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Expert Opinion on Drug Delivery Volume 5, 2008 - Issue 12
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Review

Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy

Yunching Chen University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, Campus Box 7360 Kerr Hall, Chapel Hill, NC 27599, USA +1 919 843 0736; +1 919 966 0197; [email protected]
&
Leaf Huang University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, Campus Box 7360 Kerr Hall, Chapel Hill, NC 27599, USA +1 919 843 0736; +1 919 966 0197; [email protected]
Pages 1301-1311 | Published online: 17 Nov 2008

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Eshrat Gharaei Fathabadi, Andrew N. Shelling & Raida Al-Kassas. (2012) Nanocarrier systems for delivery of siRNA to ovarian cancer tissues. Expert Opinion on Drug Delivery 9:7, pages 743-754.
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Chao Lin & Johan FJ Engbersen. (2009) The role of the disulfide group in disulfide-based polymeric gene carriers. Expert Opinion on Drug Delivery 6:4, pages 421-439.
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Nishit Pathak, Sunil K. Vimal, Cao Hongyi & Sanjib Bhattacharya. 2022. Targeted Drug Delivery. Targeted Drug Delivery 389 424 .
Rajat Goyal, Hitesh Chopra, Inderbir singh, Kamal Dua & Rupesh K. Gautam. (2022) Insights on prospects of nano-siRNA based approaches in treatment of Cancer. Frontiers in Pharmacology 13.
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Hanieh Mousazadeh, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour & Nosratollah Zarghami. (2021) Cyclodextrin based natural nanostructured carbohydrate polymers as effective non-viral siRNA delivery systems for cancer gene therapy. Journal of Controlled Release 330, pages 1046-1070.
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Abid Qureshi, Vaqar Gani Tantray, Altaf Rehman Kirmani & Abdul Ghani Ahangar. (2018) A review on current status of antiviral siRNA. Reviews in Medical Virology 28:4, pages e1976.
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Guimiao Lin, Ting Chen, Jinyun Zou, Yucheng Wang, Xiaomei Wang, Jiefeng Li, Qijun Huang, Zicai Fu, Yingying Zhao, Marie Chia-Mi Lin, Gaixia Xu & Ken-Tye Yong. (2017) Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. Frontiers in Pharmacology 8.
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Shin-Yu Lee, Chia-Ying Yang, Cheng-Liang Peng, Ming-Feng Wei, Ke-Cheng Chen, Cheng-Jung Yao & Ming-Jium Shieh. (2016) A theranostic micelleplex co-delivering SN-38 and VEGF siRNA for colorectal cancer therapy. Biomaterials 86, pages 92-105.
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Can Sarisozen, Giuseppina Salzano & Vladimir P. Torchilin. (2015) Recent advances in siRNA delivery. Biomolecular Concepts 6:5-6, pages 321-341.
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Haobo Han, Hui Shi, Di Wu, Chunjie Li, Yan Zhang, Zhen Xing, Wei Shi & Quanshun Li. (2015) Genipin-Cross-Linked Thermophilic Histone-Polyethylenimine as a Hybrid Gene Carrier. ACS Macro Letters 4:5, pages 575-578.
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Lu Han, Cui Tang & Chunhua Yin. (2015) Enhanced antitumor efficacies of multifunctional nanocomplexes through knocking down the barriers for siRNA delivery. Biomaterials 44, pages 111-121.
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Hui Shi, Haobo Han, Zhen Xing, Jiawen Chen, Yudi Wang, Aijun Zhang, Wei Shi & Quanshun Li. (2015) A protein–polymer hybrid gene carrier based on thermophilic histone and polyethylenimine. New Journal of Chemistry 39:9, pages 6718-6721.
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Zhaopei Guo, Huayu Tian, Lin Lin, Jie Chen, Chaoliang He, Zhaohui Tang & Xuesi Chen. (2014) Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier. Macromolecular Bioscience 14:10, pages 1406-1414.
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Jun Yang, Hongmei Liu & Xin Zhang. (2014) Design, preparation and application of nucleic acid delivery carriers. Biotechnology Advances 32:4, pages 804-817.
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Yizhou DongKevin T. LoveJ. Robert DorkinSasilada SirirungruangYunlong ZhangDelai ChenRoman L. BogoradHao YinYi ChenArturo J. VegasChristopher A. AlabiGaurav SahayKarsten T. OlejnikWeiheng WangAvi SchroederAbigail K. R. Lytton-JeanDaniel J. SiegwartAkin Akinc, Carmen Barnes, Scott A. Barros, Mary Carioto, Kevin Fitzgerald, Julia Hettinger, Varun Kumar, Tatiana I. Novobrantseva, June Qin, William Querbes, Victor Koteliansky, Robert LangerDaniel G. Anderson. (2014) Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proceedings of the National Academy of Sciences 111:11, pages 3955-3960.
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Demosthenes E Ziogas. (2014) Genome-based approaches for the diagnosis of breast cancer: a review with perspective. Breast Cancer Management 3:2, pages 173-193.
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Marya Ahmed, Kazuhiko Ishihara & Ravin Narain. (2014) Calcium mediated formation of phosphorylcholine-based polyplexes for efficient knockdown of epidermal growth factor receptors (EGFR) in HeLa cells. Chem. Commun. 50:22, pages 2943-2946.
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Guimiao Lin, Chengbin Yang, Rui Hu, Chih-Kuang Chen, Wing-Cheung Law, Tommy Anderson, Butian Zhang, Quoc Toan Nguyen, Hui Ting Toh, Ho Sup Yoon, Chong Cheng & Ken-Tye Yong. (2014) Interleukin-8 gene silencing on pancreatic cancer cells using biodegradable polymer nanoplexes. Biomater. Sci. 2:7, pages 1007-1015.
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Shanshan Hong, Xiaoyan Zhang, Jun Chen, Jiabing Zhou, Yufang Zheng & Congjian Xu. (2013) Targeted gene silencing using a follicle-stimulating hormone peptide-conjugated nanoparticle system improves its specificity and efficacy in ovarian clear cell carcinoma in vitro. Journal of Ovarian Research 6:1.
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QingShuo Meng, Qi Yin & YaPing Li. (2013) Nanocarriers for siRNA delivery to overcome cancer multidrug resistance. Chinese Science Bulletin 58:33, pages 4021-4030.
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Bin Shi & Marc Abrams. (2013) Technologies for Investigating the Physiological Barriers to Efficient Lipid Nanoparticle–siRNA Delivery. Journal of Histochemistry & Cytochemistry 61:6, pages 407-420.
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X. Dong, L. Lin, J. Chen, H. Tian, C. Xiao, Z. Guo, Y. Li, Y. Wei & X. Chen. (2013) Multi-armed poly(aspartate-g-OEI) copolymers as versatile carriers of pDNA/siRNA. Acta Biomaterialia 9:6, pages 6943-6952.
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V. A. Furalyov, I. V. Kravchenko & V. O. Popov. (2013) Targeted delivery of siRNA to differentiated murine myotubes in culture by a conjugate of cationic oligopeptide with FS2 venom. Biochemistry (Moscow) 78:4, pages 418-423.
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Yongmei Shen. (2012) Growth inhibition and apoptosis of human B-cell lymphoma in vitro and in vivo by Bcl-2 short hairpin RNA. Oncology Reports.
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Mehrdad Hamidi, Mohammad‐Ali Shahbazi & Kobra Rostamizadeh. (2011) Copolymers: Efficient Carriers for Intelligent Nanoparticulate Drug Targeting and Gene Therapy. Macromolecular Bioscience 12:2, pages 144-164.
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Jialiang Xia, Lei Chen, Huayu Tian, Xuesi Chen, Atsushi Maruyama & Tae Gwan Park. (2011) Synthesis of oligoethylenimine grafted net-poly(amino ester) and their application in gene delivery. Journal of Controlled Release 152, pages e176-e177.
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Seok-Jun Kim, Ji-Sun Oh, Ji-Young Shin, Kang-Duck Lee, Ki Woong Sung, Seok Jin Nam & Kyung-Hee Chun. (2011) Development of microRNA-145 for therapeutic application in breast cancer. Journal of Controlled Release 155:3, pages 427-434.
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Bin Shi, Ed Keough, Andrea Matter, Karen Leander, Stephanie Young, Ed Carlini, Alan B. Sachs, Weikang Tao, Marc Abrams, Bonnie Howell & Laura Sepp-Lorenzino. (2011) Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery. Journal of Histochemistry & Cytochemistry 59:8, pages 727-740.
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Jagat R. Kanwar, Sishir K. Kamalapuram & Rupinder K. Kanwar. (2011) Targeting survivin in cancer: the cell-signalling perspective. Drug Discovery Today 16:11-12, pages 485-494.
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Xuan Dong, Huayu Tian, Lei Chen, Jie Chen & Xuesi Chen. (2011) Biodegradable mPEG-b-P(MCC-g-OEI) copolymers for efficient gene delivery. Journal of Controlled Release 152:1, pages 135-142.
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Melissa D. Krebs & Eben Alsberg. (2011) Localized, Targeted, and Sustained siRNA Delivery. Chemistry – A European Journal 17:11, pages 3054-3062.
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Jialiang Xia, Lei Chen, Jie Chen, Huayu Tian, Feifan Li, Xiaojuan Zhu, Gao Li & Xuesi Chen. (2011) Hydrophobic Polyphenylalanine-Grafted Hyperbranched Polyethylenimine and its in vitro Gene Transfection. Macromolecular Bioscience 11:2, pages 211-218.
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Jeong-Hun Kang, Riki Toita & Yoshiki Katayama. (2010) Bio and nanotechnological strategies for tumor-targeted gene therapy. Biotechnology Advances 28:6, pages 757-763.
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