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A further consideration on long-acting injectable versus oral antipsychotics in the treatment of schizophrenia: a narrative review and critical appraisal

Pages 253-264 | Received 09 Sep 2015, Accepted 29 Oct 2015, Published online: 04 Dec 2015

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Heidi C. Waters, Maelys Touya, Soon Nan Wee, Michelle Ng, Simran Thadani, Subina Surendran, Miguel Rentería, A. John Rush, Rashmi Patel, Joydeep Sarkar, Heather M. Fitzgerald & Xue Han. (2023) Psychiatric healthcare resource utilization following initiation of aripiprazole once-monthly: a retrospective real-world study. Current Medical Research and Opinion 39:2, pages 299-306.
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Georgios Schoretsanitis, Ekkehard Haen, Daria Piacentino, Andreas Conca, Katharina Endres, Christoph Hiemke, Gerhard Gründer & Michael Paulzen. (2022) Effects of body weight, smoking status, and sex on plasma concentrations of once-monthly paliperidone palmitate. Expert Review of Clinical Pharmacology 15:2, pages 243-249.
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Renato de Filippis, Pasquale De Fazio, Raffaele Gaetano, Luca Steardo, Clemente Cedro, Antonio Bruno, Rocco Antonio Zoccali & Maria Rosaria Anna Muscatello. (2021) Current and emerging long-acting antipsychotics for the treatment of schizophrenia. Expert Opinion on Drug Safety 20:7, pages 771-790.
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Miquel Bioque & Miquel Bernardo. (2018) The current data on the 3-month paliperidone palmitate formulation for the treatment of schizophrenia. Expert Opinion on Pharmacotherapy 19:14, pages 1623-1629.
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Tingjian Yan, Mallik Greene, Eunice Chang, Ann Hartry, Maëlys Touya & Michael S. Broder. (2018) All-cause hospitalization and associated costs in patients with schizophrenia or bipolar disorder initiating long-acting injectable antipsychotics. Current Medical Research and Opinion 34:1, pages 41-47.
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Cristiana Montemagni, Tiziana Frieri & Paola Rocca. (2016) Second-generation long-acting injectable antipsychotics in schizophrenia: patient functioning and quality of life. Neuropsychiatric Disease and Treatment 12, pages 917-929.
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Miquel Bernardo & Miquel Bioque. (2016) Three-month paliperidone palmitate - a new treatment option for schizophrenia. Expert Review of Clinical Pharmacology 9:7, pages 899-904.
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Articles from other publishers (23)

Gordon Shymko, Louise Dobson, Maria Cynthia Acacio, Terina Grace, Sarah Tadier & Flavie Waters. (2023) Weight changes in people with early psychosis treated with oral or long-acting injectable aripiprazole. Schizophrenia Research 251, pages 74-81.
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Cecilio Álamo. (2022) Risperidone ISM as a New Option in the Clinical Management of Schizophrenia: A Narrative Review. Advances in Therapy 39:11, pages 4875-4891.
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José Manuel Olivares & Andrea Fagiolini. (2022) Long-Term Real-World Effectiveness of Aripiprazole Once-Monthly. Treatment Persistence and Its Correlates in the Italian and Spanish Clinical Practice: A Pooled Analysis. Frontiers in Psychiatry 13.
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L.A. Burygina, S.A. Golubev, A.Yu. Berezantsev & E.A. Shumakova. (2022) Transfer from paliperidone of one-month action to paliperidone of three-month action in schizophrenia spectrum disorders: clinical aspects, pharmacological strategies, therapeutic prediction. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 122:1, pages 13.
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Vanteemar S. Sreeraj, Venkataram Shivakumar, Naren P. Rao & Ganesan Venkatasubramanian. 2022. Long-Acting Drug Delivery Systems. Long-Acting Drug Delivery Systems 203 222 .
Miquel Bernardo, Fernando Rico-Villademoros, Clemente García-Rizo, Rosa Rojo & Ricardo Gómez-Huelgas. (2021) Real-World Data on the Adverse Metabolic Effects of Second-Generation Antipsychotics and Their Potential Determinants in Adult Patients: A Systematic Review of Population-Based Studies. Advances in Therapy 38:5, pages 2491-2512.
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Rohan Mahabaleshwarkar, Dee Lin, Jesse Fishman, Todd Blair, Timothy Hetherington, Pooja Palmer, Charmi Patel, Carmela Benson, Kruti Joshi, Constance Krull & Oleg V. Tcheremissine. (2021) The Impact of Once-Monthly Paliperidone Palmitate on Healthcare Utilization Among Patients With Schizophrenia Treated in an Integrated Healthcare System: A Retrospective Mirror-Image Study. Advances in Therapy 38:4, pages 1958-1974.
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Keisuke Asano, Takefumi Suzuki, Masaru Mimura & Hiroyuki Uchida. (2021) Prescription patterns in patients with schizophrenia who discontinued long‐acting injectable antipsychotics: A chart‐review. Psychiatry and Clinical Neurosciences.
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Yusuke Iwata, Yu Aruga, Masataka Ohtsuki, Masahiro Inoue, Kazuyuki Yasuda, Takashi Hirata, Takuji Uemura & Takefumi Suzuki. (2021) Successful Introduction of Paliperidone Palmitate for Pregnant Woman With Schizophrenia. Journal of Clinical Psychopharmacology 41:2, pages 210-212.
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Hitoshi Sakurai, Norio Yasui-Furukori, Takefumi Suzuki, Hiroyuki Uchida, Hajime Baba, Koichiro Watanabe, Ken Inada, Yuka Sugawara Kikuchi, Toshiaki Kikuchi, Asuka Katsuki, Ikuko Kishida & Masaki Kato. (2021) Pharmacological Treatment of Schizophrenia: Japanese Expert Consensus. Pharmacopsychiatry 54:02, pages 60-67.
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J. Leijala, O. Kampman, J. Suvisaari & S. Eskelinen. (2021) Daily functioning and symptom factors contributing to attitudes toward antipsychotic treatment and treatment adherence in outpatients with schizophrenia spectrum disorders. BMC Psychiatry 21:1.
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José Manuel Olivares, Ana González-Pinto & Mario Páramo. (2021) Predictors of persistence in patients with schizophrenia treated with aripiprazole once-monthly long-acting injection in the Spanish clinical practice: a retrospective, observational study. European Psychiatry 64:1.
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Nakao Iwata, Ataru Inagaki, Hiromi Sano, Kazunari Niidome, Yoshitsugu Kojima & Sakiko Yamada. (2020) Treatment Persistence Between Long-Acting Injectable Versus Orally Administered Aripiprazole Among Patients with Schizophrenia in a Real-World Clinical Setting in Japan. Advances in Therapy 37:7, pages 3324-3336.
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Sally Mustafa, Joanna Bougie, Maia Miguelez, Guerline Clerzius, Emmanouil Rampakakis, Jean Proulx & Ashok Malla. (2019) Real-life assessment of aripiprazole monthly (Abilify Maintena) in schizophrenia: a Canadian naturalistic non-interventional prospective cohort study. BMC Psychiatry 19:1.
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Tingjian Yan, Mallik Greene, Eunice Chang, Michael S Broder, Maëlys Touya, Jennifer Munday & Ann Hartry. (2019) Hospitalization risk factors in antipsychotic-treated schizophrenia, bipolar I disorder or major depressive disorder. Journal of Comparative Effectiveness Research 8:4, pages 217-227.
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KyuYoung Lee. (2019) The Long-Acting Injectable Antipsychotics in Clinical Practice. Journal of Korean Neuropsychiatric Association 58:1, pages 29.
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Marit Tveito, Robert L. Smith, Espen Molden, Tore Haslemo, Helge Refsum, Cecilie Hartberg, Christoph U. Correll & Gudrun Høiseth. (2018) Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations. Journal of Clinical Psychopharmacology 38:6, pages 570-576.
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Tingjian Yan, Mallik Greene, Eunice Chang, Ann Hartry, Maëlys Touya & Michael S. Broder. (2018) Medication Adherence and Discontinuation of Aripiprazole Once-Monthly 400 mg (AOM 400) Versus Oral Antipsychotics in Patients with Schizophrenia or Bipolar I Disorder: A Real-World Study Using US Claims Data. Advances in Therapy 35:10, pages 1612-1625.
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Baoming He, Liang Yu, Suping Li, Fei Xu, Lili Yang, Shuai Ma & Yi Guo. (2018) Neuroprotective effect of lurasidone via antagonist activities on histamine in a rat model of cranial nerve involvement. Molecular Medicine Reports.
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Fuminari MisawaTakefumi SuzukiYasuo Fujii. (2017) Effect of Clozapine vs Other Second-Generation Antipsychotics on Hospitalization and Seclusion. Journal of Clinical Psychopharmacology 37:6, pages 664-668.
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Vanteemar S. Sreeraj, Venkataram Shivakumar, Naren P. Rao & Ganesan Venkatasubramanian. (2017) A critical appraisal of long acting injectable antipsychotics: Translating research to clinics. Asian Journal of Psychiatry 28, pages 57-64.
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Giovanni Ostuzzi, Irene Bighelli, Ryuhei So, Toshi A. Furukawa & Corrado Barbui. (2017) Does formulation matter? A systematic review and meta-analysis of oral versus long-acting antipsychotic studies. Schizophrenia Research 183, pages 10-21.
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Enrico Biagi, Enrico Capuzzi, Fabrizia Colmegna, Alessandra Mascarini, Giulia Brambilla, Alessandra Ornaghi, Jacopo Santambrogio & Massimo Clerici. (2017) Long-Acting Injectable Antipsychotics in Schizophrenia: Literature Review and Practical Perspective, with a Focus on Aripiprazole Once-Monthly. Advances in Therapy 34:5, pages 1036-1048.
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