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Drug-induced liver injury: a summary of recent advances

, MD & , MD
Pages 875-890 | Published online: 21 Apr 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Jonathan G. Stine & Patrick G. Northup. (2016) Autoimmune-like drug-induced liver injury: a review and update for the clinician. Expert Opinion on Drug Metabolism & Toxicology 12:11, pages 1291-1301.
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Yue-Ming Wang, Sergio C Chai, Christopher T Brewer & Taosheng Chen. (2014) Pregnane X receptor and drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 10:11, pages 1521-1532.
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Walid M Chalhoub, Kayla D Sliman, Meera Arumuganathan & James H Lewis. (2014) Drug-induced liver injury: what was new in 2013?. Expert Opinion on Drug Metabolism & Toxicology 10:7, pages 959-980.
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Yong Zhou, Shizhen Qin & Kai Wang. (2013) Biomarkers of drug-induced liver injury. Current Biomarker Findings 3, pages 1-9.
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Articles from other publishers (43)

Rohit Sharma & Pradeep K. Prajapati. (2022) Remarks on “Herbal Immune Booster-Induced Liver Injury in the COVID-19 Pandemic - A Case Series”. Journal of Clinical and Experimental Hepatology 12:1, pages 247-248.
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Narendra Kumar, Salim Surani, George Udeani, Sara Mathew, Sharon John, Soniya Sajan & Jayshree Mishra. (2021) Drug-induced liver injury and prospect of cytokine based therapy; A focus on IL-2 based therapies. Life Sciences 278, pages 119544.
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Shunmin Huang, Maobai Liu, Fangmeng Fu, Hangmin Liu, Baochang He, Danni Xiao & Jing Yang. (2021) High Serum Estradiol Reduces Acute Hepatotoxicity Risk Induced by Epirubicin Plus Cyclophosphamide Chemotherapy in Premenopausal Women with Breast Cancer. Frontiers in Pharmacology 11.
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Shunmin Huang, Jing Yang, Fangmeng Fu, Chuan Wang, Xiaoxiong Guo, Baochang He, Danni Xiao, Hongfu Cai & Maobai Liu. (2021) Clinical and genetic risk factors for the prediction of hepatotoxicity induced by a docetaxel, epirubicin and cyclophosphamide regimen in breast cancer patients. Pharmacogenomics 22:2, pages 87-98.
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Lu Li, Sujun Zheng & Yu Chen. (2019) Stevens–Johnson syndrome and acute vanishing bile duct syndrome after the use of amoxicillin and naproxen in a child. Journal of International Medical Research 47:9, pages 4537-4543.
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Felix Hammann, Verena Schöning & Jürgen Drewe. (2019) Prediction of clinically relevant drug-induced liver injury from structure using machine learning. Journal of Applied Toxicology 39:3, pages 412-419.
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He Tingting, Zhu Yun, Wang Jiabo, Gong Man, Wang Ruilin, Niu Ming, Jing Jing, Wang Lifu, Wang Zhongxia, Zhang Ning, Bai Zhaofang, Bai Yunfeng, Li Yonggang & Xiao Xiaohe. (2017) Clinical characteristics of 96 patients with drug-induced acute liver failure: a comparison between Traditional Chinese and Western Medicine. Journal of Traditional Chinese Medicine 37:3, pages 286-297.
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Yue-cheng Yu, Yi-min Mao, Cheng-wei Chen, Jin-jun Chen, Jun Chen, Wen-ming Cong, Yang Ding, Zhong-ping Duan, Qing-chun Fu, Xiao-yan Guo, Peng Hu, Xi-qi Hu, Ji-dong Jia, Rong-tao Lai, Dong-liang Li, Ying-xia Liu, Lun-gen Lu, Shi-wu Ma, Xiong Ma, Yue-min Nan, Hong Ren, Tao Shen, Hao Wang, Ji-yao Wang, Tai-ling Wang, Xiao-jin Wang, Lai Wei, Qing Xie, Wen Xie, Chang-qing Yang, Dong-liang Yang, Yan-yan Yu, Min-de Zeng, Li Zhang, Xin-yan Zhao & Hui Zhuang. (2017) CSH guidelines for the diagnosis and treatment of drug-induced liver injury. Hepatology International 11:3, pages 221-241.
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Yehudit Shabat & Yaron Ilan. (2017) A synergistic effect of Cremophor and beta glucosylceramide to exert liver and sugar protection. Journal of Food Science and Technology 54:5, pages 1184-1191.
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Young-Eun Cho, Eun-Ju Im, Pyong-Gon Moon, Esteban Mezey, Byoung-Joon Song & Moon-Chang Baek. (2017) Increased liver-specific proteins in circulating extracellular vesicles as potential biomarkers for drug- and alcohol-induced liver injury. PLOS ONE 12:2, pages e0172463.
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Jonathan G. Stine & Naga P. Chalasani. (2017) Drug Hepatotoxicity. Clinics in Liver Disease 21:1, pages 103-113.
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Tamara Alempijevic, Simon Zec & Tomica Milosavljevic. (2017) Drug-induced liver injury: Do we know everything?. World Journal of Hepatology 9:10, pages 491.
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Maria Virginia Caballero, Ramon A. Espinoza‐Lewis & Manila Candiracci. 2016. Stem Cells in Toxicology and Medicine. Stem Cells in Toxicology and Medicine 5 25 .
Ahmet Basturk, Reha Artan, Aygen Yılmaz, Mustafa T. Gelen & Ozgur Duman. (2016) Acute vanishing bile duct syndrome after the use of ibuprofen. Arab Journal of Gastroenterology 17:3, pages 137-139.
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María José Gómez-Lechón & Laia Tolosa. (2016) Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening. Archives of Toxicology 90:9, pages 2049-2061.
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Edward Spack. 2016. Regenerative Medicine - from Protocol to Patient. Regenerative Medicine - from Protocol to Patient 51 82 .
Maria Suciu, Alexandra T. Gruia, Dragos V. Nica, Seyed M.R. Azghadi, Ani A. Mic & Felix A. Mic. (2015) Acetaminophen-induced liver injury: Implications for temporal homeostasis of lipid metabolism and eicosanoid signaling pathway. Chemico-Biological Interactions 242, pages 335-344.
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Jonathan G. Stine & Naga Chalasani. (2015) Chronic liver injury induced by drugs: a systematic review. Liver International 35:11, pages 2343-2353.
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James H. Lewis. (2015) The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond. Clinical Gastroenterology and Hepatology 13:12, pages 2173-2189.e8.
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J Jiang, X Zhang, R Huo, X Li, Y Yang, Z Gai, M Xu, L Shen, L Cai, C Wan, B Li, L He & S Qin. (2014) Association study of UGT1A9 promoter polymorphisms with DILI based on systematically regional variation screen in Chinese population. The Pharmacogenomics Journal 15:4, pages 326-331.
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Jonathan G. Stine, Nicolas Intagliata, Neeral L. Shah, Curtis K. Argo, Stephen H. Caldwell, James H. Lewis & Patrick G. Northup. (2014) Hepatic Decompensation Likely Attributable to Simeprevir in Patients with Advanced Cirrhosis. Digestive Diseases and Sciences 60:4, pages 1031-1035.
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Rachel P. L. van Swelm, Mackenzie Hadi, Coby M. M. Laarakkers, Rosalinde Masereeuw, Geny M. M. Groothuis & Frans G. M. Russel. (2014) Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury. Journal of Applied Toxicology 34:9, pages 993-1001.
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Getnet Yimer, Marcus Gry, Wondwossen Amogne, Eyasu Makonnen, Abiy Habtewold, Zelalem Petros, Getachew Aderaye, Ina Schuppe-Koistinen, Lars Lindquist & Eleni Aklillu. (2014) Evaluation of Patterns of Liver Toxicity in Patients on Antiretroviral and Anti-Tuberculosis Drugs: A Prospective Four Arm Observational Study in Ethiopian Patients. PLoS ONE 9:4, pages e94271.
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Hye-young KimHea Kyoung YangSeong Heon KimJae Hong Park. (2014) Ibuprofen Associated Acute Vanishing Bile Duct Syndrome and Toxic Epidermal Necrolysis in an Infant. Yonsei Medical Journal 55:3, pages 834.
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Oksana SirenkoJayne HesleyIvan RusynEvan F. Cromwell. (2014) High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell–Derived Cells. ASSAY and Drug Development Technologies 12:1, pages 43-54.
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Yuping Wang, Jurgen Borlak & Weida Tong. 2014. Genomic Biomarkers for Pharmaceutical Development. Genomic Biomarkers for Pharmaceutical Development 127 155 .
Ji Won Kim, Sung Ha Ryu, Siwon Kim, Hae Won Lee, Mi-sun Lim, Sook Jin Seong, Suhkmann Kim, Young-Ran Yoon & Kyu-Bong Kim. (2013) Pattern Recognition Analysis for Hepatotoxicity Induced by Acetaminophen Using Plasma and Urinary 1 H NMR-Based Metabolomics in Humans . Analytical Chemistry 85:23, pages 11326-11334.
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Chung‐Te Liu, Tso‐Hsiao Chen & Chung‐Yi Cheng. (2013) Successful treatment of drug‐induced acute liver failure with high‐volume plasma exchange. Journal of Clinical Apheresis 28:6, pages 430-434.
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Ryan E. Morgan, Carlo J. van Staden, Yuan Chen, Natarajan Kalyanaraman, Jackson Kalanzi, Robert T. DunnIIII, Cynthia A. Afshari & Hisham K. Hamadeh. (2013) A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development. Toxicological Sciences 136:1, pages 216-241.
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James H. Lewis. (2013) Drug-Induced Liver Injury Throughout the Drug Development Life Cycle: Where We Have Been, Where We are Now, and Where We are Headed. Perspectives of a Clinical Hepatologist. Pharmaceutical Medicine 27:3, pages 165-191.
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E. Ocete Hita, J.A. Martín García, F. Giménez Sánchez, J.C. Flores González, A. Abril Molina, J. Salmerón Escobar & A. Ruiz Extremera. (2013) Hepatotoxicidad por fármacos o productos naturales en niños. Anales de Pediatría 78:4, pages 248-259.
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Bernardo Frider, Andres Bruno, Marcelo Ponte & Marcelo Amante. (2013) Drug-Induced Liver Injury Caused by Adalimumab: A Case Report and Review of the Bibliography. Case Reports in Hepatology 2013, pages 1-3.
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S. Messner, I. Agarkova, W. Moritz & J. M. Kelm. (2012) Multi-cell type human liver microtissues for hepatotoxicity testing. Archives of Toxicology 87:1, pages 209-213.
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Rachel P. L. van Swelm, Coby M. M. Laarakkers, Ellen C. van der Kuur, Eva Morava-Kozicz, Ron A. Wevers, Kevin D. Augustijn, Daan J. Touw, Maro H. Sandel, Rosalinde Masereeuw & Frans G. M. Russel. (2012) Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice. PLoS ONE 7:11, pages e49524.
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Carlo J. Staden, Ryan E. Morgan, Bharath Ramachandran, Yuan Chen, Paul H. Lee & Hisham K. Hamadeh. (2012) Membrane Vesicle ABC Transporter Assays for Drug Safety Assessment. Current Protocols in Toxicology 54:1.
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A Alfirevic & M Pirmohamed. (2012) Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility. Clinical Pharmacology & Therapeutics 92:3, pages 376-380.
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Sabina Mugusi, Eliford Ngaimisi, Mohamed Janabi, Omary Minzi, Muhammad Bakari, Klaus-Dieter Riedel, Juergen Burhenne, Lars Lindquist, Ferdinand Mugusi, Eric Sandstrom & Eleni Aklillu. (2012) Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania. PLoS ONE 7:7, pages e40180.
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Rolf Teschke, Christian Frenzel, Johannes Schulze & Axel Eickhoff. (2012) Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: Was causality adequately ascertained?. Regulatory Toxicology and Pharmacology 63:1, pages 1-9.
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Rolf Teschke, Xaver Glass, Johannes Schulze & Axel Eickhoff. (2012) Suspected Greater Celandine hepatotoxicity. European Journal of Gastroenterology & Hepatology 24:3, pages 270-280.
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Xi Yang, James Greenhaw, Qiang Shi, Zhenqiang Su, Feng Qian, Kelly Davis, Donna L. Mendrick & William F. Salminen. (2012) Identification of Urinary microRNA Profiles in Rats That May Diagnose Hepatotoxicity. Toxicological Sciences 125:2, pages 335-344.
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Lars Edvinsson & Mattias Linde. (2012) CGRP antagonists for the treatment of migraine: rationale and clinical data. Clinical Investigation 2:1, pages 73-88.
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Salim S. Virani & Christie M. Ballantyne. (2011) Update on therapies targeting HDL. Current Opinion in Lipidology 22:6, pages 514-516.
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Rolf Teschke, Xaver Glass & Johannes Schulze. (2011) Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): Causality assessment of 22 spontaneous reports. Regulatory Toxicology and Pharmacology 61:3, pages 282-291.
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