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An update on the ability of St. John's wort to affect the metabolism of other drugs

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Pages 691-708 | Published online: 18 May 2012

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Dmitrij A Sychev, Ghulam Md Ashraf, Andrey A Svistunov, Maksim L Maksimov, Vadim V Tarasov, Vladimir N Chubarev, Vitalij A Otdelenov, Natal’ja P Denisenko, George E Barreto & Gjumrakch Aliev. (2018) The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo. Drug Design, Development and Therapy 12, pages 1147-1156.
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Amy C. Brown. (2018) Heart Toxicity Related to Herbs and Dietary Supplements: Online Table of Case Reports. Part 4 of 5.. Journal of Dietary Supplements 15:4, pages 516-555.
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Samaneh Soleymani, Roodabeh Bahramsoltani, Roja Rahimi & Mohammad Abdollahi. (2017) Clinical risks of St John’s Wort (Hypericum perforatum) co-administration. Expert Opinion on Drug Metabolism & Toxicology 13:10, pages 1047-1062.
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Helen M Sammons, Michael I Gubarev, Lubov V Krepkova, Valentina V Bortnikova, Fenella Corrick, Kathleen M Job, Catherine MT Sherwin & Elena Y Enioutina. (2016) Herbal medicines: challenges in the modern world. Part 2. European Union and Russia. Expert Review of Clinical Pharmacology 9:8, pages 1117-1127.
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Yong-Yeon Cho, Hyeon-Uk Jeong, Jeong-Han Kim & Hye Suk Lee. (2014) Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes. Drug Design, Development and Therapy 8, pages 2137-2145.
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Olivier Bouché & Pierre Laurent-PuigT. Lecomte. 2013. Médecine personnalisée en cancérologie digestive. Médecine personnalisée en cancérologie digestive 93 104 .

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