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Have inadequate delivery systems hampered the clinical success of inhaled disodium cromoglycate? Time for reconsideration

, PhD & , MD PhD
Pages 1-17 | Published online: 22 Dec 2010

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Madia Lozupone, Giuseppe Berardino, Anita Mollica, Rodolfo Sardone, Vittorio Dibello, Roberta Zupo, Luisa Lampignano, Fabio Castellana, Ilaria Bortone, Roberta Stallone, Antonio Daniele, Mario Altamura, Antonello Bellomo, Vincenzo Solfrizzi & Francesco Panza. (2022) ALZT-OP1: an experimental combination regimen for the treatment of Alzheimer’s disease. Expert Opinion on Investigational Drugs 31:8, pages 759-771.
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Khalid Abd-Elaziz, Hanneke Oude Elberink & Zuzana Diamant. (2020) Improved bioavailability of cromolyn sodium using inhaled PA101 delivered via eFlow® nebulizer. European Clinical Respiratory Journal 7:1.
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Michael Troy, Joseph Van Vleet, Donald Tashkin & Igor Barjaktarevic. (2023) Recent advances predict a bright future for nebulizers. Current Opinion in Pulmonary Medicine 29:2, pages 123-132.
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Surinder S Birring, Marlies S Wijsenbeek, Sanjay Agrawal, Jan W K van den Berg, Helen Stone, Toby M Maher, Ahmet Tutuncu & Alyn H Morice. (2017) A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial. The Lancet Respiratory Medicine 5:10, pages 806-815.
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Lorena Tavano, Fiore Pasquale Nicoletta, Nevio Picci & Rita Muzzalupo. (2016) Cromolyn as surface active drug (surfadrug): Effect of the self-association on diffusion and percutaneous permeation. Colloids and Surfaces B: Biointerfaces 139, pages 132-137.
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Dale R. Farkas, Michael Hindle & P. Worth Longest. (2015) Characterization of a New High-Dose Dry Powder Inhaler (DPI) Based on a Fluidized Bed Design. Annals of Biomedical Engineering 43:11, pages 2804-2815.
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T. E. Albertson, M. Schivo, N. Gidwani, N. J. Kenyon, M. E. Sutter, A. L. Chan & S. Louie. (2013) Pharmacotherapy of Critical Asthma Syndrome: Current and Emerging Therapies. Clinical Reviews in Allergy & Immunology 48:1, pages 7-30.
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Allen E. Haddrell, Graham Hargreaves, James F. Davies & Jonathan P. Reid. (2013) Control over hygroscopic growth of saline aqueous aerosol using Pluronic polymer additives. International Journal of Pharmaceutics 443:1-2, pages 183-192.
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Nikolaus C. Netzer, T. Küpper, Hans W. Voss & Arn H. Eliasson. (2012) The actual role of sodium cromoglycate in the treatment of asthma—a critical review. Sleep and Breathing 16:4, pages 1027-1032.
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