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Expert Opinion on Drug Metabolism & Toxicology Volume 2, 2006 - Issue 6
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Review

Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions

Michael J Liguori Abbott Laboratories, Department of Cellular, Molecular, and Exploratory Toxicology, 100 Abbott Park Road, Abbott Park, IL 60064, USA
&
Jeffrey F Waring Abbott Laboratories, Department of Cellular, Molecular, and Exploratory Toxicology, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Pages 835-846 | Published online: 24 Nov 2006

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Madelaine M. Wohlreich, Nayan Acharya, Indiana Strombom, Louis Kuritzky, Michael Robinson, Alexandra N. Heinloth, Arie Regev & Joachim F. Wernicke. (2008) Answers to the Most Common Questions About the Hepatic Safety Profile of Duloxetine. Postgraduate Medicine 120:2, pages 111-118.
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Articles from other publishers (17)

Guy Haskin Fernald & Russ B. Altman. (2013) Using Molecular Features of Xenobiotics to Predict Hepatic Gene Expression Response. Journal of Chemical Information and Modeling 53:10, pages 2765-2773.
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Mackenzie Hadi, Inge M. Westra, Viktoriia Starokozhko, Sanja Dragovic, Marjolijn T. Merema & Geny M. M. Groothuis. (2013) Human Precision-Cut Liver Slices as an ex Vivo Model to Study Idiosyncratic Drug-Induced Liver Injury . Chemical Research in Toxicology 26:5, pages 710-720.
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Mackenzie Hadi, Yixi Chen, Viktoriia Starokozhko, Marjolijn T. Merema & Geny M.M. Groothuis. (2012) Mouse Precision-Cut Liver Slices as an ex Vivo Model To Study Idiosyncratic Drug-Induced Liver Injury. Chemical Research in Toxicology 25:9, pages 1938-1947.
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D. J. Snodin & A. Suitters. 2011. Stephens' Detection and Evaluation of Adverse Drug Reactions. Stephens' Detection and Evaluation of Adverse Drug Reactions 157 214 .
Michael J. Liguori, Amy C. Ditewig, Jane F. Maddox, James P. Luyendyk, Lois D. Lehman-McKeeman, David M. Nelson, Vasanthi M. Bhaskaran, Jeffrey F. Waring, Patricia E. Ganey, Robert A. Roth & Eric A. G. Blomme. (2010) Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example. International Journal of Molecular Sciences 11:11, pages 4697-4714.
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Masahiro Miura, Wataru Hori, Yasushi Kasahara & Ippei Nakagawa. (2010) Quantitative assessment of the metabolic activation of alicyclic amines via aldehyde. Journal of Pharmacological and Toxicological Methods 61:1, pages 44-51.
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U.A. Boelsterli & R. Kashimshetty. 2010. Comprehensive Toxicology. Comprehensive Toxicology 383 402 .
Vito G. Sasseville, William R. Foster & Bruce D. Car. 2009. Evaluation of Drug Candidates for Preclinical Development. Evaluation of Drug Candidates for Preclinical Development 219 252 .
Eric A.G. Blomme, Yi Yang & Jeffrey F. Waring. (2009) Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development. Toxicology Letters 186:1, pages 22-31.
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Jonathon N. Bauman, Joan M. Kelly, Sakambari Tripathy, Sabrina X. Zhao, Wing W. Lam, Amit S. Kalgutkar & R. Scott Obach. (2009) Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction. Chemical Research in Toxicology 22:2, pages 332-340.
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Elise Andrews & Ann K. Daly. (2008) Flucloxacillin-induced liver injury. Toxicology 254:3, pages 158-163.
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Dimitri Semizarov & Eric Blomme. 2008. Genomics in Drug Discovery and Development. Genomics in Drug Discovery and Development 293 327 .
Dimitri Semizarov & Eric Blomme. 2008. Genomics in Drug Discovery and Development. Genomics in Drug Discovery and Development 219 291 .
Alison Vickers. 2008. Genomics. Genomics 175 189 .
R. Scott Obach, Amit S. Kalgutkar, John R. Soglia & Sabrina X. Zhao. (2008) Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose. Chemical Research in Toxicology 21:9, pages 1814-1822.
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Michael J. Liguori, Eric A.G. Blomme & Jeffrey F. Waring. (2008) Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells. Drug Metabolism and Disposition 36:2, pages 223-233.
Crossref
Wayne R. Buck, Jeffrey F. Waring & Eric A. Blomme. 2008. Essential Concepts in Toxicogenomics. Essential Concepts in Toxicogenomics 23 44 .

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