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Drug delivery across the blood–brain barrier using focused ultrasound

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Yi Qin, Xiaobo Zhao, Xiaojing Dong, Juntao Liu, Longqiong Wang, Xiaohua Wu, Bin Peng & Chengzhi Li. (2022) Low-intensity ultrasound promotes uterine involution after cesarean section: the first multicenter, randomized, controlled clinical trial. International Journal of Hyperthermia 39:1, pages 181-189.
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Wei Zhang, Ganesh Sigdel, Keenan J Mintz, Elif S Seven, Yiqun Zhou, Chunyu Wang & Roger M Leblanc. (2021) Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier. International Journal of Nanomedicine 16, pages 5003-5016.
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Zahraa S. Al-Ahmady. (2018) Selective drug delivery approaches to lesioned brain through blood brain barrier disruption. Expert Opinion on Drug Delivery 15:4, pages 335-349.
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Peter Hinow, Ami Radunskaya, Sean M. Mackay, John N. J. Reynolds, Morgan Schroeder, Eng Wui Tan & Ian G. Tucker. (2016) Signaled drug delivery and transport across the blood–brain barrier. Journal of Liposome Research 26:3, pages 233-245.
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Tinghe Yu, Li Luo & Li Wang. (2016) Ultrasound as a cancer chemotherapy sensitizer: the gap between laboratory and bedside. Expert Opinion on Drug Delivery 13:1, pages 37-47.
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Alison Burgess, Kairavi Shah, Olivia Hough & Kullervo Hynynen. (2015) Focused ultrasound-mediated drug delivery through the blood–brain barrier. Expert Review of Neurotherapeutics 15:5, pages 477-491.
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Articles from other publishers (63)

Thomas Lee Moore, Giovanna Pannuzzo, Gabriella Costabile, Anna Lisa Palange, Raffaele Spanò, Miguel Ferreira, Adriana Carol Eleonora Graziano, Paolo Decuzzi & Venera Cardile. (2023) Nanomedicines to treat rare neurological disorders: The case of Krabbe disease. Advanced Drug Delivery Reviews 203, pages 115132.
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Sarfaraz K. Niazi. (2023) Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis. Pharmaceutics 15:11, pages 2599.
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Caleb Shaw, Cecile Riviere-Cazaux, Kazi Zihan Hossain, Terry C. Burns & M. Rashed Khan. (2023) In silico investigation to optimize the convection-enhanced diffusion profile with directed extraction. Journal of Drug Delivery Science and Technology 89, pages 104951.
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Hsien-Chung Chen, Wen-Chang Chang, Jian-Ying Chuang, Kwang-Yu Chang, Jing-Ping Liou & Tsung-I Hsu. (2023) The complex role of eicosanoids in the brain: Implications for brain tumor development and therapeutic opportunities. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:5, pages 188957.
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Seung-Schik Yoo, Evgenii Kim, Kavin Kowsari, Jared Van Reet, Hyun-Chul Kim & Kyungho Yoon. (2023) Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound. Scientific Reports 13:1.
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Christopher T. Moody, Phillip G. Durham, Paul A. Dayton & Yevgeny Brudno. (2023) Loading Intracranial Drug-Eluting Reservoirs Across the Blood–Brain Barrier With Focused Ultrasound. Ultrasound in Medicine & Biology 49:7, pages 1679-1685.
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Arvin Honari & Shashank R. Sirsi. (2023) The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation. Pharmaceutics 15:6, pages 1705.
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Rohan Rao, Anjali Patel, Kunal Hanchate, Eric Robinson, Aniela Edwards, Sanjit Shah, Dominique Higgins, Kevin J. Haworth, Brandon Lucke-Wold, Daniel Pomeranz Krummel & Soma Sengupta. (2023) Advances in Focused Ultrasound for the Treatment of Brain Tumors. Tomography 9:3, pages 1094-1109.
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Ma. Stella Grace B. Lequiron, Daniel J. Joe, Sun Do Lim & Il Doh. (2023) Response Time of a Thin-Film Resistance Temperature Detector (RTD) for High-Intensity Focused Ultrasound (HIFU) Phantom Applications. Applied Sciences 13:10, pages 6220.
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Yanrong Zhang, Jing Wang, Sara Natasha Ghobadi, Haiyan Zhou, Ai Huang, Marco Gerosa, Qingyi Hou, Olivier Keunen, Anna Golebiewska, Frezghi G. Habte, Gerald A. Grant, Ramasamy Paulmurugan, Kevin S. Lee & Max Wintermark. (2023) Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model. Ultrasound in Medicine & Biology 49:5, pages 1082-1090.
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Xueke Li, Yi Zhong, Li Zhang & Mingxing Xie. (2023) Recent advances in the molecular mechanisms of low-intensity pulsed ultrasound against inflammation. Journal of Molecular Medicine 101:4, pages 361-374.
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Urvi M. Lad & Chetan K. Modi. 2023. Carbon Dots in Analytical Chemistry. Carbon Dots in Analytical Chemistry 305 317 .
Takaomi Kobayashi. 2023. Advanced and Modern Approaches for Drug Delivery. Advanced and Modern Approaches for Drug Delivery 577 591 .
Yicong Cai, Kexin Fan, Jiawei Lin, Lin Ma & Fenfang Li. (2022) Advances in BBB on Chip and Application for Studying Reversible Opening of Blood–Brain Barrier by Sonoporation. Micromachines 14:1, pages 112.
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Feng Guo, Qingman Li, Xiaolin Zhang, Yiheng Liu, Jie Jiang, Shuanghuai Cheng, Si Yu, Xingfang Zhang, Fangfang Liu, Yiying Li, Gregory Rose & Haiying Zhang. (2022) Applications of Carbon Dots for the Treatment of Alzheimer’s Disease. International Journal of Nanomedicine Volume 17, pages 6621-6638.
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Joseph Silburt & Isabelle Aubert. (2022) MORPHIOUS: an unsupervised machine learning workflow to detect the activation of microglia and astrocytes. Journal of Neuroinflammation 19:1.
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Andrew M. Hersh, Meghana Bhimreddy, Carly Weber-Levine, Kelly Jiang, Safwan Alomari, Nicholas Theodore, Amir Manbachi & Betty M. Tyler. (2022) Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier. Cancers 14:19, pages 4920.
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Praveen Bathini, Tao Sun, Mathias Schenk, Stephan Schilling, Nathan J. McDannold & Cynthia A. Lemere. (2022) Acute Effects of Focused Ultrasound-Induced Blood-Brain Barrier Opening on Anti-Pyroglu3 Abeta Antibody Delivery and Immune Responses. Biomolecules 12:7, pages 951.
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Jonathan Bao, Thomas Tangney & Julie G. Pilitsis. (2022) Focused Ultrasound for Chronic Pain. Neurosurgery Clinics of North America 33:3, pages 331-338.
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Erica A. Power, Julian S. Rechberger, Sumit Gupta, Jonathan D. Schwartz, David J. Daniels & Soumen Khatua. (2022) Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors – An update. Advanced Drug Delivery Reviews 185, pages 114303.
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Raluca Ioana Teleanu, Manuela Daniela Preda, Adelina-Gabriela Niculescu, Oana Vladâcenco, Crina Ioana Radu, Alexandru Mihai Grumezescu & Daniel Mihai Teleanu. (2022) Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier. Pharmaceutics 14:5, pages 987.
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Lulu Deng, Steven D. Yang, Meaghan A. O'Reilly, Ryan M. Jones & Kullervo Hynynen. (2022) An Ultrasound-Guided Hemispherical Phased Array for Microbubble-Mediated Ultrasound Therapy. IEEE Transactions on Biomedical Engineering 69:5, pages 1776-1787.
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Steffen H. Tretbar, Marc Fournelle, Daniel Speicher, Franz-Josef Becker, Pavlos Anastasiadis, Lisa Landgraf, Upasana Roy & Andreas Melzer. (2022) A Novel Matrix-Array-Based MR-Conditional Ultrasound System for Local Hyperthermia of Small Animals. IEEE Transactions on Biomedical Engineering 69:2, pages 758-770.
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Chrysafis Andreou, Yiota Gregoriou, Akbar Ali & Suchetan Pal. 2022. SERS for Point-Of-care and Clinical Applications. SERS for Point-Of-care and Clinical Applications 199 235 .
Ying Meng, Christopher B. Pople, Dan Budiansky, Daniel Li, Suganth Suppiah, Mary Jane Lim-Fat, James Perry, Arjun Sahgal & Nir Lipsman. (2021) Current state of therapeutic focused ultrasound applications in neuro-oncology. Journal of Neuro-Oncology 156:1, pages 49-59.
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Dania Alphonse Jose, Krishnapriya & P. S. Baby Chakrapani. 2022. Micro- and Nano-containers for Smart Applications. Micro- and Nano-containers for Smart Applications 309 325 .
Zhiqi Zhang & Kyle J. Lampe. 2022. Engineering Biomaterials for Neural Applications. Engineering Biomaterials for Neural Applications 259 305 .
Olivia M. Turk, Ryan C. Woodall, Margarita Gutova, Christine E. Brown, Russell C. Rockne & Jennifer M. Munson. (2021) Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers. Drug Delivery and Translational Research 11:6, pages 2448-2467.
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Seunghyun Lee, Hoyoon Jeon, Shinyong Shim, Maesoon Im, Jinsik Kim, Jung Hoon Kim & Byung Chul Lee. (2021) Preclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens. Scientific Reports 11:1.
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Tereza Alekou, Marinos Giannakou & Christakis Damianou. (2021) Focused ultrasound phantom model for blood brain barrier disruption. Ultrasonics 110, pages 106244.
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Giuseppe Roberto Giammalva, Cesare Gagliardo, Salvatore Marrone, Federica Paolini, Rosa Maria Gerardi, Giuseppe Emmanuele Umana, Kaan Yağmurlu, Bipin Chaurasia, Gianluca Scalia, Federico Midiri, Ludovico La Grutta, Luigi Basile, Carlo Gulì, Domenico Messina, Maria Angela Pino, Francesca Graziano, Silvana Tumbiolo, Domenico Gerardo Iacopino & Rosario Maugeri. (2021) Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives. Brain Sciences 11:1, pages 84.
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Xiaodan Liu, S. Sta Maria Naomi, Wu Lin Sharon & E. Jacobs Russell. (2021) The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies. Aging and disease 12:8, pages 1977.
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Seigo Kimura & Hideyoshi Harashima. (2020) Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB. Pharmaceutics 12:12, pages 1216.
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Tsang-Wei Tu, Zsofia I. Kovacs, Maggie Sundby, Jaclyn A. Witko, Georgios Z. Papadakis, William C. Reid, Dima A. Hammoud & Joseph A. Frank. (2020) Diffusion Tensor Imaging and Chemical Exchange Saturation Transfer MRI Evaluation on the Long-Term Effects of Pulsed Focused Ultrasound and Microbubbles Blood Brain Barrier Opening in the Rat. Frontiers in Neuroscience 14.
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Daniel D. Liu, Mujib Ullah, Waldo Concepcion, Jeremy J. Dahl & Avnesh S. Thakor. (2020) The role of ultrasound in enhancing mesenchymal stromal cell-based therapies. Stem Cells Translational Medicine 9:8, pages 850-866.
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L. Galan-Acosta, C. Sierra, A. Leppert, A.N. Pouliopoulos, N. Kwon, R.L. Noel, S. Tambaro, J. Presto, P. Nilsson, E.E. Konofagou & J. Johansson. (2020) Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons. Molecular and Cellular Neuroscience, pages 103498.
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Michael A. Valdez, Elizabeth Fernandez, Terry Matsunaga, Robert P. Erickson & Theodore P. Trouard. (2020) Distribution and Diffusion of Macromolecule Delivery to the Brain via Focused Ultrasound using Magnetic Resonance and Multispectral Fluorescence Imaging. Ultrasound in Medicine & Biology 46:1, pages 122-136.
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Sanjoy Das, Malay K. Das, Trinayan Deka, L. Ronibala Singha & Punamjyoti Das. 2020. Nano Medicine and Nano Safety. Nano Medicine and Nano Safety 99 141 .
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Zahraa S. Al-Ahmady, Dhifaf Jasim, Sabahuddin Syed Ahmad, Raymond Wong, Michael Haley, Graham Coutts, Ingo Schiessl, Stuart M. Allan & Kostas Kostarelos. (2019) Selective Liposomal Transport through Blood Brain Barrier Disruption in Ischemic Stroke Reveals Two Distinct Therapeutic Opportunities. ACS Nano 13:11, pages 12470-12486.
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Samantha M. Fix, Bhanu P. Koppolu, Anthony Novell, Jared Hopkins, Thomas M. Kierski, David A. Zaharoff, Paul A. Dayton & Virginie Papadopoulou. (2019) Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery. Ultrasound in Medicine & Biology 45:7, pages 1762-1776.
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David J. Lundy, Keng-Jung Lee, I-Chia Peng, Chia-Hsin Hsu, Jen-Hao Lin, Kun-Hung Chen, Yu-Wen Tien & Patrick C. H. Hsieh. (2018) Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme. ACS Nano 13:1, pages 97-113.
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Francesco Prada, M. Yashar S. Kalani, Kaan Yagmurlu, Pedro Norat, Massimiliano Del Bene, Francesco DiMeco & Neal F. Kassell. (2018) Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors. Neurotherapeutics 16:1, pages 67-87.
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Stecia-Marie P. Fletcher & Meaghan A. O'Reilly. (2018) Analysis of Multifrequency and Phase Keying Strategies for Focusing Ultrasound to the Human Vertebral Canal. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 65:12, pages 2322-2331.
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Layton Lamsam, Eli Johnson, Ian D. Connolly, Max Wintermark & Melanie Hayden Gephart. (2018) A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy. Neurosurgical Focus 44:2, pages E10.
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