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Expert Opinion on Drug Metabolism & Toxicology Volume 6, 2010 - Issue 2
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Mitigating permeability-mediated risks in drug discovery

Jianling Wang Novartis Institutes for Biomedical Research, Metabolism and Pharmacokinetics, 250 Massachusetts Avenue, Cambridge, MA 02139, USA +1 617 871 7140; +1 617 871 7061; [email protected]
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Suzanne Skolnik Novartis Institutes for Biomedical Research, Metabolism and Pharmacokinetics, 250 Massachusetts Avenue, Cambridge, MA 02139, USA +1 617 871 7140; +1 617 871 7061; [email protected]
Pages 171-187 | Published online: 12 Jan 2010

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Read on this site (2)

Donna A. Volpe. (2020) Advances in cell-based permeability assays to screen drugs for intestinal absorption. Expert Opinion on Drug Discovery 15:5, pages 539-549.
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Jianling Wang & Alan Collis. (2011) Maximizing the outcome of early ADMET models: strategies to win the drug-hunting battles?. Expert Opinion on Drug Metabolism & Toxicology 7:4, pages 381-386.
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Articles from other publishers (14)

Wenzhan Yang, Maya Lipert & Rebecca Nofsinger. (2023) Current screening, design, and delivery approaches to address low permeability of chemically synthesized modalities in drug discovery and early clinical development. Drug Discovery Today 28:9, pages 103685.
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Malak Yahia Qattan, Mohammad Idreesh Khan, Shudayyed Hasham Alharbi, Amit Kumar Verma, Fatimah A. Al-Saeed, Alduwish Manal Abduallah & Azza A. Al Areefy. (2022) Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways. Molecules 27:24, pages 8864.
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Hayley Atkinson, Kieron Mahon-Smith & Robert Elsby. 2022. The ADME Encyclopedia. The ADME Encyclopedia 401 412 .
Philip Butler & Robert J. Riley. 2022. The ADME Encyclopedia. The ADME Encyclopedia 537 547 .
Xavier J.H. Pepin, Jennifer Dressman, Neil Parrott, Poonam Delvadia, Amitava Mitra, Xinyuan Zhang, Andrew Babiskin, Vidula Kolhatkar, Paul Seo, Lynne S. Taylor, Erik Sjögren, James M. Butler, Edmund Kostewicz, Christer Tannergren, Mirko Koziolek, Filippos Kesisoglou, André Dallmann, Yang Zhao & Sandra Suarez-Sharp. (2021) In Vitro Biopredictive Methods: A Workshop Summary Report. Journal of Pharmaceutical Sciences 110:2, pages 567-583.
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Hayley Atkinson, Kieron Mahon-Smith & Robert Elsby. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 13 .
Philip Butler & Robert J. Riley. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 11 .
Iryna Kolosenko, Sofia Avnet, Nicola Baldini, Jenny Viklund & Angelo De Milito. (2017) Therapeutic implications of tumor interstitial acidification. Seminars in Cancer Biology 43, pages 119-133.
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Kasi Pandima Devi, Dicson Sheeja Malar, Seyed Fazel Nabavi, Antoni Sureda, Jianbo Xiao, Seyed Mohammad Nabavi & Maria Daglia. (2015) Kaempferol and inflammation: From chemistry to medicine. Pharmacological Research 99, pages 1-10.
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Andreas Reichel. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain 339 374 .
Markus Kohlmann. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 779 797 .
Jianling Wang & Leslie Bell. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 129 159 .
Donna A Volpe. (2011) Drug-permeability and transporter assays in Caco-2 and MDCK cell lines. Future Medicinal Chemistry 3:16, pages 2063-2077.
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Douglas B. Kell, Paul D. Dobson & Stephen G. Oliver. (2011) Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. Drug Discovery Today 16:15-16, pages 704-714.
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