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Pre-filled syringe – a ready-to-use drug delivery system: a review

, M Pharmacy & , MS (Biotechnology)

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Bardur Sigurgeirsson, Knut Schäkel, Chih-Ho Hong, Isaak Effendy, Waldemar Placek, Phoebe Rich, Deborah Keefe, Gerard Bruin, Pascal Charef, Rong Fu, Isabelle Hampele & Manmath Patekar. (2022) Efficacy, tolerability, patient usability, and satisfaction with a 2 mL pre-filled syringe containing secukinumab 300 mg in patients with moderate to severe plaque psoriasis: results from the phase 3 randomized, double-blind, placebo-controlled ALLURE study. Journal of Dermatological Treatment 33:3, pages 1718-1726.
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Saki Yoneda, Tetsuo Torisu & Susumu Uchiyama. (2021) Development of syringes and vials for delivery of biologics: current challenges and innovative solutions. Expert Opinion on Drug Delivery 18:4, pages 459-470.
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Ayman R. Kafal, Donald C. Vinh & Mélanie J. Langelier. (2018) Prefilled syringes for immunoglobulin G (IgG) replacement therapy: clinical experience from other disease settings. Expert Opinion on Drug Delivery 15:12, pages 1199-1209.
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Articles from other publishers (20)

Dan Benhamou, Mia Weiss, Matthias Borms, Julia Lucaci, Haymen Girgis, Cecile Frolet, Wesley T. Baisley, Gio Shoushi, Kristen A. Cribbs & Manuel Wenk. (2023) Assessing the Clinical, Economic, and Health Resource Utilization Impacts of Prefilled Syringes Versus Conventional Medication Administration Methods: Results From a Systematic Literature Review. Annals of Pharmacotherapy.
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Daniel Kullmann, Carmen Lema Martinez, Jörg Lümkemann & Jörg Huwyler. (2023) Part I: Significant reduction of lyophilization process times by using novel matrix based scaffolds. European Journal of Pharmaceutics and Biopharmaceutics 184, pages 248-261.
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Kai Huang, Nannan Chu, Ying Ding, Linglin Que, Zhenzhong Qian, Yunfei Shi, Wei Qin & Qing He. (2022) Comparative Pharmacokinetics, Safety, and Immunogenicity Study of the Prefilled Syringe and Lyophilized Formulation of a Recombinant Human Tumor Necrosis Factor‐α Receptor II:lgG Fc Fusion Protein in Healthy Chinese Male Subjects. Clinical Pharmacology in Drug Development 11:9, pages 1116-1123.
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Jie Wang, Gene Wloch, Ting Lin & Zhan Chen. (2021) Investigating Thin Silicone Oil Films Using Four-Wave Mixing Spectroscopy and Sum Frequency Generation Vibrational Spectroscopy. Langmuir 37:49, pages 14540-14549.
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Shawn Shouye Wang, Yifei (Susie) Yan & Kin Ho. (2021) US FDA-approved therapeutic antibodies with high-concentration formulation: summaries and perspectives. Antibody Therapeutics 4:4, pages 262-272.
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Mutasem Rawas-Qalaji, Rawan Bafail, Iman Saad Ahmed, Mohammad Nasir Uddin & Sami Nazzal. (2021) Modulation of the sublingual microenvironment and pH-dependent transport pathways to enhance atropine sulfate permeability for the treatment of organophosphates poisoning. International Journal of Pharmaceutics 606, pages 120898.
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Rahul G. Ingle & Wei-Jie Fang. (2021) Prefilled dual chamber devices (DCDs) – Promising high-quality and convenient drug delivery system. International Journal of Pharmaceutics 597, pages 120314.
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Xuezhen Zhou, Xi Lin, Runnan Shen, Yingying Qu, Chunling Mo, Yan Li, Qinchang Chen, Guitao Wu, Zhenhong Chen & Kai Huang. (2020) A retrospective analysis of risk factors associated with catheter-related thrombosis: a single-center study. Perfusion 35:8, pages 806-813.
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Nathan H. Joh, Lisa Thomas, Twinkle R. Christian, Alla Verlinsky, Nancy Jiao, Nilo Allotta, Vibha Jawa, Shawn Cao, Linda O. Narhi & Marisa K. Joubert. (2020) Silicone Oil Particles in Prefilled Syringes With Human Monoclonal Antibody, Representative of Real-World Drug Products, Did Not Increase Immunogenicity in In Vivo and In Vitro Model Systems. Journal of Pharmaceutical Sciences 109:1, pages 845-853.
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Vivek Thakare, Bettina Mayr, Andrej Artenjak, Dimitrios Nianios, Maike Sest, Martin Müller, Oleg V. Maltsev, Kajetan Nowicki, Andre Mischo, Christian Ehrenstrasser, Matthias Fink, Silvia Thanhaeuser & Alessandra Cerreti. (2019) Investigation of drug product and container-closure interactions: A case study of diluent containing prefilled syringe. European Journal of Pharmaceutics and Biopharmaceutics 140, pages 67-77.
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Patrick T. Wedlock, Elizabeth A. Mitgang, Sheryl S. Siegmund, Jay DePasse, Jennifer Bakal, Jim Leonard, Joel Welling, Shawn T. Brown & Bruce Y. Lee. (2018) Dual-chamber injection device for measles-rubella vaccine: The potential impact of introducing varying sizes of the devices in 3 countries. Vaccine 36:39, pages 5879-5885.
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Roman Mathaes & Alexander Streubel. 2018. Challenges in Protein Product Development. Challenges in Protein Product Development 191 202 .
Noemí Dorival-García, Iben Larsson & Jonathan Bones. (2017) Non-volatile extractable analysis of prefilled syringes for parenteral administration of drug products. Journal of Pharmaceutical and Biomedical Analysis 142, pages 337-342.
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Hanns-Christian Mahler & Roman Mathäs. 2017. Process Scale Purification of Antibodies. Process Scale Purification of Antibodies 673 697 .
Stefanie Funke, Julia Matilainen, Heiko Nalenz, Karoline Bechtold-Peters, Hanns-Christian Mahler & Wolfgang Friess. (2016) Silicone Migration From Baked-on Silicone Layers. Particle Characterization in Placebo and Protein Solutions. Journal of Pharmaceutical Sciences 105:12, pages 3520-3531.
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Stefanie Funke, Julia Matilainen, Heiko Nalenz, Karoline Bechtold-Peters, Hanns-Christian Mahler, Florian Vetter, Christoph Müller, Franz Bracher & Wolfgang Friess. (2016) Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature. European Journal of Pharmaceutics and Biopharmaceutics 105, pages 209-222.
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Stefanie Funke, Julia Matilainen, Heiko Nalenz, Karoline Bechtold-Peters, Hanns-Christian Mahler & Wolfgang Friess. (2016) Optimization of the bake-on siliconization of cartridges. Part I: Optimization of the spray-on parameters. European Journal of Pharmaceutics and Biopharmaceutics 104, pages 200-215.
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Galina Hesse. 2016. Value Creation in the Pharmaceutical Industry. Value Creation in the Pharmaceutical Industry 182 201 .
Maxime Perez, Aurélie Maiguy-Foinard, Christine Barthélémy, Bertrand Décaudin & Pascal Odou. (2016) Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients. Pharmaceutical Technology in Hospital Pharmacy 1:2.
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B. Charpiat, C. Magdinier, G. Leboucher & F. Aubrun. (2016) Erreurs médicamenteuses avec les solutés concentrés de potassium injectable : données de la littérature, état des lieux et prévention. Annales Pharmaceutiques Françaises 74:1, pages 3-11.
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