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Original Research

Andrographolide-loaded PLGA-PEG-PLGA micelles to improve its bioavailability and anticancer efficacy

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Wan Liu, Meng Cheng, Zhiyang Lu, Haocheng Li, Yulin Feng, Yi Jin, Shilin Yang, Jianfang Feng & Liangxing Tu. (2022) Multi-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy. Drug Delivery 29:1, pages 3432-3442.
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Samira Khaledi, Sevda Jafari, Samin Hamidi, Ommoleila Molavi & Soodabeh Davaran. (2020) Preparation and characterization of PLGA-PEG-PLGA polymeric nanoparticles for co-delivery of 5-Fluorouracil and Chrysin. Journal of Biomaterials Science, Polymer Edition 31:9, pages 1107-1126.
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Yi-Pin Chen, Yen-Wei Liu, Demei Lee, Jiantai Timothy Qiu, Tzung-Yan Lee & Shih-Jung Liu. (2019) Biodegradable andrographolide-eluting nanofibrous membranes for the treatment of cervical cancer. International Journal of Nanomedicine 14, pages 421-429.
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Jinming Zhang, Xiaobin Fang, Zeyong Li, Hon Fai Chan, Zhixiu Lin, Yitao Wang & Meiwan Chen. (2018) Redox-sensitive micelles composed of disulfide-linked Pluronic-linoleic acid for enhanced anticancer efficiency of brusatol. International Journal of Nanomedicine 13, pages 939-956.
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Xiaowei Zhu, Chao Liu, Jianwei Duan, Xiaoyu Liang, Xuanling Li, Hongfan Sun, Deling Kong & Jing Yang. (2016) Synthesis of three-arm block copolymer poly(lactic-co-glycolic acid)–poly(ethylene glycol) with oxalyl chloride and its application in hydrophobic drug delivery. International Journal of Nanomedicine 11, pages 6065-6077.
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Yuee Cai, Zhongqing Sun, Xiaobin Fang, Xiefan Fang, Fei Xiao, Yitao Wang & Meiwan Chen. (2016) Synthesis, characterization and anti-cancer activity of Pluronic F68–curcumin conjugate micelles. Drug Delivery 23:7, pages 2587-2595.
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Lu Wang, Yafang Wang, Xueqing Wang, Lin Sun, Zhengzheng Zhou, Jinjian Lu & Ying Zheng. (2016) Encapsulation of low lipophilic and slightly water-soluble dihydroartemisinin in PLGA nanoparticles with phospholipid to enhance encapsulation efficiency and in vitro bioactivity. Journal of Microencapsulation 33:1, pages 43-52.
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Yu Hu, Jizheng Song, Anjie Feng, Jieyu Li, Mengqi Li, Yu Shi, Wenxiu Sun & Lingjun Li. (2023) Recent Advances in Nanotechnology-Based Targeted Delivery Systems of Active Constituents in Natural Medicines for Cancer Treatment. Molecules 28:23, pages 7767.
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Rosnani Hasham, Melissa Yushan Ng, Rahimah Sabtu, Mohamad Khairul Hafiz Idris, Illani Abdul Rahman, Harisun Yaakob, Mariani Abdul Hamid, Nadia Adrus & Jamarosliza Jamaluddin. (2023) Preparation and characterization of Andrographis paniculata extract loaded onto chitosan-based nanoparticles. Materials Today: Proceedings.
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Princi VermaG.D. GuptaTanmay S. MarkandeywarDilpreet Singh. (2023) A Critical Sojourn of Polymeric Micelles: Technological Concepts, Recent Advances, and Future Prospects. ASSAY and Drug Development Technologies 21:2, pages 31-47.
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Wan Liu, Meng Cheng, Fangying Yuan, Jiaying He, Yulin Feng, Yi Jin, Jianfang Feng, Shilin Yang & Liangxing Tu. (2023) Enhancing oral bioavailability of andrographolide via sodium dodecyl sulfate and D-α-Tocopherol polyethylene glycol 1000 succinate copolymer modified nanocrystals. Journal of Drug Delivery Science and Technology 79, pages 104006.
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Hongquan Li, Xingzhou Qu, Wenhao Qian, Yang Song, Changhong Wang & Wei Liu. (2020) Andrographolide‐loaded solid lipid nanoparticles enhance anti‐cancer activity against head and neck cancer and precancerous cells. Oral Diseases 28:1, pages 142-149.
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Shirleen Miriam Marques & Lalit Kumar. 2022. Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems. Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems 273 292 .
Silpita Paul, Dia Roy, Subhadip Pati & Gaurisankar Sa. (2021) The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer. Frontiers in Pharmacology 12.
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Moumita Hazra, Dalia Dasgupta Mandal, Tamal Mandal, B. Prakash Rao & Suman Samaddar. (2021) Optimization and characterization of hepatoprotective andrographolide microspheres in the necrotic rat model. Journal of Drug Delivery Science and Technology 65, pages 102679.
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Ning Lyu, Yujin Zhao, Jun Xiang, Xiangyu Fan, Chang Huang, Xinghuai Sun, Jianjiang Xu, Zhi Ping Xu & Jianguo Sun. (2021) Inhibiting corneal neovascularization by sustainably releasing anti-VEGF and anti-inflammation drugs from silica-thermogel nanohybrids. Materials Science and Engineering: C 128, pages 112274.
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Zoya Malik, Rabea Parveen, Bushra Parveen, Sultan Zahiruddin, Mohammad Aasif Khan, Asifa Khan, Sheersh Massey, Sayeed Ahmad & Syed Akhtar Husain. (2021) Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action. Journal of Ethnopharmacology 272, pages 113936.
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Xuan Ren, Wenzhou Xu, Jiao Sun, Biao Dong, Hussein Awala & Lin Wang. (2021) Current Trends on Repurposing and Pharmacological Enhancement of Andrographolide. Current Medicinal Chemistry 28:12, pages 2346-2368.
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Badrinathan Sridharan & Meng-Jen Lee. (2021) Current developments in Nano/Micro-formulations for enhanced delivery and bioactivity of andrographolide. Materials Today: Proceedings 45, pages 4746-4752.
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Dalia Dasgupta Mandal, Tamal Mandal & Moumita Hazra. (2020) Strategic approach in hepatic delivery of andrographolide: Key challenges and new insights. Journal of Herbal Medicine 24, pages 100411.
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Hailu Yao, Junli Zhao, Zhen Wang, Jinwei Lv, Gangjun Du, Yiguang Jin, Yu Zhang, Shiyong Song & Guang Han. (2020) Enhanced anticancer efficacy of cantharidin by mPEG-PLGA micellar encapsulation: An effective strategy for application of a poisonous traditional Chinese medicine. Colloids and Surfaces B: Biointerfaces 196, pages 111285.
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Raj J. Ahiwale, Bothiraja Chellampillai & Atmaram P. Pawar. (2020) Investigation of 1,2-Dimyristoyl-sn-Glycero-3-Phosphoglycerol-Sodium (DMPG-Na) Lipid with Various Metal Cations in Nanocochleate Preformulation: Application for Andrographolide Oral Delivery in Cancer Therapy. AAPS PharmSciTech 21:7.
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Xuan Yu, Lili Sun, Lejun Tan, Meng Wang, Xiaoliang Ren, Jiaxin Pi, Miaomiao Jiang & Nan Li. (2020) Preparation and Characterization of PLGA–PEG–PLGA Nanoparticles Containing Salidroside and Tamoxifen for Breast Cancer Therapy. AAPS PharmSciTech 21:3.
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Gulshan Kumar, Davinder Singh, Javeed Ahmad Tali, Divya Dheer & Ravi Shankar. (2020) Andrographolide: Chemical modification and its effect on biological activities. Bioorganic Chemistry 95, pages 103511.
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G Bharath, K Rambabu, Fawzi Banat, Shoaib Anwer, SungMun Lee, Nouf BinSaleh, Swarna Latha & N Ponpandian. (2019) Mesoporous hydroxyapatite nanoplate arrays as pH-sensitive drug carrier for cancer therapy. Materials Research Express 6:8, pages 085409.
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Marta Casamonti, Laura Risaliti, Giulia Vanti, Vieri Piazzini, Maria Camilla Bergonzi & Anna Rita Bilia. (2019) Andrographolide Loaded in Micro- and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”. Engineering 5:1, pages 69-75.
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Rabea Parveen, Bushra Parveen, Abida Parveen & Sayeed Ahmad. 2019. Nanomaterials and Plant Potential. Nanomaterials and Plant Potential 317 345 .
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Muhammad Torequl Islam, Eunüs S. Ali, Shaikh Jamal Uddin, Md. Amirul Islam, Subrata Shaw, Ishaq N. Khan, Seyed Soheil Saeedi Saravi, Saheem Ahmad, Shahnawaz Rehman, Vijai Kumar Gupta, Mihnea-Alexandru Găman, Amelia Maria Găman, Santosh Yele, Asish Kumar Das, João Marcelo de Castro e Sousa, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S. Mubarak, Nagendra Sastry Yarla, Jamil A. Shilpi, Siddhartha Kumar Mishra, Atanas G. Atanasov & Mohammad Amjad Kamal. (2018) Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. Cancer Letters 420, pages 129-145.
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Jingjing Li, Yuran Peng, Shang Li, Yicheng Sun, Judy Yuet-Wa Chan, Guozhen Cui, Decai Wang, Guo-Chun Zhou & Simon Ming-Yuen Lee. (2016) Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs. European Journal of Pharmacology 789, pages 344-353.
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Atmaram Pawar, S. Rajalakshmi, Piyush Mehta, Karimunnisa Shaikh & Chellampillai Bothiraja. (2016) Strategies for formulation development of andrographolide. RSC Advances 6:73, pages 69282-69300.
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Yuee Cai, Shengpeng Wang, Minghui Wu, Jonathan K. Tsosie, Xi Xie, Jianbo Wan, Chengwei He, Huayu Tian, Xuesi Chen & Meiwan Chen. (2016) PCL–F68–PCL/PLGA–PEG–PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer. RSC Advances 6:42, pages 35318-35327.
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Wei Zhou, Baochang Cai, Jinjun Shan, Shouchuan Wang & Liuqing Di. (2015) Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines—Flos Lonicerae Japonicae—Fructus Forsythiae Herb Couples as an Example. International Journal of Molecular Sciences 16:12, pages 28812-28840.
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