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Clinically relevant drug–drug interactions between antiretrovirals and antifungals

, , , & , PhD (Professor of Pharmacy, Chairman-Division of Pharmaceutical Sciences, Vice-Provost for Interdisciplinary Research)

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Marcela Q. Granato, Ingrid S. Sousa, Thabatta L. S. A. Rosa, Diego S. Gonçalves, Sergio H. Seabra, Daniela S. Alviano, Maria C. V. Pessolani, André L. S. Santos & Lucimar F. Kneipp. (2020) Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 629-638.
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Josefine Schulz, Franziska Kluwe, Gerd Mikus, Robin Michelet & Charlotte Kloft. (2019) Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism. Drug Metabolism Reviews 51:3, pages 247-265.
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E. Molas, S. Luque, A. Retamero, D. Echeverría-Esnal, A. Guelar, M. Montero, R. Guerri, L. Sorli, E. Lerma, J. Villar & H. Knobel. (2018) Frequency and severity of potential drug interactions in a cohort of HIV-infected patients Identified through a Multidisciplinary team. HIV Clinical Trials 19:1, pages 1-7.
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Theejutha Meakleartmongkol, Supawit Tangpanithandee, Natcha Vanavivit, Apisada Jiso, Pisut Pongchaikul, Suppachok Kirdlarp, Phisit Khemawoot & Surakit Nathisuwan. (2023) Potential drug–drug interactions of frequently prescribed medications in long COVID detected by two electronic databases. PLOS ONE 18:11, pages e0293866.
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Sai-li Xie, Xiayan Zhu, Nanyong Gao, Qianmeng Lin, Chaojie Chen, Yun-jun Yang, Jian-ping Cai, Guo-xin Hu & Ren-ai Xu. (2023) Genetic variations of CYP3A4 on the metabolism of itraconazole in vitro. Food and Chemical Toxicology 181, pages 114101.
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Cheng Ji. (2023) Molecular Factors and Pathways of Hepatotoxicity Associated with HIV/SARS-CoV-2 Protease Inhibitors. International Journal of Molecular Sciences 24:9, pages 7938.
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Jana K Dickter & Justine A Ross. (2023) Bictegravir/Emtricitabine/Tenofovir Alafenomide for the Treatment of HIV/Hepatitis B Virus Co-infection in Patients with Cancer and Transplant Recipients. Infectious Diseases 2:1, pages 31.
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Tucker Hansen, Jodie Baris, Min Zhao & Richard E. Sutton. (2022) Cell-based and cell-free firefly luciferase complementation assay to quantify Human Immunodeficiency Virus type 1 Rev-Rev interaction. Virology 576, pages 30-41.
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Yu Maeda, Ryota Tanaka, Ryosuke Tatsuta, Kuniko Takano, Takehiro Hashimoto, Masao Ogata, Kazufumi Hiramatsu & Hiroki Itoh. (2022) Impact of Inflammation on Intra-individual Variation in Trough Voriconazole Concentration in Patients with Hematological Malignancies. Biological and Pharmaceutical Bulletin 45:8, pages 1084-1090.
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Anik Banik, Sheikh Rashel Ahmed, Hlamrasong Marma, Shiuly Sinha, Md. Mostafigur Rahman Khan & Kawsar Miah. (2022) Targeting mucormycosis polyprotein (RVT_1 region) through antifungal phytochemicals: An in-silico perspective. Informatics in Medicine Unlocked 29, pages 100851.
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Huma Jafri, Samreen, Faizan Abul Qais, Hussein Hasan Abulreesh & Iqbal Ahmad. 2022. A Complete Guidebook on Biofilm Study. A Complete Guidebook on Biofilm Study 131 157 .
Lorraine T. Pfavayi, David W. Denning, Stephen Baker, Elopy N. Sibanda & Francisca Mutapi. (2021) Determining the burden of fungal infections in Zimbabwe. Scientific Reports 11:1.
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Elliot S. Gerlach, Sophie Altamirano, J. Marina Yoder, Tony S. Luggya, Andrew Akampurira, David B. Meya, David R. Boulware, Joshua Rhein & Kirsten Nielsen. (2021) ATI-2307 Exhibits Equivalent Antifungal Activity in Cryptococcus neoformans Clinical Isolates With High and Low Fluconazole IC50. Frontiers in Cellular and Infection Microbiology 11.
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Pornpun Vivithanaporn, Teetat Kongratanapasert, Bovornpat Suriyapakorn, Pichayut Songkunlertchai, Patpicha Mongkonariyawong, Patanachai K. Limpikirati & Phisit Khemawoot. (2021) Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases. Scientific Reports 11:1.
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Quanhathai Kaewpoowat, Romanee Chaiwarith, Saowaluck Yasri, Navaporn Worasilchai, Ariya Chindamporn, Thira Sirisanthana & Tim R Cressey. (2021) Drug–drug interaction between itraconazole capsule and efavirenz in adults with HIV for talaromycosis treatment. Journal of Antimicrobial Chemotherapy 76:4, pages 1041-1045.
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Vrinda Gote, Amar Deep Sharma & Dhananjay Pal. (2021) Hyaluronic Acid-Targeted Stimuli-Sensitive Nanomicelles Co-Encapsulating Paclitaxel and Ritonavir to Overcome Multi-Drug Resistance in Metastatic Breast Cancer and Triple-Negative Breast Cancer Cells. International Journal of Molecular Sciences 22:3, pages 1257.
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Morgan A Wambaugh, Steven T Denham, Magali Ayala, Brianna Brammer, Miekan A Stonhill & Jessica CS Brown. (2020) Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections. eLife 9.
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Aisling R. Caffrey & Eric P. Borrelli. (2021) The art and science of drug titration. Therapeutic Advances in Drug Safety 11, pages 204209862095891.
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Xueyun Wu & Yinzhong Shen. (2019) Management of human immunodeficiency virus–associated cryptococcal meningitis: Current status and future directions. Mycoses 62:10, pages 874-882.
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V. V. Belakhov, A. V. Garabadzhiu & T. B. Chistyakova. (2019) Polyene Macrolide Antibotic Derivatives: Preparation, Overcoming Drug Resistance, and Prospects for Use in Medical Practice (Review). Pharmaceutical Chemistry Journal 52:11, pages 890-901.
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E P Garvey, A D Sharp, P A Warn, C M Yates & R J Schotzinger. (2018) The novel fungal CYP51 inhibitor VT-1598 is efficacious alone and in combination with liposomal amphotericin B in a murine model of cryptococcal meningitis. Journal of Antimicrobial Chemotherapy 73:10, pages 2815-2822.
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Beata Sienkiewicz, Donata Urbaniak-Kujda, Jarosław Dybko, Andrzej Dryś, Magdalena Hurkacz, Tomasz Wróbel & Anna Wiela-Hojeńska. (2017) Influence of CYP2C19 Genotypes on the Occurrence of Adverse Drug Reactions of Voriconazole among Hematological Patients after Allo-HSCT. Pathology & Oncology Research 24:3, pages 541-545.
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Bhargavi Narayanan, Julie M. Lade, Carley J. S. Heck, Kevin D. Dietz, Herschel Wade & Namandjé N. Bumpus. (2018) Probing Ligand Structure–Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8‐Hydroxyefavirenz Exhibit Divergence in Activation. ChemMedChem 13:7, pages 736-747.
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Lucie Le Meur, Claire Tantet, Minh Patrick Lê, Emilie Desselas, Christine Bonnal, Agnès Lillo-Le-Louet, Romain Sonneville, Laurent Massias, Julie Giraud, Diane Descamps, Yazdan Yazdanpanah, Sylvie Lariven & Gilles Peytavin. (2018) Serious neuropsychiatric adverse effects related to interaction between itraconazole and darunavir/ritonavir in an HIV-infected patient with cerebral histoplasmosis. Journal of Antimicrobial Chemotherapy 73:4, pages 1108-1110.
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Oluwatosin O. Ogedengbe, Edwin C. S. Naidu & Onyemaechi O. Azu. (2017) Antiretroviral Therapy and Alcohol Interactions: X-raying Testicular and Seminal Parameters Under the HAART Era. European Journal of Drug Metabolism and Pharmacokinetics 43:2, pages 121-135.
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Kenneth Crombie, Zandile Spengane, Michael Locketz, Sipho Dlamini, Rannakoe Lehloenya, Sean Wasserman, Tsidiso G. Maphanga, Nelesh P. Govender, Chris Kenyon & Ilan S. Schwartz. (2018) Paradoxical worsening of Emergomyces africanus infection in an HIV-infected male on itraconazole and antiretroviral therapy. PLOS Neglected Tropical Diseases 12:3, pages e0006173.
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Letícia Aparecida Schiave, Erika Nascimento, Fernando Crivelenti Vilar, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Cristiane Masetto de Gaitani & Roberto Martinez. (2018) Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections. The Brazilian Journal of Infectious Diseases 22:1, pages 11-15.
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Jarrett R. Amsden & Paul O. Gubbins. 2018. Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions. Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions 425 501 .
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Li Zhu, Roger J. Brüggemann, Jonathan Uy, Angela Colbers, Matthew W. Hruska, Ellen Chung, Karen Sims, Blisse Vakkalagadda, Xiaohui Xu, Ron H. N. van Schaik, David M. Burger & Richard J. Bertz. (2017) CYP2C19 Genotype-Dependent Pharmacokinetic Drug Interaction Between Voriconazole and Ritonavir-Boosted Atazanavir in Healthy Subjects . The Journal of Clinical Pharmacology 57:2, pages 235-246.
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Beatriz Bustamante, Jose A. Hidalgo & Pablo E. Campos. 2017. Current Progress in Medical Mycology. Current Progress in Medical Mycology 29 89 .
Q.F. Fernando Bernal. (2016) FARMACOLOGÍA DE LOS ANTIRRETROVIRALES. Revista Médica Clínica Las Condes 27:5, pages 682-697.
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María Jesús Hernández Arroyo, Salvador Enrique Cabrera Figueroa, María Paz Valverde Merino & Alfonso Domínguez-Gil Hurlé. (2016) A pharmacist’s role in the individualization of treatment of HIV patients. Personalized Medicine 13:2, pages 169-188.
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Sarbjit Singh, Gajulapati Veeraswamy, Deepak Bhattarai, Ja-Il Goo, Kyeong Lee & Yongseok Choi. (2015) Recent Advances in the Development of Pharmacologically Active Compounds that Contain a Benzoxazole Scaffold. Asian Journal of Organic Chemistry 4:12, pages 1338-1361.
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Ilan S. Schwartz, Nelesh P. Govender, Craig Corcoran, Sipho Dlamini, Hans Prozesky, Rosie Burton, Marc Mendelson, Jantjie Taljaard, Rannakoe Lehloenya, Greg Calligaro, Robert Colebunders & Chris Kenyon. (2015) Clinical Characteristics, Diagnosis, Management, and Outcomes of Disseminated Emmonsiosis: A Retrospective Case Series. Clinical Infectious Diseases 61:6, pages 1004-1012.
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M. M. Chau, D. C. M. Kong, S. J. van Hal, K. Urbancic, J. A. Trubiano, M. Cassumbhoy, J. Wilkes, C. M. Cooper, J. A. Roberts, D. J. E. Marriott & L. J. Worth. (2014) Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014. Internal Medicine Journal 44:12b, pages 1364-1388.
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