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Novel models for assessing blood–brain barrier drug permeation

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Pages 647-653 | Published online: 03 Apr 2012

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Marta Tajes, Eva Ramos-Fernández, Xian Weng-Jiang, Mònica Bosch-Morató, Biuse Guivernau, Abel Eraso-Pichot, Bertrán Salvador, Xavier Fernàndez-Busquets, Jaume Roquer & Francisco J. Muñoz. (2014) The blood-brain barrier: Structure, function and therapeutic approaches to cross it. Molecular Membrane Biology 31:5, pages 152-167.
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Werner J. Geldenhuys & Jeffrey R. Bloomquist. (2021) Development of an a priori computational approach for brain uptake of compounds in an insect model system. Bioorganic & Medicinal Chemistry Letters 40, pages 127930.
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Eugene V. Radchenko, Alina S. Dyabina & Vladimir A. Palyulin. (2020) Towards Deep Neural Network Models for the Prediction of the Blood–Brain Barrier Permeability for Diverse Organic Compounds. Molecules 25:24, pages 5901.
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Suraj Kewal More & Atmaram Pandurang Pawar. (2020) Preparation, optimization and preliminary pharmacokinetic study of curcumin encapsulated turmeric oil microemulsion in zebra fish. European Journal of Pharmaceutical Sciences 155, pages 105539.
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Seong Soon KimSo Hee ImJung Yoon YangYu-Ri LeeGeum Ran KimJin Sil ChaeDae-Seop ShinJin Sook SongSunjoo AhnByung Hoi LeeJae Chun WooJin Hee AhnChang Soo YunPhiho KimHyoung Rae KimKyeong-Ryoon LeeMyung Ae Bae. (2017) Zebrafish as a Screening Model for Testing the Permeability of Blood–Brain Barrier to Small Molecules. Zebrafish 14:4, pages 322-330.
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Ye Li, Xiaoqing Miao, Tongkai Chen, Xiang Yi, Ruibing Wang, Haitao Zhao, Simon Ming-Yuen Lee, Xueqing Wang & Ying Zheng. (2017) Zebrafish as a visual and dynamic model to study the transport of nanosized drug delivery systems across the biological barriers. Colloids and Surfaces B: Biointerfaces 156, pages 227-235.
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Tianzhi Yang, Brittany Fogarty, Bret LaForge, Salma Aziz, Thuy Pham, Leanne Lai & Shuhua Bai. (2016) Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer. The AAPS Journal 19:2, pages 475-486.
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Alvaro Silva-Santisteban, Nicola Steinke, Andrew J. Johnston, Guadalupe N. Ruiz, Luis Carlos Pardo & Sylvia E. McLain. (2017) On the structure of prilocaine in aqueous and amphiphilic solutions. Physical Chemistry Chemical Physics 19:20, pages 12665-12673.
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Hisham Qosa, Loqman A. Mohamed, Sweilem B. Al Rihani, Yazan S. Batarseh, Quoc-Viet Duong, Jeffrey N. Keller & Amal Kaddoumi. (2016) High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity. Journal of Alzheimer's Disease 53:4, pages 1499-1516.
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Irina Kalashnikova, Norah Albekairi, Shariq Ali, Sanaalarab Al Enazy & Erik Rytting. 2016. Drug Delivery. Drug Delivery 131 151 .
Andrew J. Johnston, Sebastian Busch, Luis Carlos Pardo, Samantha K. Callear, Philip C. Biggin & Sylvia E. McLain. (2016) On the atomic structure of cocaine in solution. Physical Chemistry Chemical Physics 18:2, pages 991-999.
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Werner J Geldenhuys, Afroz S Mohammad, Chris E Adkins & Paul R Lockman. (2015) Molecular determinants of blood–brain barrier permeation. Therapeutic Delivery 6:8, pages 961-971.
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Helena E Richardson, Lee Willoughby & Patrick O Humbert. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 14 .
Melanie A. Huntley, Nga Bien-Ly, Richard Daneman & Ryan J. Watts. (2014) Dissecting gene expression at the blood-brain barrier. Frontiers in Neuroscience 8.
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Olga Andersson, Liesbeth Badisco, Ane Håkansson Hansen, Steen Honoré Hansen, Karin Hellman, Peter Aadal Nielsen, Line Rørbæk Olsen, Rik Verdonck, N. Joan Abbott, Jozef Vanden Broeck & Gunnar Andersson. (2014) Characterization of a novel brain barrier ex vivo insect‐based P‐glycoprotein screening model. Pharmacology Research & Perspectives 2:4.
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Line Rørbæk Olsen, Charlotte Gabel-Jensen, Peter Aadal Nielsen, Steen Honoré Hansen & Lassina Badolo. (2014) Identification of a Functional Homolog of the Mammalian CYP3A4 in Locusts. Drug Metabolism and Disposition 42:7, pages 1153-1162.
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John L. MikitshAnn-Marie Chacko. (2014) Pathways for Small Molecule Delivery to the Central Nervous System across the Blood-Brain Barrier. Perspectives in Medicinal Chemistry 6, pages PMC.S13384.
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Douglas B. Kell. (2013) Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it. FEBS Journal 280:23, pages 5957-5980.
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Birgit Obermeier, Richard Daneman & Richard M Ransohoff. (2013) Development, maintenance and disruption of the blood-brain barrier. Nature Medicine 19:12, pages 1584-1596.
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Sibel Bozdağ Pehlivan. (2013) Nanotechnology-Based Drug Delivery Systems for Targeting, Imaging and Diagnosis of Neurodegenerative Diseases. Pharmaceutical Research 30:10, pages 2499-2511.
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Alan M. Palmer & Mohammad S. Alavijeh. (2018) Overview of Experimental Models of the Blood‐Brain Barrier in CNS Drug Discovery. Current Protocols in Pharmacology 62:1.
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Ralf SchirrmacherVadim Bernard-Gauthier, Andrew Reader, Jean-Paul Soucy, Esther Schirrmacher, Björn Wängler & Carmen Wängler. (2013) Design of brain imaging agents for positron emission tomography: do large bioconjugates provide an opportunity for in vivo brain imaging? . Future Medicinal Chemistry 5:14, pages 1621-1634.
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O. Andersson, S. H. Hansen, K. Hellman, L. R. Olsen, G. Andersson, L. Badolo, N. Svenstrup & P. A. Nielsen. (2013) The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake. Journal of Pharmacology and Experimental Therapeutics 346:2, pages 211-218.
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Douglas B. Kell, Paul D. Dobson, Elizabeth Bilsland & Stephen G. Oliver. (2013) The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discovery Today 18:5-6, pages 218-239.
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Margareta Hammarlund-Udenaes. 2014. The Blood Brain Barrier (BBB). The Blood Brain Barrier (BBB) 21 48 .

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