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Expert Opinion on Drug Delivery Volume 12, 2015 - Issue 6
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Original Research

Dry powder formulation of simvastatin

Alaa S TulbahSydney University, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, Respiratory Technology, Sydney, NSW 2037, [email protected];Umm Al Qura University, Faculty of Pharmacy, Makkah, Saudi Arabia
,
Hui Xin OngSydney University, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, Respiratory Technology, Sydney, NSW 2037, [email protected]
,
Lucy MorganUniversity of Sydney, Concord Clinical School, Sydney Medical School, Department of Respiratory Medicine, Sydney, NSW, Australia;Concord Repatriation General Hospital, Sydney, Australia
,
Paolo ColomboUniversity of Parma, Department of Pharmacy, Parma, Italy
,
Paul M YoungSydney University, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, Respiratory Technology, Sydney, NSW 2037, [email protected]
&
Daniela TrainiSydney University, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, Respiratory Technology, Sydney, NSW 2037, [email protected]
Pages 857-868 | Published online: 22 Sep 2014

Citations (22)

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Ziyu Zhao, Zhengwei Huang, Xuejuan Zhang, Ying Huang, Yingtong Cui, Cheng Ma, Guanlin Wang, Tim Freeman, Xiang-yun Lu, Xin Pan & Chuanbin Wu. (2018) Low density, good flowability cyclodextrin-raffinose binary carrier for dry powder inhaler: anti-hygroscopicity and aerosolization performance enhancement. Expert Opinion on Drug Delivery 15:5, pages 443-457.
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Alaa S. Tulbah, Hui Xin Ong, Paolo Colombo, Paul M. Young & Daniela Traini. (2016) Could simvastatin be considered as a potential therapy for chronic lung diseases? A debate on the pros and cons. Expert Opinion on Drug Delivery 13:10, pages 1407-1420.
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Abdelwahab Omri. (2015) Pulmonary drug and vaccine delivery: therapeutic significance and major challenges. Expert Opinion on Drug Delivery 12:6, pages 853-855.
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Articles from other publishers (19)

Aditi Negi, Shubham Nimbkar & Jeyan Arthur Moses. (2023) Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches. Pharmaceutics 15:12, pages 2706.
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Alaa S. Tulbah. (2023) In vitro bio-characterization of solid lipid nanoparticles of favipiravir in A549 human lung epithelial cancer cells. Journal of Taibah University Medical Sciences 18:5, pages 1076-1086.
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Yen My Vuu, Ashraf Kadar Shahib & Mojgan Rastegar. (2023) The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action. Pharmaceuticals 16:7, pages 914.
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Alaa S. Tulbah. (2022) Inhaled Atorvastatin Nanoparticles for Lung Cancer. Current Drug Delivery 19:10, pages 1073-1082.
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Alaa S. Tulbah, Ammar Bader, Hui Xin Ong & Daniela Traini. (2022) In vitro evaluation of nebulized eucalyptol nano-emulsion formulation as a potential COVID-19 treatment. Saudi Pharmaceutical Journal 30:12, pages 1691-1699.
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Alaa S. Tulbah & Amr Gamal. (2021) Design and Characterization of Atorvastatin Dry Powder Formulation as a potential Lung Cancer Treatment. Saudi Pharmaceutical Journal 29:12, pages 1449-1457.
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Maria F. Acosta, Priya Muralidharan, Carissa L. Grijalva, Michael D. Abrahamson, Don HayesJr.Jr., Jeffrey R. Fineman, Stephen M. Black & Heidi M. Mansour. (2021) Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy . Therapeutic Advances in Respiratory Disease 15, pages 175346662199824.
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Birendra Chaurasiya & You-Yang Zhao. (2020) Dry Powder for Pulmonary Delivery: A Comprehensive Review. Pharmaceutics 13:1, pages 31.
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Alaa S. Tulbah. (2020) The potential of Atorvastatin for chronic lung diseases therapy. Saudi Pharmaceutical Journal 28:11, pages 1353-1363.
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Emelie Landh, Lyn M. Moir, Larissa Gomes Dos Reis, Daniela Traini, Paul M. Young & Hui Xin Ong. (2020) Inhaled rapamycin solid lipid nano particles for the treatment of Lymphangioleiomyomatosis. European Journal of Pharmaceutical Sciences 142, pages 105098.
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Alaa S. Tulbah, Elvira Pisano, Emelie Landh, Santo Scalia, Paul M. Young, Daniela Traini & Hui Xin Ong. (2019) Simvastatin Nanoparticles Reduce Inflammation in LPS-Stimulated Alveolar Macrophages. Journal of Pharmaceutical Sciences 108:12, pages 3890-3897.
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Wangding Lu, Thomas Rades, Jukka Rantanen, Hak-Kim Chan & Mingshi Yang. (2019) Amino acids as stabilizers for spray-dried simvastatin powder for inhalation. International Journal of Pharmaceutics 572, pages 118724.
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M. Forstner, W. Eilenberg, F. Simon, M. Trenner, H. H. Eckstein, L. Maegdefessel & A. Busch. (2019) „Drug repurposing“ und „orphan drug usage“Drug repurposing and orphan drug usage. Gefässchirurgie 24:7, pages 564-567.
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Wing-Hin Lee, Ching-Yee Loo, Maliheh Ghadiri, Chean-Ring Leong, Paul M. Young & Daniela Traini. (2018) The potential to treat lung cancer via inhalation of repurposed drugs. Advanced Drug Delivery Reviews 133, pages 107-130.
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Peta Bradbury, Daniela Traini, Alaina J. Ammit, Paul M. Young & Hui Xin Ong. (2018) Repurposing of statins via inhalation to treat lung inflammatory conditions. Advanced Drug Delivery Reviews 133, pages 93-106.
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Jennifer M. Bratt, Kevin Y. Chang, Michelle Rabowsky, Lisa M. Franzi, Sean P. Ott, Simone Filosto, Tzipora Goldkorn, Muhammad Arif, Jerold A. Last, Nicholas J. Kenyon & Amir A. Zeki. (2018) Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation. The Journal of Immunology 200:11, pages 3840-3856.
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Alaa S Tulbah, Elvira Pisano, Santo Scalia, Paul M Young, Daniela Traini & Hui Xin Ong. (2017) Inhaled simvastatin nanoparticles for inflammatory lung disease. Nanomedicine 12:20, pages 2471-2485.
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Hui Xin Ong, Claire L. JacksonJanice L. ColePeter M. LackieDaniela Traini, Paul M. Young, Jane LucasJoy Conway. (2016) Primary Air–Liquid Interface Culture of Nasal Epithelium for Nasal Drug Delivery. Molecular Pharmaceutics 13:7, pages 2242-2252.
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Alaa S. Tulbah, Hui Xin Ong, Wing-Hin Lee, Paolo Colombo, Paul M. Young & Daniela Traini. (2015) Biological Effects of Simvastatin Formulated as pMDI on Pulmonary Epithelial Cells. Pharmaceutical Research 33:1, pages 92-101.
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