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Expert Opinion on Drug Delivery Volume 7, 2010 - Issue 2
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Mucoadhesion: a review of characterization techniques

Maya Davidovich-Pinhas Department of Chemical Engineering, Technion, Haifa 32000, Israel +972 4 8293588; +972 4 8295672; [email protected]
&
Havazelet Bianco-Peled Department of Chemical Engineering, Technion, Haifa 32000, Israel +972 4 8293588; +972 4 8295672; [email protected]
Pages 259-271 | Published online: 24 Jan 2010

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Abdelbasset Atia, Ahmed I. Gomma, Ismail Fliss, Eric Beyssac, Ghislain Garrait & Muriel Subirade. (2017) Molecular and biopharmaceutical investigation of alginate–inulin synbiotic coencapsulation of probiotic to target the colon. Journal of Microencapsulation 34:2, pages 171-184.
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András Kelemen, Mihály Gottnek, Géza Regdon$suffix/text()$suffix/text() & Klára Pintye-Hódi. (2015) New equipment for measurement of the force of adhesion of mucoadhesive films. Journal of Adhesion Science and Technology 29:13, pages 1360-1367.
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Sanjeev Rambharose, Elizabeth Ojewole, Irene Mackraj & Thirumala Govender. (2014) Comparative buccal permeability enhancement of didanosine and tenofovir by potential multifunctional polymeric excipients and their effects on porcine buccal histology. Pharmaceutical Development and Technology 19:1, pages 82-90.
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Inderbir Singh & Vikas Rana. (2012) Techniques for the Assessment of Mucoadhesion in Drug Delivery Systems: An Overview. Journal of Adhesion Science and Technology 26:18-19, pages 2251-2267.
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José das Neves, Maria Fernanda Bahia, Mansoor M Amiji & Bruno Sarmento. (2011) Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale. Expert Opinion on Drug Delivery 8:8, pages 1085-1104.
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Khosro Adibkia, Sanaz Hamedeyazdan & Yousef Javadzadeh. (2011) Drug release kinetics and physicochemical characteristics of floating drug delivery systems. Expert Opinion on Drug Delivery 8:7, pages 891-903.
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Andrea Cesari, Angela Fabiano, Anna Maria Piras, Ylenia Zambito, Gloria Uccello-Barretta & Federica Balzano. (2020) Binding and mucoadhesion of sulfurated derivatives of quaternary ammonium-chitosans and their nanoaggregates: An NMR investigation. Journal of Pharmaceutical and Biomedical Analysis 177, pages 112852.
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Someshwar Komati, Suryakanta SwainMuddana Eswara Bhanoji RaoBikash Ranjan JenaVishali Dasi. (2019) Mucoadhesive Multiparticulate Drug Delivery Systems: An ExtensiveReview of Patents. Advanced Pharmaceutical Bulletin 9:4, pages 521-538.
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Dhanasekaran Gayathri & Lakshmanan Saraswathy Jayakumari. (2019) Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide. Polímeros 29:4.
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Kenneth M. Estrellas, Mark Fiecas, Aharon Azagury, Bryan Laulicht, Daniel Y. Cho, Alexis Mancini, Joshua Reineke, Stacia Furtado & Edith Mathiowitz. (2019) Time-dependent mucoadhesion of conjugated bioadhesive polymers. Colloids and Surfaces B: Biointerfaces 173, pages 454-469.
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Sarah L. Cook, Samuel Woods, Lisa Methven, Jane K. Parker & Vitaliy V. Khutoryanskiy. (2018) Mucoadhesive polysaccharides modulate sodium retention, release and taste perception. Food Chemistry 240, pages 482-489.
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Xiaojin Chen, Jun Yan, Shuying Yu & Pingping Wang. (2017) Formulation and In Vitro Release Kinetics of Mucoadhesive Blend Gels Containing Matrine for Buccal Administration. AAPS PharmSciTech 19:1, pages 470-480.
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Sarah L. Cook, Stephanie P. Bull, Lisa Methven, Jane K. Parker & Vitaliy V. Khutoryanskiy. (2017) Mucoadhesion: A food perspective. Food Hydrocolloids 72, pages 281-296.
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Jun Yan, Xiaojin Chen, Shuying Yu & Hongping Zhou. (2017) Comparison of different in vitro mucoadhesion testing methods for hydrogels. Journal of Drug Delivery Science and Technology 40, pages 157-163.
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Chad S. Cummings, Alan S. Campbell, Stefanie L. Baker, Sheiliza Carmali, Hironobu Murata & Alan J. Russell. (2017) Design of Stomach Acid-Stable and Mucin-Binding Enzyme Polymer Conjugates. Biomacromolecules 18:2, pages 576-586.
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Muhammad Zaman, Nayab Sajid & Atta Ur Rehman. (2016) Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review. Advances in Polymer Technology 35:3, pages 269-276.
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Tal Eshel-Green, Shaked Eliyahu, Shlomit Avidan-Shlomovich & Havazelet Bianco-Peled. (2016) PEGDA hydrogels as a replacement for animal tissues in mucoadhesion testing. International Journal of Pharmaceutics 506:1-2, pages 25-34.
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Edward D. H. Mansfield, Victor R. de la Rosa, Radoslaw M. Kowalczyk, Isabelle Grillo, Richard Hoogenboom, Katy Sillence, Patrick Hole, Adrian C. Williams & Vitaliy V. Khutoryanskiy. (2016) Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier. Biomaterials Science 4:9, pages 1318-1327.
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Amanda E. Brooks. (2015) The Potential of Silk and Silk-Like Proteins as Natural Mucoadhesive Biopolymers for Controlled Drug Delivery. Frontiers in Chemistry 3.
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Pinaki Bhattacharya & Thomas Siegmund. (2014) The role of glottal surface adhesion on vocal folds biomechanics. Biomechanics and Modeling in Mechanobiology 14:2, pages 283-295.
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Julieta C. Imperiale, Pablo Nejamkin, Maria J. del Sole, Carlos E. Lanusse & Alejandro Sosnik. (2015) Novel protease inhibitor-loaded Nanoparticle-in-Microparticle Delivery System leads to a dramatic improvement of the oral pharmacokinetics in dogs. Biomaterials 37, pages 383-394.
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Alejandro Sosnik, José das Neves & Bruno Sarmento. (2014) Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review. Progress in Polymer Science 39:12, pages 2030-2075.
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Mohamed Haider, Magdy Mohamed & Muaadh Ali. (2014) Formulation and In vitro/In vivo Evaluation of Buccoadhesive Discs for Controlled Release of Calcium Channel Antagonist. American Journal of Drug Discovery and Development 4:4, pages 210-231.
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Erik Sjögren, Bertil Abrahamsson, Patrick Augustijns, Dieter Becker, Michael B. Bolger, Marcus Brewster, Joachim Brouwers, Talia Flanagan, Matthew Harwood, Christian Heinen, René Holm, Hans-Paul Juretschke, Marlies Kubbinga, Anders Lindahl, Viera Lukacova, Uwe Münster, Sibylle Neuhoff, Mai Anh Nguyen, Achiel van Peer, Christos Reppas, Amin Rostami Hodjegan, Christer Tannergren, Werner Weitschies, Clive Wilson, Patricia Zane, Hans Lennernäs & Peter Langguth. (2014) In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences 57, pages 99-151.
Crossref
Maya Davidovich-Pinhas & Havazelet Bianco-Peled. 2014. Mucoadhesive Materials and Drug Delivery Systems. Mucoadhesive Materials and Drug Delivery Systems 309 328 .
Christiane Müller & Andreas Bernkop-Schnürch. 2014. Mucoadhesive Materials and Drug Delivery Systems. Mucoadhesive Materials and Drug Delivery Systems 255 278 .
Gleb E. Yakubov, Scott Singleton & Ann-Marie Williamson. 2014. Mucoadhesive Materials and Drug Delivery Systems. Mucoadhesive Materials and Drug Delivery Systems 197 232 .
Christina Woertz, Maren Preis, Jörg Breitkreutz & Peter Kleinebudde. (2013) Assessment of test methods evaluating mucoadhesive polymers and dosage forms: An overview. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 843-853.
Crossref
Jinke Xu, Ghareb M. Soliman, Jake Barralet & Marta Cerruti. (2012) Mollusk Glue Inspired Mucoadhesives for Biomedical Applications. Langmuir 28:39, pages 14010-14017.
Crossref
Christiane Mueller, Andrea Verroken, Javed Iqbal & Andreas Bernkop‐Schnuerch. (2011) Thiolated chitosans: In vitro comparison of mucoadhesive properties . Journal of Applied Polymer Science 124:6, pages 5046-5055.
Crossref
Krzysztof Babiuch, Michael Gottschaldt, Oliver Werz & Ulrich S. Schubert. (2012) Particulate transepithelial drug carriers: barriers and functional polymers. RSC Advances 2:28, pages 10427.
Crossref
L. Rizza, G. Frasca, M. Nicholls, C. Puglia & V. Cardile. (2012) Caco-2 cell line as a model to evaluate mucoprotective proprieties. International Journal of Pharmaceutics 422:1-2, pages 318-322.
Crossref
Maya Davidovich-Pinhas & Havazelet Bianco-Peled. (2010) Novel mucoadhesive system based on sulfhydryl-acrylate interactions. Journal of Materials Science: Materials in Medicine 21:7, pages 2027-2034.
Crossref
M.C. Bonferoni, G. Sandri, F. Ferrari, S. Rossi, V. Larghi, Y. Zambito & C. Caramella. (2010) Comparison of different in vitro and ex vivo methods to evaluate mucoadhesion of glycol-palmitoyl chitosan micelles. Journal of Drug Delivery Science and Technology 20:6, pages 419-424.
Crossref
Maya Davidovich-Pinhas & Havazelet Bianco-Peled. 2011. Active Implants and Scaffolds for Tissue Regeneration. Active Implants and Scaffolds for Tissue Regeneration 439 456 .

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