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Expert Opinion on Drug Delivery Volume 9, 2012 - Issue 12
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Original Research

Preclinical evaluations of norcantharidin-loaded intravenous lipid microspheres with low toxicity

Xia LinShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
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Bo ZhangLiaoning University of Traditional Chinese Medicine, Department of Pharmacology, College of Pharmacy, Shenyang, People's Republic of China
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Keru ZhangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
,
Yu ZhangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
,
Juan WangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
,
Na QiShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
,
Shenshen YangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
,
Haibing HeShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
&
Xing TangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang 110016 Liaoning Province, People's Republic of China+8602423986343; +8602423911736; [email protected]
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Pages 1449-1462 | Published online: 13 Sep 2012

Citations (17)

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Zixu Liu, Linxuan Zhao, Xinyi Tan, Zixuan Wu, Ning Zhou, Nan Dong, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang & Song Gao. (2022) Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity. Expert Opinion on Drug Delivery 19:4, pages 451-464.
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Min-Chen Liu, Lin Liu, Xia-Rong Wang, Wu-Ping Shuai, Ying Hu, Min Han & Jian-Qing Gao. (2016) Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo. International Journal of Nanomedicine 11, pages 1395-1412.
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Fang Yan, Bo Li, Fengping Shen & Qiang Fu. (2015) Formulation and characterization of albumin microspheres containing norcantharidate for liver tumor targeting. Drug Delivery 22:6, pages 862-868.
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Articles from other publishers (14)

Weina Cheng, Qihong Chen, Xiaoning Wang, Liu Liu, Xiaofei Li, Cancan Duan & Jianyong Zhang. (2022) Illuminating the hepatotoxic mechanism of norcantharidin in rats using metabolomics analysis. Molecular & Cellular Toxicology 19:3, pages 551-564.
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Bing-Tao Zhai, Jing Sun, Ya-Jun Shi, Xiao-Fei Zhang, Jun-Bo Zou, Jiang-Xue Cheng, Yu Fan, Dong-Yan Guo & Huan Tian. (2022) Review targeted drug delivery systems for norcantharidin in cancer therapy. Journal of Nanobiotechnology 20:1.
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Qian Liu, Henglai Sun, Xinyu Li, Huagang Sheng & Liqiao Zhu. (2022) Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin. Molecules 27:22, pages 7740.
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Zixu Liu, Linxuan Zhao, Hao Liu, Nan Dong, Ning Zhou, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang, Li Yang & Song Gao. (2022) Norcantharidin liposome emulsion hybrid delivery system enhances PD-1/PD-L1 immunotherapy by agonizing the non-canonical NF-κB pathway. International Journal of Pharmaceutics 628, pages 122361.
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Ying Jiang, Xiaolin Liu, Xinyi Tan, Ye Hou, Wanxiao Sun, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang & Xing Tang. (2020) In Vitro and In Vivo Evaluation of SP94 Modified Liposomes Loaded with N-14NCTDA, a Norcantharimide Derivative for Hepatocellular Carcinoma-Targeting. AAPS PharmSciTech 21:7.
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Chi-Hyun Ahn, Kyoung-Ok Hong, Bohwan Jin, WonWoo Lee, Yun Chan Jung, Hakmo Lee, Ji-Ae Shin, Sung-Dae Cho & Seong Doo Hong. (2019) Contribution of p38 MAPK Pathway to Norcantharidin-Induced Programmed Cell Death in Human Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences 20:14, pages 3487.
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Shanshan Guo, Shenghui Mei, Qiaoyu Wang, Xingang Li, Yang Chen, Qiyang He & Zhigang Zhao. (2019) Determination of cantharidic acid in rat blood by microdialysis combined with UHPLC–MS/MS. International Journal of Mass Spectrometry 440, pages 20-26.
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Yang Liu, Bin Xie, Lin Li, Xinyu Zhang, Yu Zhang, Haibing He, Tian Yin, Xing Tang, Cuifang Cai & Jingxin Gou. (2018) PEGylated lipid microspheres loaded with cabazitaxel for intravenous administration: stability, bioavailability, antitumor efficacy, and toxicity. Drug Delivery and Translational Research 8:5, pages 1365-1379.
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Jing Zhu, Wei Zhang, Dandan Wang, Suzhen Li & Wei Wu. (2018) Preparation and characterization of norcantharidin liposomes modified with stearyl glycyrrhetinate. Experimental and Therapeutic Medicine.
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Yan Li, Haibing He, Qiao Wang & Xing Tang. (2016) Preparation, stability and pharmacokinetics evaluation of lipid microspheres loading a promising antitumor candidate, Timataxel. Asian Journal of Pharmaceutical Sciences 11:6, pages 771-779.
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Min-Chen Liu, Xiao-Qiong Ma, Yong Xu, Li-Hua Peng, Min Han & Jian-Qing Gao. (2016) Liquid chromatography?tandem mass spectrometry evaluation of the pharmacokinetics of a diacid metabolite of norcantharidin loaded in folic acid-targeted liposomes in mice. Journal of Pharmaceutical and Biomedical Analysis 119, pages 76-83.
Crossref
Zhendong Pan, Yantao Niu, Yueqi Wang, Yilin Tang, Xing Tang & Cuifang Cai. (2014) Intravenous lipid microspheres loaded with alkylated norcantharidin derivative norcantharimide: Improved stability and prolonged half‐life. European Journal of Lipid Science and Technology 117:1, pages 55-64.
Crossref
Jinlong Ma, Huan Teng, Juan Wang, Yu Zhang, Tianyang Ren, Xing Tang & Cuifang Cai. (2014) A highly stable norcantharidin loaded lipid microspheres: Preparation, biodistribution and targeting evaluation. International Journal of Pharmaceutics 473:1-2, pages 475-484.
Crossref
Minchen Liu, Xiaoqiong Ma, Zhexiu Jin, Wuchao Li, Manman Guo & Fanzhu Li. (2013) Determination and pharmacokinetic study of the diacid metabolite of norcantharidin in beagle plasma by use of liquid chromatography?tandem mass spectrometry. Analytical and Bioanalytical Chemistry 405:28, pages 9273-9283.
Crossref

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