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Pharmacogenetics of genes across the doxorubicin pathway

, PhD & , PhD (Professor)
Pages 1201-1210 | Published online: 15 Sep 2011

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Kusum Rathore & Maria Cekanova. (2015) A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro. Drug Design, Development and Therapy 9, pages 5323-5335.
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Anna Paioli, Roberto Luksch, Franca Fagioli, Angela Tamburini, Marilena Cesari, Emanuela Palmerini, Massimo Eraldo Abate, Emanuela Marchesi, Alba Balladelli, Loredana Pratelli & Stefano Ferrari. (2014) Chemotherapy-related toxicity in patients with non-metastatic Ewing sarcoma: influence of sex and age. Journal of Chemotherapy 26:1, pages 49-56.
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Anna C. Virgili Manrique, Juliana Salazar, María Jesús Arranz, Silvia Bagué, Ruth Orellana, Antonio López-Pousa, Paula Cerdà, Isidre Gracia, Katarina Majercakova, Ana Peiró, Laura Trullols, Manuel Fernández, Sandra Valverde, María Jesús Quintana, Olga Bell, Alícia Artigas-Baleri & Ana Sebio. (2022) Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy. Journal of Personalized Medicine 12:4, pages 618.
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Benedetta C. Sallustio & Alan V. Boddy. (2020) Is there scope for better individualisation of anthracycline cancer chemotherapy?. British Journal of Clinical Pharmacology 87:2, pages 295-305.
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Farina Hellmann, Swantje Völler, Miriam Krischke, David Jamieson, Nicolas André, Gianni Bisogno, Alan Boddy & Georg Hempel. (2020) Genetic Polymorphisms Affecting Cardiac Biomarker Concentrations in Children with Cancer: an Analysis from the “European Paediatric Oncology Off-patents Medicines Consortium” (EPOC) Trial. European Journal of Drug Metabolism and Pharmacokinetics 45:3, pages 413-422.
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Zeina N. Al-Mahayri, George P. Patrinos & Bassam R. Ali. (2020) Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy. Frontiers in Pharmacology 11.
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Rui Li, Tao Xu, Hongtao Wang, Nan Wu, Fei Liu, Xianjie Jia, Jing Mi, Jingzhu Lv & Huaiquan Gao. (2019) Dysregulation of the miR-325–3p/DPAGT1 axis supports HBV-positive HCC chemoresistance. Biochemical and Biophysical Research Communications 519:2, pages 358-365.
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Luke A. Wittenburg, Kristen Weishaar, Dominique Ramirez & Daniel L. Gustafson. (2019) Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers. Veterinary and Comparative Oncology 17:2, pages 147-154.
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Luciana L. Ferreira, Paulo J. Oliveira & Teresa Cunha-Oliveira. 2019. Pharmacoepigenetics. Pharmacoepigenetics 837 846 .
Hua He, Can Liu, Yun Wu, Xinyuan Zhang, Jianghong Fan & Yanguang Cao. (2018) A Multiscale Physiologically-Based Pharmacokinetic Model for Doxorubicin to Explore its Mechanisms of Cytotoxicity and Cardiotoxicity in Human Physiological Contexts. Pharmaceutical Research 35:9.
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Ilse R. Dubbelboer, Elsa Lilienberg, Erik Sjögren & Hans Lennernäs. (2017) A Model-Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition. Molecular Pharmaceutics 14:3, pages 686-698.
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C. Oury & V. Bours. 2017. Anti-Cancer Treatments and Cardiotoxicity. Anti-Cancer Treatments and Cardiotoxicity 379 386 .
Ayman Khdair, Islam Hamad, Hatim Alkhatib, Yasser Bustanji, Mohammad Mohammad, Rabab Tayem & Khaled Aiedeh. (2016) Modified-chitosan nanoparticles: Novel drug delivery systems improve oral bioavailability of doxorubicin. European Journal of Pharmaceutical Sciences 93, pages 38-44.
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Judit C Sági, Nóra Kutszegi, Andrea Kelemen, Lili E Fodor, András Gézsi, Gábor T Kovács, Dániel J Erdélyi, Csaba Szalai & Ágnes F Semsei. (2016) Pharmacogenetics of anthracyclines. Pharmacogenomics 17:9, pages 1075-1087.
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Rafet Mete, Mustafa Oran, Birol Topcu, Meltem Oznur, Erdogan Selcuk Seber, Asuman Gedikbasi & Tarkan Yetisyigit. (2013) Protective effects of onion ( Allium cepa ) extract against doxorubicin-induced hepatotoxicity in rats . Toxicology and Industrial Health 32:3, pages 551-557.
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Shaohua Chen, Yu Zhang & Daohai Zhang. (2015) Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O6-methylguanine DNA-methyltransferase, in breast cancer cells. Scientific Reports 5:1.
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Xuelin Zhou, Yan Wang, Wayne Y. W. Lee, Penelope M. Y. Or, David C. C. Wan, Yiu Wa Kwan & John H. K. Yeung. (2015) Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells. Journal of Natural Products 78:9, pages 2266-2275.
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Christopher M. Schaupp, Collin C. White, Gary F. Merrill & Terrance J. Kavanagh. (2015) Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3. Chemico-Biological Interactions 234, pages 154-161.
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Thi Thuy Trang Nguyen, Julia Sze Lynn Lim, Richard Ming Yi Tang, Louxin Zhang & Ee Sin Chen. (2015) Fitness Profiling Links Topoisomerase II Regulation of Centromeric Integrity to Doxorubicin Resistance in Fission Yeast. Scientific Reports 5:1.
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K.-A. Jung, B.-h. Choi & M.-K. Kwak. (2014) The c-MET/PI3K Signaling Is Associated with Cancer Resistance to Doxorubicin and Photodynamic Therapy by Elevating BCRP/ABCG2 Expression. Molecular Pharmacology 87:3, pages 465-476.
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Louis Tong & Vinay Tergaonkar. (2014) Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology. Bioscience Reports 34:3.
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Elsa Lilienberg, Charlotte Ebeling Barbier, Rickard Nyman, Mikael Hedeland, Ulf Bondesson, Niklas Axén & Hans Lennernäs. (2013) Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms. Molecular Pharmaceutics 11:1, pages 131-144.
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Jared M. ChurkoGary L. MantalasMichael P. SnyderJoseph C. Wu. (2013) Overview of High Throughput Sequencing Technologies to Elucidate Molecular Pathways in Cardiovascular Diseases. Circulation Research 112:12, pages 1613-1623.
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Damian G. Deavall, Elizabeth A. Martin, Judith M. Horner & Ruth Roberts. (2012) Drug-Induced Oxidative Stress and Toxicity. Journal of Toxicology 2012, pages 1-13.
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