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Toxicological and metabolic considerations for histone deacetylase inhibitors

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Pages 441-457 | Published online: 04 Jan 2013

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Yuan-Yuan Liang, Cheng-Mei Zhang & Zhao-Peng Liu. (2018) Evaluation of WO2017018805: 1,3,4-oxadiazole sulfamide derivatives as selective HDAC6 inhibitors. Expert Opinion on Therapeutic Patents 28:8, pages 647-651.
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Rossana Ruiz, Luis E Raez & Christian Rolfo. (2015) Entinostat (SNDX-275) for the treatment of non-small cell lung cancer. Expert Opinion on Investigational Drugs 24:8, pages 1101-1109.
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Hairong Tang, Yuru Liang, Min Yu, Shaowen Cai, Kuiling Ding & Yang Wang. (2023) Discovery of chiral 1,4-diarylazetidin-2-one-based hydroxamic acid derivatives as novel tubulin polymerization inhibitors with histone deacetylase inhibitory activity. Bioorganic & Medicinal Chemistry 92, pages 117437.
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Platon Megagiannis, Rahul Suresh, Guy A. Rouleau & Yang Zhou. (2022) Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models. Advanced Drug Delivery Reviews 191, pages 114562.
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Hairong Tang, Yuru Liang, Hanchen Shen, Shaowen Cai, Min Yu, Hongrui Fan, Kuiling Ding & Yang Wang. (2022) Discovery of a 2,6-diarylpyridine-based hydroxamic acid derivative as novel histone deacetylase 8 and tubulin dual inhibitor for the treatment of neuroblastoma. Bioorganic Chemistry 128, pages 106112.
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Sylvain Lamoine, Mélissa Cumenal, David A. Barriere, Vanessa Pereira, Mathilde Fereyrolles, Laëtitia Prival, Julie Barbier, Ludivine Boudieu, Emilie Brasset, Benjamin Bertin, Yoan Renaud, Elisabeth Miot-Noirault, Marie-Ange Civiale, David Balayssac, Youssef Aissouni, Alain Eschalier & Jérôme Busserolles. (2021) The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice. International Journal of Molecular Sciences 23:1, pages 98.
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Maria Novella Romanelli, Vittoria Borgonetti & Nicoletta Galeotti. (2021) Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities. Pharmacological Research 173, pages 105901.
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Tanya J. Applegate, Greta M. Krafsur, June A. Boon, Hui Zhang, Min Li, Timothy N. Holt, S. Kelly Ambler, Benjamin A. Abrams, Daniel L. Gustafson, Karsten Bartels, Franklyn B. Garry, Kurt R. Stenmark & R. Dale Brown. (2021) Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension. Frontiers in Physiology 12.
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Anton Frühauf & Franz-Josef Meyer-Almes. (2021) Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases. Molecules 26:17, pages 5151.
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Chung-Pu Wu, Cheng-Yu Hung, Sabrina Lusvarghi, Yen-Fu Chang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu & Suresh. V. Ambudkar. (2021) Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat. International Journal of Molecular Sciences 22:5, pages 2592.
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Ehab Ghazy, Patrik Zeyen, Daniel Herp, Martin Hügle, Karin Schmidtkunz, Frank Erdmann, Dina Robaa, Matthias Schmidt, Elizabeth R. Morales, Christophe Romier, Stefan Günther, Manfred Jung & Wolfgang Sippl. (2020) Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. European Journal of Medicinal Chemistry 200, pages 112338.
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Harikrishna Reddy Rallabandi, Palanivel Ganesan & Young Jun Kim. (2020) Targeting the C-Terminal Domain Small Phosphatase 1. Life 10:5, pages 57.
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Xin Chen, Xinyang Chen, Raphael R. Steimbach, Tong Wu, Hongmei Li, Wenjia Dan, Peidong Shi, Chenyu Cao, Ding Li, Aubry K. Miller, Zhixia Qiu, Jinming Gao & Yong Zhu. (2020) Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity. European Journal of Medicinal Chemistry 187, pages 111950.
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Xiaodi Qiu, Xianfang Rong, Jin Yang & Yi Lu. (2019) Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure. BMC Ophthalmology 19:1.
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Chen, Lin, Liao, Liou & Chen. (2019) MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells. Cancers 11:10, pages 1617.
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Zishuo Mou, Jianjun Gao, He Miao, Li Zhang, Li Su, Baolei Wang & Yepeng Luan. (2019) Design and synthesis of novel histone deacetylase 6 inhibitors with benzyl-triazole as the core skeleton. BioScience Trends 13:3, pages 267-272.
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Chu Tang, Yang Du, Qian Liang, Zhen Cheng & Jie Tian. (2019) A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy . Journal of Materials Chemistry B 7:22, pages 3528-3536.
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He Miao, Jianjun Gao, Zishuo Mou, Baolei Wang, Li Zhang, Li Su, Yantao Han & Yepeng Luan. (2019) Design, synthesis and biological evaluation of 4-piperidin-4-yl-triazole derivatives as novel histone deacetylase inhibitors. BioScience Trends 13:2, pages 197-203.
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Joachim Alexandre, Javid J. Moslehi, Kevin R. Bersell, Christian Funck-Brentano, Dan M. Roden & Joe-Elie Salem. (2018) Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms. Pharmacology & Therapeutics 189, pages 89-103.
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Chung-Pu Wu, Ya-Ju Hsieh, Megumi Murakami, Shahrooz Vahedi, Sung-Han Hsiao, Ni Yeh, An-Wei Chou, Yan-Qing Li, Yu-Shan Wu, Jau-Song Yu & Suresh V. Ambudkar. (2018) Human ATP-binding cassette transporters ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines. Biochemical Pharmacology 155, pages 316-325.
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Kaijie Ma, Luye Qin, Emmanuel Matas, Lara J. Duffney, Aiyi Liu & Zhen Yan. (2018) Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism. Neuropsychopharmacology 43:8, pages 1779-1788.
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Jinyu Yang, Gaoliang Cheng, Qihao Xu, Shenglin Luan, Shuxiang Wang, Dan Liu & Linxiang Zhao. (2018) Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif. Bioorganic & Medicinal Chemistry 26:8, pages 1418-1425.
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Marije Bartels, Anita Govers, Roel Polak, Stephin Vervoort, Ruben van Boxtel, Cornelieke Pals, Marc Bierings, Wouter van Solinge, Toine Egberts, Edward Nieuwenhuis, Michal Mokry & Paul James Coffer. (2018) Megakaryocyte lineage development is controlled by modulation of protein acetylation. PLOS ONE 13:4, pages e0196400.
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Luye Qin, Kaijie Ma, Zi-Jun Wang, Zihua Hu, Emmanuel Matas, Jing Wei & Zhen Yan. (2018) Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nature Neuroscience 21:4, pages 564-575.
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Xuan Wang, Xiaoye Jiang, Shiyou Sun & Yongqiong Liu. (2018) Synthesis and biological evaluation of novel quinolone derivatives dual targeting histone deacetylase and tubulin polymerization as antiproliferative agents. RSC Advances 8:30, pages 16494-16502.
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Kaushik Datta & Kyle Kolaja. (2017) Epigenetics: Druggable targets for anti-cancer therapies. Current Opinion in Toxicology 6, pages 79-86.
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Maria Domenica Sanna, Luca Guandalini, Maria Novella Romanelli & Nicoletta Galeotti. (2017) The new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model. Pharmacology Biochemistry and Behavior 160, pages 70-75.
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Sofia Esteves, Sara Duarte-Silva & Patrícia Maciel. (2017) Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts. Medicinal Research Reviews 37:4, pages 860-906.
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Edward T. Bagu, Sayem Miah, Chenlu Dai, Travis Spriggs, Yetunde Ogunbolude, Erika Beaton, Michelle Sanders, Raghuveera K. Goel, Keith Bonham & Kiven E. Lukong. (2017) Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget 8:7, pages 11442-11459.
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Rezarta Cuni, Iris Parrini, Riccardo Asteggiano & Maria Rosa Conte. (2016) Targeted Cancer Therapies and QT Interval Prolongation: Unveiling the Mechanisms Underlying Arrhythmic Complications and the Need for Risk Stratification Strategies. Clinical Drug Investigation 37:2, pages 121-134.
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Niek GJ Leus, Martijn RH Zwinderman & Frank J Dekker. (2016) Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation. Current Opinion in Chemical Biology 33, pages 160-168.
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Zhuang Yang, Taijin Wang, Fang Wang, Ting Niu, Zhuowei Liu, Xiaoxin Chen, Chaofeng Long, Minghai Tang, Dong Cao, Xiaoyan Wang, Wei Xiang, Yuyao Yi, Liang Ma, Jingsong You & Lijuan Chen. (2015) Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer. Journal of Medicinal Chemistry 59:4, pages 1455-1470.
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Florence F. Wagner, Morten Lundh, Taner Kaya, Patrick McCarren, Yan-Ling Zhang, Shrikanta Chattopadhyay, Jennifer P. Gale, Thomas Galbo, Stewart L. Fisher, Bennett C. Meier, Amedeo Vetere, Sarah RichardsonNoel G. MorganDan Ploug Christensen, Tamara J. Gilbert, Jacob M. Hooker, Mélanie Leroy, Deepika Walpita, Thomas Mandrup-Poulsen, Bridget K. Wagner & Edward B. Holson. (2015) An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chemical Biology 11:2, pages 363-374.
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Stuart Gallagher, Jessamy Tiffen & Peter Hersey. (2015) Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy. Cancers 7:4, pages 1959-1982.
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Isabelle R. Miousse, Richard Currie, Kaushik Datta, Heidrun Ellinger-Ziegelbauer, John E. French, Alison H. Harrill, Igor Koturbash, Michael Lawton, Derek Mann, Richard R. Meehan, Jonathan G. Moggs, Raegan O’Lone, Reza J. Rasoulpour, Renee A. Reijo Pera & Karol Thompson. (2015) Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute. Toxicology 335, pages 11-19.
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H.E. CovingtonIIIIII, I. Maze, V. Vialou & E.J. Nestler. (2015) Antidepressant action of HDAC inhibition in the prefrontal cortex. Neuroscience 298, pages 329-335.
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Bradley S. Ferguson & Timothy A. McKinsey. (2015) Non-sirtuin histone deacetylases in the control of cardiac aging. Journal of Molecular and Cellular Cardiology 83, pages 14-20.
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Yongfeng Gong, Nina Himmerkus, Allein Plain, Markus Bleich & Jianghui Hou. (2015) Epigenetic Regulation of MicroRNAs Controlling CLDN14 Expression as a Mechanism for Renal Calcium Handling. Journal of the American Society of Nephrology 26:3, pages 663-676.
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Pierfausto Seneci. 2015. Chemical Modulators of Protein Misfolding and Neurodegenerative Disease. Chemical Modulators of Protein Misfolding and Neurodegenerative Disease 135 172 .
Dashyant Dhanak & Paul Jackson. (2014) Development and classes of epigenetic drugs for cancer. Biochemical and Biophysical Research Communications 455:1-2, pages 58-69.
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Florence F. Wagner, Michel Weїwer, Michael C. Lewis & Edward B. Holson. (2013) Small Molecule Inhibitors of Zinc-dependent Histone Deacetylases. Neurotherapeutics 10:4, pages 589-604.
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Sophie Schweizer, Andreas Meisel & Stefanie Märschenz. (2013) Epigenetic Mechanisms in Cerebral Ischemia. Journal of Cerebral Blood Flow & Metabolism 33:9, pages 1335-1346.
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David E. Olson, Florence F. Wagner, Taner Kaya, Jennifer P. Gale, Nadia Aidoud, Emeline L. Davoine, Fanny Lazzaro, Michel Weïwer, Yan-Ling Zhang & Edward B. Holson. (2013) Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors. Journal of Medicinal Chemistry 56:11, pages 4816-4820.
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