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Editorial

Crystallisation within transdermal rotigotine patch: is there cause for concern?

Pages 1169-1171 | Published online: 01 Nov 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Nornizar Anuar, Siti Nurul’ain Yusop & Kevin J. Roberts. (2022) Crystallisation of organic materials from the solution phase: a molecular, synthonic and crystallographic perspective. Crystallography Reviews 28:2-3, pages 97-215.
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Jonathan Hadgraft & Majella E. Lane. (2016) Drug crystallization – implications for topical and transdermal delivery. Expert Opinion on Drug Delivery 13:6, pages 817-830.
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M. Michaelis & C. S. Leopold. (2015) Mixture design approach for early stage formulation development of a transdermal delivery system. Drug Development and Industrial Pharmacy 41:9, pages 1532-1540.
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Jan-Peer Elshoff, Lars Timmermann, Miriam Schmid, Christoph Arth, Michael Komenda, Marcus Brunnert & Lars Bauer. (2013) Comparison of the bioavailability and adhesiveness of different rotigotine transdermal patch formulations. Current Medical Research and Opinion 29:12, pages 1657-1662.
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Sonali S Bharate & Ram A Vishwakarma. (2013) Impact of preformulation on drug development. Expert Opinion on Drug Delivery 10:9, pages 1239-1257.
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Shadab Md, Shadabul Haque, Jasjeet Kaur Sahni, Sanjula Baboota & Javed Ali. (2011) New non-oral drug delivery systems for Parkinson's disease treatment. Expert Opinion on Drug Delivery 8:3, pages 359-374.
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Shuting Li, Binbin Liu, Ziqiao Chen, Xiao Ou, Haowei Rong & Ming Lu. (2023) Ritonavir Revisited: Melt Crystallization Can Easily Find the Late-Appearing Polymorph II and Unexpectedly Discover a New Polymorph III. Molecular Pharmaceutics 20:8, pages 3854-3863.
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Paramita Saha, Himanshu Kathuria & Murali Monohar Pandey. (2023) Nose-to-brain delivery of rotigotine redispersible nanosuspension: In vitro and in vivo characterization. Journal of Drug Delivery Science and Technology 79, pages 104049.
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Nicola Paccione, Mahdieh Rahmani, Emilia Barcia & Sofía Negro. (2022) Antiparkinsonian Agents in Investigational Polymeric Micro- and Nano-Systems. Pharmaceutics 15:1, pages 13.
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Jigar S. Bhanushali & Sonali S. Bharate. (2022) Estimating thermodynamic equilibrium solubility and solute–solvent interactions of niclosamide in eight mono-solvents at different temperatures. Journal of Molecular Liquids 367, pages 120359.
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M. Bauer, F. Lacoulonche, R. Céolin, M. Barrio, I. Khichane, B. Robert, J.-Ll. Tamarit & I.B. Rietveld. (2022) On the dimorphism of prednisolone: The topological pressure-temperature phase diagram involving forms I and II. International Journal of Pharmaceutics 624, pages 122047.
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Li-Shang Liu, Jong-Min Kim & Woo-Sik Kim. (2022) In situ discrimination of polymorphs and phase transformation of sulfamerazine using quartz crystal microbalance. Analytica Chimica Acta, pages 340137.
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Venkat Kapil & Edgar A. Engel. (2022) A complete description of thermodynamic stabilities of molecular crystals. Proceedings of the National Academy of Sciences 119:6, pages e2111769119.
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Paramita Saha & Murali Monohar Pandey. (2022) A new fluorescence-based method for rapid and specific quantification of rotigotine in chitosan nanoparticles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 267, pages 120555.
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Tamaki Miyazaki, Yukio Aso & Yukihiro Goda. (2022) Detection and Analysis of Drug Crystals in Medical Transdermal Patches by Using X-ray Diffraction MeasurementX線回折測定による医療用経皮吸収型製剤中の薬物結晶の検出と解析. YAKUGAKU ZASSHI 142:1, pages 65-74.
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Stephen A. Thompson, Daniel A. DavisJr.Jr., James C. DiNunzio, Charlie Martin, Robert O. WilliamsIIIIII & Feng Zhang. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 327 376 .
David Lee & Tamara Minko. (2021) Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier. Pharmaceutics 13:12, pages 2049.
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Eun Ji Kim & Du Hyung Choi. (2021) Quality by design approach to the development of transdermal patch systems and regulatory perspective. Journal of Pharmaceutical Investigation 51:6, pages 669-690.
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Leen N. Kalash, Jason C. Cole, Royston C. B. Copley, Colin M. Edge, Alexandru A. Moldovan, Ghazala Sadiq & Cheryl L. Doherty. (2021) First global analysis of the GSK database of small molecule crystal structures. CrystEngComm 23:32, pages 5430-5442.
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Brian Samas, Wesley D. Clark, Ai-Fang Li, Frank C. PickardIVIV & Geoffrey P. F. Wood. (2021) Five Degrees of Separation: Characterization and Temperature Stability Profiles for the Polymorphs of PD-0118057 (Molecule XXIII). Crystal Growth & Design 21:8, pages 4435-4444.
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Sivakumar Sekharan, Xuetao Liu, Zhuocen Yang, Xiang Liu, Li Deng, Shigang Ruan, Yuriy Abramov, GuangXu Sun, Sizhu Li, Tian Zhou, Baime Shi, Qun Zeng, Qiao Zeng, Chao Chang, Yingdi Jin & Xuekun Shi. (2021) Selecting a stable solid form of remdesivir using microcrystal electron diffraction and crystal structure prediction. RSC Advances 11:28, pages 17408-17412.
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GuangXu Sun, Xuetao Liu, Yuriy A. Abramov, Sten O. Nilsson Lill, Chao Chang, Virginia Burger & Anders Broo. (2021) Current State-of-the-art In-house and Cloud-Based Applications of Virtual Polymorph Screening of Pharmaceutical Compounds: A Challenging Case of AZD1305 . Crystal Growth & Design 21:4, pages 1972-1983.
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Vanessa Raeder, Iro Boura, Valentina Leta, Peter Jenner, Heinz Reichmann, Claudia Trenkwalder, Lisa Klingelhoefer & K. Ray Chaudhuri. (2021) Rotigotine Transdermal Patch for Motor and Non-motor Parkinson’s Disease: A Review of 12 Years’ Clinical Experience. CNS Drugs 35:2, pages 215-231.
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Ivo B. Rietveld, Philippe Negrier, Maria Barrio, Hassan Allouchi, René Ceolin & Josep-Lluís Tamarit. (2021) Crystalline tetrazepam as a case study on the volume change on melting of molecular organic compounds. International Journal of Pharmaceutics 593, pages 120124.
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H. A. J. Oonk & I. B. Rietveld. 2021. Molecular Mixed Crystals. Molecular Mixed Crystals 221 250 .
Mingjun Yang, Eric Dybeck, Guangxu Sun, Chunwang Peng, Brian Samas, Virginia M. Burger, Qun Zeng, Yingdi Jin, Michael A. Bellucci, Yang Liu, Peiyu Zhang, Jian Ma, Yide Alan Jiang, Bruno C. Hancock, Shuhao Wen & Geoffrey P. F. Wood. (2020) Prediction of the Relative Free Energies of Drug Polymorphs above Zero Kelvin. Crystal Growth & Design 20:8, pages 5211-5224.
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Shadab Md, Shahid Karim, Sanggetha R. Saker, Ooi A. Gie, Lim C. Hooi, Phua H. Yee, Alvin W.C. Kang, Chen K. Zhe, Ng Ian, Hibah M. Aldawsari, Khaled M. Hosny & Nabil A. Alhakamy. (2020) Current Status and Challenges in Rotigotine Delivery. Current Pharmaceutical Design 26:19, pages 2222-2232.
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Dabing Chen, Qinfang Sun, Wenjun Huang & Bing-Shiou Yang. (2020) Diverse Solvent Selection for Polymorph Landscape Investigation Based on Specific API–Solvent Interactions. Crystal Growth & Design 20:4, pages 2251-2265.
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Subrat K. Bhattamisra, Angeline Tzeyung Shak, Lim Wen Xi, Nurul Hasyanazifa Safian, Hira Choudhury, Wei Meng Lim, Naiyer Shahzad, Nabil A. Alhakamy, Md Khalid Anwer, Ammu K. Radhakrishnan & Shadab Md. (2020) Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease. International Journal of Pharmaceutics 579, pages 119148.
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Yuriy A. Abramov, Peiyu Zhang, Qiao Zeng, Mingjun Yang, Yang Liu & Sivakumar Sekharan. (2020) Computational Insights into Kinetic Hindrance Affecting Crystallization of Stable Forms of Active Pharmaceutical Ingredients. Crystal Growth & Design 20:3, pages 1512-1525.
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M. Barrio, H. Allouchi, J.-Ll. Tamarit, R. Céolin, L. Berthon-Cédille & I.B. Rietveld. (2019) Experimental and topological determination of the pressure-temperature phase diagram of racemic etifoxine, a pharmaceutical ingredient with anxiolytic properties. International Journal of Pharmaceutics 572, pages 118812.
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Angeline Tzeyung, Shadab Md, Subrat Bhattamisra, Thiagarajan Madheswaran, Nabil Alhakamy, Hibah Aldawsari & Ammu Radhakrishnan. (2019) Fabrication, Optimization, and Evaluation of Rotigotine-Loaded Chitosan Nanoparticles for Nose-To-Brain Delivery. Pharmaceutics 11:1, pages 26.
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Jonas Nyman & Susan M. Reutzel-Edens. (2018) Crystal structure prediction is changing from basic science to applied technology. Faraday Discussions 211, pages 459-476.
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Purnendu Kumar Sharma, Apoorva Panda, Adwait Pradhan, Jiaxiang Zhang, Ruchi Thakkar, Chang-Hee Whang, Michael A. Repka & S. Narasimha Murthy. (2017) Solid-State Stability Issues of Drugs in Transdermal Patch Formulations. AAPS PharmSciTech 19:1, pages 27-35.
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Chengcheng Zhang & Adam J. Matzger. (2017) A Newly Discovered Racemic Compound of Pioglitazone Hydrochloride Is More Stable than the Commercial Conglomerate. Crystal Growth & Design 17:2, pages 414-417.
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Hee J. Kim, Beom S. Jeon & Peter Jenner. 2017. Parkinson's Disease. Parkinson's Disease 295 343 .
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Michael N Pastore, Yogeshvar N Kalia, Michael Horstmann & Michael S Roberts. (2015) Transdermal patches: history, development and pharmacology. British Journal of Pharmacology 172:9, pages 2179-2209.
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Arturo Benitez, Heather Edens, Jesse Fishman, Kimberly Moran & Mahnaz Asgharnejad. (2014) Rotigotine transdermal system: developing continuous dopaminergic delivery to treat Parkinson's disease and restless legs syndrome. Annals of the New York Academy of Sciences 1329:1, pages 45-66.
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Donald A. McAfee, Jonathan Hadgraft & Majella E. Lane. (2014) Rotigotine: The first new chemical entity for transdermal drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 88:3, pages 586-593.
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Toshio Nakaki. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 255 272 .
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Vishal Sachdeva, Yun Bai, Agis Kydonieus & Ajay K. Banga. (2013) Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies. International Journal of Pharmaceutics 441:1-2, pages 9-18.
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