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Expert Opinion on Drug Delivery Volume 10, 2013 - Issue 11
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Lipid emulsions in parenteral nutrition: current applications and future developments

Tianyang RenShenyang Pharmaceutical University, Department of Pharmaceutics Science, Shenyang, China
,
Lin CongShenyang Pharmaceutical University, Department of Pharmacology Science, Shenyang, China
,
Yueqi WangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Shenyang, China
,
Yilin TangXi'an Jiaotong University, School of Materials Science and Engineering, Xi'an, China
,
Bin TianShenyang Pharmaceutical University, Department of Pharmaceutics Science, Shenyang, China
,
Xia LinShenyang Pharmaceutical University, Department of Pharmaceutics Science, Shenyang, China
,
Yu ZhangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Shenyang, China
&
Xing TangShenyang Pharmaceutical University, Department of Pharmaceutics Science, Wenhua Road 103 Shenyang, 110016 Liaoning Province, China+8602423986343; +8602423911736; [email protected]
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Pages 1533-1549 | Published online: 06 Aug 2013

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Zhenhua Yang, Tianyang Ren, De Lu, Haiyan Guo, Wanqiu Li, Chenglong Huang, Haibing He, Dongchun Liu & Xing Tang. (2016) Evaluating the safety of phytosterols removed perilla seed oil-based lipid emulsion. Expert Opinion on Drug Delivery 13:10, pages 1345-1356.
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Yuchen Zhang, Xingwang Zhang, Hongming Liu, Shaohui Cai & Baojian Wu. (2015) Mixed nanomicelles as potential carriers for systemic delivery of Z-GP-Dox, an FAPα-based doxorubicin prodrug: formulation and pharmacokinetic evaluation. International Journal of Nanomedicine 10, pages 1625-1636.
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Articles from other publishers (25)

Mark Dennis Chico Retrato, Siyuan Qiu, Anna Lundquist, Aida Zuberovic Muratovic, Farshid Mashayekhy Rad, S. J. Kumari A. Ubhayasekera & Jonas Bergquist. (2023) Simultaneous determination of 22 fatty acids in total parenteral nutrition (TPN) components by gas chromatography-mass spectrometry (GC-MS). Analytical Methods 15:20, pages 2480-2489.
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Ran Tao, Li Liu, Yingxin Xiong, Qianyu Zhang, Xiangyu Lv, Linbo He, Fang Ren, Lu Zhou, Baoyan Chen, Kexin Wu, Yan Zhang & Huali Chen. (2023) Construction and evaluation of a phospholipid-based phase transition in situ gel system for brexpiprazole. Drug Delivery and Translational Research.
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Ning Dong, Lihua Tang, Meihui Zhao, Yingchao Zhang, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Yue Yuan & Xing Tang. (2022) Progesterone Phospholipid Gel for Intramuscular Administration Prepared by In Situ-Phase Separation. AAPS PharmSciTech 23:8.
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Oscar Daniel Rangel-Huerta, María José de la Torre-Aguilar, María Dolores Mesa, Katherine Flores-Rojas, Juan Luis Pérez-Navero, María Auxiliadora Baena-Gómez, Angel Gil & Mercedes Gil-Campos. (2022) The Metabolic Impact of Two Different Parenteral Nutrition Lipid Emulsions in Children after Hematopoietic Stem Cell Transplantation: A Lipidomics Investigation. International Journal of Molecular Sciences 23:7, pages 3667.
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Marlene Costa, Sonia Losada-Barreiro, Fátima Paiva-Martins & Carlos Bravo-Díaz. (2021) Polyphenolic Antioxidants in Lipid Emulsions: Partitioning Effects and Interfacial Phenomena. Foods 10:3, pages 539.
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Eliana Lucchinetti, Phing‐How Lou, Paulina Wawrzyniak, Marcin Wawrzyniak, Michael Scharl, Gregory A. Holtzhauer, Stefanie D. Krämer, Martin Hersberger, Gerhard Rogler & Michael Zaugg. (2020) Novel Strategies to Prevent Total Parenteral Nutrition‐Induced Gut and Liver Inflammation, and Adverse Metabolic Outcomes. Molecular Nutrition & Food Research 65:5, pages 1901270.
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Xue Fan, Ying Tang, Jun Tang, Juan Chen, Jing Shi, Hua Wang, Bin Xia, Yi Qu & Dezhi Mu. (2020) New-generation intravenous fat emulsions and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis. Journal of Perinatology 40:11, pages 1585-1596.
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Vit Kosek, Marie Heczkova, Frantisek Novak, Eva Meisnerova, Olga Novákova, Jaroslav Zelenka, Kamila Bechynska, Nikola Vrzacova, Jiri Suttnar, Alzbeta Hlavackova, Helena Dankova, Miriam Bratova, Nikola Daskova, Hana Malinska, Olena Oliyarnyk, Petr Wohl, Hana Bastova, Jana Hajslova & Monika Cahova. (2020) The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach. Nutrients 12:8, pages 2351.
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Phing-How Lou, Eliana Lucchinetti, Martin Hersberger, Alexander S. ClanachanMichael Zaugg. (2020) Lipid Emulsion Containing High Amounts of n3 Fatty Acids (Omegaven) as Opposed to n6 Fatty Acids (Intralipid) Preserves Insulin Signaling and Glucose Uptake in Perfused Rat Hearts. Anesthesia & Analgesia 130:1, pages 37-48.
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Kamila Bechynska, Nikola Daskova, Nikola Vrzackova, Karel Harant, Marie Heczková, Katerina Podzimkova, Miriam Bratova, Helena Dankova, Zuzana Berkova, Vit Kosek, Jaroslav Zelenka, Jana Hajslova, Radislav Sedlacek, Jiri Suttnar, Alzbeta Hlavackova, Lenka Bartonova & Monika Cahova. (2019) The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration. Scientific Reports 9:1.
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Mohd. Haz Hairul Amran, Mohd. Hanif Zulfakar, Mohd. Fairuz Danik, Mohd. Shakrie Palan Abdullah & Ahmad Fuad Shamsuddin. (2019) A new alternative for intravenous lipid emulsion 20% w/w from superolein oil and its effect on lipid and liver profiles in an animal model. DARU Journal of Pharmaceutical Sciences 27:1, pages 191-201.
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Huizi Li, Yinghua Liu, Xinsheng Zhang, Qing Xu, Yong Zhang, Changyong Xue & Changjiang Guo. (2018) Medium-chain fatty acids decrease serum cholesterol via reduction of intestinal bile acid reabsorption in C57BL/6J mice. Nutrition & Metabolism 15:1.
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Lifeng Luo, Qiuyue Chen, Haoyu Gong, Lu Liu, Lingli Zhou, Haibing He, Yu Zhang, Tian Yin & Xing Tang. (2018) Capacity of cholesteryl hemisuccinate in ion pair/phospholipid complex to improve drug-loading, stability and antibacterial activity of clarithromycin intravenous lipid microsphere. Colloids and Surfaces B: Biointerfaces 172, pages 262-271.
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Mario I Perman, Agustín Ciapponi, Juan VA Franco, Cecilia Loudet, Adriana Crivelli, Virginia Garrote & Gastón Perman. (2018) Prescribed hypocaloric nutrition support for critically-ill adults. Cochrane Database of Systematic Reviews 2018:12.
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Yi-Chi Peng, Fwu-Lin Yang, Yi-Maun Subeq, Chin-Chieh Tien, Yann-Fen C. Chao & Ru-Ping Lee. (2017) Lipid Emulsion Enriched in Omega-3 PUFA Accelerates Wound Healing: A Placebo-Controlled Animal Study. World Journal of Surgery 42:6, pages 1714-1720.
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Dong Dong, Enxi Quan, Xue Yuan, Qian Xie, Zhijie Li & Baojian Wu. (2016) Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism. Molecular Pharmaceutics 14:9, pages 2864-2874.
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Hanmei Li, Tao Liu, Yuxuan Zhu, Qiang Fu, Wanxia Wu, Jie Deng, Li Lan & Sanjun Shi. (2017) An in situ-forming phospholipid-based phase transition gel prolongs the duration of local anesthesia for ropivacaine with minimal toxicity. Acta Biomaterialia 58, pages 136-145.
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Yan Li, Haibing He, Qiao Wang & Xing Tang. (2016) Preparation, stability and pharmacokinetics evaluation of lipid microspheres loading a promising antitumor candidate, Timataxel. Asian Journal of Pharmaceutical Sciences 11:6, pages 771-779.
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Yu-Jie Dai, Li-Li Sun, Meng-Ying Li, Cui-Ling Ding, Yu-Cheng Su, Li-Juan Sun, Sen-Hai Xue, Feng Yan, Chang-Hai Zhao & Wen Wang. (2016) Comparison of Formulas Based on Lipid Emulsions of Olive Oil, Soybean Oil, or Several Oils for Parenteral Nutrition: A Systematic Review and Meta-Analysis. Advances in Nutrition 7:2, pages 279-286.
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W. Manzanares & P.L. Langlois. (2016) Emulsiones lipídicas con aceite de pescado en el paciente crítico: análisis crítico y perspectivas futuras. Medicina Intensiva 40:1, pages 39-45.
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William Manzanares, Pascal L Langlois, Rupinder Dhaliwal, Margot Lemieux & Daren K Heyland. (2015) Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis. Critical Care 19:1.
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María Baena-Gómez, María Aguilar, María Mesa, Juan Navero & Mercedes Gil-Campos. (2015) Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation. Nutrients 7:9, pages 7242-7255.
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Juliane Frank, Marwa Elewa, Mohamed M. Said, Hosam A. El Shihawy, Mohamed El-Sadek, Diana Müller, Annette Meister, Gerd Hause, Simon Drescher, Hendrik Metz, Peter Imming & Karsten Mäder. (2015) Synthesis, Characterization, and Nanoencapsulation of Tetrathiatriarylmethyl and Tetrachlorotriarylmethyl (Trityl) Radical Derivatives—A Study To Advance Their Applicability as in Vivo EPR Oxygen Sensors. The Journal of Organic Chemistry 80:13, pages 6754-6766.
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Yu Zhang, Jingxin Gou, Feng Sun, SiCong Geng, Xi Hu, Keru Zhang, Xia Lin, Wei Xiao & Xing Tang. (2014) Impact of electrolytes on double emulsion systems (W/O/W) stabilized by an amphiphilic block copolymer. Colloids and Surfaces B: Biointerfaces 122, pages 368-374.
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Jan Wernerman. (2014) Feeding the gut. Current Opinion in Critical Care 20:2, pages 196-201.
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