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Original Research

Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences

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Mizuki Yamane, Fumihiko Igarashi, Tsuyoshi Yamauchi & Toshito Nakagawa. (2021) Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout. Xenobiotica 51:1, pages 61-71.
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Li Wang, Xiaodan Hong, Zhihong Yao, Yi Dai, Guoping Zhao, Zifei Qin, Baojian Wu, Frank J. Gonzalez & Xinsheng Yao. (2018) Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes. Xenobiotica 48:4, pages 357-367.
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Articles from other publishers (16)

Arpad Szallasi. (2022) Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?. Biomolecules 12:12, pages 1783.
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Han Xing, Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang, Zhihong Yao, Frank J Gonzalez & Xinsheng Yao. (2020) Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases . Journal of Pharmacy and Pharmacology 72:12, pages 1865-1878.
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Liangliang He, Jinjin Xu, Qi Wang, Yezi Zhang, Zifei Qin, Yang Yu, Zhengming Qian, Zhihong Yao & Xinsheng Yao. (2018) Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor. RSC Advances 8:72, pages 41368-41375.
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Zifei Qin, Shishi Li, Zhihong Yao, Xiaodan Hong, Jinjin Xu, Pei Lin, Guoping Zhao, Frank J. Gonzalez & Xinsheng Yao. (2018) Metabolic profiling of corylin in vivo and in vitro. Journal of Pharmaceutical and Biomedical Analysis 155, pages 157-168.
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Xiaokang Wang, Caiyun Jiang, Xiaosong Wu, Peng Zou & Zhufeng Wu. (2018) Substrate Selectivity for UDP-glucuronosyltransferase1A8 using the Pharmacophore Approach. International Journal of Pharmacology 14:3, pages 320-328.
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Xiaodan Hong, Yuanru Zheng, Zifei Qin, Baojian Wu, Yi Dai, Hao Gao, Zhihong Yao, Frank Gonzalez & Xinsheng Yao. (2017) In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes. International Journal of Molecular Sciences 18:9, pages 1983.
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Nan Li, Jian Miao, Jing Li, Yu-Ru Zhao, Hong-Mei Li, Yi-Qun Dai, Qiang Huo, Cheng-Zhu Wu & Tao Ma. (2017) Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase. Carbohydrate Research 446-447, pages 61-67.
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Fanxing Meng, Yan Li, Guiyuan He, Guangbo Ge & Shumin Liu. (2017) Identification of human UDP-glucuronosyltransferase isoforms involved in the isofraxidin glucuronidation and assessment of the species differences of the reaction. Fitoterapia 117, pages 118-125.
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Beibei Zhang, Xiaoli Chen, Rui Zhang, Fangfang Zheng, Shuzhang Du & Xiaojian Zhang. (2017) Metabolite Profiling, Pharmacokinetics, and In Vitro Glucuronidation of Icaritin in Rats by Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry. Journal of Analytical Methods in Chemistry 2017, pages 1-13.
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Xuejun Zeng, Jian Shi, Min Zhao, Qingwei Chen, Liping Wang, Huangyu Jiang, Feifei Luo, Lijun Zhu, Linlin Lu, Xinchun Wang & Zhongqiu Liu. (2016) Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells. PLOS ONE 11:11, pages e0166239.
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C. Mary Schooling, Lauren C. Houghton & Mary Beth Terry. (2016) Potential Intervention Targets in Utero and Early Life for Prevention of Hormone Related Cancers. Pediatrics 138:Supplement_1, pages S22-S33.
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Peimin Dai, Feifei Luo, Ying Wang, Huangyu Jiang, Liping Wang, Guiyu Zhang, Lijun Zhu, Ming Hu, Xinchun Wang, Linlin Lu & Zhongqiu Liu. (2015) Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. Biopharmaceutics & Drug Disposition 36:9, pages 622-635.
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Hua Sun, Xiaotong Zhou, Xingwang Zhang & Baojian Wu. (2015) Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling. Journal of Agricultural and Food Chemistry 63:26, pages 6001-6008.
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Hua Sun, Zhiguo Ma, Danyi Lu & Baojian Wu. (2015) Regio- and Isoform-Specific Glucuronidation of Psoralidin: Evaluation of 3-O-Glucuronidation as a Functional Marker for UGT1A9. Journal of Pharmaceutical Sciences 104:7, pages 2369-2377.
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Xingwang Zhang, Dong Dong, Huailing Wang, Zhiguo Ma, Yifei Wang & Baojian Wu. (2015) Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay. Molecular Pharmaceutics 12:4, pages 1268-1278.
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Xiaotong Zhou, Xingwang Zhang, Yanghuan Ye, Tianpeng Zhang, Huan Wang, Zhiguo Ma & Baojian Wu. (2015) Nanostructured lipid carriers used for oral delivery of oridonin: An effect of ligand modification on absorption. International Journal of Pharmaceutics 479:2, pages 391-398.
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