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Utilizing food effects to overcome challenges in delivery of lipophilic bioactives: structural design of medical and functional foods

Pages 1621-1632 | Published online: 21 Sep 2013

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Amir Rezvankhah, Zahra Emam-Djomeh & Gholamreza Askari. (2020) Encapsulation and delivery of bioactive compounds using spray and freeze-drying techniques: A review. Drying Technology 38:1-2, pages 235-258.
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Khaled Omer Aboalnaja, Soonham Yaghmoor, Taha Abdullah Kumosani & David Julian McClements. (2016) Utilization of nanoemulsions to enhance bioactivity of pharmaceuticals, supplements, and nutraceuticals: Nanoemulsion delivery systems and nanoemulsion excipient systems. Expert Opinion on Drug Delivery 13:9, pages 1327-1336.
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Palanivel Ganesan, Hyun-Myung Ko, In-Su Kim & Dong-Kug Choi. (2015) Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models. International Journal of Nanomedicine 10, pages 6757-6772.
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Asmita Poudel, George Gachumi, Phyllis G. Paterson, Anas El-Aneed & Ildiko Badea. (2023) Liposomal Phytosterols as LDL-Cholesterol-Lowering Agents in Diet-Induced Hyperlipidemia. Molecular Pharmaceutics.
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Hualu Zhou, David Julian McClements & Long Chen. 2023. Bioactive Delivery Systems for Lipophilic Nutraceuticals. Bioactive Delivery Systems for Lipophilic Nutraceuticals 84 106 .
Yashu Chen, Hongjian Chen, Qianchun Deng, Long Chen & David Julian McClements. 2023. Bioactive Delivery Systems for Lipophilic Nutraceuticals. Bioactive Delivery Systems for Lipophilic Nutraceuticals 12 33 .
G. I. Darul Raiyaan, A. Sameera Khathoon & Kantha D. Arunachalam. 2023. Advances in Novel Formulations for Drug Delivery. Advances in Novel Formulations for Drug Delivery 491 519 .
Fernanda Luisa Lüdtke, Renato Grimaldi, Lisandro Pavie Cardoso, Mirna Lúcia Gigante, António Augusto Vicente & Ana Paula Badan Ribeiro. (2023) Development and Characterization of Fully Hydrogenated Soybean Oil and High Oleic Sunflower Oil β-carotene Loaded Nanostructured Lipid Carriers. Food Biophysics.
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Muhammed Abdur Rauf. 2023. Liposomal Encapsulation in Food Science and Technology. Liposomal Encapsulation in Food Science and Technology 189 222 .
Tushar Kanti Maiti, Sumit Parvate, Prakhar Dixit, Jitendra Singh, Vennapusa Jagadeeswara Reddy, E. Bhuvanesh & Sujay Chattopadhyay. 2023. Liposomal Encapsulation in Food Science and Technology. Liposomal Encapsulation in Food Science and Technology 113 124 .
Ali Ubeyitogullari, Safoura Ahmadzadeh, Gurshagan Kandhola & Jin‐Woo Kim. (2022) Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities. Comprehensive Reviews in Food Science and Food Safety 21:6, pages 4610-4639.
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Srividya Gorantla, Geetika Wadhwa, Shailja Jain, Shridula Sankar, Kshitij Nuwal, Arisha Mahmood, Sunil Kumar Dubey, Rajeev Taliyan, Prashant Kesharwani & Gautam Singhvi. (2021) Recent advances in nanocarriers for nutrient delivery. Drug Delivery and Translational Research 12:10, pages 2359-2384.
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Olalla Novo Fernández, Diego Oliveros, Ramon Canela Garayoa, Mercè Balcells Fluvià, Jonh J. Méndez Arteaga & Jordi Eras Joli. (2022) Introducing Lipophilicity to (Polyhydroxyalkyl)thiazolidine Carboxylic Acids Via Acylation. ACS Omega 7:13, pages 11075-11081.
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Ekta Jagtiani. (2021) Advancements in nanotechnology for food science and industry. Food Frontiers 3:1, pages 56-82.
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Pheakdey Yun, Sakamon Devahastin & Naphaporn Chiewchan. (2021) Microstructures of encapsulates and their relations with encapsulation efficiency and controlled release of bioactive constituents: A review. Comprehensive Reviews in Food Science and Food Safety 20:2, pages 1768-1799.
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Rajendran Mala, Ravichandran Keerthana & Preetha Mohan. 2021. Sustainable Agriculture Reviews 55. Sustainable Agriculture Reviews 55 263 315 .
Ali Ubeyitogullari & Syed S. H. Rizvi. (2020) Heat stability of emulsions using functionalized milk protein concentrate generated by supercritical fluid extrusion. Food & Function 11:12, pages 10506-10518.
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Seung Jun Choi & David Julian McClements. (2020) Nanoemulsions as delivery systems for lipophilic nutraceuticals: strategies for improving their formulation, stability, functionality and bioavailability. Food Science and Biotechnology 29:2, pages 149-168.
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Tomasz Chmiel, Anna Mieszkowska, Dagmara Kempińska-Kupczyk, Agata Kot-Wasik, Jacek Namieśnik & Zofia Mazerska. (2019) The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components. Microchemical Journal 146, pages 393-406.
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Dagmara Kempińska, Tomasz Chmiel, Agata Kot-Wasik, Anna Mróz, Zofia Mazerska & Jacek Namieśnik. (2019) State of the art and prospects of methods for determination of lipophilicity of chemical compounds. TrAC Trends in Analytical Chemistry 113, pages 54-73.
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Claver Numviyimana, Tomacz Chmiel, Agata Kot-Wasik & Jacek Namieśnik. (2019) Study of pH and temperature effect on lipophilicity of catechol-containing antioxidants by reversed phase liquid chromatography. Microchemical Journal 145, pages 380-387.
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Sheila C. Oliveira-Alves, Ana Teresa Serra & Maria R. Bronze. 2019. Nutraceuticals and Natural Product Pharmaceuticals. Nutraceuticals and Natural Product Pharmaceuticals 197 233 .
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Shinjae Park, Saehun Mun & Yong-Ro Kim. (2018) Emulsifier Dependent in vitro Digestion and Bioaccessibility of β-Carotene Loaded in Oil-in-Water Emulsions. Food Biophysics 13:2, pages 147-154.
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Rachel E. Kopec & Mark L. Failla. (2018) Recent advances in the bioaccessibility and bioavailability of carotenoids and effects of other dietary lipophiles. Journal of Food Composition and Analysis 68, pages 16-30.
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Xi Yuan, Xiaojuan Liu, David Julian McClements, Yong Cao & Hang Xiao. (2018) Enhancement of phytochemical bioaccessibility from plant-based foods using excipient emulsions: impact of lipid type on carotenoid solubilization from spinach. Food & Function 9:8, pages 4352-4365.
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Daniele B. Rodrigues, Chureeporn Chitchumroonchokchai, Lilian R. B. Mariutti, Adriana Z. Mercadante & Mark L. Failla. (2017) Comparison of Two Static in Vitro Digestion Methods for Screening the Bioaccessibility of Carotenoids in Fruits, Vegetables, and Animal Products. Journal of Agricultural and Food Chemistry 65:51, pages 11220-11228.
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Cory Philion, Dennis Ma, Ivan Ruvinov, Fadi Mansour, Christopher Pignanelli, Megan Noel, Ammar Saleem, John Arnason, Mark Rodrigues, Inderpal Singh, Jesse Ropat & Siyaram Pandey. (2017) Cymbopogon citratus and Camellia sinensis extracts selectively induce apoptosis in cancer cells and reduce growth of lymphoma xenografts in vivo . Oncotarget 8:67, pages 110756-110773.
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Pimchanok Witayaudom & Utai Klinkesorn. (2017) Effect of surfactant concentration and solidification temperature on the characteristics and stability of nanostructured lipid carrier (NLC) prepared from rambutan (Nephelium lappaceum L.) kernel fat. Journal of Colloid and Interface Science 505, pages 1082-1092.
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David Julian McClements & Hang Xiao. (2017) Designing food structure and composition to enhance nutraceutical bioactivity to support cancer inhibition. Seminars in Cancer Biology 46, pages 215-226.
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C. Fernandez-Avila & A.J. Trujillo. (2017) Enhanced stability of emulsions treated by Ultra-High Pressure Homogenization for delivering conjugated linoleic acid in Caco-2 cells. Food Hydrocolloids 71, pages 271-281.
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Braulio Cervantes-Paz, José de Jesús Ornelas-Paz, Saul Ruiz-Cruz, Claudio Rios-Velasco, Vrani Ibarra-Junquera, Elhadi M. Yahia & Alfonso A. Gardea-Béjar. (2017) Effects of pectin on lipid digestion and possible implications for carotenoid bioavailability during pre-absorptive stages: A review. Food Research International 99, pages 917-927.
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Saehun Mun & David Julian McClements. (2017) Influence of simulated in-mouth processing (size reduction and alpha-amylase addition) on lipid digestion and β-carotene bioaccessibility in starch-based filled hydrogels. LWT 80, pages 113-120.
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Saehun Mun & Yong-Ro Kim. (2017) Influence of Starch Concentration and Mastication on the Lipid Digestion and Bioaccessibility of β-carotene loaded in Filled Hydrogels. Korean Journal of Food & Cookery Science 33:2, pages 181-189.
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D.M. Mostafa, S.H. Abd El-Alim & A.A. Kassem. 2017. Nanotechnology Applications in Food. Nanotechnology Applications in Food 107 127 .
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Seid Mahdi Jafari, Iman Katouzian, Hamid Rajabi & Mohammad Ganje. 2017. Nanoencapsulation Technologies for the Food and Nutraceutical Industries. Nanoencapsulation Technologies for the Food and Nutraceutical Industries 494 523 .
Maarit J. Rein & Marcia da Silva Pinto. 2017. Engineering Foods for Bioactives Stability and Delivery. Engineering Foods for Bioactives Stability and Delivery 401 416 .
Paul Owusu Donkor, Ying Chen, Liqin Ding & Feng Qiu. (2016) Locally and traditionally used Ligusticum species – A review of their phytochemistry, pharmacology and pharmacokinetics. Journal of Ethnopharmacology 194, pages 530-548.
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Xiaojia He & Huey-Min Hwang. (2016) Nanotechnology in food science: Functionality, applicability, and safety assessment. Journal of Food and Drug Analysis 24:4, pages 671-681.
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Saehun Mun, Shinjae Park, Yong-Ro Kim & David Julian McClements. (2016) Influence of methylcellulose on attributes of β-carotene fortified starch-based filled hydrogels: Optical, rheological, structural, digestibility, and bioaccessibility properties. Food Research International 87, pages 18-24.
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John P. Gleeson, Sinéad M. Ryan & David J. Brayden. (2016) Oral delivery strategies for nutraceuticals: Delivery vehicles and absorption enhancers. Trends in Food Science & Technology 53, pages 90-101.
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Xuan Liu, Jinfeng Bi, Hang Xiao & David Julian McClements. (2016) Enhancement of Nutraceutical Bioavailability using Excipient Nanoemulsions: Role of Lipid Digestion Products on Bioaccessibility of Carotenoids and Phenolics from Mangoes. Journal of Food Science 81:3, pages N754-N761.
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Laura Salvia-Trujillo, Olga Martín-Belloso & David McClements. (2016) Excipient Nanoemulsions for Improving Oral Bioavailability of Bioactives. Nanomaterials 6:1, pages 17.
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Canan Ece Tamer & Ömer Utku Çopur. 2016. Nutraceuticals. Nutraceuticals 535 591 .
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David Julian McClements, Liqiang Zou, Ruojie Zhang, Laura Salvia-Trujillo, Taha Kumosani & Hang Xiao. (2015) Enhancing Nutraceutical Performance Using Excipient Foods: Designing Food Structures and Compositions to Increase Bioavailability. Comprehensive Reviews in Food Science and Food Safety 14:6, pages 824-847.
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Xuan Liu, Jinfeng Bi, Hang Xiao & David Julian McClements. (2015) Increasing Carotenoid Bioaccessibility from Yellow Peppers Using Excipient Emulsions: Impact of Lipid Type and Thermal Processing. Journal of Agricultural and Food Chemistry 63:38, pages 8534-8543.
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David Julian McClements, Fang LiHang Xiao. (2015) The Nutraceutical Bioavailability Classification Scheme: Classifying Nutraceuticals According to Factors Limiting their Oral Bioavailability. Annual Review of Food Science and Technology 6:1, pages 299-327.
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Saehun Mun, Yong-Ro Kim & David Julian McClements. (2015) Control of β-carotene bioaccessibility using starch-based filled hydrogels. Food Chemistry 173, pages 454-461.
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Mingfei Yao, David Julian McClements & Hang Xiao. (2015) Improving oral bioavailability of nutraceuticals by engineered nanoparticle-based delivery systems. Current Opinion in Food Science 2, pages 14-19.
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Zipei Zhang, Ruojie Zhang, Qunyi Tong, Eric Andrew Decker & David Julian McClements. (2015) Food-grade filled hydrogels for oral delivery of lipophilic active ingredients: Temperature-triggered release microgels. Food Research International 69, pages 274-280.
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Bozena Smolkova, Naouale El Yamani, Andrew R. Collins, Arno C. Gutleb & Maria Dusinska. (2015) Nanoparticles in food. Epigenetic changes induced by nanomaterials and possible impact on health. Food and Chemical Toxicology 77, pages 64-73.
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Saehun Mun, Yong-Ro Kim, Malshick Shin & David Julian McClements. (2015) Control of lipid digestion and nutraceutical bioaccessibility using starch-based filled hydrogels: Influence of starch and surfactant type. Food Hydrocolloids 44, pages 380-389.
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Jingjing Chen, Jinkai Zheng, Eric A. Decker, David Julian McClements & Hang Xiao. (2015) Improving nutraceutical bioavailability using mixed colloidal delivery systems: lipid nanoparticles increase tangeretin bioaccessibility and absorption from tangeretin-loaded zein nanoparticles. RSC Advances 5:90, pages 73892-73900.
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Frédéric Leroy & Luc De Vuyst. (2014) Fermented food in the context of a healthy diet. Current Opinion in Clinical Nutrition and Metabolic Care 17:6, pages 574-581.
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Yves Raymond & Claude P. Champagne. (2014) Dissolution of Lipid-Based Matrices in Simulated Gastrointestinal Solutions to Evaluate Their Potential for the Encapsulation of Bioactive Ingredients for Foods. International Journal of Food Science 2014, pages 1-7.
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David Julian McClements & Hang Xiao. (2014) Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals. Food Funct. 5:7, pages 1320-1333.
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