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Compressed orally disintegrating tablets: excipients evolution and formulation strategies

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Pages 651-663 | Published online: 07 Feb 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Ai Wei Lim, Nicholas J. Talley, Marjorie M. Walker, Gert Storm & Susan Hua. (2023) Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors. Drug Delivery 30:1.
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Raphael Wiedey, Marcel Kokott & Jörg Breitkreutz. (2021) Orodispersible tablets for pediatric drug delivery: current challenges and recent advances. Expert Opinion on Drug Delivery 18:12, pages 1873-1890.
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Hesham M. Tawfeek, Waleed Faisal & Ghareb M. Soliman. (2018) Enalapril maleate orally disintegrating tablets: tableting and in vivo evaluation in hypertensive rats. Pharmaceutical Development and Technology 23:5, pages 496-503.
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Aurica P. Chiriac, Alina Diaconu, Loredana E. Nita, Nita Tudorachi, Liliana Mititelu-Tartau, Andreea Creteanu, Oana Dragostin, Daniela Rusu & Gratiela Popa. (2017) The influence of excipients on physical and pharmaceutical properties of oral lyophilisates containing a pregabalin-acetaminophen combination. Expert Opinion on Drug Delivery 14:5, pages 589-599.
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Carin Ru Shan Siow, Paul Wan Sia Heng & Lai Wah Chan. (2016) Application of freeze-drying in the development of oral drug delivery systems. Expert Opinion on Drug Delivery 13:11, pages 1595-1608.
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Helal Abdo Moqbel, Aliaa Nabil ElMeshad & Mohamed Ahmed El-Nabarawi. (2016) A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation. Drug Delivery 23:8, pages 2998-3007.
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Felipe L Lopez, Terry B Ernest, Catherine Tuleu & Mine Orlu Gul. (2015) Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms. Expert Opinion on Drug Delivery 12:11, pages 1727-1740.
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Min Xu, Paul Wan Sia Heng & Celine Valeria Liew. (2015) Evaluation of coat uniformity and taste-masking efficiency of irregular-shaped drug particles coated in a modified tangential spray fluidized bed processor. Expert Opinion on Drug Delivery 12:10, pages 1597-1606.
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Ali Al-khattawi & Afzal R Mohammed. (2014) Challenges and emerging solutions in the development of compressed orally disintegrating tablets. Expert Opinion on Drug Discovery 9:10, pages 1109-1120.
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Articles from other publishers (44)

Avani Gupta, Juber Akhtar, KC Rastogi, Badruddeen, Mohammad Irfan Khan & Mohammad Ahmad. (2023) Oral Disintegrating Tablets of Proton Pump Inhibitors for Chronic Gastroesophageal Reflux Disease: An Update. Current Drug Research Reviews 15:3, pages 199-206.
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Mohamad Farhan bin Roslan & Riyanto Teguh Widodo. (2023) Current perspective on the challenges in the development of metformin orally disintegrating tablets (ODTs). Journal of Drug Delivery Science and Technology 86, pages 104650.
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Robert-Alexandru Vlad, Cezara Pintea, Diana-Andreea Chirteș, Paula Antonoaea, Emöke Margit Rédai, Nicoleta Todoran, Magdalena Bîrsan & Adriana Ciurba. (2023) The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations. Pharmaceutics 15:8, pages 2147.
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Cheng Jin, Fei Wu, Yanlong Hong, Lan Shen, Xiao Lin, Lijie Zhao & Yi Feng. (2023) Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders. Carbohydrate Polymers 311, pages 120731.
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Klervi Golhen, Michael Buettcher, Jonas Kost, Jörg Huwyler & Marc Pfister. (2023) Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children. Pharmaceutics 15:4, pages 1033.
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Asma Irshad, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Faaiza Qazi, Muhammad Talha Saleem, Fahad Siddiqui, Farrukh Rafiq Ahmed, Rauf-ur- Rehman, Sabahat Jabeen, Sadaf Farooqi, Momina Zarish Khan & Rida Masood. (2023) Effect of starch, cellulose and povidone based superdisintegrants in a QbD-based approach for the development and optimization of Nitazoxanide orodispersible tablets: Physicochemical characterization, compaction behavior and in-silico PBPK modeling of its active metabolite Tizoxanide. Journal of Drug Delivery Science and Technology 79, pages 104079.
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Ekapol Limpongsa, Peera Tabboon, Thaned Pongjanyakul & Napaphak Jaipakdee. (2022) Preparation and Evaluation of Directly Compressible Orally Disintegrating Tablets of Cannabidiol Formulated Using Liquisolid Technique. Pharmaceutics 14:11, pages 2407.
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R Canadell-Heredia, M Suñé-Pou, A Nardi-Ricart, P Pérez-Lozano, JM Suñé-Negre & E García-Montoya. (2022) Formulation and development of paediatric orally disintegrating carbamazepine tablets. Saudi Pharmaceutical Journal 30:11, pages 1612-1622.
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Yuxin Yang, Jia Liu, Anna Hu, Ting Nie, Zeneng Cheng & Wenjie Liu. (2022) A Critical Review on Engineering of d-Mannitol Crystals: Properties, Applications, and Polymorphic Control. Crystals 12:8, pages 1080.
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Jan Macku, Katerina Kubova, Martina Urbanova, Jan Muselik, Ales Franc, Gabriela Koutna, Miroslava Pavelkova, David Vetchy, Josef Masek, Eliska Maskova & Jiri Brus. (2022) Rational Design of Self-Emulsifying Pellet Formulation of Thymol: Technology Development Guided by Molecular-Level Structure Characterization and Ex Vivo Testing. Pharmaceutics 14:8, pages 1545.
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Mahmoud Teaima, Sandra Hababeh, Mai Khanfar, Fares Alanazi, Doaa Alshora & Mohammed El-Nabarawi. (2022) Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet. Pharmaceutics 14:2, pages 425.
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Samuel Orubu, Richard A. Kendall, Yucheng Sheng & Catherine Tuleu. (2022) Evaluating the Taste Masking Ability of Two Novel Dispersible Tablet Platforms Containing Zinc Sulfate and Paracetamol Reconstituted in a Breast Milk Substitute. Pharmaceutics 14:2, pages 420.
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Marcel Kokott, Ard Lura, Jörg Breitkreutz & Raphael Wiedey. (2021) Evaluation of two novel co-processed excipients for direct compression of orodispersible tablets and mini-tablets. European Journal of Pharmaceutics and Biopharmaceutics 168, pages 122-130.
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Arkadiusz Hejduk, Sebastian Czajka & Janina Lulek. (2021) Impact of co-processed excipient particles solidity and circularity on critical quality attributes of orodispersible minitablets. Powder Technology 387, pages 494-508.
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Gabriela Wiergowska, Dominika Ludowicz, Kamil Wdowiak, Andrzej Miklaszewski, Kornelia Lewandowska & Judyta Cielecka-Piontek. (2021) Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as a Way to Enhance Dissolution Rate and Permeability. Pharmaceuticals 14:5, pages 453.
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Utkarsh Bhutani, Tithi Basu & Saptarshi Majumdar. (2021) Oral Drug Delivery: Conventional to Long Acting New-Age Designs. European Journal of Pharmaceutics and Biopharmaceutics 162, pages 23-42.
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Brecht Vanbillemont & Thomas De Beer. (2020) Model-based optimization of the primary drying phase of oral lyophilizates. International Journal of Pharmaceutics: X 2, pages 100057.
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Atsushi Kosugi, Kok Hoong Leong, Eri Urata, Yoshihiro Hayashi, Shungo Kumada, Kotaro Okada & Yoshinori Onuki. (2020) Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet Properties Investigated Using a Kohonen Self-Organizing Map and Elastic Net Regression Model. Pharmaceutics 12:9, pages 886.
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Atsushi Kosugi, Kok Hoong Leong, Hinako Tsuji, Yoshihiro Hayashi, Shungo Kumada, Kotaro Okada & Yoshinori Onuki. (2020) Characterization of Powder- and Tablet Properties of Different Direct Compaction Grades of Mannitol Using a Kohonen Self-organizing Map and a Lasso Regression Model. Journal of Pharmaceutical Sciences 109:8, pages 2585-2593.
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Qing-Xi Wu, Zi-Dan Wang, Meng-Fei Zheng, Ting Su, Xiao-Hui Wang, Yi-Xin Guan & Yan Chen. (2020) Development of metformin hydrochloride loaded dissolving tablets with novel carboxymethylcellulose/poly-l-lysine/TPP complex. International Journal of Biological Macromolecules 155, pages 411-420.
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Zeeshan Ali, Fatima Qureshi, Dilshad Hussain, Hira Munir & Muhammad Sajid. (2020) Polyacrylamide grafted Eucalyptus camaldulensis (EC-g-PAM) gum as an efficient binding agent in drug formulations. Materials Research Express 7:4, pages 045307.
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Jaime Conceição, Oluwatomide Adeoye, Helena Cabral-Marques, Angel Concheiro, Carmen Alvarez-Lorenzo & José Manuel Sousa Lobo. (2020) Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression with Five-in-One Co-processed Excipients. AAPS PharmSciTech 21:2.
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Takatoshi Sakamoto, Shigeto KachiShohei Nakamura & Hiroshi Yuasa. (2019) Potential Use of Magnesium Oxide as an Excipient to Maintain the Hardness of Orally Disintegrating Tablets during Unpackaged Storage. Chemical and Pharmaceutical Bulletin 67:3, pages 284-288.
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May Almukainzi, Gabriel L. B. Araujo & Raimar Löbenberg. (2018) Orally disintegrating dosage forms. Journal of Pharmaceutical Investigation 49:2, pages 229-243.
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Christoph Englert, Johannes C. Brendel, Tobias C. Majdanski, Turgay Yildirim, Stephanie Schubert, Michael Gottschaldt, Norbert Windhab & Ulrich S. Schubert. (2018) Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications. Progress in Polymer Science 87, pages 107-164.
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Shubhajit Paul, Shao-Yu Chang, Jiangnan Dun, Wei-Jhe Sun, Kunlin Wang, Pirjo Tajarobi, Catherine Boissier & Changquan Calvin Sun. (2018) Comparative analyses of flow and compaction properties of diverse mannitol and lactose grades. International Journal of Pharmaceutics 546:1-2, pages 39-49.
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Run Han, Yilong Yang, Xiaoshan Li & Defang Ouyang. (2018) Predicting oral disintegrating tablet formulations by neural network techniques. Asian Journal of Pharmaceutical Sciences 13:4, pages 336-342.
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Nguyen-Thach Tung, Cao-Son Tran, Tran-Linh Nguyen, Tung Hoang, Thanh-Dat Trinh & Thi-Ngan Nguyen. (2018) Formulation and biopharmaceutical evaluation of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. European Journal of Pharmaceutics and Biopharmaceutics 126, pages 187-200.
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Fabrizio Fina, Christine M. Madla, Alvaro Goyanes, Jiaxin Zhang, Simon Gaisford & Abdul W. Basit. (2018) Fabricating 3D printed orally disintegrating printlets using selective laser sintering. International Journal of Pharmaceutics 541:1-2, pages 101-107.
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Jennifer Walsh, Sejal R. Ranmal, Terry B. Ernest & Fang Liu. (2018) Patient acceptability, safety and access: A balancing act for selecting age-appropriate oral dosage forms for paediatric and geriatric populations. International Journal of Pharmaceutics 536:2, pages 547-562.
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Francesco Cilurzo, Umberto M. Musazzi, Silvia Franzé, Francesca Selmin & Paola Minghetti. (2018) Orodispersible dosage forms: biopharmaceutical improvements and regulatory requirements. Drug Discovery Today 23:2, pages 251-259.
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Pavlína Vodáčková, Barbora Vraníková, Petra Svačinová, Aleš Franc, Jan Elbl, Jan Muselík, Roman Kubalák & Tomaš Solný. (2018) Evaluation and Comparison of Three Types of Spray Dried Coprocessed Excipient Avicel® for Direct Compression. BioMed Research International 2018, pages 1-15.
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MiaoMiao Zhou, YouJie Wang, Fei Wu, Lan Shen, Xiao Lin & Yi Feng. (2018) Development on porous particles of Pueraria lobatae Radix for improving its compactibility and dissolution . RSC Advances 8:43, pages 24250-24260.
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Aleksandra Amelian, Katarzyna Wasilewska, Małgorzata Wesoły, Patrycja Ciosek-Skibińska & Katarzyna Winnicka. (2017) Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles. Saudi Pharmaceutical Journal 25:8, pages 1144-1150.
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Saleh Abd El Rasoul & Gamal A. Shazly. (2017) Propafenone HCl fast dissolving tablets containing subliming agent prepared by direct compression method. Saudi Pharmaceutical Journal 25:7, pages 1086-1092.
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Samuel E F Orubu, Nicholas J Hobson, Abdul W Basit & Catherine Tuleu. (2017) The Milky Way: paediatric milk-based dispersible tablets prepared by direct compression – a proof-of-concept study. Journal of Pharmacy and Pharmacology 69:4, pages 417-431.
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Jennifer Walsh. (2016) Reflection on the Pharmaceutical Formulation Challenges Associated with a Paediatric Investigation Plan for an Off-Patent Drug. AAPS PharmSciTech 18:2, pages 250-256.
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Saadya A. Tayel, Mohamed A. El Nabarawi, Maha M. Amin & Mohamed H. H. AbouGhaly. (2016) Comparative Study Between Different Ready-Made Orally Disintegrating Platforms for the Formulation of Sumatriptan Succinate Sublingual Tablets. AAPS PharmSciTech 18:2, pages 410-423.
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Miaomiao Zhou, Lan Shen, Xiao Lin, Yanlong Hong & Yi Feng. (2017) Design and pharmaceutical applications of porous particles. RSC Advances 7:63, pages 39490-39501.
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Jasdip S. Koner, Ali Rajabi-Siahboomi, James Bowen, Yvonne Perrie, Daniel Kirby & Afzal R. Mohammed. (2015) A Holistic Multi Evidence Approach to Study the Fragmentation Behaviour of Crystalline Mannitol. Scientific Reports 5:1.
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Ali Al-Khattawi, Jasdip Koner, Peter Rue, Dan Kirby, Yvonne Perrie, Ali Rajabi-Siahboomi & Afzal R. Mohammed. (2015) A pragmatic approach for engineering porous mannitol and mechanistic evaluation of particle performance. European Journal of Pharmaceutics and Biopharmaceutics 94, pages 1-10.
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Su-Eon Jin, Jangik Ike Lee & Sung-Joo Hwang. (2015) Case Study of Pharmaceutical Ingredients Derived from Clay Minerals. Economic and Environmental Geology 48:3, pages 221-229.
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Ali Al-khattawi, Hamad Alyami, Bill Townsend, Xianghong Ma & Afzal R. Mohammed. (2014) Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally Disintegrating Tablets. PLoS ONE 9:7, pages e101369.
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Nguyen-Thach Tung, Man-Van Hung, Xuan-Minh Vo, Thanh-Hai Nguyen & Thi-Minh-Hue Pham. (2013) Formulation optimization of orally disintegrating tablets containing solid dispersion of felodipine and hydroxypropyl methylcellulose using face-centered central composite design. Journal of Pharmaceutical Investigation 44:2, pages 111-118.
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