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Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics

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Pages 285-293 | Published online: 05 Mar 2010

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G. Pizzichelli, B. Kehlet, Ø. Evju, B. A. Martin, M. E. Rognes, K. A. Mardal & E. Sinibaldi. (2017) Numerical study of intrathecal drug delivery to a permeable spinal cord: effect of catheter position and angle. Computer Methods in Biomechanics and Biomedical Engineering 20:15, pages 1599-1608.
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Rana Ajeeb & John R. Clegg. (2023) Intrathecal delivery of Macromolecules: Clinical status and emerging technologies. Advanced Drug Delivery Reviews 199, pages 114949.
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Smrithi Padmakumar, Anisha D'Souza, Neha N. Parayath, Benjamin S. Bleier & Mansoor M. Amiji. (2022) Nucleic acid therapies for CNS diseases: Pathophysiology, targets, barriers, and delivery strategies. Journal of Controlled Release 352, pages 121-145.
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Terhi J. Lohela, Tuomas O. Lilius & Maiken Nedergaard. (2022) The glymphatic system: implications for drugs for central nervous system diseases. Nature Reviews Drug Discovery 21:10, pages 763-779.
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Akari Seiner, Goutham Kumar Reddy Burla, Dev Shrestha, Mayumi Bowen, Joshua D. Horvath & Bryn A. Martin. (2022) Investigation of Human Intrathecal Solute Transport Dynamics Using a Novel in vitro Cerebrospinal Fluid System Analog. Frontiers in Neuroimaging 1.
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Mohammadreza Khani, Goutham Kumar Reddy Burla, Lucas R. Sass, Ostin N. Arters, Tao Xing, Haiming Wu & Bryn A. Martin. (2022) Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology. Fluids and Barriers of the CNS 19:1.
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Amal Kumar Dhara & Amit Kumar Nayak. 2022. Biological Macromolecules. Biological Macromolecules 3 22 .
Guoying Wang, Xiaowei Zhao, Haigang Wu, David B. Lovejoy, Meng Zheng, Albert Lee, Libing Fu, Kaiting Miao, Yi An, Nima Sayyadi, Kunjie Ding, Roger S. Chung, Yiqing Lu, Jia Li, Marco Morsch & Bingyang Shi. (2020) A Robust Intrinsically Green Fluorescent Poly(Amidoamine) Dendrimer for Imaging and Traceable Central Nervous System Delivery in Zebrafish. Small 16:39.
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Archana Khosa, Ranendra Narayan Saha & Gautam Singhvi. 2019. Nanomaterials for Drug Delivery and Therapy. Nanomaterials for Drug Delivery and Therapy 461 514 .
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Rokon Uz Zaman, Nihal S. Mulla, Keegan Braz Gomes, Cherilyn D'Souza, Kevin Sean Murnane & Martin J. D'Souza. (2018) Nanoparticle formulations that allow for sustained delivery and brain targeting of the neuropeptide oxytocin. International Journal of Pharmaceutics 548:1, pages 698-706.
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Per Thomas Haga, Giulia Pizzichelli, Mikael Mortensen, Miroslav Kuchta, Soroush Heidari Pahlavian, Edoardo Sinibaldi, Bryn A. Martin & Kent-Andre Mardal. (2017) A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space. PLOS ONE 12:3, pages e0173680.
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Chad Curtis, Mengying Zhang, Rick Liao, Thomas Wood & Elizabeth Nance. (2016) Systems‐level thinking for nanoparticle‐mediated therapeutic delivery to neurological diseases. WIREs Nanomedicine and Nanobiotechnology 9:2.
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Mansoor M. Amiji. Multifunctional combinatorial-designed nanoparticles for nucleic acid therapy. Multifunctional combinatorial-designed nanoparticles for nucleic acid therapy.
G. Pizzichelli, F. Di Michele & E. Sinibaldi. (2016) An analytical model for nanoparticles concentration resulting from infusion into poroelastic brain tissue. Mathematical Biosciences 272, pages 6-14.
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David Stepensky. 2016. Nanomedicine. Nanomedicine 201 220 .
Maurizio Scarpa, Cinzia Maria Bellettato, Christina Lampe & David J. Begley. (2015) Neuronopathic lysosomal storage disorders: Approaches to treat the central nervous system. Best Practice & Research Clinical Endocrinology & Metabolism 29:2, pages 159-171.
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Daniel Schweizer, Igor Vostiar, Annabelle Heier, Tim Serno, Karin Schoenhammer, Michael Jahn, Stewart Jones, Aline Piequet, Christian Beerli, Hermann Gram & Achim Goepferich. (2013) Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation. Journal of Controlled Release 172:3, pages 975-982.
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Aoife M. O’Mahony, Bruno M.D.C. Godinho, John F. Cryan & Caitriona M. O’Driscoll. (2013) Non-Viral Nanosystems for Gene and Small Interfering RNA Delivery to the Central Nervous System: Formulating the Solution. Journal of Pharmaceutical Sciences 102:10, pages 3469-3484.
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Mikhail I. Papisov, Vasily V. Belov & Kimberley S. Gannon. (2013) Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS. Molecular Pharmaceutics 10:5, pages 1522-1532.
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Daniel Schweizer, Karin Schönhammer, Michael Jahn & Achim Göpferich. (2012) Protein–Polyanion Interactions for the Controlled Release of Monoclonal Antibodies. Biomacromolecules 14:1, pages 75-83.
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Pericles Calias, Mikhail Papisov, Jing Pan, Nancy Savioli, Vasily Belov, Yan Huang, Jason Lotterhand, Mary Alessandrini, Nan Liu, Alan J. Fischman, Jan L. Powell & Michael W. Heartlein. (2012) CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder. PLoS ONE 7:1, pages e30341.
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Ana Maria Gonzalez, Wendy Leadbeater, Sonia Podvin, Alexandra Borboa, Michael Burg, Ritsuko Sawada, James Rayner, Karen Sims, Tetsuya Terasaki, Conrad Johanson, Edward Stopa, Brian Eliceiri & Andrew Baird. (2010) Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid. Brain Research 1359, pages 1-13.
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