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Expert Opinion on Drug Metabolism & Toxicology Volume 7, 2011 - Issue 10
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Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease

Qiang MaReceptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Rd, Morgantown, WV 26505, USA+1 304 285 6241; +1 304 285 5708; [email protected]
(Lead Toxicologist and Team Leader)
Pages 1267-1293 | Published online: 02 Sep 2011

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Bettina Ebert, Michael Kisiela & Edmund Maser. (2016) Transcriptional regulation of human and murine short-chain dehydrogenase/reductases (SDRs) – an in silico approach. Drug Metabolism Reviews 48:2, pages 183-217.
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Liudmila Korkina. (2016) Metabolic and redox barriers in the skin exposed to drugs and xenobiotics. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 377-388.
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Sabine Gerbal-Chaloin, Irena Iankova, Patrick Maurel & Martine Daujat-Chavanieu. (2013) Nuclear receptors in the cross-talk of drug metabolism and inflammation. Drug Metabolism Reviews 45:1, pages 122-144.
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Articles from other publishers (36)

Zhiwei Wang, Feihong Chen, Yuanjiang Wang & Shaohua Gou. (2023) Blockade of chemo-resistance to 5-FU by a CK2-targeted combination via attenuating AhR-TLS-promoted genomic instability in human colon cancer cells. Toxicology and Applied Pharmacology 475, pages 116647.
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Yaqian Shi, Yangfan Xiao, Jiangfan Yu, Jiani Liu, Licong Liu, Yan Ding, Xiangning Qiu, Yi Zhan, Rui Tang, Zhuotong Zeng & Rong Xiao. (2023) UVA1 irradiation attenuates collagen production via Ficz/AhR/MAPK signaling activation in scleroderma. International Immunopharmacology 116, pages 109764.
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Laetitia Bey, Xavier Coumoul & Min Ji Kim. (2022) TCDD aggravates the formation of the atherosclerotic plaque in ApoE KO mice with a sexual dimorphic pattern. Biochimie 195, pages 54-58.
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Agneta Rannug. (2022) 6-Formylindolo[3,2-b]carbazole, a Potent Ligand for the Aryl Hydrocarbon Receptor Produced Both Endogenously and by Microorganisms, can Either Promote or Restrain Inflammatory Responses. Frontiers in Toxicology 4.
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Yuanyuan Jiang, Hua Xiao, Lingling Sun, Yan Zhang, Shuzhen Liu & Bing Luo. (2021) LMP2A suppresses the role of AHR pathway through ERK signal pathway in EBV-associated gastric cancer. Virus Research 297, pages 198399.
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Sudha Priya Soundara Pandi, J. Arjuna Ratnayaka, Andrew J. Lotery & Jessica L. Teeling. (2021) Progress in developing rodent models of age-related macular degeneration (AMD). Experimental Eye Research 203, pages 108404.
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Monika Szelest, Katarzyna Walczak & Tomasz Plech. (2021) A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes. International Journal of Molecular Sciences 22:3, pages 1104.
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Yota Sato, Taku Fujimura, Takanori Hidaka, Chunbing Lyu, Kayo Tanita, Shigeto Matsushita, Masayuki Yamamoto & Setsuya Aiba. (2020) Possible Roles of Proinflammatory Signaling in Keratinocytes Through Aryl Hydrocarbon Receptor Ligands for the Development of Squamous Cell Carcinoma. Frontiers in Immunology 11.
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Sarah J Phelan-Dickinson, Brian C Palmer, Yue Chen & Lisa A DeLouise. (2020) The UVR Filter Octinoxate Modulates Aryl Hydrocarbon Receptor Signaling in Keratinocytes via Inhibition of CYP1A1 and CYP1B1. Toxicological Sciences 177:1, pages 188-201.
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Eskedar Getachew Assefa, Qiaoqiao Yan, Siameregn Berhe Gezahegn, Maibouge Tanko Mahamane Salissou, Shuiqing He, Nannan Wu, Xuezhi Zuo & Chenjiang Ying. (2019) Role of Resveratrol on Indoxyl Sulfate-Induced Endothelial Hyperpermeability via Aryl Hydrocarbon Receptor (AHR)/Src-Dependent Pathway. Oxidative Medicine and Cellular Longevity 2019, pages 1-15.
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Etienne Bourgart, Renaud Persoons, Marie Marques, Alex Rivier, Franck Balducci, Anne von Koschembahr, David Béal, Marie-Thérèse Leccia, Thierry Douki & Anne Maitre. (2019) Influence of exposure dose, complex mixture, and ultraviolet radiation on skin absorption and bioactivation of polycyclic aromatic hydrocarbons ex vivo. Archives of Toxicology 93:8, pages 2165-2184.
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Cunyu Zhang, Katrina L. Creech, William J. Zuercher & Timothy M. Willson. (2019) Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor. Scientific Reports 9:1.
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Dieter Lang, Martin Radtke & Michaela Bairlein. (2019) Highly Variable Expression of CYP1A1 in Human Liver and Impact on Pharmacokinetics of Riociguat and Granisetron in Humans. Chemical Research in Toxicology 32:6, pages 1115-1122.
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Babak Memari, Loan Nguyen-Yamamoto, Reyhaneh Salehi-Tabar, Michela Zago, Jorg H. Fritz, Carolyn J. Baglole, David Goltzman & John H. White. (2019) Endocrine aryl hydrocarbon receptor signaling is induced by moderate cutaneous exposure to ultraviolet light. Scientific Reports 9:1.
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Yu Zhou, Shujin Li, Lulin Huang, Yeming Yang, Lin Zhang, Mu Yang, Wenjing Liu, Kim Ramasamy, Zhilin Jiang, Periasamy Sundaresan, Xianjun Zhu & Zhenglin Yang. (2018) A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa. Human Molecular Genetics 27:14, pages 2563-2572.
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S. Koch, T. J. Stroisch, J. Vorac, N. Herrmann, N. Leib, S. Schnautz, H. Kirins, I. Förster, H. Weighardt & T. Bieber. (2017) AhR mediates an anti‐inflammatory feedback mechanism in human Langerhans cells involving Fcε RI and IDO . Allergy 72:11, pages 1686-1693.
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Tingting Hu, Duo Wang, Qian Yu, Li Li, Xiaohui Mo, Zhanyan Pan, Christos C. Zouboulis, Luying Peng, Longqing Xia & Qiang Ju. (2016) Aryl hydrocarbon receptor negatively regulates lipid synthesis and involves in cell differentiation of SZ95 sebocytes in vitro. Chemico-Biological Interactions 258, pages 52-58.
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In-Sung Kim, Ji-Hee Hwang, Masashi Hirano, Hisato Iwata & Eun-Young Kim. (2016) In vitro and in silico evaluation of transactivation potencies of avian AHR1 and AHR2 by endogenous ligands: Implications for the physiological role of avian AHR2. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 187, pages 1-9.
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Karl Walter Bock. (2016) Toward elucidation of dioxin-mediated chloracne and Ah receptor functions. Biochemical Pharmacology 112, pages 1-5.
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Martyn T. Smith, Kathryn Z. Guyton, Catherine F. Gibbons, Jason M. Fritz, Christopher J. Portier, Ivan Rusyn, David M. DeMarini, Jane C. Caldwell, Robert J. Kavlock, Paul F. Lambert, Stephen S. Hecht, John R. Bucher, Bernard W. Stewart, Robert A. Baan, Vincent J. Cogliano & Kurt Straif. (2016) Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environmental Health Perspectives 124:6, pages 713-721.
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Anna Smirnova, Emma Wincent, Linda Vikström Bergander, Tomas Alsberg, Jan Bergman, Agneta Rannug & Ulf Rannug. (2015) Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ. Chemical Research in Toxicology 29:1, pages 75-86.
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Aysegul Cort, Tomris Ozben, Luciano Saso, Chiara De Luca & Liudmila Korkina. (2016) Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants. Oxidative Medicine and Cellular Longevity 2016, pages 1-17.
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Richard A. Becker, Grace Patlewicz, Ted W. Simon, J. Craig Rowlands & Robert A. Budinsky. (2015) The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Regulatory Toxicology and Pharmacology 73:1, pages 172-190.
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Deeba N. Syed & Hasan Mukhtar. (2015) FICZ: A Messenger of Light in Human Skin. Journal of Investigative Dermatology 135:6, pages 1478-1481.
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Charlotte Esser & Agneta Rannug. (2015) The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology. Pharmacological Reviews 67:2, pages 259-279.
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Chun Wang, Zhi-Ming Zhang, Can-Xin Xu & Shelley Tischkau. (2014) Interplay between Dioxin-Mediated Signaling and Circadian Clock: A Possible Determinant in Metabolic Homeostasis. International Journal of Molecular Sciences 15:7, pages 11700-11712.
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Karl Walter Bock. (2014) Homeostatic control of xeno- and endobiotics in the drug-metabolizing enzyme system. Biochemical Pharmacology 90:1, pages 1-6.
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Conghui Zhu, Qunhui Xie & Bin Zhao. (2014) The Role of AhR in Autoimmune Regulation and Its Potential as a Therapeutic Target against CD4 T Cell Mediated Inflammatory Disorder. International Journal of Molecular Sciences 15:6, pages 10116-10135.
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Qiang Ma & Anthony Y.H. Lu. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 22 .
Charlotte Esser, Imke Bargen, Heike Weighardt, Thomas Haarmann-Stemmann & Jean Krutmann. (2013) Functions of the aryl hydrocarbon receptor in the skin. Seminars in Immunopathology 35:6, pages 677-691.
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J. Bergman. (2012) Synthesis and studies of two marine indole alkaloids, barettin and caulersin. Phytochemistry Reviews 12:3, pages 487-494.
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E. Dupont, J. Gomez & D. Bilodeau. (2013) Beyond UV radiation: A skin under challenge . International Journal of Cosmetic Science 35:3, pages 224-232.
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Saori Yamashita, Ryosuke Segawa, Nozomi Satou, Masahiro Hiratsuka, Warren J Leonard & Noriyasu Hirasawa. (2013) Induction of Thymic Stromal Lymphopoietin Production by Nonanoic Acid and Exacerbation of Allergic Inflammation in Mice. Allergology International 62:4, pages 463-471.
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Ariane Ambolet-Camoit, Min Ji Kim, Alix Leblanc & Martine Aggerbeck. (2012) Les polluants organiques persistants : implication dans l’obésité et le syndrome métabolique. Cahiers de Nutrition et de Diététique 47:4, pages 183-192.
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Liping Wang, Xiaoqing He, Yongyi Bi & Qiang Ma. (2012) Stem Cell and Benzene-Induced Malignancy and Hematotoxicity. Chemical Research in Toxicology 25:7, pages 1303-1315.
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Emma Wincent, Johanna Bengtsson, Afshin Mohammadi Bardbori, Tomas Alsberg, Sandra LueckeUlf Rannug & Agneta Rannug. (2012) Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences 109:12, pages 4479-4484.
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