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Review

An update on multipurpose prevention technologies for the prevention of HIV transmission and pregnancy

Pages 533-545 | Received 01 Oct 2015, Accepted 16 Dec 2015, Published online: 22 Jan 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Thesla Palanee-Phillips, Marc M. Baum, John A. Moss, Meredith R. Clark, Jeremy Nuttall & Joseph W. Romano. (2022) Drug-releasing vaginal rings for HIV/STI and pregnancy prevention: a review of recent advances and clinical applications. Expert Opinion on Drug Delivery 19:1, pages 47-58.
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Trinette Fernandes, Krishna Baxi, Sujata Sawarkar, Bruno Sarmento & José das Neves. (2020) Vaginal multipurpose prevention technologies: promising approaches for enhancing women’s sexual and reproductive health. Expert Opinion on Drug Delivery 17:3, pages 379-393.
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Articles from other publishers (21)

Isabella C. Young, Aryani Pallerla, Mackenzie L. Cottrell, Panita Maturavongsadit, Alka Prasher, Roopali Shrivastava, Gabriela De la Cruz, Stephanie A. Montgomery, Amanda Schauer, Craig Sykes, Angela D.M. Kashuba & S. Rahima Benhabbour. (2023) Long-acting injectable multipurpose prevention technology for prevention of HIV and unplanned pregnancy. Journal of Controlled Release 363, pages 606-620.
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Clément M. Haeck, Peter Boyd, Nastasia Dimant, Aurélie Barrail-Tran, Hélène Gouget, Roger Le Grand, Delphine Desjardins & R. Karl Malcolm. (2023) Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention. Journal of Drug Delivery Science and Technology 85, pages 104590.
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Nelly R. Mugo, Victor Mudhune, Renee Heffron, Katherine K. Thomas, Eleanor McLellan-Lemal, Betty Njoroge, Sue Peacock, Siobhán M. O’Connor, Beatrice Nyagol, Eunice Ouma, Renee Ridzon, Jeffrey Wiener, Nina Isoherranen, David W. Erikson, Louise A. Ouattara, Nazita Yousefieh, Terry A. Jacot, Richard E. Haaland, Susan A. Morrison, Harald S. Haugen, Andrea R. Thurman, Shannon A. Allen, Jared M. Baeten, Taraz Samandari & Gustavo F. Doncel. (2023) Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya. Frontiers in Reproductive Health 5.
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Jutamas Shaughnessy, Aleyo Chabeda, Y. Tran, Bo Zheng, Nancy Nowak, Carolynn Steffens, Rosane B. DeOliveira, Sunita Gulati, Lisa A. Lewis, James Maclean, John A. Moss, Keith L. Wycoff & Sanjay Ram. (2022) An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae. Frontiers in Immunology 13.
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Linying Li, Gregory J. Gatto, Rhonda M. Brand, Sai Archana Krovi, Mackenzie L. Cottrell, Chasity Norton, Ariane van der Straten & Leah M. Johnson. (2021) Long-acting biodegradable implant for sustained delivery of antiretrovirals (ARVs) and hormones. Journal of Controlled Release 340, pages 188-199.
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Isabella C. Young & Soumya Rahima Benhabbour. (2021) Multipurpose Prevention Technologies: Oral, Parenteral, and Vaginal Dosage Forms for Prevention of HIV/STIs and Unplanned Pregnancy. Polymers 13:15, pages 2450.
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Peter Vickerman, Matthew Quaife, Maggie Kilbourne-Brook, Mercy Mvundura, Robyn Eakle & Fern Terris-Prestholt. (2020) HIV prevention is not all about HIV – using a discrete choice experiment among women to model how the uptake and effectiveness of HIV prevention products may also rely on pregnancy and STI protection. BMC Infectious Diseases 20:1.
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Mary Weitzel, Barbara Best North & Donald Waller. (2020) Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development†. Biology of Reproduction 103:2, pages 299-309.
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Tietz & Klein. (2019) In Vitro Methods for Evaluating Drug Release of Vaginal Ring Formulations—A Critical Review. Pharmaceutics 11:10, pages 538.
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Jenna S. HynesAnandi N. ShethEva LathropJessica M. SalesLisa B. Haddad. (2019) Preferred Product Attributes of Potential Multipurpose Prevention Technologies for Unintended Pregnancy and Sexually Transmitted Infections or HIV Among U.S. Women. Journal of Women's Health 28:5, pages 665-672.
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Burcin Yavuz, Jessica L. Morgan, Laura Showalter, Katti R. Horng, Satya Dandekar, Carolina Herrera, Patricia LiWang & David L. Kaplan. (2018) Pharmaceutical Approaches to HIV Treatment and Prevention. Advanced Therapeutics 1:6, pages 1800054.
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Kathleen L. Vincent, John A. Moss, Mark A. Marzinke, Craig W. Hendrix, Peter A. Anton, Richard B. Pyles, Kate M. Guthrie, Lauren Dawson, Trevelyn J. Olive, Irina Butkyavichene, Scott A. Churchman, John M. Cortez, Rob Fanter, Manjula Gunawardana, Christine S. Miller, Flora Yang, Rochelle K. Rosen, Sara E. Vargas & Marc M. Baum. (2018) Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial. PLOS Medicine 15:9, pages e1002655.
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Cristina Tintori, Giulia Iovenitti, Elisa Rita Ceresola, Roberto Ferrarese, Claudio Zamperini, Annalaura Brai, Giulio Poli, Elena Dreassi, Valeria Cagno, David Lembo, Filippo Canducci & Maurizio Botta. (2018) Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides. PLOS ONE 13:6, pages e0198478.
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Jenna S. Hynes, Jessica M. Sales, Anandi N. Sheth, Eva Lathrop & Lisa B. Haddad. (2018) Interest in multipurpose prevention technologies to prevent HIV/STIs and unintended pregnancy among young women in the United States. Contraception 97:3, pages 277-284.
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Matthew Quaife, Fern Terris‐Prestholt, Robyn Eakle, Maria A. Cabrera Escobar, Maggie Kilbourne‐Brook, Mercy Mvundura, Gesine Meyer‐Rath, Sinead Delany‐Moretlwe & Peter Vickerman. (2018) The cost‐effectiveness of multi‐purpose HIV and pregnancy prevention technologies in South Africa . Journal of the International AIDS Society 21:3.
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Matthew QuaifeRobyn EakleMaria A. Cabrera EscobarPeter VickermanMaggie Kilbourne-BrookMercy MvunduraSinead Delany-MoretlweFern Terris-Prestholt. (2017) Divergent Preferences for HIV Prevention: A Discrete Choice Experiment for Multipurpose HIV Prevention Products in South Africa. Medical Decision Making 38:1, pages 120-133.
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Zheng Shen, Marta Rodriguez-Garcia, Mickey V. Patel, Jack Bodwell, Angela D. M. Kashuba & Charles R. Wira. (2017) Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells. Scientific Reports 7:1.
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James M. Smith, John A. Moss, Priya Srinivasan, Irina Butkyavichene, Manjula Gunawardana, Rob Fanter, Christine S. Miller, Debbie Sanchez, Flora Yang, Shanon Ellis, Jining Zhang, Mark A. Marzinke, Craig W. Hendrix, Amita Kapoor & Marc M. Baum. (2017) Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model. PLOS ONE 12:10, pages e0185946.
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Richard E. Haaland, Angela Holder, Tammy Evans-Strickfaden, Beatrice Nyagol, Mumbi Makanga, Boaz Oyaro, Felix Humwa, Tiffany Williams, Eleanor McLellan-Lemal, Mitesh Desai & Michael J. Huey. (2017) Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use. Contraception 95:6, pages 602-604.
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Matthew Quaife, Fern Terris-Prestholt & Peter Vickerman. (2017) The promise of multipurpose pregnancy, STI, and HIV prevention. The Lancet Infectious Diseases 17:1, pages 21-22.
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Chelsea B. Polis, Sharon J. Phillips, Sharon L. Hillier & Sharon L. Achilles. (2016) Levonorgestrel in contraceptives and multipurpose prevention technologies. AIDS 30:17, pages 2571-2576.
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