deepak Jakhar. (2023) Nail Society of India (NSI) recommendations for pharmacologic therapy of onychomycosis. Indian Dermatology Online Journal 14:3, pages 330.
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Tom Bellmann, Ruth Luber, Lisa Kischio, Berit Karl, Yvette Pötzinger, Uwe Beekmann, Dana Kralisch, Cornelia Wiegand & Dagmar Fischer. (2022) Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases. International Journal of Pharmaceutics 628, pages 122267.
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Vinam Puri, Riya Savla, Kevin Chen, Keyaara Robinson, Amitkumar Virani & Bozena Michniak-Kohn. (2022) Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate. Pharmaceutics 14:10, pages 2204.
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Syeda Nashvia Adin, Isha Gupta, Asad Ali, Mohd Aqil, Mohd Mujeeb & Yasmin Sultana. (2022) Investigation on utility of some novel terpenes on transungual delivery of fluconazole for the management of onychomycosis. Journal of Cosmetic Dermatology 21:10, pages 5103-5110.
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Vessela V. Ouzounova-Raykova. (2022) Green nail syndrome on the nail plate and bed related with Enterococcus and Fusarium coinfection. Folia Medica 64:3, pages 547-550.
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Yashwant Giri, Amulyaratna Behera, Biswaranjan Mohanty, Gurudutta Pattnaik & S.K. Habibullah. (2022) Transungual Drug Delivery System for the Topical Treatment of Onychomycosis: A Review. Drug Delivery Letters 12:1, pages 2-18.
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K. Rizi, K. Xu, T. Begum, J. Faull, S. Bhakta & S. Murdan. (2022) A drug-in-adhesive anti-onychomycotic nail patch: Influence of drug and adhesive nature on drug release, ungual permeation, in vivo residence in human and anti-fungal efficacy. International Journal of Pharmaceutics 614, pages 121437.
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Andrey V. Belikov, Anastasia D. Tavalinskaya & Sergey N. Smirnov. (2021) Investigation of the Dual‐Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser‐Induced Transformations of the Drug Extinction Spectrum. Lasers in Surgery and Medicine 53:8, pages 1122-1131.
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Kamran Hidayat Ullah, Faisal Raza, Syed Mohsin Munawar, Muhammad Sohail, Hajra Zafar, Mazhar Iqbal Zafar & Tofeeq Ur-Rehman. (2021) Poloxamer 407 Based Gel Formulations for Transungual Delivery of Hydrophobic Drugs: Selection and Optimization of Potential Additives. Polymers 13:19, pages 3376.
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A. V. Belikov, S. N. Smirnov & A. D. Tavalinskaya. (2021) Laser Delivery and Spectral Study of a Chlorine-Containing Drug for the Treatment of Onychomycosis at Sequential Laser (λ = 2810 nm) and Photodynamic (λ = 656 ± 10 nm) Impact. Optics and Spectroscopy 129:7, pages 754-762.
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Rabia Aslam, Talib Hussain, Abid Mehmood Yousaf, Muhammad U. Ghori, Ikram U. Khan, Syed A.A. Rizvi & Yasser Shahzad. (2021) Onychomycosis: Current Understanding and Strategies for Enhancing Drug Delivery into Human Nail Tissue. Current Drug Research Reviews 13:1, pages 25-35.
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Abdelrahman M. Helmy. (2021) Overview of recent advancements in the iontophoretic drug delivery to various tissues and organs. Journal of Drug Delivery Science and Technology 61, pages 102332.
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Diba Abdollahi, Zahra Jafariazar & Minoo Afshar. (2020) Effect of monoterpenes on ex vivo transungual delivery of itraconazole for the management of onychomycosis. Journal of Cosmetic Dermatology 19:10, pages 2745-2751.
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Ali Reza Khosravi, Hojjatollah Shokri & Zahra Saffarian. (2020) Anti-fungal activity of some native essential oils against emerging multi-drug resistant human nondermatophytic moulds. Journal of Herbal Medicine 23, pages 100370.
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A.K. Gupta, N. Stec, R.C. Summerbell, N.H. Shear, V. Piguet, A. Tosti & B.M. Piraccini. (2020) Onychomycosis: a review. Journal of the European Academy of Dermatology and Venereology 34:9, pages 1972-1990.
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R. Aggarwal, M. Targhotra, B. Kumar, P.K. Sahoo & M.K. Chauhan. (2020) Treatment and management strategies of onychomycosis. Journal de Mycologie Médicale 30:2, pages 100949.
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Agrawal Vikas, Patel Rashmin, Patel Mrunali, Rahul B. Chavan & Thanki Kaushik. (2020) Mechanistic Insights of Formulation Approaches for the Treatment of Nail Infection: Conventional and Novel Drug Delivery Approaches. AAPS PharmSciTech 21:2.
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Nancy Khammo, Dave Chesters, Lauren Goldstone, Gayle Kennedy & Carolyn Buckley. (2019) A prospective study using image analysis to assess the efficacy of a topical treatment kit for mild onychomycosis. Mycoses 63:2, pages 233-240.
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Tainá Kreutz, Sheila Porto de Matos & Letícia Scherer Koester. (2020) Recent Patents on Permeation Enhancers for Drug Delivery Through Nails. Recent Patents on Drug Delivery & Formulation 13:3, pages 203-218.
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Simon Vanstone, James M. Stone, Sergey N. Gordeev & Richard H. Guy. (2019) Mechanism of human nail poration by high-repetition-rate, femtosecond laser ablation. Drug Delivery and Translational Research 9:5, pages 956-967.
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Andrey V. Belikov, Anastasia D. Tavalinskaya, Sergey N. Smirnov & Andrey N. Sergeev. (2019) Active Er-laser drug delivery using drug-impregnated gel for treatment of nail diseases. Biomedical Optics Express 10:7, pages 3232.
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Mahmoud Ghannoum, Lisa Long, Gernot Kunze, Marlis Sarkany & Hanan Osman‐Ponchet. (2019) A pilot, layerwise, ex vivo evaluation of the antifungal efficacy of amorolfine 5% nail lacquer vs other topical antifungal nail formulations in healthy toenails. Mycoses 62:6, pages 494-501.
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Shari R. Lipner & Richard K. Scher. (2019) Onychomycosis. Journal of the American Academy of Dermatology 80:4, pages 853-867.
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Sanjukta Duarah, Manisha Sharma & Jingyuan Wen. (2019) Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population. European Journal of Pharmaceutics and Biopharmaceutics 136, pages 48-69.
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A.K. Gupta, S.G. Versteeg & N.H. Shear. (2019) A practical application of onychomycosis cure - combining patient, physician and regulatory body perspectives. Journal of the European Academy of Dermatology and Venereology 33:2, pages 281-287.
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Aditya K. Gupta, Sarah G. Versteeg, Neil H. Shear, Vincent Piguet, Antonella Tosti & Bianca Maria Piraccini. (2018) A Practical Guide to Curing Onychomycosis: How to Maximize Cure at the Patient, Organism, Treatment, and Environmental Level. American Journal of Clinical Dermatology 20:1, pages 123-133.
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Elena Cutrín-Gómez, Soledad Anguiano-Igea, M. Delgado-Charro, José Gómez-Amoza & Francisco Otero-Espinar. (2018) Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers. Pharmaceutics 10:4, pages 273.
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Nedaa Shamali, Annegret Preuß, Irena Saltsman, Atif Mahammed, Zeev Gross, Georg Däschlein & Beate Röder. (2018) In vitro photodynamic inactivation (PDI) of pathogenic germs inducing onychomycosis. Photodiagnosis and Photodynamic Therapy 24, pages 358-365.
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Elena Cutrín-Gómez, Soledad Anguiano-Igea, M. Delgado-Charro, José Gómez-Amoza & Francisco Otero-Espinar. (2018) Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer. Pharmaceutics 10:3, pages 156.
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