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Review

Applications of hot-melt extrusion for drug delivery

, DDS PhD, , , &
Pages 1357-1376 | Published online: 01 Dec 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (22)

Junqi Wu, Sawnaz Shaidani, Sophia K. Theodossiou, Emily J. Hartzell & David L. Kaplan. (2022) Localized, on-demand, sustained drug delivery from biopolymer-based materials. Expert Opinion on Drug Delivery 19:10, pages 1317-1335.
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Vishal Sharad Chaudhari, Tushar Kanti Malakar, Upadhyayula Suryanarayana Murty & Subham Banerjee. (2021) Extruded filaments derived 3D printed medicated skin patch to mitigate destructive pulmonary tuberculosis: design to delivery. Expert Opinion on Drug Delivery 18:2, pages 301-313.
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Zhaoyang Zhang, Luning Dong, Jueshuo Guo, Li Li, Bin Tian, Qipeng Zhao & Jianhong Yang. (2021) Prediction of the physical stability of amorphous solid dispersions: relationship of aging and phase separation with the thermodynamic and kinetic models along with characterization techniques. Expert Opinion on Drug Delivery 18:2, pages 249-264.
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C. Kulkarni, A. L. Kelly, T. Gough, V. Jadhav, K. K. Singh & A. Paradkar. (2018) Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug. Drug Development and Industrial Pharmacy 44:2, pages 206-214.
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Sandra Lindert & Jörg Breitkreutz. (2017) Oromucosal multilayer films for tailor-made, controlled drug delivery. Expert Opinion on Drug Delivery 14:11, pages 1265-1279.
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Chia Miang Khor, Wai Kiong Ng, Parijat Kanaujia, Kok Ping Chan & Yuancai Dong. (2017) Hot-melt extrusion microencapsulation of quercetin for taste-masking. Journal of Microencapsulation 34:1, pages 29-37.
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Michał Teżyk, Bartłomiej Milanowski, Andrzej Ernst & Janina Lulek. (2016) Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review. Drug Development and Industrial Pharmacy 42:8, pages 1195-1214.
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Chinna Reddy Palem, Narendar Reddy Dudhipala, Sunil Kumar Battu, Michael A. Repka & Madhusudan Rao Yamsani. (2016) Development, optimization and in vivo characterization of domperidone-controlled release hot-melt-extruded films for buccal delivery. Drug Development and Industrial Pharmacy 42:3, pages 473-484.
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Roshan V. Tiwari, Hemlata Patil & Michael A. Repka. (2016) Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century. Expert Opinion on Drug Delivery 13:3, pages 451-464.
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Anastasia W. Irwan, Jacqueline E. Berania & Xueming Liu. (2016) A comparative study on the effects of amphiphilic and hydrophilic polymers on the release profiles of a poorly water-soluble drug. Pharmaceutical Development and Technology 21:2, pages 231-238.
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Xin Feng, Xingyou Ye, Jun-Bom Park, Wenli Lu, Joe Morott, Brad Beissner, Zhuoyang John Lian, Elanor Pinto, Vivian Bi, Stu Porter, Tom Durig, Soumyajit Majumdar & Michael A. Repka. (2015) Evaluation of the recrystallization kinetics of hot-melt extruded polymeric solid dispersions using an improved Avrami equation. Drug Development and Industrial Pharmacy 41:9, pages 1479-1487.
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Jun-Bom Park, Suneela Prodduturi, Joe Morott, Vijay I Kulkarni, Melissa R Jacob, Shabana I Khan, Steven P Stodghill & Michael A Repka. (2015) Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology. Expert Opinion on Drug Delivery 12:1, pages 1-13.
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Sorin Emilian Leucuta. (2014) Selecting oral bioavailability enhancing formulations during drug discovery and development. Expert Opinion on Drug Discovery 9:2, pages 139-150.
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Maren Preis, Christina Woertz, Peter Kleinebudde & Jörg Breitkreutz. (2013) Oromucosal film preparations: classification and characterization methods. Expert Opinion on Drug Delivery 10:9, pages 1303-1317.
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Weibin Deng, Soumyajit Majumdar, Abhilasha Singh, Sejal Shah, Noorullah Naqvi Mohammed, Seongbong Jo, Elanor Pinto, Divya Tewari, Thomas Durig & Michael A. Repka. (2013) Stabilization of fenofibrate in low molecular weight hydroxypropylcellulose matrices produced by hot-melt extrusion. Drug Development and Industrial Pharmacy 39:2, pages 290-298.
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Indrajit Ghosh, Radha Vippagunta, Shoufeng Li & Sudha Vippagunta. (2012) Key considerations for optimization of formulation and melt-extrusion process parameters for developing thermosensitive compound. Pharmaceutical Development and Technology 17:4, pages 502-510.
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Michael A Repka, Sejal Shah, Jiannan Lu, Sindhuri Maddineni, Joe Morott, Ketaki Patwardhan & Noorullah Naqvi Mohammed. (2012) Melt extrusion: process to product. Expert Opinion on Drug Delivery 9:1, pages 105-125.
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Parijat Kanaujia, Grace Lau, Wai Kiong Ng, Effendi Widjaja, Martin Schreyer, Andrea Hanefeld, Matthias Fischbach, Christoph Saal, Mario Maio & Reginald B.H. Tan. (2011) Investigating the effect of moisture protection on solid-state stability and dissolution of fenofibrate and ketoconazole solid dispersions using PXRD, HSDSC and Raman microscopy. Drug Development and Industrial Pharmacy 37:9, pages 1026-1035.
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Li Tan, Anthony J. Carella, Yukun Ren & Julian B. Lo. (2011) Process optimization for continuous extrusion wet granulation. Pharmaceutical Development and Technology 16:4, pages 302-315.
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Dennis Douroumis. (2011) Orally disintegrating dosage forms and taste-masking technologies; 2010. Expert Opinion on Drug Delivery 8:5, pages 665-675.
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