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The pharmacokinetic considerations and adverse effects of DDP-4 inhibitors

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Ashwani Sharma, Tarun Virmani, Anjali Sharma, Vaishnavi Chhabra, Girish Kumar, Kamla Pathak & Abdulsalam Alhalmi. (2022) Potential Effect of DPP-4 Inhibitors Towards Hepatic Diseases and Associated Glucose Intolerance. Diabetes, Metabolic Syndrome and Obesity 15, pages 1845-1864.
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Mingkai Zhang, Ling Zhu, Gangcheng Wu, Tongtong Liu, Xiguang Qi & Hui Zhang. (2022) Food-derived dipeptidyl peptidase IV inhibitory peptides: Production, identification, structure-activity relationship, and their potential role in glycemic regulation. Critical Reviews in Food Science and Nutrition 0:0, pages 1-23.
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Caleb Acquah, Christian K. O. Dzuvor, Susan Tosh & Dominic Agyei. (2022) Anti-diabetic effects of bioactive peptides: recent advances and clinical implications. Critical Reviews in Food Science and Nutrition 62:8, pages 2158-2171.
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Theodosios D. Filippatos, Angelos Liontos, Ioanna Papakitsou & Moses S. Elisaf. (2019) SGLT2 inhibitors and cardioprotection: a matter of debate and multiple hypotheses. Postgraduate Medicine 131:2, pages 82-88.
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Christos V. Rizos, Theodosios D. Filippatos & Moses S. Elisaf. (2018) Pharmacokinetic drug evaluation of empagliflozin plus linagliptin for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 14:1, pages 117-125.
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Sebastian Filippas-Ntekouan, Theodosios D. Filippatos & Moses S. Elisaf. (2018) SGLT2 inhibitors: are they safe?. Postgraduate Medicine 130:1, pages 72-82.
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Theodosios Filippatos, Eleftheria Tzavella, Christos Rizos, Moses Elisaf & George Liamis. (2017) Acid-base and electrolyte disorders associated with the use of antidiabetic drugs. Expert Opinion on Drug Safety 16:10, pages 1121-1132.
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Vasilios Tsimihodimos, Theodosios D. Filippatos & Moses S. Elisaf. (2017) Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies. Expert Opinion on Drug Metabolism & Toxicology 13:4, pages 399-408.
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Takashi Kadowaki, Fuyuhiko Marubayashi, Shoko Yokota, Makoto Katoh & Hiroaki Iijima. (2015) Safety and efficacy of teneligliptin in Japanese patients with type 2 diabetes mellitus: a pooled analysis of two Phase III clinical studies. Expert Opinion on Pharmacotherapy 16:7, pages 971-981.
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Articles from other publishers (42)

Nikunj N Dave, Janvi P Shah & Akruti S Khodakiya. (2023) Concise review on anti-diabetic agents: Traditional to modern. Current Trends in Pharmacy and Pharmaceutical Chemistry 5:4, pages 114-122.
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Mingkai Zhang, Ling Zhu, Hui Zhang, Xingguo Wang, Gangcheng Wu & Xiguang Qi. (2023) Transepithelial Transport of the Bifunctional Peptide IPYWTY Indirectly Induced Insulin Release Mediated by Active GLP-1. Journal of Agricultural and Food Chemistry 71:34, pages 12749-12756.
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Seung Min Chung, Jun Sung Moon, Jun Hwa Hong, In‐Chang Hwang & Soo Lim. (2023) Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi‐heart study . Diabetes, Obesity and Metabolism 25:8, pages 2181-2190.
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Hong-Hong Ma, Jing Zhang, Ci-Qin Li & Li-Wei Zou. (2023) Discovery of anthraquinones as DPP-IV inhibitors: Structure-activity relationships and inhibitory mechanism. Fitoterapia 168, pages 105549.
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Eiji Kutoh, Alexandra N. Kuto, Midori Akiyama, Eri Ozawa & Rumi Kurihara. (2023) Alogliptin: a DPP-4 inhibitor modulating adipose tissue insulin resistance and atherogenic lipid. European Journal of Clinical Pharmacology 79:7, pages 947-959.
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Yosuke Nakagawa, Masao Toyoda, Nobumichi Saito, Noriko Kaneyama, Tomomichi Shimizu, Tomotaka Mabuchi & Masafumi Fukagawa. (2023) Clinical Phenotypes and the Clinical Course of Bullous Pemphigoid Receiving Dipeptidyl Pepitidase-4 Inhibitor Treatment: An Analysis of Cases in a Single Japanese Center. Internal Medicine 62:12, pages 1715-1722.
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Sae Im Jeong, Yun Kim, Jae Jin Nah, Wan Huh, In‐Jin Jang, Jun Gi Hwang & SeungHwan Lee. (2023) Pharmacokinetic and pharmacodynamic interaction of DWP16001, a sodium–glucose cotransporter 2 inhibitor, with gemigliptin and metformin in healthy adults. British Journal of Clinical Pharmacology 89:6, pages 1780-1788.
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Bhawna Puri, Sunita Meena, Sathish Kumar M H, Prashant Ashok Shelke, Latha Sabikhi & Ashutosh. (2023) Encapsulation and Assessment of Antidiabetic Potential of α-Lactalbumin-Derived Hydrolysates. Journal of Agricultural and Food Chemistry 71:14, pages 5547-5553.
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Eugenia Piragine, Davide Petri, Alma Martelli, Vincenzo Calderone & Ersilia Lucenteforte. (2023) Adherence to Oral Antidiabetic Drugs in Patients with Type 2 Diabetes: Systematic Review and Meta-Analysis. Journal of Clinical Medicine 12:5, pages 1981.
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Toru Ogura & Chihiro Shiraishi. (2023) Comparison of Adverse Events Occurred During Administration of Dipeptidyl Peptidase-4 Inhibitor in Patients with Diabetes Using FDA Adverse Event Reporting System. Clinical Drug Investigation 43:2, pages 129-140.
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Federica Ferrari, Antonio Moretti & Roberto Federico Villa. (2022) Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives. Pharmacology & Therapeutics 239, pages 108277.
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Mingkai Zhang, Ling Zhu, Gangcheng Wu, Tongtong Liu, Xiguang Qi & Hui Zhang. (2022) Rapid Screening of Novel Dipeptidyl Peptidase-4 Inhibitory Peptides from Pea ( Pisum sativum L. ) Protein Using Peptidomics and Molecular Docking . Journal of Agricultural and Food Chemistry 70:33, pages 10221-10228.
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Alba Miguéns-Gómez, Àngela Casanova-Martí, M. Teresa Blay, Ximena Terra, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Anna Ardévol & Montserrat Pinent. (2021) Glucagon-like peptide-1 regulation by food proteins and protein hydrolysates. Nutrition Research Reviews 34:2, pages 259-275.
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Hojin Oh, Hai Duc Nguyen, In Mo Yoon, Byung-Ryong Ahn & Min-Sun Kim. (2021) Antidiabetic effect of gemigliptin: a systematic review and meta-analysis of randomized controlled trials with Bayesian inference through a quality management system. Scientific Reports 11:1.
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Hojin Oh, Hai Duc Nguyen, In Mo Yoon & Min-Sun Kim. (2021) Efficacy and Tolerability of Evogliptin in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis with Bayesian Inference Through a Quality-management System. Clinical Therapeutics 43:8, pages 1336-1355.
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Chin-Ying Ray, Victor Chien-Chia Wu, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Chang-Fu Kuo & Shang-Hung Chang. (2021) Hypoglycemia Associated With Drug–Drug Interactions in Patients With Type 2 Diabetes Mellitus Using Dipeptidylpeptidase-4 Inhibitors. Frontiers in Pharmacology 12.
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Omnia Azmy Nabeh, Magdy Ishak Attallah & Nawal El‐Sayed El‐Gawhary. (2020) The pivotal relation between glucagon‐like peptides, NFκB and inflammatory bowel disease. Clinical and Experimental Pharmacology and Physiology 47:10, pages 1641-1648.
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Yuliet, Elin Y. Sukandar & I.K. Adnyana. (2020) Active Subfractions, Phytochemical Constituents, Dipeptidyl Peptidase-IV Inhibitory Activity and Antioxidant of Leaf Extract from Hibiscus surattensis L.. The Natural Products Journal 10:4, pages 400-410.
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Ágnes Kinyó. 2020. Cellular Metabolism and Related Disorders. Cellular Metabolism and Related Disorders.
Analía Verónica Yamaguchi, Pablo René Costanzo, Verónica Andrea Peuchot & Pablo Knoblovits. (2019) Testosterone Replacement Therapy and the Risk of Hypoglycemia. Case Reports in Endocrinology 2019, pages 1-5.
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Nordin MJ Hanssen & Karin AM Jandeleit-Dahm. (2019) Dipeptidyl peptidase-4 inhibitors and cardiovascular and renal disease in type 2 diabetes: What have we learned from the CARMELINA trial?. Diabetes and Vascular Disease Research 16:4, pages 303-309.
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Naina Mohamed Pakkir Maideen. (2019) Drug interactions of dipeptidyl peptidase 4 inhibitors involving CYP enzymes and P-gp efflux pump. World Journal of Meta-Analysis 7:4, pages 156-161.
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Yohei Kawaguchi, Risa Shimauchi, Nobuhiro Nishibori, Kiyohito Kawashima, So Oshitani, Atsushi Fujiya, Taiga Shibata, Norimi Ohashi, Kentaro Izumi, Wataru Nishie, Hiroshi Shimizu, Hiroshi Arima & Hiroshi Sobajima. (2018) Dipeptidyl peptidase‐4 inhibitors‐associated bullous pemphigoid: A retrospective study of 168 pemphigoid and 9,304 diabetes mellitus patients. Journal of Diabetes Investigation 10:2, pages 392-398.
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Isabelle M. E. Lacroix, Irene Dávalos Terán, Vincenzo Fogliano & Harry J. Wichers. (2018) Investigation into the potential of commercially available lesser mealworm ( A. diaperinus ) protein to serve as sources of peptides with DPP‐IV inhibitory activity . International Journal of Food Science & Technology 54:3, pages 696-704.
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Rui Liu, Jianming Cheng & Hao Wu. (2019) Discovery of Food-Derived Dipeptidyl Peptidase IV Inhibitory Peptides: A Review. International Journal of Molecular Sciences 20:3, pages 463.
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Xiaoxuan Li, Xuefei Huang, Chongfei Bai, Dalian Qin, Shousong Cao, Qibing Mei, Yun Ye & Jianming Wu. (2018) Efficacy and Safety of Teneligliptin in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Pharmacology 9.
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Gulmira Turdu, Hongwei Gao, Yingying Jiang & Madina Kabas. (2018) Plant dipeptidyl peptidase-IV inhibitors as antidiabetic agents: a brief review. Future Medicinal Chemistry 10:10, pages 1229-1239.
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Christoph Reichetzeder, Karoline von Websky, Oleg Tsuprykov, Azadeh Mohagheghi Samarin, Luise Gabriele Falke, Sulistyo Emantoko Dwi Putra, Ahmed Abdallah Hasan, Viktoriia Antonenko, Caterina Curato, Jörg Rippmann, Thomas Klein & Berthold Hocher. (2017) Head‐to‐head comparison of structurally unrelated dipeptidyl peptidase 4 inhibitors in the setting of renal ischemia reperfusion injury. British Journal of Pharmacology 174:14, pages 2273-2286.
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Ankit Gupta, Herbert F. Jelinek & Hayder Al-Aubaidy. (2017) Glucagon like peptide-1 and its receptor agonists: Their roles in management of Type 2 diabetes mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 11:3, pages 225-230.
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Isabelle M. E. Lacroix, Xiu-Min Chen, David D. Kitts & Eunice C. Y. Li-Chan. (2017) Investigation into the bioavailability of milk protein-derived peptides with dipeptidyl-peptidase IV inhibitory activity using Caco-2 cell monolayers. Food & Function 8:2, pages 701-709.
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Nobumasa Ohara, Masanori Kaneko, Kazuhiro Sato, Ryoko Maruyama, Tomoyasu Furukawa, Junta Tanaka, Kenzo Kaneko & Kyuzi Kamoi. (2016) Vildagliptin-induced acute lung injury: a case report. Journal of Medical Case Reports 10:1.
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Pablo Yang, Verónica Ojeda Heredia, Dante M. Beltramo & Néstor W. Soria. (2016) Pharmacogenetics and personalized treatment of type 2 diabetes mellitus. International Journal of Diabetes in Developing Countries 36:4, pages 508-518.
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Sung-Ho Kim, Eunsoo Jung, Min Kyung Yoon, O. Hwan Kwon, Dal-Mi Hwang, Dong-Wook Kim, Junghyun Kim, Sun-Mee Lee & Hyeon Joo Yim. (2016) Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo. European Journal of Pharmacology 788, pages 54-64.
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Isabelle M.E. Lacroix & Eunice C.Y. Li-Chan. (2016) Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations. Trends in Food Science & Technology 54, pages 1-16.
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Marcus May & Christoph Schindler. (2016) Clinically and pharmacologically relevant interactions of antidiabetic drugs. Therapeutic Advances in Endocrinology and Metabolism 7:2, pages 69-83.
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Isabelle M.E. Lacroix, Guangtao Meng, Imelda W.Y. Cheung & Eunice C.Y. Li-Chan. (2016) Do whey protein-derived peptides have dual dipeptidyl-peptidase IV and angiotensin I-converting enzyme inhibitory activities?. Journal of Functional Foods 21, pages 87-96.
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Sen Shi, Keizo Kanasaki & Daisuke Koya. (2016) Linagliptin but not Sitagliptin inhibited transforming growth factor-β2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition. Biochemical and Biophysical Research Communications 471:1, pages 184-190.
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Sung-Ho KimJung-Hwa YooWoo Je LeeCheol-Young Park. (2016) Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus. Diabetes & Metabolism Journal 40:5, pages 339.
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Enrique Z. Fisman & Alexander Tenenbaum. (2015) Antidiabetic treatment with gliptins: focus on cardiovascular effects and outcomes. Cardiovascular Diabetology 14:1.
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Isabelle M.E. Lacroix & Eunice C.Y. Li-Chan. (2015) Comparison of the susceptibility of porcine and human dipeptidyl-peptidase IV to inhibition by protein-derived peptides. Peptides 69, pages 19-25.
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M. K. Kim, E.‐J. Rhee, K. A. Han, A. C. Woo, M.‐K. Lee, B. J. Ku, C. H. Chung, K.‐A. Kim, H. W. Lee, I. B. Park, J. Y. Park, H. C. Chul Jang, K. S. Park, W. I. Jang & B. Y. Cha. (2015) Efficacy and safety of teneligliptin, a dipeptidyl peptidase‐4 inhibitor, combined with metformin in K orean patients with type 2 diabetes mellitus: a 16‐week, randomized, double‐blind, placebo‐controlled phase III trial . Diabetes, Obesity and Metabolism 17:3, pages 309-312.
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Theodosios D. Filippatos, Evangelos N. Liberopoulos & Moses S. Elisaf. (2014) Dapagliflozin in patients with type 2 diabetes mellitus. Therapeutic Advances in Endocrinology and Metabolism 6:1, pages 29-41.
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