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The effect and clinical consequences of hypoxia on cytochrome P450, membrane carrier proteins activity and expression

, MD PhD (Professor and Director) & , PhD (Director)
Pages 1083-1100 | Published online: 28 May 2011

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Xue Bai, Jianxin Yang, Guiqin Liu, Junbo Zhu, Qian Wang, Wenqi Gu, Linli La & Xiangyang Li. (2022) Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia. Frontiers in Pharmacology 13.
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Xiao-Bin Zhang, Xiao-Yang Chen, Kam Yu Chiu, Xiu-Zhen He, Jian-Ming Wang, Hui-Qing Zeng & Yiming Zeng. (2022) Intermittent Hypoxia Inhibits Hepatic CYP1a2 Expression and Delays Aminophylline Metabolism. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-9.
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Ya-bin Duan, Jun-bo Zhu, Jian-xin Yang, Gui-qin Liu, Xue Bai, Ning Qu, Xue-jun Wang & Xiang-yang Li. (2020) Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR. Frontiers in Pharmacology 11.
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Siqi Feng, Anqi Li, Yi-Chao Zheng & Hong-Min Liu. (2020) Role of Drug-metabolizing Enzymes in Cancer and Cancer Therapy. Current Drug Metabolism 21:1, pages 67-76.
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Sophie Gravel, Benoit Panzini, Francois Belanger, Jacques Turgeon & Veronique Michaud. (2019) A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum. International Journal of Molecular Sciences 20:13, pages 3257.
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Eleni A. Rekka, Panos N. Kourounakis & Maria Pantelidou. (2019) Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design. Current Topics in Medicinal Chemistry 19:4, pages 276-291.
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Xin Luan, Ying-Yun Guan, Hai-Jun Liu, Qin Lu, Mei Zhao, Duxin Sun, Jonathan F. Lovell, Peng Sun, Hong-Zhuan Chen & Chao Fang. (2018) A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia. Advanced Science 5:8, pages 1800034.
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Md Saydur Rahman & Peter Thomas. (2018) Interactive effects of hypoxia and PCB co-exposure on expression of CYP1A and its potential regulators in Atlantic croaker liver. Environmental Toxicology 33:4, pages 411-421.
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Sarah Maximos, Michel Chamoun, Sophie Gravel, Jacques Turgeon & Veronique Michaud. (2017) Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues. Pharmaceutics 9:4, pages 40.
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M. Thiersch, E.R. Swenson, T. Haider & M. Gassmann. (2017) Reduced cancer mortality at high altitude: The role of glucose, lipids, iron and physical activity. Experimental Cell Research 356:2, pages 209-216.
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Damian M. Bailey. (2017) On the Significance of Altered Drug Pharmacokinetics-Pharmacodynamics at High Altitude. High Altitude Medicine & Biology 18:1, pages 88-89.
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Wenwen Gong, Pingxiang Xu, Shanshan Guo, Xiaorong Li, Zengliang Jin, Yuming Zhao, Ming Fan & Ming Xue. (2017) Effect of hypoxia on the pharmacokinetics and metabolism of zaleplon as a probe of CYP3A1/2 activity. RSC Advances 7:41, pages 25414-25421.
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Alexia Grangeon, Sophie Gravel, Fleur Gaudette, Jacques Turgeon & Veronique Michaud. (2017) Highly sensitive LC–MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human. Journal of Chromatography B 1040, pages 144-158.
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R. Sane & M. Sinz. 2017. Drug Metabolism in Diseases. Drug Metabolism in Diseases 1 19 .
Marianne Olufsen & Augustine Arukwe. (2014) Endocrine, biotransformation, and oxidative stress responses in salmon hepatocytes exposed to chemically induced hypoxia and perfluorooctane sulfonamide (PFOSA), given singly or in combination. Environmental Science and Pollution Research 22:22, pages 17350-17366.
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Aude Jacob, Sophie Potin, Bruno Saubaméa, Dominique Crete, Jean-Michel Scherrmann, Emmanuel Curis, Carole Peyssonnaux & Xavier Declèves. (2015) Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells. Journal of Neurochemistry 132:4, pages 373-383.
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Maria Konstandi, Elizabeth O. Johnson & Matti A. Lang. (2014) Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism. Neuroscience & Biobehavioral Reviews 45, pages 149-167.
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M.D. Chanyshev, N.I. Kosorotikov, S.E. Titov, N.N. Kolesnikov & L.F. Gulyaeva. (2014) Expression of microRNAs, CYP1A1 and CYP2B1 in the livers and ovaries of female rats treated with DDT and PAHs. Life Sciences 103:2, pages 95-100.
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Farah Koraïchi, Lilia Inoubli, Nadjem Lakhdari, Léo Meunier, Aurélie Vega, Claire Mauduit, Mohamed Benahmed, Caroline Prouillac & Sylvaine Lecoeur. (2013) Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Toxicology 310, pages 29-38.
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Ziqi Wu, Liwen Guan, Biying Pan, Haitian Xu, Yujia Luo, Min Zhou, Jiayong Zhang, Shigui Wang, Can Li & Bin Tang. (2022) Mechanism of Hif1-Α-Mediated Regulation of Tribolium Castaneum Metabolism Under High Co2 Concentration. SSRN Electronic Journal.
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