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Review

Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects

, PhD (Candidate) , (Professor) & (Professor, Chairman of the Division of Clinical Pharmacy, Head of the PharmD Program)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

Eesha Shukla, Divya Dhatri Kara, Tanvi Katikala & Mahalaxmi Rathnanand. (2023) Self-nanoemulsifying drug delivery systems (SNEDDS) of anti-cancer drugs: a multifaceted nanoplatform for the enhancement of oral bioavailability. Drug Development and Industrial Pharmacy 49:1, pages 1-16.
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Seyedeh Nika Rezvanjou, Mohammad Reza Niavand, Omid Heydari Shayesteh, Ehsan Mehrani Yeganeh, Davood Ahmadi Moghadam, Katayoun Derakhshandeh & Reza Mahjub. (2023) Preparation and characterisation of self-emulsifying drug delivery system (SEDDS) for enhancing oral bioavailability of metformin hydrochloride using hydrophobic ion pairing complexation. Journal of Microencapsulation 40:1, pages 53-66.
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Thapa Chhitij, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Santosh Bashyal, Shrawani Lamichhane, Jung Hwan Kim, Jae Heon Lee, Jee Hun Park, Jaewoong Choi, Se Hyun Song & Sangkil Lee. (2022) Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10 . Drug Delivery 29:1, pages 2330-2342.
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Adnan Burhan Qader, Shobhit Kumar, Kanchan Kohli & Ahmed Abbas Hussein. (2022) Garlic oil loaded rosuvastatin solid self-nanoemulsifying drug delivery system to improve level of high-density lipoprotein for ameliorating hypertriglyceridemia. Particulate Science and Technology 40:2, pages 165-181.
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Teruo Murakami, Erik Bodor & Nicholas Bodor. (2021) Factors and dosage formulations affecting the solubility and bioavailability of P-glycoprotein substrate drugs. Expert Opinion on Drug Metabolism & Toxicology 17:5, pages 555-580.
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Mohammad Mahmoudian, Hadi Valizadeh, Raimar Löbenberg & Parvin Zakeri-Milani. (2021) Bortezomib-loaded lipidic-nano drug delivery systems; formulation, therapeutic efficacy, and pharmacokinetics. Journal of Microencapsulation 38:3, pages 192-202.
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Khaled M. Hosny, Amal M. Sindi, Hala M. Alkhalidi, Mallesh Kurakula, Nabil K. Alruwaili, Nabil A. Alhakamy, Walaa A. Abualsunun, Rana B. Bakhaidar, Rahaf H. Bahmdan, Waleed Y. Rizg, Sarah A. Ali, Wesam H. Abdulaal, Majed S. Nassar, Mohammed S. Alsuabeyl, Adel F. Alghaith & Sultan Alshehri. (2021) Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis. Drug Delivery 28:1, pages 1043-1054.
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Xin Nie, Zhejie Chen, Lan Pang, Lin Wang, Huajuan Jiang, Yi Chen, Zhen Zhang, Chaomei Fu, Bo Ren & Jinming Zhang. (2020) Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds. International Journal of Nanomedicine 15, pages 10215-10240.
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Nayera Nasser, Rania M. Hathout, Hend Abd-Allah & Omaima A. Sammour. (2020) Enhancement of oral bioavailability of drugs using lipid-based carriers: a meta-analysis study. Drug Development and Industrial Pharmacy 46:12, pages 2105-2110.
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Mohammad Mahmoudian, Hadi Valizadeh, Raimar Löbenberg & Parvin Zakeri-Milani. (2020) Enhancement of the intestinal absorption of bortezomib by self-nanoemulsifying drug delivery system. Pharmaceutical Development and Technology 25:3, pages 351-358.
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Jingyi Ye, Huiyi Wu, Chuanli Huang, Wanting Lin, Caifeng Zhang, Bei Huang, Banyi Lu, Hongyu Xu, Xiaoling Li & Xiaoying Long. (2019) Comparisons of in vitro Fick’s first law, lipolysis, and in vivo rat models for oral absorption on BCS II drugs in SNEDDS. International Journal of Nanomedicine 14, pages 5623-5636.
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Babita Garg, Sarwar Beg, Ranjot Kaur, Rajendra Kumar, Om Prakash Katare & Bhupinder Singh. (2018) Long-chain triglycerides-based self-nanoemulsifying oily formulations (SNEOFs) of darunavir with improved lymphatic targeting potential. Journal of Drug Targeting 26:3, pages 252-266.
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Fiza Ur Rehman, Kifayat Ullah Shah, Shefaat Ullah Shah, Ikram Ullah Khan, Gul Majid Khan & Amjad Khan. (2017) From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opinion on Drug Delivery 14:11, pages 1325-1340.
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Hitesh Dalvadi, Nikita Patel & Komal Parmar. (2017) Systematic development of design of experiments (DoE) optimised self-microemulsifying drug delivery system of Zotepine. Journal of Microencapsulation 34:3, pages 308-318.
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Ying Liu, Xin Wu, Yushuai Mi, Bimeng Zhang, Shengying Gu, Gaolin Liu & Xiaoyu Li. (2017) PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies. Drug Delivery 24:1, pages 443-451.
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Bappaditya Chatterjee, Samah Hamed Almurisi, Ather Ahmed Mahdi Dukhan, Uttam Kumar Mandal & Pinaki Sengupta. (2016) Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug Delivery 23:9, pages 3639-3652.
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Yanfei Miao, Jiqin Sun, Guoguang Chen, Ren Lili & Pingkai Ouyang. (2016) Enhanced oral bioavailability of lurasidone by self-nanoemulsifying drug delivery system in fasted state. Drug Development and Industrial Pharmacy 42:8, pages 1234-1240.
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Shasank S. Swain, Sudhir K. Paidesetty, Rabindra N. Padhy & Tahziba Hussain. (2023) Nano-technology platforms to increase the antibacterial drug suitability of essential oils: A drug prospective assessment. OpenNano 9, pages 100115.
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Tarek A. Ahmed, Hanadi A. Alotaibi, Alshaimaa M. Almehmady, Martin K. Safo & Khalid M. El-Say. (2022) Influences of Glimepiride Self-Nanoemulsifying Drug Delivery System Loaded Liquisolid Tablets on the Hypoglycemic Activity and Pancreatic Histopathological Changes in Streptozotocin-Induced Hyperglycemic Rats. Nanomaterials 12:22, pages 3966.
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Fiza Ur Rehman, Arshad Farid, Shefaat Ullah Shah, Muhammad Junaid Dar, Asim Ur Rehman, Naveed Ahmed, Sheikh Abdur Rashid, Irfan Shaukat, Muddaser Shah, Ghadeer M. Albadrani, Mohamed Kamel, Ahmed E. Altyar, Mohamed M. Abdel-Daim & Kifayat Ullah Shah. (2022) Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability. Pharmaceuticals 15:9, pages 1064.
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Kamal A. Qureshi, Salman A. A. Mohammed, Omar Khan, Hussein M. Ali, Mahmoud Z. El-Readi & Hamdoon A. Mohammed. (2022) Cinnamaldehyde-Based Self-Nanoemulsion (CA-SNEDDS) Accelerates Wound Healing and Exerts Antimicrobial, Antioxidant, and Anti-Inflammatory Effects in Rats’ Skin Burn Model. Molecules 27:16, pages 5225.
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Syed Abul Layes Gausuzzaman, Mithun Saha, Shahid Jaman Dip, Shaiful Alam, Arup Kumar, Harinarayan Das, Shazid Md. Sharker, Md Abdur Rashid, Mohsin Kazi & Hasan Mahmud Reza. (2022) A QbD Approach to Design and to Optimize the Self-Emulsifying Resveratrol–Phospholipid Complex to Enhance Drug Bioavailability through Lymphatic Transport. Polymers 14:15, pages 3220.
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Virginia Campani, Iris Chiara Salaroglio, Valeria Nele, Joanna Kopecka, Andreas Bernkop-Schnürch, Chiara Riganti & Giuseppe De Rosa. (2022) Targeted Self-Emulsifying Drug Delivery Systems to Restore Docetaxel Sensitivity in Resistant Tumors. Pharmaceutics 14:2, pages 292.
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Jing Yang, Bo Song & Junzi Wu. (2022) Herbal Nanoformulations for Asthma Treatment. Current Pharmaceutical Design 28:1, pages 46-57.
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Walaa A. El-Dakroury, Moataz B. Zewail, Mahmoud Elsabahy, Marwa E. Shabana & Gihan F. Asaad. (2022) Famotidine-loaded solid self-nanoemulsifying drug delivery system demonstrates exceptional efficiency in amelioration of peptic ulcer. International Journal of Pharmaceutics 611, pages 121303.
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Shaimaa A. Khalid, Kholoud K. Arafa & Ibrahim M. El-Sherbiny. 2022. Systems of Nanovesicular Drug Delivery. Systems of Nanovesicular Drug Delivery 55 68 .
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Yaxin Li, Cody M. Orahoske, Raina Dano, Wenjing Zhang, Bibo Li & Bin Su. (2021) Pharmacokinetic study of an anti‐trypanosome agent with different formulations and administration routes in mice by HPLC–MS/MS. Biomedical Chromatography 35:10.
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Rakesh Kumar Dhritlahre, Ruchika, Yogendra Padwad & Ankit Saneja. (2021) Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to clinic. Trends in Food Science & Technology 115, pages 347-365.
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Rui Xue Zhang, Ken Dong, Zhigao Wang, Ruimin Miao, Weijia Lu & Xiao Yu Wu. (2021) Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine. Pharmaceutics 13:8, pages 1261.
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Xi Liang, Yabing Hua, Qian Liu, Zhiguo Li, Fanglin Yu, Jing Gao, Hui Zhang & Aiping Zheng. (2021) Solid Self-Emulsifying Drug Delivery System (Solid SEDDS) for Testosterone Undecanoate: In Vitro and In Vivo Evaluation. Current Drug Delivery 18:5, pages 620-633.
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Wenjing Li, Dongjie Huang, Yang Jiang, Yuqian Liu, Feng Li, Qingrong Huang & Dapeng Li. (2021) Preparation of pickering emulsion stabilised by Zein/Grape seed proanthocyanidins binary composite. International Journal of Food Science & Technology 56:8, pages 3763-3772.
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Merve Celik-Tekeli, Nevin Celebi, M. Yasin Tekeli & Yesim Aktas. (2021) Evaluation of the hypoglycemic effect of exendin-4’s new oral self-nanoemulsifying system in rats. European Journal of Pharmaceutical Sciences 158, pages 105644.
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Victoria Nahum & Abraham J. Domb. (2021) Recent Developments in Solid Lipid Microparticles for Food Ingredients Delivery. Foods 10:2, pages 400.
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Gurinder Singh. (2020) Resveratrol: nanocarrier-based delivery systems to enhance its therapeutic potential. Nanomedicine 15:28, pages 2801-2817.
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Dvora Izgelov, Elyad Davidson, Dinorah Barasch, Aviva Regev, Abraham J. Domb & Amnon Hoffman. (2020) Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers. European Journal of Pharmaceutics and Biopharmaceutics 154, pages 108-115.
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Naseem Akhtar, Salman A.A. Mohammed, Riaz A. Khan, Mohammad Yusuf, Varsha Singh, Hamdoon A. Mohammed, Mohsen S. Al-Omar, Ahmed A.H. Abdellatif, Mamuna Naz & Habeeb Khadri. (2020) Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and miscellaneous drugs of natural, and synthetic origins. Journal of Drug Delivery Science and Technology 58, pages 101808.
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Gabriel Silva Marques Borges, Micael de Oliveira Ferencs, Cristina de Mello Gomide Loures, Mostafa AL Abdel-Salam, Fernanda Cristina Gontijo Evangelista, Camila Campos Sales, Pedro Henrique Reis da Silva, Renata Barbosa de Oliveira, Ângelo Malachias, Maria Irene Yoshida, Elaine Maria de Souza-Fagundes, Adriano de Paula Sabino, Christian Fernandes & Lucas Antônio Miranda Ferreira. (2020) Novel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all- trans retinoic acid . Nanomedicine 15:15, pages 1471-1486.
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Hanan Fael & A. Levent Demirel. (2020) Tannic acid as a co-former in co-amorphous systems: Enhancing their physical stability, solubility and dissolution behavior. International Journal of Pharmaceutics 581, pages 119284.
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Dvora Izgelov, Eliyahu Shmoeli, Abraham J. Domb & Amnon Hoffman. (2020) The effect of medium chain and long chain triglycerides incorporated in self-nano emulsifying drug delivery systems on oral absorption of cannabinoids in rats. International Journal of Pharmaceutics 580, pages 119201.
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Ana Lia Mazzeti, Liliam Teixeira Oliveira, Karolina R. Gonçalves, Géssica C. Schaun, Vanessa Carla Furtado Mosqueira & Maria Terezinha Bahia. (2020) Benznidazole self-emulsifying delivery system: A novel alternative dosage form for Chagas disease treatment. European Journal of Pharmaceutical Sciences 145, pages 105234.
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Beibei Yan, Yingying Ma, Juan Guo & Yancai Wang. (2020) Self-microemulsifying delivery system for improving bioavailability of water insoluble drugs. Journal of Nanoparticle Research 22:1.
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Nabil Alhakamy, Usama Fahmy & Osama Ahmed. (2019) RETRACTED: Attenuation of Benign Prostatic Hyperplasia by Optimized Tadalafil Loaded Pumpkin Seed Oil-Based Self Nanoemulsion: In Vitro and In Vivo Evaluation. Pharmaceutics 11:12, pages 640.
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Xinnuo Xiong, Man Zhang, Quan Hou, Peixiao Tang, Zili Suo, Yujie Zhu & Hui Li. (2019) Solid dispersions of telaprevir with improved solubility prepared by co-milling: formulation, physicochemical characterization, and cytotoxicity evaluation. Materials Science and Engineering: C 105, pages 110012.
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Susan Hua. (2019) Physiological and Pharmaceutical Considerations for Rectal Drug Formulations. Frontiers in Pharmacology 10.
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Jia Zhao, Dan Luo, Zhong Zhang, Ni Fan, Yu Wang, Hong Nie & Jianhui Rong. (2019) Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice. Journal of Controlled Release 310, pages 188-197.
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Teófilo Vasconcelos, Francisca Araújo, Carlos Lopes, Ana Loureiro, José das Neves, Sara Marques & Bruno Sarmento. (2019) Multicomponent self nano emulsifying delivery systems of resveratrol with enhanced pharmacokinetics profile. European Journal of Pharmaceutical Sciences 137, pages 105011.
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Monika Sharma, Rajeev Garg & Satish Sardana. (2019) Enhanced Release Kinetics and Stability of Resveratrol Loaded Self Nanoemulsifying Delivery Systems Developed using Experimental Design. Current Nanomedicine 9:2, pages 128-145.
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Sarwar Beg, Mohammad Naushad Alam, Farhan Jalees Ahmad & Bhupinder Singh. (2019) Chylomicron mimicking nanocolloidal carriers of rosuvastatin calcium for lymphatic drug targeting and management of hyperlipidemia. Colloids and Surfaces B: Biointerfaces 177, pages 541-549.
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Georgios K. Eleftheriadis, Panagiota Mantelou, Christina Karavasili, Paschalina Chatzopoulou, Dimitrios Katsantonis, Maria Irakli, Aggeliki Mygdalia, Ioannis S. Vizirianakis & Dimitrios G. Fatouros. (2019) Development and Characterization of a Self-Nanoemulsifying Drug Delivery System Comprised of Rice Bran Oil for Poorly Soluble Drugs. AAPS PharmSciTech 20:2.
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Luiza Ianny de Lima, Karen Rapp Py-Daniel, Maria Adelaide Guimarães, Luís Alexandre Muehlmann, Ana Carolina Mafud, Yvonne Primerano Mascarenhas, Josué de Moraes, José Roberto de Souza de Almeida Leite, Cheng-Shi Jiang, Ricardo Bentes Azevedo & João Paulo Figueiró Longo. (2018) Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine. Nanomedicine 13:7, pages 689-702.
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Teófilo Vasconcelos, Sara Marques & Bruno Sarmento. (2018) Measuring the emulsification dynamics and stability of self-emulsifying drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics 123, pages 1-8.
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Saad M. Alshahrani, Abdullah S. Alshetaili, Ahmed Alalaiwe, Bader B. Alsulays, Md. Khalid Anwer, Ramadan Al-Shdefat, Faisal Imam & Faiyaz Shakeel. (2017) Anticancer Efficacy of Self-Nanoemulsifying Drug Delivery System of Sunitinib Malate. AAPS PharmSciTech 19:1, pages 123-133.
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Marko Krstić, Đorđe Medarević, Jelena Đuriš & Svetlana Ibrić. 2018. Lipid Nanocarriers for Drug Targeting. Lipid Nanocarriers for Drug Targeting 473 508 .
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Noa Fine-Shamir, Avital Beig, Moran Zur, David Lindley, Jonathan M. Miller & Arik Dahan. (2017) Toward Successful Cyclodextrin Based Solubility-Enabling Formulations for Oral Delivery of Lipophilic Drugs: Solubility–Permeability Trade-Off, Biorelevant Dissolution, and the Unstirred Water Layer. Molecular Pharmaceutics 14:6, pages 2138-2146.
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