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Polysaccharides: a targeting strategy for colonic drug delivery

, MPharm, , MPharm PhD & , MPharm PhD
Pages 779-796 | Published online: 21 Apr 2011

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Manoj Kumar Sarangi, M. E. Bhanoji Rao & Versha Parcha. (2021) Smart polymers for colon targeted drug delivery systems: a review. International Journal of Polymeric Materials and Polymeric Biomaterials 70:16, pages 1130-1166.
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Hao Cheng, Shiyu Huang & Gangliang Huang. (2019) Design and application of oral colon administration system. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1590-1596.
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Cheng-mei Liu, Xiao-hong He, Rui-hong Liang, Wei Liu, Wen-Li Guo & Jun Chen. (2017) Relating physicochemical properties of alginate-HMP complexes to their performance as drug delivery systems. Journal of Biomaterials Science, Polymer Edition 28:18, pages 2242-2254.
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Wooseong Kim, Yejin Yang, Dohoon Kim, Seongkeun Jeong, Jin-Wook Yoo, Jeong-Hyun Yoon & Yunjin Jung. (2017) Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes. Drug Design, Development and Therapy 11, pages 419-429.
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Nitesh Shah, Om Prakash Sharma, Tejal Mehta & Avani Amin. (2016) Design of experiment approach for formulating multi-unit colon-targeted drug delivery system: in vitro and in vivo studies. Drug Development and Industrial Pharmacy 42:5, pages 825-835.
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Xiuli Wei, Yi Lu, Jianping Qi, Baojian Wu, Jian Chen, Huinan Xu & Wei Wu. (2015) An in situ crosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin. Drug Delivery 22:3, pages 298-305.
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Yellela S. R. Krishnaiah & Mansoor A. Khan. (2012) Strategies of targeting oral drug delivery systems to the colon and their potential use for the treatment of colorectal cancer. Pharmaceutical Development and Technology 17:5, pages 521-540.
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Alfonso Martínez-Felipe. (2011) Liquid crystal polymers and ionomers for membrane applications. Liquid Crystals 38:11-12, pages 1607-1626.
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Articles from other publishers (43)

Carlos Illanes-Bordomás, Mariana Landin & Carlos A. García-González. (2023) Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery. Pharmaceutics 15:11, pages 2639.
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Zhijie Wen, Li Kang, Hudie Fu, Shengpeng Zhu, Xuexin Ye, Xuedan Yang, Shangwen Zhang, Jie Hu, Xiaojun Li, Lvyi Chen, Yan Hu & Xinzhou Yang. (2023) Oral delivery of porous starch-loaded bilayer microgels for controlled drug delivery and treatment of ulcerative colitis. Carbohydrate Polymers 314, pages 120887.
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S. Moutaharrik, A. Maroni, C. Neut, C. Dubuquoy, L. Dubuquoy, A. Foppoli, M. Cerea, L. Palugan, F. Siepmann, J. Siepmann & A. Gazzaniga. (2023) In vitro and in vivo evaluation of a pH-, microbiota- and time-based oral delivery platform for colonic release. European Journal of Pharmaceutics and Biopharmaceutics 183, pages 13-23.
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Ibrahim M Ibrahim. (2023) Advances in Polysaccharide-Based Oral Colon-Targeted Delivery Systems: The Journey So Far and the Road Ahead. Cureus.
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Samia Farhaj, Theodora L. Agbotui, Jorabar Singh Nirwan, Qaisar Mahmood, Abid Mehmood Yousaf, Talib Hussain, Yasser Shahzad, Nemat Khan, Barbara R. Conway & Muhammad Usman Ghori. (2022) Carbohydrate Polymer-Based Targeted Pharmaceutical Formulations for Colorectal Cancer: Systematic Review of the Literature. Polysaccharides 3:4, pages 692-714.
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Luhui Wang, Zihao Wei, Changhu Xue, Qingjuan Tang, Tiantian Zhang, Yaoguang Chang & Yuming Wang. (2022) Fucoxanthin-loaded nanoparticles composed of gliadin and chondroitin sulfate: Synthesis, characterization and stability. Food Chemistry 379, pages 132163.
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Niyaz Ahmad, Ahmed A. Albassam, Mohd Faiyaz Khan, Zabih Ullah, Taysser Mohammed Buheazah, Hussain Salman AlHomoud & Hassan Ali Al-Nasif. (2022) A novel 5-Fluorocuracil multiple-nanoemulsion used for the enhancement of oral bioavailability in the treatment of colorectal cancer. Saudi Journal of Biological Sciences 29:5, pages 3704-3716.
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Zahra Izadiyan, Kamyar Shameli, Sin-Yeang Teow, Mostafa Yusefi, Pooneh Kia, Elisa Rasouli & Mohammad Ali Tareq. (2021) Anticancer Activity of 5-Fluorouracil-Loaded Nanoemulsions Containing Fe3O4/Au Core-Shell Nanoparticles. Journal of Molecular Structure 1245, pages 131075.
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Jaskiran Kaur, Monica Gulati, K. Gowthamarajan, Sukriti Vishwas, Dinesh Kumar Chellappan, Gaurav Gupta, Kamal Dua, Narendra Kumar Pandey, Bimlesh Kumar & Sachin Kumar Singh. (2021) Combination therapy of vanillic acid and oxaliplatin co-loaded in polysaccharide based functionalized polymeric micelles could offer effective treatment for colon cancer: A hypothesis. Medical Hypotheses 156, pages 110679.
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Saumyakanti Giri, Pallobi Dutta & Tapan Kumar Giri. (2021) Inulin-based carriers for colon drug targeting. Journal of Drug Delivery Science and Technology 64, pages 102595.
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Brijesh M. Shah, Sushesh Srivatsa Palakurthi, Tripti Khare, Sharad Khare & Srinath Palakurthi. (2020) Natural proteins and polysaccharides in the development of micro/nano delivery systems for the treatment of inflammatory bowel disease. International Journal of Biological Macromolecules 165, pages 722-737.
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Susan Hua. (2020) Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors. Frontiers in Pharmacology 11.
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Yan Wen, Peng Wen, Teng-Gen Hu, Robert J. Linhardt, Min-Hua Zong, Hong Wu & Zhi-Yi Chen. (2020) Encapsulation of phycocyanin by prebiotics and polysaccharides-based electrospun fibers and improved colon cancer prevention effects. International Journal of Biological Macromolecules 149, pages 672-681.
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Bee Lin Chua, Shin Fong Tang, Ameena Ali & Yin Hui Chow. (2020) Optimisation of pectin production from dragon fruit peels waste: drying, extraction and characterisation studies. SN Applied Sciences 2:4.
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S. P. Sawarkar, S. G. Deshpande, A. N. Bajaj, P. S. Soni, P. Pandit & V. S. Nikam. (2019) Potential of low molecular weight natural polysaccharides for colon targeted formulation and its evaluation in human by Gamma Scintigraphy. Journal of Pharmaceutical Investigation 50:2, pages 173-187.
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Yossi Maatuf, Matan Geron & Avi Priel. (2019) The Role of Toxins in the Pursuit for Novel Analgesics. Toxins 11:2, pages 131.
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Mudassir Ansari, Bhakti Sadarani & Anuradha Majumdar. (2019) Colon targeted beads loaded with pterostilbene: Formulation, optimization, characterization and in vivo evaluation. Saudi Pharmaceutical Journal 27:1, pages 71-81.
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Lirong Tang, Fengcai Lin, Tao Li, Zhenghan Cai, Biyun Hong & Biao Huang. (2018) Design and synthesis of functionalized cellulose nanocrystals-based drug conjugates for colon-targeted drug delivery. Cellulose 25:8, pages 4525-4536.
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Claudia Lara-Espinoza, Elizabeth Carvajal-Millán, René Balandrán-Quintana, Yolanda López-Franco & Agustín Rascón-Chu. (2018) Pectin and Pectin-Based Composite Materials: Beyond Food Texture. Molecules 23:4, pages 942.
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Pingping Bie, Ling Chen, Xiaoxi Li & Lin Li. (2016) Characterization of concanavalin A-conjugated resistant starch acetate bioadhesive film for oral colon-targeting microcapsule delivery system. Industrial Crops and Products 84, pages 320-329.
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Rui Jiao, Yingxia Liu, Hao Gao, Jia Xiao & Kwok Fai So. (2016) The Anti-Oxidant and Antitumor Properties of Plant Polysaccharides. The American Journal of Chinese Medicine 44:03, pages 463-488.
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Faiyaz Shakeel, Nazrul Haq, Abdullah Al-Dhfyan, Fars K. Alanazi & Ibrahim A. Alsarra. (2014) Double w/o/w nanoemulsion of 5-fluorouracil for self-nanoemulsifying drug delivery system. Journal of Molecular Liquids 200, pages 183-190.
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Michael Drechsler, Grzegorz Garbacz, Ralf Thomann & Rolf Schubert. (2014) Development and evaluation of chitosan and chitosan/Kollicoat® Smartseal 30 D film-coated tablets for colon targeting. European Journal of Pharmaceutics and Biopharmaceutics 88:3, pages 807-815.
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Xiaoan Li, Tao Tang, Yan Zhou, Yanfeng Zhang & Yuhan Sun. (2014) Applicability of enzyme-responsive mesoporous silica supports capped with bridged silsesquioxane for colon-specific drug delivery. Microporous and Mesoporous Materials 184, pages 83-89.
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