Citations (63)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Huan Lan, Ying Zhang, Minqi Fan, Bingxin Wu & Caiyan Wang. (2023) Pregnane X receptor as a therapeutic target for cholestatic liver injury. Drug Metabolism Reviews 55:4, pages 371-387.
Read now
Read now
Zhenyue Wang, Yongtao Liu, Xiaohui Ai, Liqiao Zhong, Gang Han, Jinlong Song, Qiuhong Yang & Jing Dong. (2020) Effects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line. Xenobiotica 50:9, pages 1043-1051.
Read now
Read now
Tiehua Zhang, Shuning Zhong, Tiezhu Li & Jie Zhang. (2020) Saponins as modulators of nuclear receptors. Critical Reviews in Food Science and Nutrition 60:1, pages 94-107.
Read now
Read now
Madhav Sachar & Xiaochao Ma. (2013) Nuclear receptors in herb–drug interactions. Drug Metabolism Reviews 45:1, pages 73-78.
Read now
Read now
Xiaochao Ma, Jeffrey R Idle & Frank J Gonzalez. (2008) The pregnane X receptor: from bench to bedside. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 895-908.
Read now
Read now
Articles from other publishers (58)
Gerardo Vázquez-Gómez, Jiří Petráš, Zdeněk Dvořák & Jan Vondráček. (2023) Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis. Biochemical Pharmacology 216, pages 115797.
Crossref
Crossref
Yuan Liang, Yiyao Gong, Qiuyan Jiang, Yifan Yu & Jie Zhang. (2023) Environmental endocrine disruptors and pregnane X receptor action: A review. Food and Chemical Toxicology 179, pages 113976.
Crossref
Crossref
Adam Yasgar, Danielle Bougie, Richard T. Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K. Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V. Zakharov & Anton Simeonov. (2023) Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS Pharmacology & Translational Science 6:5, pages 683-701.
Crossref
Crossref
Islam Husain, Olivia R. Dale, Katherine Martin, Bill J. Gurley, Sebastian J. Adams, Bharathi Avula, Amar G. Chittiboyina, Ikhlas A. Khan & Shabana I. Khan. (2023) Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters. Journal of Ethnopharmacology 301, pages 115822.
Crossref
Crossref
Kristoff M. Nieves, Simon A. Hirota & Kyle L. Flannigan. (2022) Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota. American Journal of Physiology-Gastrointestinal and Liver Physiology 322:2, pages G268-G281.
Crossref
Crossref
Rahat Andleeb, Aliza Mazhar, Shabana Naz, Tajammul Hussain, Derya Karataş Yeni & Asma Ashraf. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes
161
190
.
T. PullaiahT. Pullaiah. 2022. Forskolin. Forskolin
65
106
.
T. PullaiahT. Pullaiah. 2022. Forskolin. Forskolin
1
3
.
Robert S. Rogers, Annemarie Parker, Phill D. Vainer, Elijah Elliott, Dakota Sudbeck, Kaushal Parimi, Venkata P. Peddada, Parker G. Howe, Nick D’Ambrosio, Gregory Ruddy, Kaitlin Stackable, Megan Carney, Lauren Martin, Thomas Osterholt & Jeff L. Staudinger. (2021) The Interface between Cell Signaling Pathways and Pregnane X Receptor. Cells 10:11, pages 3262.
Crossref
Crossref
Stamatios Theocharis, Constantinos Giaginis, Stefania Gourzi, Paraskevi Alexandrou, Gerasimos Tsourouflis, Panagiotis Sarantis, Eugene Danas, Artemis Michail, Nikolaos Tsoukalas, Alexandros Pergaris, Panagiotis K. Politis & Lydia Nakopoulou. (2021) High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma. Diagnostics 11:11, pages 1946.
Crossref
Crossref
Rajan T. Reddy & Toru Nyunoya. (2021) Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation. Biochemical and Biophysical Research Communications 555, pages 1-6.
Crossref
Crossref
Wenqi Cui, Xunan Shen, Emre Agbas, Brandon Tompkins, Hadley Cameron-Carter & Jeff L. Staudinger. (2020) Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor. Journal of Pharmacology and Experimental Therapeutics 373:3, pages 370-380.
Crossref
Crossref
Barbora Vyhlídalová, Iveta Bartoňková, Eva Jiskrová, Hao Li, Sridhar Mani & Zdeněk Dvořák. (2020) Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models. Toxicology Letters 324, pages 104-110.
Crossref
Crossref
Nilofer Sayed, Amit Khurana & Chandraiah Godugu. (2019) Pharmaceutical perspective on the translational hurdles of phytoconstituents and strategies to overcome. Journal of Drug Delivery Science and Technology 53, pages 101201.
Crossref
Crossref
Grace Hudson, Kyle L. Flannigan, Vivek Krishna Pulakazhi Venu, Laurie Alston, Christina F. Sandall, Justin A. MacDonald, Daniel A. Muruve, Thomas K.H. Chang, Sridhar Mani & Simon A. Hirota. (2019) Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation. Journal of Pharmacology and Experimental Therapeutics 370:1, pages 44-53.
Crossref
Crossref
Hanan M. Al-Yousef, Tawfeq A. Alhowiriny, Nasir A. Siddiqui, Perwez Alam, Wafaa Hassan Badr Hassan & Musarat Amina. (2019)
Quantification of two biomarker compounds by a validated high-performance thin-layer chromatographic method from different extracts of
Pluchea dioscoridis
growing in Saudi Arabia
. JPC - Journal of Planar Chromatography - Modern TLC 32:3, pages 243-249.
Crossref
Crossref
Jeff L. Staudinger. (2019) Clinical applications of small molecule inhibitors of Pregnane X receptor. Molecular and Cellular Endocrinology 485, pages 61-71.
Crossref
Crossref
Brett R. Blackwell, Gerald T. Ankley, Paul M. Bradley, Keith A. Houck, Sergei S. Makarov, Alexander V. Medvedev, Joe Swintek & Daniel L. Villeneuve. (2018) Potential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals. Environmental Science & Technology 53:2, pages 973-983.
Crossref
Crossref
Brett C. Hogle, Xiudong Guan, M. Maggie Folan & Wen Xie. (2018) PXR as a mediator of herb–drug interaction. Journal of Food and Drug Analysis 26:2, pages S26-S31.
Crossref
Crossref
Surulivelrajan Mallayasamy & Scott R. Penzak. 2018. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions
205
242
.
Jeff L. Staudinger. 2017. SUMO Regulation of Cellular Processes. SUMO Regulation of Cellular Processes
99
110
.
A. Garg, A. Zhao, S. L. Erickson, S. Mukherjee, A. J. Lau, L. Alston, T. K. H. Chang, S. Mani & S. A. Hirota. (2016) Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation. Journal of Pharmacology and Experimental Therapeutics 359:1, pages 91-101.
Crossref
Crossref
Divya Singh, William C. Cho & Ghanshyam Upadhyay. (2016) Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview. Frontiers in Physiology 6.
Crossref
Crossref
Simon A. Hirota, Aito Ueno, Sarah E. Tulk, Helen M. Becker, L. Patrick Schenck, Mireille S. Potentier, Yan Li, Subrata Ghosh, Daniel A. Muruve, Justin A. MacDonald & Paul L. Beck. (2016) Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice. Mediators of Inflammation 2016, pages 1-12.
Crossref
Crossref
Harmit S. Ranhotra, Kyle L. Flannigan, Martina Brave, Subhajit Mukherjee, Dana J. Lukin, Simon A. Hirota & Sridhar Mani. (2016) Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity. Nuclear Receptor Research 3.
Crossref
Crossref
Ioannis Koutsounas, Constantinos Giaginis, Paraskevi Alexandrou, Adamantia Zizi-Serbetzoglou, Efstratios Patsouris, Gregorios Kouraklis & Stamatios Theocharis. (2015) Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma. Pancreas 44:7, pages 1134-1140.
Crossref
Crossref
Ingrid Richter & Andrew E. Fidler. (2015) Tunicate pregnane X receptor (PXR) orthologs: Transcript characterization and natural variation. Marine Genomics 23, pages 99-108.
Crossref
Crossref
Tiong Chai Seah, Yea Lu Tay, Heng Kean Tan, Tengku Sifzizul Tengku Muhammad, Habibah Abdul Wahab & Mei Lan Tan. (2015) Determination of CYP3A4 Inducing Properties of Compounds Using a Laboratory-Developed Cell-Based Assay. International Journal of Toxicology 34:5, pages 454-468.
Crossref
Crossref
Steven A. Kliewer. (2015) Nuclear receptor PXR: discovery of a pharmaceutical anti-target. Journal of Clinical Investigation 125:4, pages 1388-1389.
Crossref
Crossref
Satyanarayana R. Pondugula, Patrick C. Flannery, Udayan Apte, Jeganathan Ramesh Babu, Thangiah Geetha, Shraddha D. Rege, Taosheng Chen & Kodye L. Abbott. (2015)
Mg
2+
/Mn
2+
-Dependent Phosphatase 1A Is Involved in Regulating Pregnane X Receptor–Mediated Cytochrome p450 3A4 Gene Expression
. Drug Metabolism and Disposition 43:3, pages 385-391.
Crossref
Crossref
Ingrid Richter & Andrew E. Fidler. (2015) Detection of marine microalgal biotoxins using bioassays based on functional expression of tunicate xenobiotic receptors in yeast. Toxicon 95, pages 13-22.
Crossref
Crossref
Zhijie Cui, Hong Kang, Kailin Tang, Qi Liu, Zhiwei Cao & Ruixin Zhu. (2015) Screening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb-Drug Interactions: Combining Pharmacophore and Docking-Based Rank Aggregation. BioMed Research International 2015, pages 1-8.
Crossref
Crossref
Chandra Prakash, Baltazar Zuniga, Chung Seog Song, Shoulei Jiang, Jodie Cropper, Sulgi Park & Bandana Chatterjee. (2015) Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions. Nuclear Receptor Research 2.
Crossref
Crossref
Ingrid Richter & Andrew Fidler. (2014) Marine Invertebrate Xenobiotic-Activated Nuclear Receptors: Their Application as Sensor Elements in High-Throughput Bioassays for Marine Bioactive Compounds. Marine Drugs 12:11, pages 5590-5618.
Crossref
Crossref
Monimoy Banerjee & Taosheng Chen. (2014) Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1. Biochemical Pharmacology 92:2, pages 389-402.
Crossref
Crossref
Donghua Hu, Yuguang Wang, Zhiwu Chen, Zengchun Ma, Qing You, Xianxie Zhang, Tao Zhou, Yong Xiao, Qiande Liang, Hongling Tan, Chengrong Xiao, Xianglin Tang, Boli Zhang & Yue Gao. (2014) Artemisinin protects against dextran sulfate-sodium-induced inflammatory bowel disease, which is associated with activation of the pregnane X receptor. European Journal of Pharmacology 738, pages 273-284.
Crossref
Crossref
Monimoy Banerjee & Taosheng Chen. (2013) Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor. Biochemical Pharmacology 86:6, pages 824-835.
Crossref
Crossref
Ling Huang, Min Huang, Yu-Hua Li, Rui-Ming Li, Yu Zeng, Shao-Yi Kuang, Li Zhang, Yi-Tao Wang & Hui-Chang Bi. (2013) Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn. Journal of Ethnopharmacology 148:2, pages 596-602.
Crossref
Crossref
Aneta Doricakova, Aneta Novotna, Radim Vrzal, Petr Pavek & Zdenek Dvorak. (2012) The role of residues T248, Y249 and T422 in the function of human pregnane X receptor. Archives of Toxicology 87:2, pages 291-301.
Crossref
Crossref
A. Attar, C. Ripoli, E. Riccardi, P. Maiti, D. D. Li Puma, T. Liu, J. Hayes, M. R. Jones, K. Lichti-Kaiser, F. Yang, G. D. Gale, C.-h. Tseng, M. Tan, C.-W. Xie, J. L. Straudinger, F.-G. Klarner, T. Schrader, S. A. Frautschy, C. Grassi & G. Bitan. (2012) Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain 135:12, pages 3735-3748.
Crossref
Crossref
Yu-Guang Wang, Jian-Ming Zhou, Zeng-Chun Ma, Hua Li, Qian-De Liang, Hong-Ling Tan, Cheng-Rong Xiao, Bo-Li Zhang & Yue Gao. (2012) Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: A possible mechanism for its hepatoprotective property against lithocholic acid-induced injury. Chemico-Biological Interactions 200:1, pages 11-20.
Crossref
Crossref
Hans Matter, Lennart T. Anger, Clemens Giegerich, Stefan Güssregen, Gerhard Hessler & Karl-Heinz Baringhaus. (2012) Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules. Bioorganic & Medicinal Chemistry 20:18, pages 5352-5365.
Crossref
Crossref
Andrew E. Fidler, Patrick T. Holland, Erica J. Reschly, Sean Ekins & Matthew D. Krasowski. (2012) Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants. Toxicon 59:2, pages 365-372.
Crossref
Crossref
Alexander V. LyubimovEmily A. Fraser, Colin J. Henderson & C. Roland Wolf. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
34
.
Kuo-Hsiung Lee, Susan Morris-Natschke, Keduo Qian, Yizhou Dong, Xiaoming Yang, Ting Zhou, Eileen Belding, Shou-Fang Wu, Koji Wada & Toshiyuki Akiyama. (2012) Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon (神農本草經 Shén Nóng Běn Cǎo Jīng). Journal of Traditional and Complementary Medicine 2:1, pages 6-26.
Crossref
Crossref
Maryam Modarai, Elisabete Silva, Andy Suter, Michael Heinrich & Andreas Kortenkamp. (2011) Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression. Evidence-Based Complementary and Alternative Medicine 2011, pages 1-7.
Crossref
Crossref
Scott R. Penzak. 2011. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases
131
165
.
Nagendra Kumar Chaturvedi, Sanjay Kumar, Seema Negi & Rakesh K. Tyagi. (2010) Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders. Molecular and Cellular Biochemistry 345:1-2, pages 291-308.
Crossref
Crossref
Curtis Klaassen & Hong Lu. 2010. Nuclear Receptors. Nuclear Receptors
287
305
.
Stefanie D. Krämer & Bernard Testa. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:10, pages 1477-1660.
Crossref
Crossref
Thomas K. H. Chang. (2009) Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines. The AAPS Journal 11:3.
Crossref
Crossref
Changcheng Zhou, Suman Verma & Bruce Blumberg. (2009) The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nuclear Receptor Signaling 7:1, pages nrs.07001.
Crossref
Crossref
Salvador Máñez. (2019) A Fresh Insight into the Interaction of Natural Products with Pregnane X Receptor. Natural Product Communications 3:12, pages 1934578X0800301.
Crossref
Crossref
Bin ZhangWen XieMatthew D Krasowski. (2008) PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics 9:11, pages 1695-1709.
Crossref
Crossref
Kristin Lichti-Kaiser & Jeff L. Staudinger. (2008) The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes. Drug Metabolism and Disposition 36:8, pages 1538-1545.
Crossref
Crossref
Birgit Holst & Gary Williamson. (2008) Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants. Current Opinion in Biotechnology 19:2, pages 73-82.
Crossref
Crossref
Scott Carlson, Ning Peng, Jeevan K. Prasain & J. Michael Wyss. (2008) Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females. Gender Medicine 5, pages S76-S90.
Crossref
Crossref
Islam Husain, Olivia R. Dale, Katherine Martin, Bill J. Gurley, John S. Adams, Bharathi Avula, Amar G. Chittiboyina, Ikhlas A. Khan & Shabana Khan. (2022) Screening of Medicinal Plants for Possible Herb-Drug Interactions Through Modulating Nuclear Receptors, Drug-Metabolizing Enzymes and Transporters. SSRN Electronic Journal.
Crossref
Crossref