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Review

DNAzyme Delivery Systems: Getting Past First Base

, & , PhD
Pages 127-138 | Published online: 24 Feb 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Zhen Xing, Sai Gao, Yan Duan, Haobo Han, Li Li, Yan Yang & Quanshun Li. (2015) Delivery of DNAzyme targeting aurora kinase A to inhibit the proliferation and migration of human prostate cancer. International Journal of Nanomedicine 10, pages 5715-5727.
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Alesya A Fokina, Dmitry A Stetsenko & Jean-Christophe François. (2015) DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes. Expert Opinion on Biological Therapy 15:5, pages 689-711.
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Yan Chen, Lifang Yang, Suping Huang, Zhi Li, Lu Zhang, Jiang He, Zhijie Xu, Liyu Liu, Ya Cao & Lunquan Sun. (2013) Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model. International Journal of Nanomedicine 8, pages 3107-3118.
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Articles from other publishers (31)

Ashok Saini, Sandeep Yadav & Indra Mani. 2022. Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine. Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine 227 249 .
Xia Li, Fang Yang, Wenjiao Zhou, Ruo Yuan & Yun Xiang. (2020) Targeted and direct intracellular delivery of native DNAzymes enables highly specific gene silencing. Chemical Science 11:33, pages 8966-8972.
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Xiaoqin Qian, Xiaoxia Han, Luodan Yu, Tianming Xu & Yu Chen. (2019) Manganese‐Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability. Advanced Functional Materials 30:3, pages 1907066.
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Levon M. Khachigian. (2019) Deoxyribozymes as Catalytic Nanotherapeutic Agents. Cancer Research 79:5, pages 879-888.
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Elham Zokaei, Arastoo Badoei-dalfrad, Mehdi Ansari, Zahra Karami, Touba Eslaminejad & Seyed Noureddin Nematollahi-Mahani. (2018) Therapeutic Potential of DNAzyme Loaded on Chitosan/Cyclodextrin Nanoparticle to Recovery of Chemosensitivity in the MCF-7 Cell Line. Applied Biochemistry and Biotechnology 187:3, pages 708-723.
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Lingxian Meng, Wenjuan Ma, Shiyu Lin, Sirong Shi, Yanjing Li & Yunfeng Lin. (2019) Tetrahedral DNA Nanostructure-Delivered DNAzyme for Gene Silencing to Suppress Cell Growth. ACS Applied Materials & Interfaces 11:7, pages 6850-6857.
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Fatemeh Farrokhi, Zahra Karami, Saeed Esmaeili-Mahani & Abolfazl Heydari. (2018) Delivery of DNAzyme targeting c-Myc gene using β-cyclodextrin polymer nanocarrier for therapeutic application in human breast cancer cell line. Journal of Drug Delivery Science and Technology 47, pages 477-484.
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Evgeny Katz. 2018. Signal-Switchable Electrochemical Systems. Signal-Switchable Electrochemical Systems 229 261 .
Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar & Yadollah Omidi. (2018) Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective. Journal of Molecular Medicine 96:9, pages 885-902.
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Alyssa K. Hartmann, Dominic F. Cairns-Gibson, Joshua J. Santiana, Mark Q. Tolentino, Halle M. Barber & Jessica L. Rouge. (2018) Enzymatically Ligated DNA-Surfactants: Unmasking Hydrophobically Modified DNA for Intracellular Gene Regulation. ChemBioChem 19:16, pages 1734-1739.
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Hien Bao Dieu Thai, Fabienne Levi-Acobas, Soo-Young Yum, Goo Jang, Marcel Hollenstein & Dae-Ro Ahn. (2018) Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity. Chemical Communications 54:68, pages 9410-9413.
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Huanhuan Fan, Xiaobing Zhang & Yi Lu. (2017) Recent advances in DNAzyme-based gene silencing. Science China Chemistry 60:5, pages 591-601.
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Shivangi Goyal, Nidhi Gupta & Ramesh Chandra. 2017. Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids. Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids 151 164 .
Shujun Fu & Lun-Quan Sun. (2015) DNAzyme-based therapeutics for cancer treatment. Future Medicinal Chemistry 7:13, pages 1701-1707.
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Ming Zhou. (2015) Recent Progress on the Development of Biofuel Cells for Self-Powered Electrochemical Biosensing and Logic Biosensing: A Review. Electroanalysis 27:8, pages 1786-1810.
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Kay Marquardt, Anna-Carola Eicher, Dorota Dobler, Ulf Mäder, Thomas Schmidts, Harald Renz & Frank Runkel. (2015) Development of a protective dermal drug delivery system for therapeutic DNAzymes. International Journal of Pharmaceutics 479:1, pages 150-158.
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Ilya Ulasov, Ruiyang Yi, Donna Guo, Purvaba Sarvaiya & Charles Cobbs. (2014) The emerging role of MMP14 in brain tumorigenesis and future therapeutics. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846:1, pages 113-120.
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Wei-Yun Lai, Chi-Yuan Chen, Shuenn-Chen Yang, Jer-Yuarn Wu, Cheng-Ju Chang, Pan-Chyr Yang & Konan Peck. (2014) Overcoming EGFR T790M-based Tyrosine Kinase Inhibitor Resistance with an Allele-specific DNAzyme. Molecular Therapy - Nucleic Acids 3, pages e150.
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Khaleelulla Saheb Shaik & Bernard Moussian. 2013. Handbook of Biopolymer‐Based Materials. Handbook of Biopolymer‐Based Materials 109 142 .
Yu Xiang, Peiwen Wu, Li Huey Tan & Yi Lu. 2014. Biosensors Based on Aptamers and Enzymes. Biosensors Based on Aptamers and Enzymes 93 120 .
Lu Zhang, Lifang Yang, Jian Jian Li & Lunquan Sun. (2012) Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy. Cancer Letters 323:1, pages 1-10.
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ZhiJie Xu, LiFang Yang, LunQuan Sun & Ya Cao. (2012) Use of DNAzymes for cancer research and therapy. Chinese Science Bulletin 57:26, pages 3404-3408.
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John J. Rossi. (2012) Resurrecting DNAzymes as Sequence-Specific Therapeutics. Science Translational Medicine 4:139.
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Ming Zhou, Filiz Kuralay, Joshua R. Windmiller & Joseph Wang. (2012) DNAzyme logic-controlled biofuel cells for self-powered biosensors. Chemical Communications 48:32, pages 3815.
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P. I. Pradeepkumar & Claudia Höbartner. 2012. From Nucleic Acids Sequences to Molecular Medicine. From Nucleic Acids Sequences to Molecular Medicine 371 410 .
Vuk Uskoković & Dragan P. Uskoković. (2011) Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents. Journal of Biomedical Materials Research Part B: Applied Biomaterials 96B:1, pages 152-191.
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Mei Lin Tan, Peter FM Choong & Crispin R Dass. (2010) Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours. Cancer Cell International 10:1.
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Nikolaos P. Mastroyiannopoulos, James B. Uney & Leonidas A. Phylactou. (2010) The Application of Ribozymes and DNAzymes in Muscle and Brain. Molecules 15:8, pages 5460-5472.
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Crispin R. DassStuart J. GallowayPeter F.M. Choong. (2010) Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation. Oligonucleotides 20:3, pages 137-146.
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Crispin R. DassMei Lin TanStuart J. GallowayPeter F.M. Choong. (2010) Dz13 Induces a Cytotoxic Stress Response with Upregulation of E2F1 in Tumor Cells Metastasizing to or from Bone. Oligonucleotides 20:2, pages 79-91.
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Junming LiNa WangQing LuoLagen Wan. (2010) The 10–23 DNA Enzyme Generated by a Novel Expression Vector Mediate Inhibition of Taco Expression in Macrophage. Oligonucleotides 20:2, pages 61-68.
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