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Drug Evaluation

Pharmacokinetics, toxicology and safety of lamotrigine in epilepsy

Pages 1009-1018 | Published online: 24 Nov 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Alberto Verrotti, Giulia Iapadre, Giulia Di Donato, Ludovica Di Francesco, Luca Zagaroli, Sara Matricardi, Vincenzo Belcastro & Maria Laura Iezzi. (2019) Pharmacokinetic considerations for anti-epileptic drugs in children. Expert Opinion on Drug Metabolism & Toxicology 15:3, pages 199-211.
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Alessandra Morano, Luigi Iannone, Caterina Palleria, Martina Fanella, Anna Teresa Giallonardo, Giovambattista De Sarro, Emilio Russo & Carlo Di Bonaventura. (2019) Pharmacology of new and developing intravenous therapies for the management of seizures and epilepsy. Expert Opinion on Pharmacotherapy 20:1, pages 25-39.
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Bader Alyahya, Marjorie Friesen, Bénédicte Nauche & Martin Laliberté. (2018) Acute lamotrigine overdose: a systematic review of published adult and pediatric cases. Clinical Toxicology 56:2, pages 81-89.
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P. W. Moore, J. W. Donovan, K. K. Burkhart & D. Haggerty. (2013) A case series of patients with lamotrigine toxicity at one center from 2003 to 2012. Clinical Toxicology 51:7, pages 545-549.
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Articles from other publishers (55)

Isidro Badillo-Ramírez, Selina A. J. Janssen, Gohar Soufi, Roman Slipets, Kinga Zór & Anja Boisen. (2023) Label-free SERS assay combined with multivariate spectral data analysis for lamotrigine quantification in human serum. Microchimica Acta 190:12.
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Lucia Bernasconi, Azzurra Schicchi, Valeria M. Petrolini, Alberto Malovini, Davide Lonati, Federico Fassio, Eleonora Buscaglia, Giulia Scaravaggi, Francesca Crema & Carlo A. Locatelli. (2023) Clinical characteristics of acute lacosamide poisoning: Pavia Poison Control Centre experience. British Journal of Clinical Pharmacology.
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Nada Božina, Ivana Šušak Sporiš, Iva Klarica Domjanović, Lana Ganoci, Livija Šimičević, Mila Lovrić, Zrinka Čolak Romić, Željka Petelin Gadže & Vladimir Trkulja. (2023) Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. European Journal of Clinical Pharmacology 79:8, pages 1117-1129.
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Bárbara Costa & Nuno Vale. (2023) Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution. International Journal of Molecular Sciences 24:7, pages 6050.
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Kamil Kośmider, Maciej Kamieniak, Stanisław J. Czuczwar & Barbara Miziak. (2023) Second Generation of Antiepileptic Drugs and Oxidative Stress. International Journal of Molecular Sciences 24:4, pages 3873.
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Yiqian Chen, Jingzhen Chen, Xiaorong Zhuang, Xingyu Chen, Jianqi Zeng, Ru Wang & Jiayin Miao. (2022) Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. Medicine 101:26, pages e29780.
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Kelly E. Wood, Kendra L. Palmer & Matthew D. Krasowski. (2021) Data on the relationship between lamotrigine and levetiracetam serum/plasma levels and toxicity: Experience at an academic medical center. Data in Brief 39, pages 107555.
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Alicia MastroccoAlex L. BlutingerSamantha A. BaineJennifer E. Prittie. (2021) Use of injectable lipid emulsion and sodium bicarbonate to treat severe cardiovascular collapse secondary to lamotrigine toxicosis in a dog. Journal of the American Veterinary Medical Association 258:5, pages 510-514.
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Frank M.C. Besag, Michael J. Vasey, Aditya N. Sharma & Ivan C.H. Lam. (2021) Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review. Therapeutic Advances in Psychopharmacology 11, pages 204512532110458.
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Kelly E. Wood, Kendra L. Palmer & Matthew D. Krasowski. (2021) Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center. Toxicology Reports 8, pages 1592-1598.
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Karina Sommerfeld-Klatta, Barbara Zielińska-Psuja, Marta Karaźniewcz-Łada & Franciszek K. Główka. (2020) New Methods Used in Pharmacokinetics and Therapeutic Monitoring of the First and Newer Generations of Antiepileptic Drugs (AEDs). Molecules 25:21, pages 5083.
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Janthima Methaneethorn & Nattawut Leelakanok. (2020) Sources of lamotrigine pharmacokinetic variability: A systematic review of population pharmacokinetic analyses. Seizure 82, pages 133-147.
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Patsy Ramey, Melissa Osborn, Howard Kirshner & Bassel Abou-Khalil. (2020) Misdiagnosis of lamotrigine toxicity as posterior circulation transient ischemic attack or stroke. Epilepsy & Behavior 111, pages 107284.
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Cinthya Eloisa Chávez-Castillo, Susanna Edith Medellín-Garibay, Rosa del Carmen Milán-Segovia, Ildefonso Rodríguez-Leyva & Silvia Romano-Moreno. (2020) Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy. Journal of Pharmaceutical Sciences 109:9, pages 2902-2908.
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Amitava Dasgupta & Matthew D. Krasowski. 2020. Therapeutic Drug Monitoring Data. Therapeutic Drug Monitoring Data 99 158 .
Abhinav Agrawal, Joshua N. Nogar & Seth Koenig. (2019) Management of lamotrigine overdose using hemodialysis. The American Journal of Emergency Medicine 37:8, pages 1603.e1-1603.e2.
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Puja K. Gangurde, Navya Ajitkumar B.Lalit Kumar. (2018) Lamotrigine Lipid Nanoparticles for Effective Treatment of Epilepsy: a Focus on Brain Targeting via Nasal Route. Journal of Pharmaceutical Innovation 14:2, pages 91-111.
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Shansen Xu, Limin Liu, Yanan Chen, Mei Liu, Tong Lu, Huanxin Wang, Shihao Liu, Mingming Zhao & Limei Zhao. (2018) Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling. European Journal of Clinical Pharmacology 74:5, pages 583-591.
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T. Yu. Noskova, D. A. Abaimov, A. K. Sariev, P. A. Fedin, A. V. Krasnikov, V. V. Shvedkov & R. D. Sejfulla. (2018) The clinical significance of the lamotrigine pharmacokinetic variability. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 118:1, pages 23.
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EM Tunbridge, MJ Attenburrow, A Gardiner, JM Rendell, C Hinds, GM Goodwin, PJ Harrison & JR Geddes. (2017) Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial. Bipolar Disorders 19:6, pages 477-486.
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Gali Pariente, Tom Leibson, Talya Shulman, Thomasin Adams-Webber, Eran Barzilay & Irena Nulman. (2017) Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. CNS Drugs 31:6, pages 439-450.
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Akiyoshi Kikkawa, Yoshihisa Kitamura, Tetsuya Aiba, Koichi Hiraki & Toshiaki Sendo. (2017) Correlation between the Efficacy of Lamotrigine and the Serum Lamotrigine Level during the Remission Phase of Acute Bipolar II Depression: A Naturalistic and Unblinded Prospective Pilot Study. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:4, pages 413-418.
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Akintunde Alabi, Adam Todd, Andrew Husband & Joe Reilly. (2016) Safety profile of lamotrigine in overdose. Therapeutic Advances in Psychopharmacology 6:6, pages 369-381.
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Sandra Gastrup, Tore Bjerregaard Stage, Palle Bach Nielsen Fruekilde & Per Damkier. (2016) Paracetamol decreases steady-state exposure to lamotrigine by induction of glucuronidation in healthy subjects. British Journal of Clinical Pharmacology 81:4, pages 735-741.
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