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The use of in vivo zebrafish assays in drug toxicity screening

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Pages 393-401 | Published online: 15 Apr 2009

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David Hernández-Silva, Francisca Alcaraz-Pérez, Horacio Pérez-Sánchez & Maria Luisa Cayuela. (2023) Virtual screening and zebrafish models in tandem, for drug discovery and development. Expert Opinion on Drug Discovery 18:8, pages 903-915.
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Naceur Hamdi, Lamjed Mansour, Jameel Al-Tamimi, Sadeq M. Al-Hazmy, Nevin Gurbuz & Ismail Özdemir. (2022) Synthesis and Investigation of Antimicrobial, Antioxidant, Enzymatic Inhibitory, and Antiproliferative Activities of Ruthenium (II) Complexes Bearing Benzimidazole-Based N-Heterocyclic Carbene (NHC) Ligands. Polycyclic Aromatic Compounds 0:0, pages 1-25.
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Sarah D. Burnett, Alexander D Blanchette, Weihsueh A. Chiu & Ivan Rusyn. (2021) Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: strengths and weaknesses for hazard identification and risk characterization. Expert Opinion on Drug Metabolism & Toxicology 17:8, pages 887-902.
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Helinor J. Johnston, Rachel Verdon, Suzanne Gillies, David M. Brown, Teresa F. Fernandes, Theodore B. Henry, Adriano G. Rossi, Lang Tran, Carl Tucker, Charles R. Tyler & Vicki Stone. (2018) Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials. Critical Reviews in Toxicology 48:3, pages 252-271.
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Adrian Hill, Natalie Mesens, Margino Steemans, Jinghai James Xu & Michael D. Aleo. (2012) Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development. Drug Metabolism Reviews 44:1, pages 127-140.
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Hendrian Sukardi, Hui Ting Chng, Eric Chun Yong Chan, Zhiyuan Gong & Siew Hong Lam. (2011) Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert Opinion on Drug Metabolism & Toxicology 7:5, pages 579-589.
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W. Alderton, S. Berghmans, P. Butler, H. Chassaing, A. Fleming, Z. Golder, F. Richards & I. Gardner. (2010) Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae. Xenobiotica 40:8, pages 547-557.
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