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The use of gentamicin-impregnated foam in the management of diabetic foot infections: a promising delivery system?

, MA CCRP, , FCPodS, , PhD, , MD & , DPM PhD
Pages 639-642 | Published online: 12 Jun 2009

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Dóra Farkas, Nikolett Kállai-Szabó, Ágnes Sárádi-Kesztyűs, Miléna Lengyel, Sabrina Magramane, Éva Kiss & István Antal. (2021) Investigation of propellant-free aqueous foams as pharmaceutical carrier systems. Pharmaceutical Development and Technology 26:3, pages 253-261.
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Veera Venkata Satyanarayana Reddy Karri, Gowthamarajan Kuppusamy, Siddhartha Venkata Talluri, Karthik Yamjala, Sai Sandeep Mannemala & Rajkumar Malayandi. (2016) Current and emerging therapies in the management of diabetic foot ulcers. Current Medical Research and Opinion 32:3, pages 519-542.
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Kaissar Yammine, Bilal Alqaysi, Jad Mansour, Joeffroy Otayek, Jimmy Daher & Chahine Assi. (2023) Gentamicin-permeated cement to sustain mechanical support for the treatment of a chronic calcaneal abscess. A case report. International Journal of Surgery Case Reports 111, pages 108846.
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T Ajayakumar, N Nizaj, PrinceShanavas Khan, Aebel Raju, SanjaiP Johny & Vidya Ajay. (2023) The use of antibiotic-loaded absorbable calcium sulfate beads in open fractures: A prospective study. Journal of Orthopaedic Association of South Indian States 20:1, pages 33.
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Abdulaziz I. Alzarea, Nabil K. Alruwaili, Muhammad Masood Ahmad, Muhammad Usman Munir, Adeel Masood Butt, Ziyad A. Alrowaili, Muhammad Syafiq Bin Shahari, Ziyad S. Almalki, Saad S. Alqahtani, Anton V. Dolzhenko & Naveed Ahmad. (2022) Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films as Antibacterial Wound Dressing. International Journal of Molecular Sciences 23:5, pages 2899.
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Yuval Ramot, Shlomo Nedvetzki, Sefi Rosenfeld, Serge D. Rousselle, Abraham Nyska & Noam Emanuel. (2020) D-PLEX 100 in an Abdominal Surgery Incision Model in Miniature Swine: Safety Study . Toxicologic Pathology 48:5, pages 677-685.
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Diana Gomes, Raquel Santos, Rui S. Soares, Solange Reis, Sandra Carvalho, Pedro Rego, Maria C. Peleteiro, Luís Tavares & Manuela Oliveira. (2020) Pexiganan in Combination with Nisin to Control Polymicrobial Diabetic Foot Infections. Antibiotics 9:3, pages 128.
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Yuval Ramot, Shlomo Nedvetzki, Sefi Rosenfeld, Noam Emanuel & Abraham Nyska. (2019) Toxicity and Safety Study of D-PLEX 100 in a Sternal Surgical Defect in New Zealand White Rabbits . Toxicologic Pathology 47:4, pages 504-514.
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Chiara Tonda-Turo, Francesca Ruini, Chiara Ceresa, Piergiorgio Gentile, Patrícia Varela, Ana M. Ferreira, Letizia Fracchia & Gianluca Ciardelli. (2018) Nanostructured scaffold with biomimetic and antibacterial properties for wound healing produced by ‘green electrospinning’. Colloids and Surfaces B: Biointerfaces 172, pages 233-243.
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Mohanapriya Madheswara, Saranya Asokan, Nitya Meenakshi, Nidhiya Anil Kumar & Suganthi Ramasamy. (2017) Biofilm Formation and its Susceptibility Testing of Myroides odoratimimus SKS05-GRD Using MBEC™ High-throughput Assay. Research Journal of Microbiology 13:1, pages 1-12.
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N. Patel, D. Hatch, C.M. Wells, D. Ahn, M. Harris, J.A. Jennings, W. Haggard & D.G. Armstrong. (2017) Characteristics and clinical assessment of antibiotic delivery by chitosan sponge in the high-risk diabetic foot: a case series. Journal of Wound Care 26:sup4, pages S32-S38.
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Bianca L. Price, Andrew M. Lovering, Frank L. Bowling & Curtis B. Dobson. (2016) Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection. Antimicrobial Agents and Chemotherapy 60:11, pages 6880-6889.
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C.E. Costa Almeida. (2016) Collagen implant with gentamicin sulphate as an option to treat a neuroischaemic diabetic foot ulcer: Case report. International Journal of Surgery Case Reports 21, pages 48-51.
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G.A. ter Boo, D.W. Grijpma, R.G. Richards, T.F. Moriarty & D. Eglin. (2015) Preparation of gentamicin dioctyl sulfosuccinate loaded poly(trimethylene carbonate) matrices intended for the treatment of orthopaedic infections. Clinical Hemorheology and Microcirculation 60:1, pages 89-98.
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Gert-Jan A. ter Boo, Dirk W. Grijpma, Thomas F. Moriarty, Robert G. Richards & David Eglin. (2015) Antimicrobial delivery systems for local infection prophylaxis in orthopedic- and trauma surgery. Biomaterials 52, pages 113-125.
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Takashi Iwakura, Sang Yang Lee, Takahiro Niikura, Masahiko Miwa, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda & Masahiro Kurosaka. (2014) Gentamycin-Impregnated Calcium Phosphate Cement for Calcaneal Osteomyelitis: A Case Report. Journal of Orthopaedic Surgery 22:3, pages 437-439.
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Luís Jesuíno de Oliveira Andrade, Larissa Santos França, Paulo Roberto Santana de Melo & Marcelo Araújo. (2014) Off-label prescriptions in diabetic foot. Jornal Vascular Brasileiro 13:3, pages 192-197.
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Galina M. Hayes, Thomas W.G. Gibson, Noel. M.M. Moens, Beatriz Monteiro & Ron J. Johnson. (2014) Intra-Articular Pharmacokinetics of a Gentamicin Impregnated Collagen Sponge in the Canine Stifle: An Experimental Study. Veterinary Surgery 43:2, pages 166-173.
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G. Hayes, N. Moens & T. Gibson. (2013) A review of local antibiotic implants and applications to veterinary orthopaedic surgery. Veterinary and Comparative Orthopaedics and Traumatology 26:4, pages 251-259.
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Benjamin A. Lipsky, Anthony R. Berendt, Paul B. Cornia, James C. Pile, Edgar J. G. Peters, David G. Armstrong, H. Gunner Deery, John M. Embil, Warren S. Joseph, Adolf W. Karchmer, Michael S. Pinzur & Eric Senneville. (2012) 2012 Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infectionsa. Clinical Infectious Diseases 54:12, pages e132-e173.
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. (2012) Topical Application of a Gentamicin-Collagen Sponge Combined with Systemic Antibiotic Therapy for the Treatment of Diabetic Foot Infections of Moderate Severity. Journal of the American Podiatric Medical Association 102:3, pages 223-232.
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Wahid Khan, Deepak Yadav, Abraham J. Domb & Neeraj Kumar. 2011. Biodegradable Polymers in Clinical Use and Clinical Development. Biodegradable Polymers in Clinical Use and Clinical Development 59 89 .
Erin Yiling Teo, Shin-Yeu Ong, Mark Seow Khoon Chong, Zhiyong Zhang, Jia Lu, Shabbir Moochhala, Bow Ho & Swee-Hin Teoh. (2011) Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds. Biomaterials 32:1, pages 279-287.
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I Yetim, OV Özkan, A Dervişoglu, K Erzurumlu & E Canbolant. (2010) Effect of Local Gentamicin Application on Healing and Wound Infection in Patients with Modified Radical Mastectomy: A Prospective Randomized Study. Journal of International Medical Research 38:4, pages 1442-1447.
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