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Technology Evaluation

Review on Medusa®:a polymer-based sustained release technology for protein and peptide drugs

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Pages 441-451 | Published online: 07 Aug 2007

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Andrea Gonella, Sylvestre Grizot, Fang Liu, Adolfo López Noriega & Joël Richard. (2022) Long-acting injectable formulation technologies: challenges and opportunities for the delivery of fragile molecules. Expert Opinion on Drug Delivery 19:8, pages 927-944.
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Vladimir N Uversky. (2013) The alphabet of intrinsic disorder. Intrinsically Disordered Proteins 1:1.
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José Vicente González-Aramundiz, María Victoria Lozano, Ana Sousa-Herves, Eduardo Fernandez-Megia & Noemi Csaba. (2012) Polypeptides and polyaminoacids in drug delivery. Expert Opinion on Drug Delivery 9:2, pages 183-201.
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Marcus Wanselius, Sean Searle, Agnes Rodler, Maria Tenje, Susanna Abrahmsén-Alami & Per Hansson. (2022) Microfluidics platform for studies of peptide – polyelectrolyte interaction. International Journal of Pharmaceutics 621, pages 121785.
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May Wenche Jøraholmen, Selenia Ternullo, Ann Mari Holsæter, Gøril Eide Flaten & Nataša Škalko‐Basnet. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 231 261 .
Xiangxue Lyu, Qiufen Zhang, Dehai Liang & Yanbin Huang. (2019) Interaction between human serum albumin and cholesterol-grafted polyglutamate as the potential carriers of protein drugs. Acta Pharmaceutica Sinica B 9:1, pages 186-193.
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Christoph Englert, Johannes C. Brendel, Tobias C. Majdanski, Turgay Yildirim, Stephanie Schubert, Michael Gottschaldt, Norbert Windhab & Ulrich S. Schubert. (2018) Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications. Progress in Polymer Science 87, pages 107-164.
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Antoine Henninot, James C. Collins & John M. Nuss. (2017) The Current State of Peptide Drug Discovery: Back to the Future?. Journal of Medicinal Chemistry 61:4, pages 1382-1414.
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Ludger M Ickenstein & Patrick Garidel. (2018) Hydrogel formulations for biologicals: current spotlight from a commercial perspective. Therapeutic Delivery 9:3, pages 221-230.
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Uli Binder & Arne Skerra. (2017) PASylation®: A versatile technology to extend drug delivery. Current Opinion in Colloid & Interface Science 31, pages 10-17.
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Jianfeng Zhang, Ben Muirhead, Megan Dodd, Lina Liu, Fei Xu, Nicole Mangiacotte, Todd Hoare & Heather Sheardown. (2016) An Injectable Hydrogel Prepared Using a PEG/Vitamin E Copolymer Facilitating Aqueous-Driven Gelation. Biomacromolecules 17:11, pages 3648-3658.
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Laurent Leclercq, Xiaoyun Jin & Hervé Cottet. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry 1 25 .
Shizhu Chen, Keni Yang, Ruslan G. Tuguntaev, Anbu Mozhi, Jinchao Zhang, Paul C. Wang & Xing-Jie Liang. (2016) Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance. Nanomedicine: Nanotechnology, Biology and Medicine 12:2, pages 269-286.
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Andrew L Lewis & Joël Richard. (2015) Challenges in the delivery of peptide drugs: an industry perspective. Therapeutic Delivery 6:2, pages 149-163.
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Alexandra Beumer Sassi, Radhika Nagarkar & Paul Hamblin. 2015. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies 199 217 .
Kenneth Lundstrom. 2015. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies 15 39 .
Won Il Choi, Nazila Kamaly, Lorena Riol-Blanco, In-Hyun Lee, Jun Wu, Archana Swami, Cristian Vilos, Basit Yameen, Mikyung Yu, Jinjun Shi, Ira Tabas, Ulrich H. von Andrian, Sangyong Jon & Omid C. Farokhzad. (2014) A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins. Nano Letters 14:11, pages 6449-6455.
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Samir Mitragotri, Paul A. Burke & Robert Langer. (2014) Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nature Reviews Drug Discovery 13:9, pages 655-672.
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Nicolas Duhem, Fabienne Danhier & Véronique Préat. (2014) Vitamin E-based nanomedicines for anti-cancer drug delivery. Journal of Controlled Release 182, pages 33-44.
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Christophe BourdeauxChristophe Lurquin, Isabelle Jacquemart, Bernard Lethé, Francis Brasseur, Nicolas van Baren, Jean-François BaurainJulian Dyson, Jacques Van Snick, Catherine Uyttenhove & Thierry Boon. (2014) Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy. Proceedings of the National Academy of Sciences 111:9, pages 3502-3507.
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Xiaoyun Jin, Laurent Leclercq & Hervé Cottet. (2013) Determination of polymer log D distributions by micellar and microemulsion electrokinetic chromatography. Journal of Chromatography A 1318, pages 244-250.
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Amal Ibrahim, Rémi Meyrueix, Gauthier Pouliquen, You Ping Chan & Hervé Cottet. (2013) Size and charge characterization of polymeric drug delivery systems by Taylor dispersion analysis and capillary electrophoresis. Analytical and Bioanalytical Chemistry 405:16, pages 5369-5379.
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Mariano Licciardi, Giovanna Pitarresi, Gennara Cavallaro & Gaetano Giammona. (2013) Nanoaggregates Based on New Poly-Hydroxyethyl-Aspartamide Copolymers for Oral Insulin Absorption. Molecular Pharmaceutics 10:5, pages 1644-1654.
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Sibyll Pollok, Torsten Ginter, Katharina Günzel, Jana Pieper, Andreas Henke, Roland H. Stauber, Werner Reichardt & Oliver H. Krämer. (2013) Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses. Cellular Signalling 25:4, pages 989-998.
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Abeer H. A. Mohamed-AhmedKarolina A. LesKarin SeifertSimon L. CroftStephen Brocchini. (2013) Noncovalent Complexation of Amphotericin-B with Poly(α-glutamic acid). Molecular Pharmaceutics 10:3, pages 940-950.
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Vanessa M.S. Duncan & Deborah A. O'Neil. (2013) Commercialization of antifungal peptides. Fungal Biology Reviews 26:4, pages 156-165.
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Qian Liu & Weiliang Xia. 2013. New Advances on Disease Biomarkers and Molecular Targets in Biomedicine. New Advances on Disease Biomarkers and Molecular Targets in Biomedicine 231 242 .
Shobhan Sabnis & Michael J. Rathbone. 2013. Long Acting Animal Health Drug Products. Long Acting Animal Health Drug Products 1 14 .
Jing Sun, Juliette Ruchmann, A. Pallier, L. Jullien, M. Desmadril & Christophe Tribet. (2012) Unfolding of Cytochrome c upon Interaction with Azobenzene-Modified Copolymers . Biomacromolecules 13:11, pages 3736-3746.
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Takashi Nakai, Tai Hirakura, Yuji Sakurai, Tsuyoshi Shimoboji, Masaki Ishigai & Kazunari Akiyoshi. (2012) Injectable Hydrogel for Sustained Protein Release by Salt‐Induced Association of Hyaluronic Acid Nanogel. Macromolecular Bioscience 12:4, pages 475-483.
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Carla A. Borgoño & Bernard Zinman. (2012) Insulins: Past, Present, and Future. Endocrinology and Metabolism Clinics of North America 41:1, pages 1-24.
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William Kemp & Stuart K. Roberts. 2012. Chronic Hepatitis C Virus. Chronic Hepatitis C Virus 115 130 .
Cynthia L. Stevenson, Christopher A. Rhodes & Steven J. Prestrelski. 2012. Long Acting Injections and Implants. Long Acting Injections and Implants 409 427 .
Lin Bi, Lei Yang, Ganesan Narsimhan, Arun K. Bhunia & Yuan Yao. (2011) Designing carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide. Journal of Controlled Release 150:2, pages 150-156.
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Jeremy D. Heidel & Mark E. Davis. (2010) Clinical Developments in Nanotechnology for Cancer Therapy. Pharmaceutical Research 28:2, pages 187-199.
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Andrew L Lewis & Lisbeth Illum. (2010) Formulation strategies for sustained release of proteins. Therapeutic Delivery 1:3, pages 457-479.
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Dipak S. Pisal, Matthew P. Kosloski & Sathy V. Balu-Iyer. (2010) Delivery of Therapeutic Proteins. Journal of Pharmaceutical Sciences 99:6, pages 2557-2575.
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Tai Hirakura, Kenji Yasugi, Takayuki Nemoto, Mika Sato, Tsuyoshi Shimoboji, Yoshinori Aso, Nobuyuki Morimoto & Kazunari Akiyoshi. (2010) Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: New system for sustained delivery of protein with a chaperone-like function. Journal of Controlled Release 142:3, pages 483-489.
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Kenneth Lundstrom. 2009. Delivery Technologies for Biopharmaceuticals. Delivery Technologies for Biopharmaceuticals 193 205 .
Sabine Ponader, Heike Brandt, Eleftherios Vairaktaris, Cornelius von Wilmowsky, Wolfgang Göthel, Rainer Lutz, Karl A. Schlegel, Friedrich W. Neukam, Peter Greil, Frank A. Müller & Emeka Nkenke. (2009) In vivo Performance of Osteoactivated Cellulose‐Based Scaffolds in Bony Critical‐Size Defects. Advanced Engineering Materials 11:8.
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Mohamed A. Shaker & Husam M. Younes. (2009) Interleukin-2: Evaluation of Routes of Administration and Current Delivery Systems in Cancer Therapy. Journal of Pharmaceutical Sciences 98:7, pages 2268-2298.
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Sumalee Thitinan & Jason T. McConville. (2009) Interferon alpha delivery systems for the treatment of hepatitis C. International Journal of Pharmaceutics 369:1-2, pages 121-135.
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