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Expert Opinion on Drug Delivery Volume 11, 2014 - Issue 9
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Orally active-targeted drug delivery systems for proteins and peptides

Xiuying LiShanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China+86 21 20231000 1424; +86 21 20231000 1425; [email protected]
,
Miaorong YuShanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China+86 21 20231000 1424; +86 21 20231000 1425; [email protected]
,
Weiwei FanShanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China+86 21 20231000 1424; +86 21 20231000 1425; [email protected]
,
Yong GanShanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China+86 21 20231000 1424; +86 21 20231000 1425; [email protected]
,
Lars HovgaardOral Formulation Development, Novo Nordisk A/S, Maalov, 2760, Denmark
&
Mingshi YangUniversity of Copenhagen, Department of Pharmacy, Faculty of Health and Medical Sciences, Copenhagen, 2100, Demark
Pages 1435-1447 | Published online: 25 Jun 2014

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Haisheng Peng, Jiahe Wang, Jiayu Chen, Yanbo Peng, Xiaoxian Wang, Ying Chen, David L. Kaplan & Qun Wang. (2023) Challenges and opportunities in delivering oral peptides and proteins. Expert Opinion on Drug Delivery 20:10, pages 1349-1369.
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Ya-Wen Zhang, Ling-Lan Tu, Zhan Tang, Qiao Wang, Gao-Li Zheng & Li-Na Yin. (2021) pH-sensitive chitosan-deoxycholic acid/alginate nanoparticles for oral insulin delivery. Pharmaceutical Development and Technology 26:9, pages 943-952.
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Shiming He, Zhongcheng Liu & Donggang Xu. (2019) Advance in oral delivery systems for therapeutic protein. Journal of Drug Targeting 27:3, pages 283-291.
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Xinyi Tan, Xiaolin Liu, Yan Zhang, Hongjuan Zhang, Xiaoyang Lin, Chenguang Pu, Jingxin Gou, Haibing He, Tian Yin, Yu Zhang & Xing Tang. (2018) Silica nanoparticles on the oral delivery of insulin. Expert Opinion on Drug Delivery 15:8, pages 805-820.
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Chenyu Yan, Chengqun Chen, Lin Hou, Huijuan Zhang, Yingyu Che, Yuedong Qi, Xiaojian Zhang, Jingliang Cheng & Zhenzhong Zhang. (2017) Single-walled carbon nanotube-loaded doxorubicin and Gd-DTPA for targeted drug delivery and magnetic resonance imaging. Journal of Drug Targeting 25:2, pages 163-171.
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Stephen T. Buckley, František Hubálek & Ulrik Lytt Rahbek. (2016) Chemically modified peptides and proteins - critical considerations for oral delivery. Tissue Barriers 4:2.
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Yuehong Ren, Wei Wu & Xingwang Zhang. (2023) The feasibility of oral targeted drug delivery: Gut immune to particulates?. Acta Pharmaceutica Sinica B 13:6, pages 2544-2558.
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Zichen Zhang, Yi Lu, Jianping Qi & Wei Wu. (2021) An update on oral drug delivery via intestinal lymphatic transport. Acta Pharmaceutica Sinica B 11:8, pages 2449-2468.
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Yina Song, Yanan Shi, Liping Zhang, Haiyan Hu, Chunyan Zhang, Miaomiao Yin, Xuemei Zhang & Kaoxiang Sun. (2019) Oral delivery system for low molecular weight protamine-dextran-poly(lactic-co-glycolic acid) carrying exenatide to overcome the mucus barrier and improve intestinal targeting efficiency. Nanomedicine 14:8, pages 989-1009.
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Sabrina Sepúlveda-Rivas, Hans Fritz, Camila Valenzuela, Carlos Santiviago & Javier Morales. (2019) Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety. Pharmaceutics 11:3, pages 103.
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Akash Pandya, Mark Howard, Mire Zloh & Paul Dalby. (2018) An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations. Pharmaceutics 10:4, pages 165.
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Elena Presas, Fiona McCartney, Eric Sultan, Corina Hunger, Sabine Nellen, Clara V. Alvarez, Ulrich Werner, Didier Bazile, David J. Brayden & Caitriona M. O'Driscoll. (2018) Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin. Journal of Controlled Release 286, pages 402-414.
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Cláudia Azevedo, Maria Helena Macedo & Bruno Sarmento. (2018) Strategies for the enhanced intracellular delivery of nanomaterials. Drug Discovery Today 23:5, pages 944-959.
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Weiwei Fan, Dengning Xia, Quanlei Zhu, Xiuying Li, Shufang He, Chunliu Zhu, Shiyan Guo, Lars Hovgaard, Mingshi Yang & Yong Gan. (2018) Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials 151, pages 13-23.
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Rajan Jog & Diane J. Burgess. 2018. Fundamentals of Nanoparticles. Fundamentals of Nanoparticles 279 342 .
Ye Li, Xiaoning Song, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Xueqing Wang & Ying Zheng. (2017) Zebrafish: A Visual Model To Evaluate the Biofate of Transferrin Receptor-Targeted 7Peptide-Decorated Coumarin 6 Micelles. ACS Applied Materials & Interfaces 9:44, pages 39048-39058.
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Daniel S. Nielsen, Nicholas E. Shepherd, Weijun Xu, Andrew J. Lucke, Martin J. Stoermer & David P. Fairlie. (2017) Orally Absorbed Cyclic Peptides. Chemical Reviews 117:12, pages 8094-8128.
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M.A. Oyama, P.F. Solter, C.L. Thorn & J.A. Stern. (2017) Feasibility, safety, and tolerance of subcutaneous synthetic canine B-type natriuretic peptide (syncBNP) in healthy dogs and dogs with stage B1 mitral valve disease. Journal of Veterinary Cardiology 19:3, pages 211-217.
Crossref
M.L. Smythe. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 157 170 .
Catherine H. Smith. 2016. Rook's Textbook of Dermatology, Ninth Edition. Rook's Textbook of Dermatology, Ninth Edition 1 13 .
. 2016. Drug Delivery. Drug Delivery 169 200 .
Ying Wang, Amgad R. Rezk, Jasmeet Singh Khara, Leslie Y. Yeo & Pui Lai Rachel Ee. (2016) Stability and efficacy of synthetic cationic antimicrobial peptides nebulized using high frequency acoustic waves. Biomicrofluidics 10:3.
Crossref
Weiwei Fan, Dengning Xia, Quanlei Zhu, Lei Hu & Yong Gan. (2016) Intracellular transport of nanocarriers across the intestinal epithelium. Drug Discovery Today 21:5, pages 856-863.
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Quanlei Zhu, Wenyi Song, Dengning Xia, Weiwei Fan, Miaorong Yu, Shiyan Guo, Chunliu Zhu & Yong Gan. (2015) A poly- l -glutamic acid functionalized nanocomplex for improved oral drug absorption . Journal of Materials Chemistry B 3:43, pages 8508-8517.
Crossref
Christopher J Roberts. (2014) Protein aggregation and its impact on product quality. Current Opinion in Biotechnology 30, pages 211-217.
Crossref

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