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Expert Opinion on Drug Delivery Volume 2, 2005 - Issue 6
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Technology Evaluation

Pulmonary insulin delivery by means of the Technosphere™ drug carrier mechanism

Andreas Pfützner Institute for Clinical Research and Development, Parcusstr. 8, D-55116 Mainz, Germany. [email protected]
&
Thomas Forst Institute for Clinical Research and Development, Parcusstr. 8, D-55116 Mainz, Germany. [email protected]
Pages 1097-1106 | Published online: 04 Nov 2005

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Kathleen H. Ang & Jennifer L. Sherr. (2017) Moving beyond subcutaneous insulin: the application of adjunctive therapies to the treatment of type 1 diabetes. Expert Opinion on Drug Delivery 14:9, pages 1113-1131.
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Sandra Soares, Ana Costa & Bruno Sarmento. (2012) Novel non-invasive methods of insulin delivery. Expert Opinion on Drug Delivery 9:12, pages 1539-1558.
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Claudio González, Diego Kanevsky, Rubén De Marco, Guillermo Di Girolamo & Silvina Santoro. (2006) Non-invasive routes for insulin administration: current state and perspectives. Expert Opinion on Drug Delivery 3:6, pages 763-770.
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Pak Kheong Tan, Umah Rani Kuppusamy, Kek Heng Chua & Bavani Arumugam. (2023) Emerging Strategies to Improve the Stability and Bioavailability of Insulin: An Update on Formulations and Delivery Approaches. Current Drug Delivery 20:8, pages 1141-1162.
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Sandip Karmakar, Manas Bhowmik, Bibek Laha & Sreejan Manna. (2023) Recent advancements on novel approaches of insulin delivery. Medicine in Novel Technology and Devices 19, pages 100253.
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Wei-Ren Ke, Rachel Yoon Kyung Chang & Hak-Kim Chan. (2022) Engineering the right formulation for enhanced drug delivery. Advanced Drug Delivery Reviews 191, pages 114561.
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F. Bahman & S. Taurin. 2022. Nanotechnology for Diabetes Management. Nanotechnology for Diabetes Management 165 187 .
Malihe Karimi, Hossein Kamali, Marzieh Mohammadi & Mohsen Tafaghodi. (2022) Evaluation of various techniques for production of inhalable dry powders for pulmonary delivery of peptide and protein. Journal of Drug Delivery Science and Technology 69, pages 103186.
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Marieke E. Klijn & Jürgen Hubbuch. (2021) Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies. European Journal of Pharmaceutics and Biopharmaceutics 165, pages 319-336.
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Yajie Zhang, Daniel A. Davis, Khaled AboulFotouh, Jieliang Wang, Donna Williams, Akhilesh Bhambhani, Michael Zakrewsky, Mohammed Maniruzzaman, Zhengrong Cui & Robert O. WilliamsIIIIII. (2021) Novel formulations and drug delivery systems to administer biological solids. Advanced Drug Delivery Reviews 172, pages 183-210.
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Harsha Jain, Arpita Bairagi, Saurabh Srivastava, Shashi Bala Singh & Neelesh Kumar Mehra. (2020) Recent advances in the development of microparticles for pulmonary administration. Drug Discovery Today 25:10, pages 1865-1872.
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Seán M. Cunningham & David A. Tanner. (2020) A Review: The Prospect of Inhaled Insulin Therapy via Vibrating Mesh Technology to Treat Diabetes. International Journal of Environmental Research and Public Health 17:16, pages 5795.
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Nasser Alhajj, Zabliza Zakaria, Idanawati Naharudin, Fakhrul Ahsan, Wenji Li & Tin Wui Wong. (2020) Critical physicochemical attributes of chitosan nanoparticles admixed lactose-PEG 3000 microparticles in pulmonary inhalation. Asian Journal of Pharmaceutical Sciences 15:3, pages 374-384.
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Sunil Kumar Dubey, Amit Alexander, K. Sai Pradhyut, Mukta Agrawal, Rupesh Jain, Ranendra Narayana Saha, Gautam Singhvi, Swarnlata Saraf & Shailendra Saraf. (2020) Recent Avenues in Novel Patient-Friendly Techniques for the Treatment of Diabetes. Current Drug Delivery 17:1, pages 3-14.
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Tomasz R. Sosnowski. 2020. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications 327 344 .
Chaeho Moon, Sawittree Sahakijpijarn, John J. Koleng & Robert O. WilliamsIIIIII. (2019) Processing design space is critical for voriconazole nanoaggregates for dry powder inhalation produced by thin film freezing. Journal of Drug Delivery Science and Technology 54, pages 101295.
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Chaeho Moon, Hugh D. C. Smyth, Alan B. Watts & Robert O. WilliamsIIIIII. (2019) Delivery Technologies for Orally Inhaled Products: an Update. AAPS PharmSciTech 20:3.
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Hong-Goo Lee, Dong-Wook Kim & Chung-Woong Park. (2017) Dry powder inhaler for pulmonary drug delivery: human respiratory system, approved products and therapeutic equivalence guideline. Journal of Pharmaceutical Investigation 48:6, pages 603-616.
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Fakhrossadat Emami, Alireza Vatanara, Eun Park & Dong Na. (2018) Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals. Pharmaceutics 10:3, pages 131.
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Ntethelelo Sibiya, Phikelelani Ngubane & Musa Mabandla. (2017) Cardioprotective effects of pectin–insulin patch in streptozotocin‐induced diabetic rats. Journal of Diabetes 9:12, pages 1073-1081.
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Gauravkumar R. Agrawal, Pravin Wakte & Santosh Shelke. (2017) Formulation, physicochemical characterization and in vitro evaluation of human insulin-loaded microspheres as potential oral carrier. Progress in Biomaterials 6:3, pages 125-136.
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Stephen P Newman. (2017) Drug delivery to the lungs: challenges and opportunities. Therapeutic Delivery 8:8, pages 647-661.
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Javier O. Morales, Kristin R. Fathe, Ashlee Brunaugh, Silvia Ferrati, Song Li, Miguel Montenegro-Nicolini, Zeynab Mousavikhamene, Jason T. McConville, Mark R. Prausnitz & Hugh D. C. Smyth. (2017) Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes. The AAPS Journal 19:3, pages 652-668.
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Jason Chan & Angela Cheng-Lai. (2017) Inhaled Insulin. Cardiology in Review 25:3, pages 140-146.
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Gerhard W. Schmeisl & Yasmin Kretzschmar. (2016) Kurzwirksame Insuline — Neuentwicklungen hin zu mehr Flexibilität für den PatientenFast-acting insulin — new developments towards more flexibility for the patient. MMW - Fortschritte der Medizin 158:S6, pages 5-11.
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Caslin A. Gilroy, Kelli M. Luginbuhl & Ashutosh Chilkoti. (2016) Controlled release of biologics for the treatment of type 2 diabetes. Journal of Controlled Release 240, pages 151-164.
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Shuguang Hou, Jiangyue Wu, Xu Li & Hong Shu. (2015) Practical, regulatory and clinical considerations for development of inhalation drug products. Asian Journal of Pharmaceutical Sciences 10:6, pages 490-500.
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Zachary L. Anderson & Jennifer N. Clements. (2015) Inhaled technosphere regular insulin powder. Journal of the American Academy of Physician Assistants 28:11, pages 56-58.
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Anastassios G Pittas, Gregory P Westcott & Ethan M Balk. (2015) Efficacy, safety, and patient acceptability of Technosphere inhaled insulin for people with diabetes: a systematic review and meta-analysis. The Lancet Diabetes & Endocrinology 3:11, pages 886-894.
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Kai Berkenfeld, Alf Lamprecht & Jason T. McConville. (2015) Devices for Dry Powder Drug Delivery to the Lung. AAPS PharmSciTech 16:3, pages 479-490.
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Wesley Nuffer, Jennifer M. Trujillo & Samuel L. Ellis. (2014) Technosphere Insulin (Afrezza). Annals of Pharmacotherapy 49:1, pages 99-106.
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Michael Yifei Yang, John Gar Yan Chan & Hak-Kim Chan. (2014) Pulmonary drug delivery by powder aerosols. Journal of Controlled Release 193, pages 228-240.
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Tricia Santos Cavaiola & Steven Edelman. (2014) Inhaled Insulin: A Breath of Fresh Air? A Review of Inhaled Insulin. Clinical Therapeutics 36:8, pages 1275-1289.
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Anne Marie Healy, Maria Inês Amaro, Krzysztof J. Paluch & Lidia Tajber. (2014) Dry powders for oral inhalation free of lactose carrier particles. Advanced Drug Delivery Reviews 75, pages 32-52.
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Sarah Claus, Claudius Weiler, Joerg Schiewe & Wolfgang Friess. (2014) How can we bring high drug doses to the lung?. European Journal of Pharmaceutics and Biopharmaceutics 86:1, pages 1-6.
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António J. Almeida & Ana Grenha. 2014. Mucosal Delivery of Biopharmaceuticals. Mucosal Delivery of Biopharmaceuticals 483 498 .
Paul Zarogoulidis, Dimitris Petridis, Christos Ritzoulis, Qiang Li, Haidong Huang, Yunye Ning, Kaid Darwiche, Lutz Freitag & Konstantinos Zarogoulidis. (2013) Further experimentation of inhaled; Lantus, Actrapid and Humulin with todays’ production systems. International Journal of Pharmaceutics 458:1, pages 39-47.
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Flore Depreter, Gabrielle Pilcer & Karim Amighi. (2013) Inhaled proteins: Challenges and perspectives. International Journal of Pharmaceutics 447:1-2, pages 251-280.
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Anders H. Boss, Richard Petrucci & Daniel Lorber. (2012) Coverage of Prandial Insulin Requirements by Means of an Ultra-Rapid-Acting Inhaled Insulin. Journal of Diabetes Science and Technology 6:4, pages 773-779.
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F. Depreter, A. Burniat, D. Blocklet, S. Lacroix, M. Cnop, F. Fery, N. Van Aelst, G. Pilcer, M. Deleers, S. Goldman & K. Amighi. (2012) Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients. European Journal of Pharmaceutics and Biopharmaceutics 80:1, pages 4-13.
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N Sarala, Girish Bengalorkar & K Bhuvana. (2012) Technosphere insulin: a new inhaled insulin. Practical Diabetes 29:1, pages 23-25.
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Mark PeyrotRichard R. Rubin. (2011) Patient-Reported Outcomes in Adults with Type 2 Diabetes Using Mealtime Inhaled Technosphere Insulin and Basal Insulin Versus Premixed Insulin. Diabetes Technology & Therapeutics 13:12, pages 1201-1206.
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Paul ZarogoulidisNikolaos PapanasGeorgios KouliatsisDionysis SpyratosKostas ZarogoulidisEfstratios Maltezos. (2011) Inhaled Insulin: Too Soon To Be Forgotten?. Journal of Aerosol Medicine and Pulmonary Drug Delivery 24:5, pages 213-223.
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Joshua J Neumiller, R Keith Campbell & Lindy D Wood. (2010) A Review of Inhaled Technosphere Insulin. Annals of Pharmacotherapy 44:7-8, pages 1231-1239.
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Joshua J. Neumiller & R. Keith Campbell. (2010) Technosphere® Insulin. BioDrugs 24:3, pages 165-172.
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Julio Rosenstock, Daniel L Lorber, Luigi Gnudi, Campbell P Howard, David W Bilheimer, P-C Chang, Richard E Petrucci, Anders H Boss & Peter C Richardson. (2010) Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial. The Lancet 375:9733, pages 2244-2253.
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Mark PeyrotRichard R. Rubin. (2010) Effect of Technosphere Inhaled Insulin on Quality of Life and Treatment Satisfaction. Diabetes Technology & Therapeutics 12:1, pages 49-55.
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A. Leone-Bay, M. Grant, S. Greene, G. Stowell, S. Daniels, A. Smithson, S. Villanueva, S. Cope, K. Carrera, S. Reyes & P. Richardson. (2009) Evaluation of novel particles as an inhalation system for GLP-1. Diabetes, Obesity and Metabolism 11:11, pages 1050-1059.
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Chad C. Smutney, Emil M. Friedman, John M. Polidoro & Nikhil Amin. (2009) Inspiratory Efforts Achieved in Use of the Technosphere® Insulin Inhalation System. Journal of Diabetes Science and Technology 3:5, pages 1175-1182.
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K. Rave, E. Potocka, A. H. Boss, M. Marino, D. Costello & R. Chen. (2009) Pharmacokinetics and linear exposure of AFRESA™ compared with the subcutaneous injection of regular human insulin. Diabetes, Obesity and Metabolism 11:7, pages 715-720.
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Robert Angelo, Kathleen Rousseau, Marshall Grant, Andrea Leone-Bay & Peter Richardson. (2009) Technosphere® Insulin: Defining the Role of Technosphere Particles at the Cellular Level. Journal of Diabetes Science and Technology 3:3, pages 545-554.
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Julio Rosenstock, Richard Bergenstal, Ralph A. DeFronzo, Irl B. Hirsch, David Klonoff, Anders H. Boss, David Kramer, Richard Petrucci, Wen Yu & Brian Levy. (2008) Efficacy and Safety of Technosphere Inhaled Insulin Compared With Technosphere Powder Placebo in Insulin-Naive Type 2 Diabetes Suboptimally Controlled With Oral Agents. Diabetes Care 31:11, pages 2177-2182.
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Anders H. Boss, Wen Yu & Karen Ellerman. (2008) Prandial insulin: is inhaled enough?. Drug Development Research 69:3, pages 138-142.
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Klaus Rave, Tim Heise, Lutz Heinemann & Anders H. Boss. (2008) Inhaled Technosphere® Insulin in Comparison to Subcutaneous Regular Human Insulin: Time Action Profile and Variability in Subjects with Type 2 Diabetes. Journal of Diabetes Science and Technology 2:2, pages 205-212.
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Klaus Rave, Tim Heise, Andreas Pfützner & Anders H. Boss. (2007) Coverage of Postprandial Blood Glucose Excursions With Inhaled Technosphere Insulin in Comparison to Subcutaneously Injected Regular Human Insulin in Subjects With Type 2 Diabetes. Diabetes Care 30:9, pages 2307-2308.
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Negar Sadrzadeh, Michael J. Glembourtt & Cynthia L. Stevenson. (2007) Peptide Drug Delivery Strategies for the Treatment of Diabetes. Journal of Pharmaceutical Sciences 96:8, pages 1925-1954.
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Peter C. RichardsonAnders H. Boss. (2007) Technosphere ® Insulin Technology . Diabetes Technology & Therapeutics 9:s1, pages S-65-S-72.
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Per WollmerThomas R. PieberMari-Anne GallStephen Brunton. (2007) Delivering Needle-Free Insulin Using AERx ® iDMS (Insulin Diabetes Management System) Technology . Diabetes Technology & Therapeutics 9:s1, pages S-57-S-64.
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John P. Mayer, Faming Zhang & Richard D. DiMarchi. (2007) Insulin structure and function. Biopolymers 88:5, pages 687-713.
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Chikamasa Yamashita. (2006) The present state and future of dry powder inhalation system. Drug Delivery System 21:4, pages 417-425.
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