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Expert Opinion on Drug Metabolism & Toxicology Volume 9, 2013 - Issue 10
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Drug Evaluations

The pharmacokinetics of ilaprazole for gastro-esophageal reflux treatment

Nicola de BortoliUniversity of Pisa, Division of Gastroenterology, Department of Internal Medicine, Pisa, Italy
, MD,
Irene MartinucciUniversity of Pisa, Division of Gastroenterology, Department of Internal Medicine, Pisa, Italy
, MD,
Maria GiacchinoUniversity of Genoa, Division of Gastroenterology, Department of Internal Medicine, Genoa, Italy
, MD,
Corrado BlandizziUniversity of Pisa, Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, Pisa, Italy
,
Santino MarchiUniversity of Pisa, Division of Gastroenterology, Department of Internal Medicine, Pisa, Italy
, MD,
Vincenzo SavarinoUniversity of Genoa, Division of Gastroenterology, Department of Internal Medicine, Genoa, Italy
, MD &
Edoardo SavarinoUniversity of Padua, Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Via Giustiniani 2, 35128 Padua, Italy+0039 049 8217749; +0039 010 3538956; [email protected]
, MD PhD show all
Pages 1361-1369 | Published online: 27 Jun 2013

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Elisa Marabotto, Sebastiano Ziola, Vincenzo Savarino, Edoardo Giovanni Giannini, Manuele Furnari, Giorgia Bodini, Fabiana Zingone, Matteo Ghisa, Brigida Barberio, Patrizia Zentilin & Edoardo Savarino. (2020) Vonoprazan Fumarate for the Treatment of Gastric Ulcers: A Short Review on Emerging Data. Clinical and Experimental Gastroenterology 13, pages 99-104.
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Irene Martinucci, Corrado Blandizzi, Giorgia Bodini, Elisa Marabotto, Vincenzo Savarino, Santino Marchi, Nicola de Bortoli & Edoardo Savarino. (2017) Vonoprazan fumarate for the management of acid-related diseases. Expert Opinion on Pharmacotherapy 18:11, pages 1145-1152.
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Hongyun Wang, Ning Ou, Liwei Lang, Ruihua Shi, Pei Hu & Ji Jiang. (2016) Pharmacokinetics and pharmacodynamics of intravenous ilaprazole in healthy subjects after single ascending doses. Xenobiotica 46:12, pages 1133-1141.
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Edoardo Savarino, Irene Martinucci, Manuele Furnari, Chiara Romana, Gaia Pellegatta, Alessandro Moscatelli, Giorgia Bodini, Elisa Marabotto, Vincenzo Savarino, Nicola de Bortoli & Corrado Blandizzi. (2016) Vonoprazan for treatment of gastroesophageal reflux: pharmacodynamic and pharmacokinetic considerations. Expert Opinion on Drug Metabolism & Toxicology 12:11, pages 1333-1341.
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Edoardo Savarino, Andrea Ottonello, Irene Martinucci, Pietro Dulbecco & Vincenzo Savarino. (2016) Ilaprazole for the treatment of gastro-esophageal reflux. Expert Opinion on Pharmacotherapy 17:15, pages 2107-2113.
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Articles from other publishers (21)

Jianping Cheng, Chanjuan Fan, Kun Huang, Lili Zhai, Hui Wang, Dongling Xie, Yong Cai, Zhen Li, Qixuan Bai, Pan Wang & Haiou Ding. (2023) Efficacy and safety of high-dose ilaprazole-amoxicillin dual therapy for Helicobacter pylori eradication: a prospective, single-center, randomized trial. Frontiers in Pharmacology 14.
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Jonathan Leis, Chi-Hao Luan, James E. Audia, Sara F. Dunne & Carissa M. Heath. (2021) Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells. Journal of Virology 95:11.
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He-Jian Zhang, Xue-Hui Zhang, Jie Liu, Lu-Ning Sun, Yi-Wen Shen, Chen Zhou, Hong-Wen Zhang, Li-Jun Xie, Juan Chen, Yun Liu & Yong-Qing Wang. (2020) Effects of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of proton pump inhibitors. Pharmacological Research 152, pages 104606.
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Seung Woo Lee, Sung Jin Moon, Sae Hee Kim, Sung Hee Jung, Kyung Ho Song, Sun Moon Kim, Jae Kyu Sung & Dong Soo Lee. (2020) The prolongation effect of ilaprazole-based standard triple therapy for Helicobacter pylori. Medicine 99:38, pages e22137.
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Hongyun Wang, Feng Shao, Xuemei Liu, Wen Xu, Ning Ou, Xianghong Qin, Fang Liu, Xuemei Hou, Haitang Hu & Ji Jiang. (2019) Efficacy, safety and pharmacokinetics of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control. British Journal of Clinical Pharmacology 85:11, pages 2547-2558.
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S. Sobrino-Cossío, O. Teramoto-Matsubara, G. Mateos-Pérez, J.M. Abdo-Francis, J. Tawil, C. Olguín-Ramírez, A. Orozco-Gamiz & E.S. Galvis-García. (2019) In search of the grail: A race for acid suppression. Revista de Gastroenterología de México (English Edition) 84:3, pages 344-356.
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S. Sobrino-Cossío, O. Teramoto-Matsubara, G. Mateos-Pérez, J.M. Abdo-Francis, J. Tawil, C. Olguín-Ramírez, A. Orozco-Gamiz & E.S. Galvis-García. (2019) La búsqueda del Grial: una carrera por la supresión ácida. Revista de Gastroenterología de México 84:3, pages 344-356.
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Chang Seok Bang, Woon Geon Shin, Seung In Seo, Min Ho Choi, Hyun Joo Jang, Se Woo Park, Sea Hyub Kae, Young Joo Yang, Suk Pyo Shin, Gwang Ho Baik & Hak Yang Kim. (2018) Effect of ilaprazole on the healing of endoscopic submucosal dissection-induced gastric ulcer: randomized-controlled, multicenter study. Surgical Endoscopy 33:5, pages 1376-1385.
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Richard H. Hunt & Carmelo Scarpignato. (2018) Potent Acid Suppression with PPIs and P-CABs: What’s New?. Current Treatment Options in Gastroenterology 16:4, pages 570-590.
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Jie Pu, Fen Wang, Wei Tang & Mingshe Zhu. (2018) Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction. Drug Metabolism and Disposition 46:10, pages 1453-1461.
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Byung Hak Jin, Byung Won Yoo, Jungsin Park, Jung Hye Kim, Jun Yeon Lee, Jae Soo Shin & Min Soo Park. (2018) Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study. European Journal of Clinical Pharmacology 74:9, pages 1149-1157.
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In Ji SongHyun Ki KimNa Keum LeeSang Kil Lee. (2018) Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis. Yonsei Medical Journal 59:8, pages 951.
Crossref
Duowu Zou & Khean‐Lee Goh. (2017) East Asian perspective on the interaction between proton pump inhibitors and clopidogrel. Journal of Gastroenterology and Hepatology 32:6, pages 1152-1159.
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Arun Karyampudi, Uday C Ghoshal, Rajan Singh, Abhai Verma, Asha Misra & Vivek A Saraswat. (2017) Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease. Journal of Neurogastroenterology and Motility 23:2, pages 208-217.
Crossref
Hyo Jun Ahn, Dong Pil Kim, Myeong Su Chu, Hyeon Jeong Yun, Seok-Hwan Kim, Seung Woo Lee & Dong Soo Lee. (2017) Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections . Gastroenterology Research and Practice 2017, pages 1-6.
Crossref
Vincenzo Savarino, Pietro Dulbecco, Nicola de Bortoli, Andrea Ottonello & Edoardo Savarino. (2017) The appropriate use of proton pump inhibitors (PPIs): Need for a reappraisal. European Journal of Internal Medicine 37, pages 19-24.
Crossref
Jeong Hwan Kim. (2016) Pharmacologic Management of Nonvariceal Upper Gastrointestinal Bleeding. The Korean Journal of Helicobacter and Upper Gastrointestinal Research 16:4, pages 189.
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WonGun Kwack, YunJeong Lim, ChiYeon Lim & David Y. Graham. (2016) High Dose Ilaprazole/Amoxicillin as First-Line Regimen for Helicobacter pylori Infection in Korea . Gastroenterology Research and Practice 2016, pages 1-7.
Crossref
Xiao-Min Liao. (2015) Modified sequential therapy vs quadruple therapy as initial therapy in patients with Helicobacter infection . World Journal of Gastroenterology 21:20, pages 6310.
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Gang Yu, Xin-Qiang Lu, Rui-Bin Su, Ze-Hui Gong, He-Zhi Xie, Hai-Tang Hu & Xue-Mei Hou. (2014) Intravenous Ilaprazole Is More Potent than Oral Ilaprazole Against Gastric Lesions in Rats. Digestive Diseases and Sciences 59:10, pages 2417-2422.
Crossref
Jung Hwan Oh. (2014) Pharmacological Therapy of Peptic Ulcer. The Korean Journal of Helicobacter and Upper Gastrointestinal Research 14:1, pages 13.
Crossref

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