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Expert Opinion on Drug Metabolism & Toxicology Volume 6, 2010 - Issue 1
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The cladribine conundrum: deciphering the drug's mechanism of action

Patricia Hentosh Old Dominion University, School of Medical Laboratory and Radiation Sciences College of Health Sciences, Room HS2118, Norfolk, VA 23529, USA +1 757 683 3611; +1 757 683 5028; [email protected]
, ScD (Professor) &
Dennis M Peffley Kronos Science, Phoenix, AZ 85016, USA
, PhD (Vice President and Scientific Director)
Pages 75-81 | Published online: 07 Dec 2009

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PaulaX. Fernández-Calotti, Dolors Colomer & Marçal Pastor-Anglada. (2011) Translocation of Nucleoside Analogs Across the Plasma Membrane in Hematologic Malignancies. Nucleosides, Nucleotides & Nucleic Acids 30:12, pages 1324-1340.
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Articles from other publishers (13)

Elina Järvinen, Fumi Suomi, James B Stewart, Dimitri Guala, Miko Valori, Lilja Jansson, Janne Nieminen, Thomas G McWilliams & Pentti J Tienari. (2023) Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine. Clinical and Experimental Immunology.
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Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 69 105 .
Jesús Quezada‐Vidal, Rocío Ortíz‐Muñiz, Elsa Cervantes‐Ríos, Virginia Cruz‐Vallejo & Pedro Morales‐Ramírez. (2020) In vivo kinetics of the genotoxic and cytotoxic activities of cladribine and clofarabine. Environmental and Molecular Mutagenesis 61:9, pages 922-927.
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Virginia Cruz‐Vallejo, Rocío Ortíz‐Muñiz, Teresita Vallarino‐Kelly, Elsa Cervantes‐Ríos & Pedro Morales‐Ramírez. (2019) In vivo Characterization of the Radiosensitizing Effect of a Very Low Dose of BrdU in Murine Cells Exposed to Low‐Dose Radiation . Environmental and Molecular Mutagenesis.
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Emma D. Deeks. (2018) Cladribine Tablets: A Review in Relapsing MS. CNS Drugs 32:8, pages 785-796.
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Gavin Giovannoni. (2017) Cladribine to Treat Relapsing Forms of Multiple Sclerosis. Neurotherapeutics 14:4, pages 874-887.
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Tabetha Sundin, Dennis M. Peffley, David Gauthier & Patricia Hentosh. (2012) The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. Biochimie 94:12, pages 2639-2648.
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Kyle Jensen, L’Aurelle A. Johnson, Pamala A. Jacobson, Sonja Kachler, Mark N. Kirstein, Jatinder Lamba & Karl-Norbert Klotz. (2012) Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology 385:5, pages 519-525.
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Tokumi Maruyama, Norikazu Sakakibara & Ai Kakoh. (2012) First Synthesis of [6-15N]-Cladribine Using Ribonucleoside as a Starting Material. HETEROCYCLES 85:1, pages 171.
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Bruno Laugel, Frédéric Borlat, Laurent Galibert, Alain Vicari, Robert Weissert, Yolande Chvatchko & Denis Bruniquel. (2011) Cladribine inhibits cytokine secretion by T cells independently of deoxycytidine kinase activity. Journal of Neuroimmunology 240-241, pages 52-57.
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Gavin Giovannoni & Stuart D. Cook. 2011. Multiple Sclerosis Therapeutics. Multiple Sclerosis Therapeutics 358 369 .
. 2011. Multiple Sclerosis Therapeutics. Multiple Sclerosis Therapeutics 300 582 .
Ekaitz Errasti-Murugarren & Marçal Pastor-Anglada. (2010) Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics 11:6, pages 809-841.
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